3 completed, 2 recruiting, 2 terminated, 2 withdrawn. 3 Not applicable, 2 Phase 1, 2 Phase 2, 1 Early Phase 1, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 3 | Recruiting 1, Terminated 1, Unknown 1 |
| Phase 1 | 2 | Completed 1, Withdrawn 1 |
| Phase 2 | 2 | Active not recruiting 1, Recruiting 1 |
| Early Phase 1 | 1 | Terminated 1 |
| Phase 4 | 1 | Withdrawn 1 |
Follow Anal Dysplasia: new trials by email Literature Review of Anal Dysplasia trials Research Report on Anal Dysplasia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluating Gardasil HPV Vaccine Humoral and Cellular Immune Responses in People With and Without HIV Human papillomavirus (HPV) vaccine, 9-valent - Human Papilloma Virus, Anal Dysplasia | Phase 2 | Recruiting | University of Maryland, Baltimore | 120 | 2025-03-15 | 2026-08-05 |
| Assessing the Utility of Plasma ctHPVDNA for Anal Cancer Screening Anal Dysplasia | Completed | Massachusetts Eye and Ear Infirmary | 104 | 2024-04-03 | 2026-04-28 | |
| Artesunate Suppositories for the Treatment of HIV-negative Patients With Intra-anal HSIL Artesunate, Placebo - Anal High Grade Squamous Intraepithelial Lesion, Anal Precancerous Condition | Phase 2 | Active not recruiting | Frantz Viral Therapeutics, LLC | 17 | 2023-02-10 | 2025-05-18 |
| Screening for Anal Cancer in Women With High-grade Vulvar Dysplasia or Vulvar Cancer. Screening anal Pap smear - No high-resolution anoscopy, Screening anal Pap smear - High-resolution anoscopy - Vulvar Cancer, Cervical Cancer | Not applicable | Recruiting | Dr. Danielle Vicus | 110 | 2021-02-01 | 2025-05-16 |
| PDT Plus Vitamin D3 for Anal Dysplasia Gliolan, Vitamin D3 cholecalciferol), Photodynamic Therpay - Anal Dysplasia, Carcinoma in Situ | Phase 1 | Withdrawn | Abramson Cancer Center at Penn Medicine | 2019-12-01 | 2026-08-04 | |
| Application of Oral Bacteriotherapy to Promote Anal HPV Clearance in HIV Positive Individuals Vivomixx, Placebo - HIV, Anal Dysplasia | Not applicable | Unknown | University of Roma La Sapienza | 40 | 2019-03-01 | 2019-09-23 |
| Intra-Anally Administered Artesunate in Patients With High-Grade Anal Intraepithelial Neoplasia (AIN 2/3) Artesunate Suppositories - HPV-Related Anal Intraepithelial Neoplasia, AIN2/3 | Phase 1 | Completed | Johns Hopkins University | 18 | 2017-04-20 | 2021-11-03 |
| The HPV-SAVE Study Team: HPV Screening and Vaccine Evaluation in Men Who Have Sex With Men The Hyfrecator ® 2000 Electrosurgical System, Observation Alone - Anal Dysplasia, Human Papillomavirus | Not applicable | Terminated | University Health Network, Toronto | 71 | 2015-11-01 | 2022-06-13 |
| Anal Dysplasia Study of Men Who Have Sex With Men Living With HIV imiquimod, ablative - Anal Dysplasia, Human Papilloma Virus | Phase 4 | Withdrawn | United States Naval Medical Center, San Diego | 2015-05-01 | 2016-08-22 | |
| Evaluation of a Low-Cost High Resolution Microendoscope for the Detection of Lower Gastrointestinal Neoplasia Proflavine Hemisulfate - Colon Polyps, Colonic Dysplasia | Early Phase 1 | Terminated | Anandasabapathy, Sharmila, M.D. | 183 | 2010-04-01 | 2016-01-12 |
| Screening for HIV-Associated Anal Cancer HIV Infections, Anal Cancer | Completed | University Health Network, Toronto | 401 | 2002-08-01 | 2016-03-08 |
Anus Neoplasms (4) · Papillomavirus Infections (2) · Acquired Immunodeficiency Syndrome (1) · Carcinoma in Situ (1) · Carcinoma, Squamous Cell (1) · Colonic Polyps (1) · HIV Infections (1) · Homosexuality (1) · Immunologic Deficiency Syndromes (1) · Precancerous Conditions (1) · Squamous Intraepithelial Lesions (1) · Uterine Cervical Dysplasia (1) · Uterine Cervical Neoplasms (1) · Vulvar Neoplasms (1)
Neoplasms (6) · Anus Diseases (4) · Colorectal Neoplasms (4) · Digestive System Diseases (4) · Digestive System Neoplasms (4) · Gastrointestinal Diseases (4) · Gastrointestinal Neoplasms (4) · Genital Diseases (4) · Intestinal Diseases (4) · Intestinal Neoplasms (4) · Neoplasms by Site (4) · Pathological Conditions, Signs and Symptoms (4) · Rectal Diseases (4) · Rectal Neoplasms (4) · Urogenital Diseases (4)
artemisinin (2) · 1-phenyl-3,3-dimethyltriazene (1) · Artesunate (1) · Cholecalciferol (1) · Imiquimod (1) · Observation (1) · Papillomavirus Vaccines (1) · Proflavine (1) · Vaccines (1) · artenimol (1) · artesunic acid (1)
University Health Network, Toronto (2) · Abramson Cancer Center at Penn Medicine (1) · Anandasabapathy, Sharmila, M.D. (1) · Dr. Danielle Vicus (1) · Frantz Viral Therapeutics, LLC (1) · Johns Hopkins University (1) · Massachusetts Eye and Ear Infirmary (1) · United States Naval Medical Center, San Diego (1) · University of Maryland, Baltimore (1) · University of Roma La Sapienza (1)
United States (7) · Canada (3) · Italy (1)
Daniel L. Faden, M.D. (1) · Danielle Vicus, MD (1) · Irving E Salit, MD (1) · Irving Salit, MD (1) · Joel Palefsky, MD (1) · John D Malone, MD (1) · Keith Cengel, MD, PhD (1) · Omar Harfouch, MD (1) · Sandy H Fang, MD (1) · Sharmila Anandasabapathy, MD (1)