14 completed, 6 recruiting, 3 active not recruiting, 3 unknown. 15 Phase 2, 6 Phase 3, 4 Phase 4, 3 Phase 1, 1 Early Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Multicentre, Randomised, Double-blind, Positive-control Clinical Trial Evaluating Dihydroartemisinin Tablets for the Treatment of Discoid Lupus Erythematosus Dihydroartemisinin tablets, Hydroxychloroquine tablets - Discoid Lupus Erythematosus | Phase 2 | Not yet recruiting | Kunming Pharmaceuticals, Inc. | 100 | 2026-04-30 | 2026-04-30 |
| Dihydroartemisinin for MAFLD Dihydroartemisinin - MAFLD | Phase 1 / Phase 2 | Recruiting | The First Affiliated Hospital with Nanjing Medical University | 30 | 2026-03-30 | 2026-07-01 |
| Efficacy of Dihydroartemisinin for Treating Acne Vulgaris dihydroartemisinin - Acne Vulgaris | Early Phase 1 | Recruiting | Shanghai Zhongshan Hospital | 60 | 2025-06-01 | 2025-06-05 |
| Dihydroartemisinin for the Treatment of Polycystic Ovary Syndrome Dihydroartemisinin, Placebo - Polycystic Ovary Syndrome (PCOS) | Phase 2 | Recruiting | Shanghai Zhongshan Hospital | 150 | 2025-04-16 | 2025-04-20 |
| Targeted Antimalarial Drug Administration for Seasonal Migrant Populations in Amhara Region, Ethiopia Dihydroartemisinin-piperaquine - Plasmodium Falciparum, Malaria | Phase 3 | Active not recruiting | PATH | 10350 | 2024-08-21 | 2025-05-06 |
| Southeast Asia Dose Optimization of Tafenoquine Tafenoquine, Chloroquine, Artemether 20 mg-Lumefantrine 120 mg - Plasmodium Vivax Malaria | Phase 4 | Recruiting | University of Oxford | 820 | 2024-07-22 | 2026-10-09 |
| CapeOx Combined With Anti-PD1 Antibody Plus Dihydroartemisinin as Neoadjuvant or Conversion Therapy for Microsatellite Stable Locally Advanced and Metastatic Colorectal Cancer Capecitabine, Oxaliplatin, Dihydroartemisinin - Locally Advanced Colorectal Cancer, Metastatic Colorectal Cancer | Phase 2 | Active not recruiting | Shanghai Changzheng Hospital | 15 | 2024-07-01 | 2026-09-03 |
| Efficacy of Dihydroartemisinin for Treating PCOS Dihydroartemisinin - Polycystic Ovary Syndrome | Phase 2 | Completed | Shanghai Zhongshan Hospital | 30 | 2024-05-24 | 2025-04-23 |
| Artesunate Ointment for the Treatment of Anal HSIL in HIV-negative Participants Artesunate ointment, Placebo - Anal High-grade Squamous Intraepithelial Lesion, Anal HSIL | Phase 2 | Recruiting | Frantz Viral Therapeutics, LLC | 48 | 2024-01-12 | 2025-05-18 |
| Phase II Study of Artesunate Ointment for the Treatment of Vulvar High Grade Squamous Intraepithelial Lesions (Vulvar HSIL, VIN2/3) Artesunate ointment, Placebo ointment - Vulvar Diseases, HPV Infection | Phase 2 | Recruiting | Frantz Viral Therapeutics, LLC | 27 | 2023-12-06 | 2025-08-14 |
| Innovative Intermittent Preventive Treatment Approaches to Reduce Malaria Burden in School-age Children in Burkina Faso Sulphadoxine-Pyrimethamine/Amodiaquine, Dihydroartemisinin/Piperaquine (DP) plus Ivermectin (IVM) - Malaria | Phase 3 | Unknown | Malaria Consortium | 13000 | 2023-07-15 | 2023-11-22 |
| Artesunate Suppositories for the Treatment of HIV-negative Patients With Intra-anal HSIL Artesunate, Placebo - Anal High Grade Squamous Intraepithelial Lesion, Anal Precancerous Condition | Phase 2 | Active not recruiting | Frantz Viral Therapeutics, LLC | 17 | 2023-02-10 | 2025-05-18 |
| Momordica Charantia and Dihydroartemisinin-piperaquined-primaquine for Uncomplicated Plasmodium Falciparum Malaria Patients in Southwest Sumba Regency Dihydroartemisinin, Piperaquine, Primaquine - Uncomplicated Plasmodium Falciparum | Phase 2 | Completed | Syamsudin Abdillah,Ph.D, Pharm D | 36 | 2022-11-01 | 2023-05-16 |
| The Effect of Dihydroartemisinin in PCOS Dihydroartemisinin - Polycystic Ovary Syndrome | Phase 4 | Completed | Shanghai Zhongshan Hospital | 19 | 2022-07-01 | 2024-05-17 |
| Single Low Dose Tafenoquine to Reduce P. Falciparum Transmission in Mali (NECTAR2) Dihydroartemisinin/Piperaquine, Tafenoquine 100mg [Arakoda] - Malaria, Falciparum | Phase 2 | Completed | London School of Hygiene and Tropical Medicine | 80 | 2020-10-29 | 2022-06-09 |
| Pyronaridine-artesunate With Low Dose Primaquine for Preventing P. Falciparum Transmission Pyronaridine Tetraphosphate/Artesunate, Dihydroartemisinin/Piperaquine, Primaquine Diphosphate - Malaria,Falciparum | Phase 2 / Phase 3 | Completed | London School of Hygiene and Tropical Medicine | 100 | 2019-09-12 | 2020-01-30 |
| Combination Momordica Charantia Extract and Primaquine Againts Plasmodium Falciparum Uncomplicated and Plasmodium Vivax Uncomplicated Treatment in Manokwari, West Papua Dihydroartemisinin, Piperaquine, Primaquine - Malaria,Falciparum, Malaria, Vivax | Phase 2 | Completed | Syamsudin Abdillah,Ph.D, Pharm D | 50 | 2019-01-11 | 2023-09-13 |
| Exploratory Study of DHA in Systemic Lupus Erythematosus Patients Dihydroartemisinin tablet, Placebo tablet - Systemic Lupus Erythematosus | Phase 2 | Unknown | Kunming Pharmaceuticals, Inc. | 120 | 2018-03-01 | 2018-01-23 |
| A Study to Evaluate the Pharmacokinetics of a Single Dose of Tafenoquine Co-administered With Either Artemether + Lumefantrine or Dihydroartemisinin + Piperaquine Tetraphosphate Tafenoquine, Dihydroartemisinin + Piperaquine tetraphosphate, Artemether + Lumefantrine - Malaria, Vivax | Phase 1 | Completed | GlaxoSmithKline | 120 | 2014-07-31 | 2017-07-13 |
| Eurartesim® in Patients With Imported Uncomplicated Plasmodium Vivax Malaria Eurartesim tablets - Malaria, Vivax | Phase 2 | Terminated | Alfasigma S.p.A. | 27 | 2014-06-18 | 2018-09-17 |
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Malaria, Falciparum (8) · Malaria, Vivax (7) · Malaria (6) · Polycystic Ovary Syndrome (3) · Papillomavirus Infections (2) · Acne Vulgaris (1) · Colorectal Neoplasms (1) · Infections (1) · Lupus Erythematosus, Discoid (1) · Lupus Erythematosus, Systemic (1) · Recurrence (1) · Vulvar Diseases (1)
Shanghai Zhongshan Hospital (4) · Frantz Viral Therapeutics, LLC (3) · London School of Hygiene and Tropical Medicine (3) · University of Oxford (3) · Kunming Pharmaceuticals, Inc. (2) · Syamsudin Abdillah,Ph.D, Pharm D (2) · sigma-tau i.f.r. S.p.A. (2) · Alfasigma S.p.A. (1) · GlaxoSmithKline (1) · INDEPTH Network (1) · Ifakara Health Institute (1) · Malaria Consortium (1) · Oxford University Clinical Research Unit, Vietnam (1) · PATH (1) · Shanghai Changzheng Hospital (1)
China (7) · Indonesia (4) · United States (4) · Burkina Faso (3) · Tanzania (3) · France (2) · Mali (2) · Mozambique (2) · Netherlands (2) · Vietnam (2) · Afghanistan (1) · Cambodia (1) · Democratic Republic of the Congo (1) · Ethiopia (1) · Germany (1)
Xiaoying Li, MD (2) · Adam Bennett, PhD (1) · Alassane Dicko, PhD, MD (1) · Ayodhia Pitaloka Pasaribu, MD (1) · Badara Cisse, PhD (1) · Ben Willem Mol, MD, PhD (1) · Christoph Hatz, Prof Dr Med (1) · Cindy Chu, MD, PhD (1) · Enrique O Bassat, MD (1) · Fengchun Zhang, Prof. (1) · Fred N Binka, MD, PhD (1) · Ghulam R Awab, MD (1) · Gudissa Assefa Bayissa (1) · Haiyang Zhou, MD (1)
PMID 26654101, PMID 19784374, PMID 20409302, PMID 23926329, PMID 26917051, PMID 27697758, PMID 29061746, PMID 30692558, PMID 32312783, PMID 33289099, PMID 35028628, PMID 35465706, PMID 35544095, PMID 42320967