104 completed, 49 recruiting, 30 unknown, 19 active not recruiting. 68 Not applicable, 57 Phase 2, 36 Phase 1, 23 Phase 3, 2 Early Phase 1.
Follow Vulvar Neoplasms: new trials by email Literature Review of Vulvar Neoplasms trials Research Report on Vulvar Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Tisotumab Vedotin in Squamous Cell Carcinoma of the Vulva Tisotumab Vedotin - Vulvar Carcinoma, Recurrent or Metastatic Vulvar Cancer | Phase 2 | Not yet recruiting | GOG Foundation | 28 | 2026-11-01 | 2026-06-29 |
| Needlefree Lidocaine Application for Vulvar Biopsies J-Tip, Lidocaine HCl 1% - Vulvar Cancers, Vulva Neoplasm | Not applicable | Not yet recruiting | Tufts Medical Center | 106 | 2026-11-01 | 2026-08-28 |
| Radiotherapy for Gynecologic Cancer With Up to 10 Active Metastatic Lesions Routine-care metastasis-directed radiotherapy - Cervical Cancer, Gynecologic Cancer | Recruiting | Affidea Nu-med Center of Oncological DIagnostics and Therapy | 500 | 2026-10-06 | 2026-10-23 | |
| Comparative Trial Between Open and Single-port Robotic-assisted Groin Lymphadenectomy in Vulvar Cancer Inguinofemoral lymphadenectomy - Vulvar Cancers | Not applicable | Not yet recruiting | Karolinska Institutet | 64 | 2026-10-01 | 2026-10-01 |
| A Blended e-Health Intervention to Improve Fear of Progression in Women With Gynecologic or Breast Cancer Best Practice, Interview, Supportive Care - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | Not applicable | Recruiting | City of Hope Medical Center | 126 | 2026-09-09 | 2026-10-16 |
| Intraoperative Microscopic Assessment of Lymph Node Status in Gynecological Malignancies Gynecologic Cancer, Cervical Cancer | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 160 | 2026-08-01 | 2026-07-14 | |
| Virtual Mental Health Intervention to Address Fear of Progression for Women With High Risk or Stage III-IV Gynecologic or Breast Cancer Behavioral Intervention, Educational Intervention, Internet-Based Intervention - Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8 | Not applicable | Withdrawn | City of Hope Medical Center | 2026-07-16 | 2026-02-04 | |
| Methylation Profiling in Self-samples for Identification of (Epi)Genetic Biomarkers for Gynecological Cancers Colli-Pee 20 mL device with UCM, Evalyn Brush - Gynaecological Cancers, Ovarian Cancer | Not applicable | Recruiting | Universiteit Antwerpen | 730 | 2026-06-19 | 2026-10-28 |
| A Single-arm, Multicenter Clinical Study of Becotatug Vedotin Combined With Zimberelimab in the Treatment of Recurrent and Metastatic Cervical Cancer, Vulvar Cancer and Vaginal Cancer Becotatug Vedotin in combination with Zimberelimab - Uterine Cervical Neoplasms, Recurrent; Uterine Cervical Neoplasms, Metastatic; Vulvar Neoplasms; Vaginal Neoplasms | Phase 2 | Recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 30 | 2026-06-11 | 2026-06-16 |
| Reirradiation and Total Ablative Strategies for Recurrent Gynecologic Cancer Reirradiation, Total Ablative Strategy - Recurrent Gynecologic Cancer, Recurrent Uterine Cancer | Recruiting | Affidea Nu-med Center of Oncological DIagnostics and Therapy | 500 | 2026-06-11 | 2026-10-16 | |
| A Phase III Randomised Clinical Trial of Ultrasound Groin Monitoring Versus Groin Lymph Node Dissection to De-Escalate the Extent of Surgery in Vulvar Cancer High-resolution bilateral groin ultrasound monitoring - Vulvar Cancer Stage I, Vulvar Cancer Stage II | Phase 3 | Not yet recruiting | Queensland Centre for Gynaecological Cancer | 640 | 2026-06-01 | 2026-03-24 |
| Quality of Life and Sexuality After Pelvic Exenteration for Gynecologic Cancer Cervical Cancers, Vaginal Cancers | Enrolling by invitation | Tampere University Hospital | 21 | 2026-05-01 | 2026-05-22 | |
| Pembrolizumab Plus Lenvatinib in Vulvar Cancer Patients: MITO VULVA-01 Pembrolizumab, Lenvatinib Capsules - Vulva Cancer | Phase 2 | Recruiting | National Cancer Institute, Naples | 80 | 2026-03-12 | 2026-04-02 |
| Vaginal DHEA to Improve Vaginal Health After Radiation for Women With Gynecologic, Anal or Rectal Cancer Biospecimen Collection, Prasterone, Survey Administration - Anal Carcinoma, Cervical Carcinoma | Phase 2 | Recruiting | Ohio State University Comprehensive Cancer Center | 25 | 2026-03-12 | 2026-04-21 |
| Cancer Loyalty Card Study 2 (CLOCS-2) Cases & Controls - Pancreatic Cancer, Colon Cancer | Recruiting | Imperial College London | 2900 | 2026-02-04 | 2026-03-25 | |
| [177Lu]Lu-AKIR001 First-in-human Study [177Lu]Lu-AKIR001 - Thyroid Gland Anaplastic Carcinoma, Poorly Differentiated Thyroid Carcinoma | Early Phase 1 | Recruiting | Karolinska University Hospital | 15 | 2026-01-28 | 2026-01-30 |
| Contribution of Oncovascular Surgery in the Treatment of Gynecological Advanced Malignant Diseases. Ovarian Carcinoma, Cervical Carcinoma | Not yet recruiting | National Cancer Institute, Naples | 130 | 2025-12-01 | 2025-12-05 | |
| A PHASE II, RANDOMIZED TRIAL TO ASSESS MAINTENANCE THERAPY WITH CEMIPLIMAB VERSUS BEST SUPPORTIVE CARE AFTER 1ST LINE PLATINUM-BASED CHEMOTHERAPY IN ADVANCED/RECURRENT VULVAR CANCER Cemiplimab - Vulvar Cancers | Phase 2 | Not yet recruiting | Hospital Israelita Albert Einstein | 42 | 2025-11-01 | 2025-08-03 |
| SLN Mapping and ICG Dye for Vulvar Cancer Indocyanine green - Vulva Cancer | Not yet recruiting | Tufts Medical Center | 10 | 2025-11-01 | 2025-09-29 | |
| The Effect of Dose and Storage Conditions of Indocyanine Green on Efficacy and Cost in Sentinel Lymph Node Mapping in Gynecological Cancer Endometrial Cancer, Vulvar Cancers | Recruiting | Cukurova University | 30 | 2025-10-03 | 2026-02-02 |
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Uterine Cervical Neoplasms (156) · Vaginal Neoplasms (115) · Endometrial Neoplasms (75) · Ovarian Neoplasms (73) · Anus Neoplasms (46) · Fallopian Tube Neoplasms (39) · Breast Neoplasms (31) · Penile Neoplasms (31) · Uterine Neoplasms (31) · Neoplasms (27) · Carcinoma, Ovarian Epithelial (25) · Esophageal Neoplasms (24) · Prostatic Neoplasms (22) · Sarcoma (22)
Female Urogenital Diseases (237) · Female Urogenital Diseases and Pregnancy Complications (237) · Genital Diseases (237) · Urogenital Diseases (237) · Genital Diseases, Female (236) · Neoplasms by Site (236) · Urogenital Neoplasms (235) · Vulvar Diseases (233) · Genital Neoplasms, Female (227) · Neoplasms (210) · Uterine Diseases (163) · Uterine Cervical Diseases (157) · Uterine Neoplasms (132) · Vaginal Diseases (115) · Endocrine Gland Neoplasms (98)
Radiotherapy (10) · Cisplatin (9) · Methods (6) · Surveys and Questionnaires (6) · pembrolizumab (6) · Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18 (5) · Brachytherapy (4) · Cyclophosphamide (4) · Early Intervention, Educational (4) · Palliative Care (4) · Papillomavirus Vaccines (4) · fludarabine (4) · 1,2-diaminocyclohexaneplatinum II citrate (3) · Biopsy (3) · Bleomycin (3)
Gynecologic Oncology Group (11) · Merck Sharp & Dohme LLC (11) · M.D. Anderson Cancer Center (8) · National Cancer Institute (NCI) (8) · Ohio State University Comprehensive Cancer Center (6) · Dana-Farber Cancer Institute (5) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (5) · Shanghai Bovax Biotechnology Co., Ltd. (5) · City of Hope Medical Center (4) · Memorial Sloan Kettering Cancer Center (4) · Northwestern University (4) · Royal Marsden NHS Foundation Trust (4) · Alliance for Clinical Trials in Oncology (3) · Beijing Health Guard Biotechnology, Inc (3) · Queensland Centre for Gynaecological Cancer (3)
United States (107) · China (21) · United Kingdom (16) · Italy (15) · Canada (11) · France (10) · Germany (6) · Sweden (6) · Australia (5) · Turkey (Türkiye) (5) · Switzerland (4) · Belgium (3) · Brazil (3) · Denmark (3) · Netherlands (3)
Anne Reb (3) · Clare Shaw, Phd (3) · Yongjiang Liu, Bachelor (3) · Allison M Quick, MD (2) · Christian S Hinrichs, MD (2) · Diana Zach, MD (2) · Emma Barber, MD, MS (2) · Jian Zhang, Doctor (2) · Levi S. Downs, MD (2) · Lilie L Lin (2) · Martin King, MD, PhD (2) · William P. Tew, MD (2)
PMID 27422279, PMID 19949018, PMID 20686386, PMID 22002018, PMID 23290987, PMID 29211620, PMID 29269325, PMID 29767739, PMID 33326342, PMID 18482765, PMID 18768432, PMID 19487487, PMID 19701032, PMID 20068553, PMID 22480131, PMID 22675922, PMID 22753905, PMID 23107862, PMID 23335087, PMID 23384847, PMID 23526734, PMID 23535473, PMID 23849695, PMID 24067488, PMID 24201015, PMID 25278227, PMID 25618900, PMID 25693011, PMID 25749310, PMID 25912208, PMID 25912475, PMID 26086587, PMID 26101366, PMID 26366475, PMID 26411885, PMID 26411953, PMID 26807639, PMID 27020837, PMID 27550406, PMID 27865255, PMID 28596000, PMID 28653559, PMID 28744123, PMID 28789851, PMID 28886907, PMID 29149611, PMID 29186019, PMID 29420364, PMID 30157166, PMID 30184767
2023 (4), P30CA033572 (3), U10CA027469 (3), U10CA101165 (3), U10CA180868 (3), 2019 (2), P30CA012197 (2), R21CA293326 (2), UG1CA189867 (2), 2009 (1), 2015 (1), 2016 (1), 2017 (1), P30CA013330 (1), P30CA014520 (1)