5 completed, 3 recruiting, 2 unknown, 1 active not recruiting. 6 Phase 2, 2 Phase 4, 1 Not applicable, 1 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 6 | Recruiting 3, Active not recruiting 1, Unknown 1, Withdrawn 1 |
| Phase 4 | 2 | Completed 2 |
| Not applicable | 1 | Completed 1 |
| Phase 1 | 1 | Completed 1 |
| Phase 3 | 1 | Completed 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Artesunate Ointment for the Treatment of Anal HSIL in HIV-negative Participants Artesunate ointment, Placebo - Anal High-grade Squamous Intraepithelial Lesion, Anal HSIL | Phase 2 | Recruiting | Frantz Viral Therapeutics, LLC | 48 | 2024-01-12 | 2025-05-18 |
| Phase II Study of Artesunate Ointment for the Treatment of Vulvar High Grade Squamous Intraepithelial Lesions (Vulvar HSIL, VIN2/3) Artesunate ointment, Placebo ointment - Vulvar Diseases, HPV Infection | Phase 2 | Recruiting | Frantz Viral Therapeutics, LLC | 27 | 2023-12-06 | 2025-08-14 |
| Artesunate Suppositories for the Treatment of HIV-negative Patients With Intra-anal HSIL Artesunate, Placebo - Anal High Grade Squamous Intraepithelial Lesion, Anal Precancerous Condition | Phase 2 | Active not recruiting | Frantz Viral Therapeutics, LLC | 17 | 2023-02-10 | 2025-05-18 |
| Evaluating the Efficacy of Artesunate in Adults With Mild Symptoms of COVID-19 Artemisinin / Artesunate, placebo - Covid 19 Positive, Corona Virus Infection | Phase 2 | Withdrawn | Princess Nourah Bint Abdulrahman University | 2022-01-01 | 2022-05-02 | |
| A Study to Evaluate the Safety and Efficacy of OT-101+Artemisinin in Hospitalized COVID-19 Subjects OT-101, Artemisinin, Placebo - COVID-19 | Phase 2 | Unknown | Oncotelic Inc. | 18 | 2021-04-01 | 2021-03-16 |
| A Study to Evaluate the Safety and Efficacy of Artemisinin- a Herbal Supplement on COVID-19 Subjects Artemisinin, Dexamethasone - Covid19 | Phase 4 | Completed | Mateon Therapeutics | 120 | 2020-09-30 | 2021-09-09 |
| Artesunate Vaginal Inserts for the Treatment of Cervical Intraepithelial Neoplasia (CIN2/3) Artesunate vaginal insert, Placebo vaginal insert - CIN 2/3, HPV Infection | Phase 2 | Recruiting | Frantz Viral Therapeutics, LLC | 78 | 2020-09-09 | 2025-10-02 |
| Airway Intervention Registry (AIR): Recurrent Respiratory Papillomatosis (RRP) Microdebrider, Cold-steel surgery (forceps), Carbon dioxide laser - Recurrent Respiratory Papillomatosis, Human Papilloma Virus | Unknown | Newcastle-upon-Tyne Hospitals NHS Trust | 400 | 2018-04-01 | 2022-01-11 | |
| Intra-Anally Administered Artesunate in Patients With High-Grade Anal Intraepithelial Neoplasia (AIN 2/3) Artesunate Suppositories - HPV-Related Anal Intraepithelial Neoplasia, AIN2/3 | Phase 1 | Completed | Johns Hopkins University | 18 | 2017-04-20 | 2021-11-03 |
| Safety, Tolerability, Pharmacokinetics and Efficacy of ARCO artemisinin/naphthoquine, dihydroartemisinin/piperaquine phosphate - Plasmodium Falciparum, Malaria, Falciparum | Phase 4 | Completed | Ifakara Health Institute | 60 | 2014-01-07 | 2018-03-14 |
| Artemisinin With Risperidone for First-Episode and Drug-Naive Schizophrenia Artemisinin, Placebo - Schizophrenia | Phase 3 | Completed | Beijing HuiLongGuan Hospital | 88 | 2008-09-01 | 2016-07-12 |
| Artemisinin to Reduce The Symptoms of Schizophrenia Artemisinin, Identical looking placebo capsule - Schizophrenia, Schizoaffective Disorder | Not applicable | Completed | Sheppard Pratt Health System | 66 | 2008-08-01 | 2012-02-28 |
Papillomavirus Infections (3) · COVID-19 (2) · Schizophrenia (2) · Coronavirus Infections (1) · Malaria, Falciparum (1) · Precancerous Conditions (1) · Psychotic Disorders (1) · Recurrent respiratory papillomatosis (1) · Uterine Cervical Dysplasia (1) · Vulvar Diseases (1)
Frantz Viral Therapeutics, LLC (4) · Beijing HuiLongGuan Hospital (1) · Ifakara Health Institute (1) · Johns Hopkins University (1) · Mateon Therapeutics (1) · Newcastle-upon-Tyne Hospitals NHS Trust (1) · Oncotelic Inc. (1) · Princess Nourah Bint Abdulrahman University (1) · Sheppard Pratt Health System (1)
United States (6) · Brazil (1) · China (1) · India (1) · Saudi Arabia (1) · Tanzania (1) · United Kingdom (1)
Adam Donne (1) · Faith B Dickerson, PhD, MPH (1) · Joel Palefsky, MD (1) · Lian Y Cao, MD (1) · Mukesh Kumar (1) · Osama Kentab, MD (1) · Salim Abdulla, MD, PhD (1) · Sandy H Fang, MD (1) · Vuong Trieu, PhD (1)