8 completed, 2 terminated, 1 not yet recruiting, 1 recruiting. 11 Phase 2, 4 Phase 1, 4 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 11 | Completed 7, Terminated 2, Not yet recruiting 1, Recruiting 1 |
| Phase 1 | 4 | Completed 3, Recruiting 1 |
| Phase 3 | 4 | Completed 2, Not yet recruiting 1, Terminated 1 |
Follow Dantrolene: new trials by email Literature Review of Dantrolene trials Research Report on Dantrolene
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Dantrolene in Statin-induced Myopathy Dantrolene, Placebo - Statins Induced Myopathy | Phase 2 / Phase 3 | Not yet recruiting | Tanta University | 23 | 2027-10-01 | 2025-05-13 |
| A Clinical Trial Utilizing Dantrolene in Patients With Ventricular Arrhythmias. Dantrolene/Ryanodex, Placebo - Ventricular Tachycardia | Phase 2 / Phase 3 | Completed | Vanderbilt University Medical Center | 68 | 2020-08-21 | 2026-10-08 |
| The Use of Dantrolene to Improve Analgesia in Posterior Lumbar Surgery Dantrolene, Placebo Oral Tablet - Lumbar Spine Injury | Phase 2 | Completed | Beth Israel Deaconess Medical Center | 116 | 2019-07-29 | 2026-06-18 |
| Study to Assess the Efficacy and Safety of Ryanodex as Adjuvant Treatment in Subjects With EHS Ryanodex and Standard of Care, Standard of Care - Exertional Heat Stroke | Phase 3 | Completed | Eagle Pharmaceuticals, Inc. | 17 | 2018-08-19 | 2021-05-19 |
| Efficacy and Safety Study of Ryanodex as Adjuvant Treatment in Subjects With Psychostimulant Drug-Induced Toxicity (PDIT) Ryanodex (dantrolene sodium) for injectable suspension - Drug Toxicity Psychotropic Agents Psychostimulants | Phase 2 | Terminated | Eagle Pharmaceuticals, Inc. | 2 | 2017-08-12 | 2021-03-30 |
| Targeting Residual Activity By Precision, Biomarker-Guided Combination Therapies of Multiple Sclerosis (TRAP-MS) Cilostazol, Leucovorin, Pirfenidone - Multiple Sclerosis | Phase 1 / Phase 2 | Recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 250 | 2017-08-11 | 2026-10-20 |
| A Clinical Trial of Dantrolene Sodium in Pediatric and Adult Patients With Wolfram Syndrome dantrolene sodium - Wolfram Syndrome, Diabetes Mellitus | Phase 1 / Phase 2 | Completed | Washington University School of Medicine | 21 | 2017-01-01 | 2024-03-13 |
| Efficacy and Safety of Ryanodex® (EGL-4104) as Adjuvant Treatment in Subjects With Exertional Heat Stroke (EHS) Dantrolene sodium for injectable suspension - Heat Stroke | Phase 2 | Completed | Eagle Pharmaceuticals, Inc. | 34 | 2015-09-01 | 2021-06-29 |
| Study of Human Non-Shivering Thermogenesis and Basal Metabolic Rate Propranolol, Pindolol, Dantrolene - Healthy Volunteers | Phase 2 | Completed | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 47 | 2014-02-07 | 2024-10-16 |
| Safety Study of Dantrolene in Subarachnoid Hemorrhage Dantrolene, Placebo - Subarachnoid Hemorrhage, Cerebral Vasospasm | Phase 1 / Phase 2 | Completed | University of Massachusetts, Worcester | 31 | 2009-10-01 | 2015-03-05 |
| Dantrolene for Treatment of Hyperthermia in Subarachnoidal Hemorrhage (SAH) Dantrolene, Placebo - Hyperthermia | Phase 2 / Phase 3 | Terminated | Medical University of Vienna | 34 | 2008-05-01 | 2011-05-12 |
| Safety Study of Dantrolene to Treat Cerebral Vasospasm After Subarachnoid Hemorrhage Dantrolene - Cerebral Vasospasm After Subarachnoid Hemorrhage | Phase 1 / Phase 2 | Completed | University of Massachusetts, Worcester | 10 | 2007-07-01 | 2012-05-25 |
Subarachnoid Hemorrhage (2) · Aneurysm (1) · Ataxia (1) · Diabetes Mellitus (1) · Heat Stroke (1) · Hyperthermia (1) · Multiple Sclerosis (1) · Multiple Sclerosis, Chronic Progressive (1) · Optic Atrophy (1) · Spinal Injuries (1) · Tachycardia, Ventricular (1) · Vasospasm, Intracranial (1) · Wolfram Syndrome (1)
Eagle Pharmaceuticals, Inc. (3) · University of Massachusetts, Worcester (2) · Beth Israel Deaconess Medical Center (1) · Medical University of Vienna (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (1) · Tanta University (1) · Vanderbilt University Medical Center (1) · Washington University School of Medicine (1)
United States (8) · Saudi Arabia (2) · Austria (1)
Susanne Muehlschlegel, MD (2) · Adrian Hepner (1) · Adrian Hepner, MD (1) · Andrea Holzer, MD (1) · Bibiana Bielekova, M.D. (1) · Fumihiko Urano, MD (1) · John R Sims, MD (1) · Kong Y Chen, Ph.D. (1) · Richard J Pollard, MD (1) · William Stevenson, MD (1)
PMID 21454813, PMID 25344064, PMID 29980535, PMID 33848093, PMID 34185708, PMID 40371642, PMID 40894163
R21DK113487 (1)