29 completed, 10 unknown, 4 terminated, 4 withdrawn. 51 Phase 1, 10 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 51 | Completed 29, Unknown 10, Terminated 4, Withdrawn 4, Recruiting 3, Not yet recruiting 1 |
| Phase 2 | 10 | Completed 6, Recruiting 2, Unknown 1, Withdrawn 1 |
Follow Aneurysm: new trials by email Literature Review of Aneurysm trials Research Report on Aneurysm
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| HEART: Pilot Randomized Controlled Trial Spironolactone, Placebo - Thoracic Aortic Aneurysm | Phase 1 / Phase 2 | Recruiting | Mayo Clinic | 50 | 2026-05-25 | 2026-06-08 |
| Study to Evaluate the TUBE Device Ability to Treat Unruptured, Wide-neck or Fusiform Aneurysms TUBE Flow Diverter - Aneurysm Cerebral | Phase 1 | Not yet recruiting | NVMedTech | 20 | 2025-10-01 | 2025-07-23 |
| Infliximab Therapy for Dolichoectactic Vertebrobasilar Aneurysms Infliximab - Aneurysm, Stroke | Phase 1 / Phase 2 | Recruiting | University of California, San Francisco | 8 | 2024-10-01 | 2026-06-11 |
| Nicotinamide Riboside (NR) to Treat Moyamoya-like Cerebrovascular Disease in Smooth Muscle Dysfunction Syndrome (SMDS) Nicotinamide riboside (NR) - Smooth Muscle Dysfunction Syndrome (SMDS) | Phase 1 | Recruiting | The University of Texas Health Science Center, Houston | 15 | 2024-03-06 | 2025-09-12 |
| Onabotulinum Toxin A (Botox) for the Treatment of Persistent Post-Stroke and Vascular Headache Botox 200 UNT Injection, Non Botox based Standard of Care Treatments for Headache/Migraine - Stroke (CVA) or TIA, Headache, Migraine | Phase 1 | Withdrawn | University of Alberta | 2023-12-01 | 2024-09-19 | |
| Deferoxamine in Aneurysmal Subarachnoid Hemorrhage Trial Deferoxamine, placebo - Intracranial Aneurysm, Subarachnoid Hemorrhage | Phase 1 / Phase 2 | Unknown | Radboud University Medical Center | 40 | 2022-12-02 | 2023-04-24 |
| Methylprednisolone Pulse Therapy for Coronary Artery Dilatation or Aneurysm Formation in Kawasaki Disease Methylprednisolone Injection - Mucocutaneous Lymph Node Syndrome | Phase 1 | Unknown | Chang Gung Memorial Hospital | 10 | 2020-04-15 | 2020-08-11 |
| Canadian eCLIPs™ Safety and Feasibility Study Protocol eCLIPs™ Family of Products - Intracranial Aneurysms | Phase 1 | Withdrawn | Evasc Medical Systems Corp. | 2020-01-01 | 2019-02-08 | |
| Comparison of Carbon Dioxide and Saline Flush to Saline Flush in TEVAR and TAVI Procedures to Reduce Cerebral Ischemia Carbon Dioxide and Saline Flush, Standard Saline Flush - Thoracic Aortic Aneurysm, Aortic Stenosis Symptomatic | Phase 1 | Unknown | University Health Network, Toronto | 20 | 2019-07-20 | 2020-09-23 |
| Detection of Hypoxia in Human Thoracic Aorta Using Pimonidazole Hydrochloride Pimonidazole hydrochloride - Aortic Aneurysm, Thoracic | Phase 1 | Completed | Thomas Gleason | 9 | 2018-09-01 | 2026-01-23 |
| Radial Artery Vasodilation Heat Study Topical Heat - Radial Artery | Phase 1 / Phase 2 | Completed | Oregon Health and Science University | 45 | 2018-08-03 | 2019-09-25 |
| The Nitrite and Coronary Flow Study Sodium Nitrite - Cardiovascular Diseases, Vasodilation | Phase 1 / Phase 2 | Completed | University of East Anglia | 14 | 2018-07-01 | 2020-04-21 |
| Mechanisms of Cerebrovascular Control NOS Inhibition, ET-1 Inhibition, NOS Inhibition Placebo - Metabolic Syndrome X | Phase 1 | Completed | University of Wisconsin, Madison | 59 | 2017-01-31 | 2021-10-18 |
| Safety and Efficacy of Allogeneic MSCs in Promoting T-regulatory Cells in Patients With Small Abdominal Aortic Aneurysms 1 million MSCs/kg, 3 million MSCs/kg, Placebo - Abdominal Aortic Aneurysm | Phase 1 | Terminated | VA Office of Research and Development | 28 | 2016-12-05 | 2024-08-09 |
| The Haem and Nitrite Study - The Effects of Haemoglobin NO-blockade on Nitrite-induced Forearm Vessel Dilatation Sodium Nitrite - Healthy Volunteers | Phase 1 | Unknown | University of East Anglia | 41 | 2016-12-01 | 2017-03-20 |
| The Effect of Antioxidants on Skin Blood Flow During Local Heating Control (Lactated Ringer's), Tempol, Apocynin - Cardiovascular Diseases, Cardiovascular Risk Factor | Phase 1 | Completed | The University of Texas at Arlington | 44 | 2016-09-07 | 2018-09-21 |
| Safety/Pharmacokinetic Study Comparing Intracisternal EG-1962 to Standard of Care Enteral Nimodipine in Adults With aSAH EG-1962 (nimodipine microparticles), Enteral Nimodipine - Subarachnoid Hemorrhage, Aneurysmal | Phase 1 | Terminated | Edge Therapeutics Inc | 6 | 2016-09-01 | 2018-07-26 |
| Intraoperative Nasal Insulin Effect on Plasma and CSF Insulin Concentration and Blood Glucose Humulin R, Normal Saline - Ischemic Heart Disease, Aortic Aneurysm | Phase 1 | Unknown | Hiroaki Sato, MD., PhD. | 141 | 2016-09-01 | 2021-02-24 |
| Study of Safety and Tolerability of UNIFUZOL (Solution for Infusions) in Healthy Volunteers arginine sodium succinate - Peripheral Vascular Disease | Phase 1 | Completed | POLYSAN Scientific & Technological Pharmaceutical Company | 48 | 2016-07-15 | 2020-07-14 |
| Effect of Intraventricular tPA Following Aneurysmal Subarachnoid Hemorrhage Tissue Plasminogen Activator - Subarachnoid Hemorrhage, Cerebral Vasospasm | Phase 1 / Phase 2 | Withdrawn | Rush University Medical Center | 2015-03-01 | 2015-11-11 |
Showing 20 of 51. Sign in to see all of them.
Aortic Aneurysm, Abdominal (10) · Subarachnoid Hemorrhage (8) · Intracranial Aneurysm (6) · Stroke (6) · Aortic Aneurysm, Thoracic (5) · Aortic Aneurysm (4) · Hypertension (3) · Hypoxia (3) · Arteriovenous Malformations (2) · Cardiovascular Diseases (2) · Hypercholesterolemia (2) · Obesity (2) · Vasospasm, Intracranial (2) · Anemia, Sickle Cell (1)
Vascular Diseases (51) · Cardiovascular Diseases (49) · Aortic Diseases (17) · Brain Diseases (15) · Central Nervous System Diseases (15) · Nervous System Diseases (15) · Pathological Conditions, Signs and Symptoms (15) · Cerebrovascular Disorders (14) · Aortic Aneurysm (13) · Pathologic Processes (9) · Hemorrhage (8) · Intracranial Hemorrhages (8) · Intracranial Arterial Diseases (6) · Nutritional and Metabolic Diseases (6)
Sodium Nitrite (4) · omega-N-Methylarginine (3) · Doxycycline (2) · Allopurinol (1) · Aspirin (1) · Bradykinin (1) · Carbon Dioxide (1) · Dantrolene (1) · Deferoxamine (1) · EG-1962 (1) · Glucose Tolerance Test (1) · Hot Temperature (1) · Infliximab (1) · Insulin (1) · Lactose (1)
National Heart, Lung, and Blood Institute (NHLBI) (4) · Codman & Shurtleff (3) · University of California, San Francisco (3) · University Health Network, Toronto (2) · University of East Anglia (2) · University of Wisconsin, Madison (2) · Aarhus University Hospital (1) · Altura Medical Inc. (1) · Arizona Heart Institute (1) · Bolton Medical (1) · Boston Scientific Corporation (1) · Chang Gung Memorial Hospital (1) · Cordis US Corp. (1) · Duke Vascular, Inc. (1) · Edge Therapeutics Inc (1)
United States (28) · Canada (6) · United Kingdom (3) · Chile (2) · Argentina (1) · Brazil (1) · Denmark (1) · Finland (1) · Germany (1) · Italy (1) · Latvia (1) · Netherlands (1) · Norway (1) · Russia (1) · Switzerland (1)
Albrecht Kramer, MD (1) · Chanhung Lee, MD (1) · Daniel L Cooke, MD (1) · Dianna Milewicz, MD, PhD (1) · Edoardo Boccardi, MD (1) · Edward B Diethrich, M.D. (1) · Ekkehard Kunze, MD (1) · Francisco Valdes, MD (1) · Frode Manstad-Hulaas, MD (1) · Jeroen Boogaarts, M.D., Ph.D. (1) · John F Tisdale, M.D. (1) · John R Sims, MD (1) · Kartikeshwar Kasirajan, M.D. (1) · Kong Teng Tan, MD (1) · Kong Teng Tan, MD, FRCPC (1)
PMID 17476494, PMID 18212521, PMID 20137879, PMID 21249218, PMID 21454813, PMID 22313205, PMID 23416349, PMID 23525414, PMID 23793234, PMID 23978572, PMID 24763187, PMID 25072112, PMID 25148012, PMID 25164919, PMID 25204854, PMID 25500317, PMID 26381856, PMID 27207552, PMID 27910097, PMID 28382529, PMID 29765218, PMID 30152015, PMID 30232673, PMID 30617735, PMID 30895515, PMID 32985652, PMID 33236783, PMID 33721199, PMID 34083595, PMID 35920945, PMID 36645250, PMID 37624739
P50HL083800 (1), R01HL105820 (1)