71 completed, 12 unknown, 5 terminated, 3 recruiting. 28 Phase 2, 21 Phase 3, 21 Phase 4, 17 Not applicable, 9 Phase 1.
Follow Artesunate: new trials by email Literature Review of Artesunate trials Research Report on Artesunate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study Evaluating the Safety and Tolerability of Artesunate in Patients With Pulmonary Arterial Hypertension Artesunate - Pulmonary Arterial Hypertension (PAH) | Phase 1 | Recruiting | Joseph C. Wu | 15 | 2026-04-01 | 2026-04-23 |
| Safety and Effectiveness Study of Pre-operative Artesunate in Stage II/ III Colorectal Cancer Artesunate, Artesunate matching Placebo - Stage II/III Colon Cancer, Bowel Cancer | Phase 2 | Not yet recruiting | Metanoic Health Ltd. | 120 | 2025-08-15 | 2025-07-31 |
| Study Evaluating the Efficacy and Safety of Artesunate Artesunate, Ganciclovir (GCV) - CMV Infection | Phase 2 | Recruiting | Amivas Inc. | 90 | 2025-08-01 | 2026-08-03 |
| Safety and Efficacy of Oral Artesunate for Pre-cervical Cancer Artesunate - CIN 2/3 | Phase 2 | Not yet recruiting | Metanoic Health Ltd. | 28 | 2025-08-01 | 2025-07-31 |
| Improving Treatment Outcomes in Chronic Myeloid Leukaemia Patients Using Imatinib and Artesunate Combination Therapy Imatinib, Artesunate - Chronic Myeloid Leukemia (CML) | Phase 2 | Active not recruiting | Obafemi Awolowo University | 75 | 2025-07-01 | 2026-10-14 |
| Evaluation of Artesunate in Infants Being Treated for Severe Malaria Artesunate Injection - Malaria | Recruiting | Amivas Inc. | 15 | 2024-10-06 | 2024-12-10 | |
| Parasite Clearance and Protection From Infection (PCPI) in Zambia SP (Macleods Pharmaceuticals Ltd), AS (Guilin Pharmaceuticals) - Malaria | Phase 3 | Completed | London School of Hygiene and Tropical Medicine | 600 | 2024-07-24 | 2025-03-12 |
| A Study to Evaluate Antimalarial Activity and Safety of MK-7602 in Healthy Adults (MK-7602-003) Plasmodium falciparum, MK-7602, Artemether/lumefantrine - Malaria | Phase 1 | Completed | Merck Sharp & Dohme LLC | 16 | 2024-04-18 | 2025-01-13 |
| Pharmacokinetic Study of IV Artesunate to Treat Children With Severe Malaria Artesunate - Plasmodium Falciparum Infection | Phase 4 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 90 | 2023-11-29 | 2026-06-18 |
| Efficacy of Only IV Artesunate Versus IV Artesunate Plus IV Quinine in the Treatment of Severe Malaria in Children: A Comparative Study IV Artesunate, IV Quinine Hydrochloride - Malaria | Not applicable | Completed | RESnTEC, Institute of Research | 104 | 2023-03-01 | 2024-06-26 |
| Artesunate Suppositories for the Treatment of HIV-negative Patients With Intra-anal HSIL Artesunate, Placebo - Anal High Grade Squamous Intraepithelial Lesion, Anal Precancerous Condition | Phase 2 | Active not recruiting | Frantz Viral Therapeutics, LLC | 17 | 2023-02-10 | 2025-05-18 |
| To Evaluate Efficacy, Safety, Tolerability and PK of Intravenous Cipargamin in Participants With Severe Plasmodium Falciparum Malaria Cipargamin, IV Artesunate, Coartem - Severe Malaria | Phase 2 | Completed | Novartis Pharmaceuticals | 254 | 2022-03-07 | 2026-04-09 |
| Evaluating the Efficacy of Artesunate in Adults With Mild Symptoms of COVID-19 Artemisinin / Artesunate, placebo - Covid 19 Positive, Corona Virus Infection | Phase 2 | Withdrawn | Princess Nourah Bint Abdulrahman University | 2022-01-01 | 2022-05-02 | |
| Add-on Study on WHO Solidarity Trial Plus for COVID-19 in Nepal Artesunate Injection - COVID-19 | Phase 4 | Unknown | Nepal Health Research Council | 400 | 2021-12-06 | 2022-03-25 |
| Rigorous Assessment of P. Vivax Relapses and Primaquine Efficacy for Radical Cure Primaquine, Artesunate - Vivax Malaria | Phase 4 | Completed | University of Maryland, Baltimore | 160 | 2021-04-15 | 2026-06-03 |
| Safety and Efficacy of Artesunate & Curcumin in Crohn's Disease Artesunate, Curcumin, Placebo A - Crohn's Disease | Phase 2 | Unknown | Sanjay Gandhi Postgraduate Institute of Medical Sciences | 40 | 2021-01-21 | 2023-05-23 |
| Novel Agents for Treatment of High-risk COVID-19 Positive Patients Ivermectin, Camostat Mesilate, Artemesia annua - COVID, Sars-CoV2 | Phase 2 | Terminated | Susanne Arnold | 13 | 2020-05-01 | 2022-01-20 |
| Treatments for COVID-19: Canadian Arm of the SOLIDARITY Trial Artesunate, Imatinib, Infliximab - COVID-19 | Phase 3 | Unknown | Sunnybrook Health Sciences Centre | 2900 | 2020-03-18 | 2023-10-13 |
| Evaluation of Artesunate-mefloquine as a Novel Alternative Treatment for Schistosomiasis in African Children Praziquantel, Artesunate + Mefloquine - Schistosoma Haematobium, Schistosoma Mansoni | Phase 3 | Completed | Institute of Tropical Medicine, Belgium | 726 | 2019-10-14 | 2021-04-05 |
| Pyronaridine-artesunate With Low Dose Primaquine for Preventing P. Falciparum Transmission Pyronaridine Tetraphosphate/Artesunate, Dihydroartemisinin/Piperaquine, Primaquine Diphosphate - Malaria,Falciparum | Phase 2 / Phase 3 | Completed | London School of Hygiene and Tropical Medicine | 100 | 2019-09-12 | 2020-01-30 |
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Malaria (52) · Malaria, Falciparum (29) · Malaria, Vivax (5) · Anemia (2) · COVID-19 (2) · Colorectal Neoplasms (2) · Cytomegalovirus Infections (2) · Fever (2) · Intestinal Neoplasms (2) · Anemia, Sickle Cell (1) · Anthrax (1) · Birth Weight (1) · Breast Neoplasms (1) · Carcinoma, Hepatocellular (1) · Communicable Diseases (1)
London School of Hygiene and Tropical Medicine (11) · National Institute of Allergy and Infectious Diseases (NIAID) (7) · Centers for Disease Control and Prevention (6) · University of Oxford (6) · Armed Forces Research Institute of Medical Sciences, Thailand (4) · Medical University of Vienna (4) · Heidelberg University (3) · Institute of Tropical Medicine, Belgium (3) · Sanofi (3) · University of Cape Town (3) · Amivas Inc. (2) · Medicines for Malaria Venture (2) · Metanoic Health Ltd. (2) · Bernhard Nocht Institute for Tropical Medicine (1) · Centro Internacional de Entrenamiento e Investigaciones Médicas (1)
Burkina Faso (7) · Cambodia (7) · Kenya (7) · Mozambique (7) · Tanzania (7) · Thailand (7) · Malawi (5) · Mali (4) · Nigeria (4) · Uganda (4) · United States (4) · Vietnam (4) · Bangladesh (3) · Cameroon (3) · Democratic Republic of the Congo (3)
Karen Barnes, MBChB (3) · Paul J Milligan, PhD (3) · Bryan Smith, MD (2) · Dr Yolanda Augustin (2) · Duong Socheat, MD (2) · Ghulam Rahim Awab, MD (2) · Rachel N Bronzan, MD, MPH (2) · Salim Abdulla, MD, PhD (2) · Sam K Dunyo, PhD (2) · Alexandre Macedo de Oliveira, MD, MSc (1) · Anna Rosanas-Urgell, MD, PhD (1) · Anne Gasasira (1) · Antoinette Tshefu, M.D., M.P.H. (1) · Ben Andagalu, MD (1)
PMID 19558654, PMID 26917051, PMID 17971864, PMID 18000538, PMID 18213379, PMID 18286187, PMID 18328518, PMID 19112496, PMID 19352498, PMID 19415120, PMID 19641202, PMID 19769536, PMID 20194698, PMID 20350192, PMID 20368815, PMID 20557237, PMID 20658481, PMID 21028985, PMID 21070142, PMID 21352601, PMID 21603629, PMID 21864343, PMID 22087077, PMID 22180622, PMID 22303437, PMID 22412865, PMID 22427705, PMID 22443344, PMID 22475593, PMID 23272227, PMID 23433102, PMID 24674654, PMID 25248945, PMID 25267980, PMID 25701866, PMID 26342427, PMID 26666916, PMID 26793976, PMID 27068396, PMID 27094900, PMID 27923381, PMID 28439738, PMID 28818049, PMID 29889239, PMID 30326952, PMID 30380038, PMID 30649381, PMID 32437557, PMID 33264556, PMID 33983371
2014 (1), 5UM1AI148689-03 (1)