88 completed, 15 unknown, 11 terminated, 5 recruiting. 36 Phase 2, 33 Not applicable, 24 Phase 4, 17 Phase 3, 14 Phase 1.
Follow Lactose: new trials by email Literature Review of Lactose trials Research Report on Lactose
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Human Cerebrovascular Blood Flow and Sex Differences in Metabolic Syndrome Indomethacin, Placebo, MRI - Metabolic Syndrome | Early Phase 1 | Not yet recruiting | University of Wisconsin, Madison | 72 | 2026-10-01 | 2026-09-29 |
| Evaluating the Impact of Synbiotic Supplementation on Infants and Toddlers Synbiotic Supplement, Lactose (inactive placebo) - Gastrointestinal Tolerance of Probiotics in Infants | Not applicable | Completed | Persephone Biosciences | 110 | 2025-01-01 | 2026-08-25 |
| Evaluation of the Efficacy and Tolerability of an Exclusion Diet in Patients With Juvenile Idiopathic Arthritis complete, polymeric formula, fiber, lactose and gluten free - Juvenile Idiopathic Arthritis (JIA) | Not applicable | Recruiting | Meyer Children's Hospital IRCCS | 20 | 2024-12-12 | 2025-03-13 |
| Testing the Capability of the Smart Underwear Device to Detect Increased Microbiome Activity Following Lactose Consumption Lactose, Sucrose, Wear smart underwear - Lactose Intolerance, Adult Type | Not applicable | Completed | University of Maryland, College Park | 37 | 2024-12-05 | 2026-05-01 |
| Perioperative Vitamin C to Reduce Persistent Pain After Total Knee Arthroplasty Vitamin C, Placebo - Chronic Pain, Knee Pain Chronic | Phase 2 | Recruiting | University Health Network, Toronto | 400 | 2024-04-16 | 2026-06-23 |
| Methylphenidate for the Treatment of Epilepsy-related Cognitive Deficits Methylphenidate, Placebo - Epilepsy | Phase 4 | Recruiting | VA Office of Research and Development | 226 | 2023-08-14 | 2026-04-20 |
| Effects of Caffeine on Reinforcement Learning in Healthy Adults Using PET/MRI Caffeine (200 mg), Placebo - Healthy, Caffeine | Phase 4 | Recruiting | Hsiao-Ying Wey | 12 | 2023-05-17 | 2025-01-09 |
| The Role of Colchicine in Reducing The Rate of Myocardial Reperfusion Injury Colchicine, Placebo (lactose) - Reperfusion Injury, Myocardial | Phase 3 | Unknown | Universitas Indonesia | 80 | 2022-12-04 | 2023-02-21 |
| Study Design of the Diacerein in Patients With Covid-19 Diacerein, placebo capsules - COVID-19 | Phase 2 | Unknown | University of Campinas, Brazil | 40 | 2022-04-01 | 2022-08-02 |
| Preoperative Melatonin to Decrease Analgesia Usage After Third Molar Surgery Melatonin 10 MG, Lactose pill - Pain, Postoperative, Narcotic Use | Phase 2 | Completed | Montefiore Medical Center | 60 | 2021-11-16 | 2026-01-30 |
| Role of Strontium Ranelate in Proximal Femur Fragility Fractures. Strontium Ranelate, Lacto-N-Hexaose - Fragility Fracture, Femur; Fracture, Pertrochanteric | Phase 4 | Unknown | Aga Khan University Hospital, Pakistan | 100 | 2021-11-01 | 2023-02-03 |
| Validation of the Drug Impaired Driving Scenario (DIDS) on the CRCDS-miniSim Placebo (Lactose) Capsule, 0.75 mg Alprazolam Capsule, Cannabis (6.18% THC / <0.025% CBD) - Driving Behavior, Driving Under the Influence | Phase 1 | Completed | Timothy L. Brown | 13 | 2021-07-16 | 2023-07-25 |
| Sildenafil for Treatment of Urinary Incontinence in Patients With Spinal Cord Injuries Sildenafil Citrate, Placebo - Spinal Cord Injuries, Urinary Incontinence | Phase 2 | Active not recruiting | The University of Texas Medical Branch, Galveston | 24 | 2021-07-07 | 2026-09-09 |
| Effect of Lactose on Blood Lipids Maltodextrin, Sucrose, Lactose - Cardiovascular Risk Factor, Lipaemia | Not applicable | Completed | University of Bath | 26 | 2021-06-07 | 2024-09-23 |
| Acetazolamide Efficacy in Ataxia in PMM2-CDG Placebo, Acetazolamide - Pmm2-CDG, CDG1A | Phase 2 / Phase 3 | Terminated | Mayo Clinic | 25 | 2021-03-17 | 2025-03-20 |
| Low-FODMAP vs Lactose-Gluten-Free Diet in Patients With Irritable Bowel Syndrome Low-FODMAP Diet, Lactose- and Gluten-Free Diet - Irritable Bowel Syndrome | Not applicable | Completed | Antalya Bilim University | 72 | 2020-09-01 | 2026-07-23 |
| A Comparison of Two Different Single Doses of Prednisolone on Endodontic Inter-appointment Pain Prednisolone, lactose in capsules gelatin - Endodontics, Pain | Phase 2 | Unknown | King Saud University | 72 | 2020-08-09 | 2020-07-22 |
| Efficacy of a Standardized Centella Asiatica Extract in Patients With Temporomandibular Disorder ECa 233, Ibuprofen, Placebo - Temporomandibular Disorder | Phase 2 / Phase 3 | Completed | Chulalongkorn University | 23 | 2020-08-05 | 2024-02-07 |
| Mirtogenol and Bimatoprost on IOP in Hispanics With Open-Angle Glaucoma Experimental: Oral Mirtogenol, Placebo of oral Dietary supplement - Glaucoma | Not applicable | Unknown | University of Puerto Rico | 72 | 2020-05-15 | 2020-05-08 |
| Feasibility of a Clinical Trial Comparing the Use of Cetirizine to Replace Diphenhydramine in the Prevention of Reactions Related to Paclitaxel Diphenhydramine, Cetirizine, Lactose pill - Breast Cancer, Lung Cancer | Phase 3 | Completed | Ciusss de L'Est de l'Île de Montréal | 27 | 2020-02-14 | 2020-10-12 |
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Pain (7) · Anxiety Disorders (5) · Pain, Postoperative (5) · Alcoholism (3) · Depression (3) · Inflammation (3) · Lactose Intolerance (3) · Mental Disorders (3) · Metabolic Syndrome (3) · Obesity (3) · Psychotic Disorders (3) · Pulmonary Disease, Chronic Obstructive (3) · Schizophrenia (3) · Vitamin D Deficiency (3) · Asthma (2)
University of Wisconsin, Madison (4) · Centre for Addiction and Mental Health (3) · Samuel Lunenfeld Research Institute, Mount Sinai Hospital (3) · The Alfred (3) · Biota Scientific Management Pty Ltd (2) · Hospital Italiano de Buenos Aires (2) · Mayo Clinic (2) · Nantes University Hospital (2) · Resilient Pharmaceuticals (2) · Ullevaal University Hospital (2) · Universidad Nacional Andres Bello (2) · University Health Network, Toronto (2) · University Hospital, Clermont-Ferrand (2) · University of Toronto (2) · Aga Khan University Hospital, Pakistan (1)
United States (40) · Canada (20) · France (11) · United Kingdom (9) · Australia (5) · Norway (4) · Belgium (3) · Iran (3) · South Korea (3) · Argentina (2) · Brazil (2) · Chile (2) · Denmark (2) · Germany (2) · Indonesia (2)
Jose CA Carvalho, MD (3) · Bernard Le Foll, MD, PhD (2) · Gaute Lyngstad, DDS (2) · K. Rajender Reddy, MD (2) · Mariely A Navarrete, MSc (2) · Michael Fried, MD (2) · Nezam Afdhal, MD (2) · Victor Navarro, MD (2) · Ahmaed Y Gamal (1) · Ahmed S Mahmood, MSc (1) · Allan L Reiss (1) · Allan Struthers, MD FRCP (1) · Andrei C Sposito, MD.PHD (1) · Andrew Szilagyi, MD (1)
PMID 15643744, PMID 31415936, PMID 12751655, PMID 16488940, PMID 18618008, PMID 21770996, PMID 22220591, PMID 22797645, PMID 22870441, PMID 22998754, PMID 23316132, PMID 23335901, PMID 23822797, PMID 24012319, PMID 24190578, PMID 24515444, PMID 24616831, PMID 24684534, PMID 24937541, PMID 24948402, PMID 25027286, PMID 25167977, PMID 25389003, PMID 25590214, PMID 25673981, PMID 25716971, PMID 25827058, PMID 25835160, PMID 26297500, PMID 26304941, PMID 26582405, PMID 27438995, PMID 28003052, PMID 28243404, PMID 28623320, PMID 30431582, PMID 30686636, PMID 30774444, PMID 31073924, PMID 31094746, PMID 31447547, PMID 31536511, PMID 32043983, PMID 32143990, PMID 32346093, PMID 32364251, PMID 32534337, PMID 32588430, PMID 32612617, PMID 32678530
2015 (4), 2008 (1), 2009 (1), 2014 (1), 2016 (1), P01HL069999 (1), P50DA018197 (1), P50MH099910 (1), P60AA003510 (1), R01DA047391 (1), R01DK073354 (1), R01HL073980 (1), R01HL179276 (1), R21AA019994 (1), R21MH138923 (1)