40 completed, 25 unknown, 14 recruiting, 8 not yet recruiting. 26 Phase 2, 22 Not applicable, 9 Phase 1, 7 Phase 3, 4 Phase 4.
Follow Squamous Intraepithelial Lesions: new trials by email Literature Review of Squamous Intraepithelial Lesions trials Research Report on Squamous Intraepithelial Lesions
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Papilozumib Vaginal Gel for Exocervical Mucosal Restoration in Women With Human Papillomavirus (HPV) Papilozumib vaginal gel, Papilozumib oral supplement - Human Papillomavirus Infection, Human Papillomavirus Infections | Not applicable | Not yet recruiting | Hifas da Terra S.L. | 81 | 2027-07-01 | 2026-10-05 |
| Use of ACU-D1 in HPV Associated Vulvar and Perianal Lesions in People With HIV Dose Level 1 ACU-D1 ointment, Dose Level 2 ACU-D1 ointment, Dose Level 3 ACU-D1 ointment - Human Papilloma Virus, Human Immunodeficiency Virus | Phase 1 | Not yet recruiting | Emory University | 9 | 2026-12-01 | 2026-08-18 |
| Predictive Biomarkers for Precision Management of Pre-cancerous Cervical Neoplasia DNA methylation - HSIL, High Grade Squamous Intraepithelial Lesion, DNA Methylation | Active not recruiting | Lund University | 199 | 2026-09-19 | 2026-10-26 | |
| CASCADE 2002: PROTECT Study, "PRObiotics to TrEat Anal preCancer Trial EXE-346 Probiotic, Placebo, Usual Care High Resolution Anoscopy (HRA) - HSIL, High Grade Squamous Intraepithelial Lesion, HPV-Related Squamous Cell Carcinoma | Phase 2 | Recruiting | University of California, San Francisco | 90 | 2026-09-04 | 2026-09-15 |
| Hair Regrowth Following Partial Thickness Removal of SSCIS Partial Thickness Excision - Squamous Cell Carcinoma (Skin), Squamous Cell Carcinoma in Situ | Not applicable | Not yet recruiting | The Cooper Health System | 15 | 2026-09-01 | 2026-09-09 |
| Evaluation of NWRD09 for HPV-16 Related Cervical HSIL NWRD09 Injection, NWRD09 Placebo - High-grade Squamous Intraepithelial Lesion (HSIL) | Phase 2 | Not yet recruiting | Newish Biotech (Wuxi) Co., Ltd. | 156 | 2026-08-01 | 2026-07-17 |
| Hexaminolevulinate Photodynamic Therapy (HAL-PDT) With Deferred Surgery Versus Surgery for High-grade Squamous Intraepithelial Lesions (HSIL) Loop Electrosurgical Excision Procedure (LEEP) or Cold Knife Conization (CKC), HAL 5% with illumination - Cervical Intraepithelial Neoplasia, Papillomavirus Infections | Phase 2 | Not yet recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 230 | 2026-07-01 | 2026-07-09 |
| Trial to Evaluate Nonavalent HPV Vaccine as a Secondary Prevention in Patients Treated for Human Papilloma Virus Related High-grade Squamous Intraepithelial Lesions HPV vaccine, Placebo vaccine - Patients With Primary HPV High-grade Squamous Intra-epithelial Lesions (HSIL) at Vulvar Site, Patients With Primary HPV High-grade Squamous Intra-epithelial Lesions (HSIL) at Vaginal Site | Phase 3 | Not yet recruiting | Gustave Roussy, Cancer Campus, Grand Paris | 984 | 2026-05-01 | 2026-02-27 |
| Phase II Study of Dysplasix™ Intravaginal Suppositories in Patients Patients With High-Risk HPV and Mild Cervical Cytologic Abnormalities EGCG and Quinine Sulfate Vaginal Suppository, Placebo - High-risk HPV (Any Strain), LSIL, Low Grade Squamous Intraepithelial Lesion | Phase 2 | Recruiting | Amplexd Therapeutics, Inc. | 45 | 2026-04-30 | 2026-05-14 |
| Dual-Modality Immunotherapy for HPV Clearance (DUAL-HPV) Oral Immunomodulator, Vaginal Ovule, Standard Supportive Care - Human Papillomavirus Infection, Cervical Intraepithelial Neoplasia (CIN) | Not applicable | Active not recruiting | Dr. Lutfi Kirdar Kartal Training and Research Hospital | 76 | 2026-04-28 | 2026-07-29 |
| Comparison Between Liquid-Based Cytology And Molecular Screening For Detecting Precursor Lesions and Cervical Cancer Physical examination, Liquid-based cytology, Molecular screening - I) Atypical Squamous Cells of Undetermined Significance (ASC-US), II) Atypical Glandular Cells of Uncertain Significance (AGUS) | Not applicable | Recruiting | Timser SAPI de CV | 558 | 2026-02-03 | 2026-03-18 |
| Study Assessing Reduced HPV Infectivity and Transmission in HPV-Positive Women Following Vaccination With 9vHPV Nonavalent HPV vaccine (9vHPV) - HPV, High-risk HPV (Any Strain) | Phase 2 | Not yet recruiting | Institut d'Investigació Biomèdica de Bellvitge | 80 | 2026-02-01 | 2026-02-11 |
| Multicenter Prospective Non-randomized Controlled Study of Ella Photodynamic Therapy for Cervical HSIL/CIN2 ALA-PDT, LEEP surgery - HSIL, High Grade Squamous Intraepithelial Lesion, CIN 2 | Not applicable | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 560 | 2026-01-29 | 2026-10-14 |
| Multicenter Prospective Non-randomized Controlled Study of ALA-PDT for LSIL With HPV16/18 Infection ALA-PDT - HPV-16/18, Photodynamic Therapy (PDT) | Not applicable | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 225 | 2026-01-21 | 2026-10-16 |
| Evaluation of NWRD08 for HPV-16 and/or HPV-18 Related Cervical HSIL NWRD08 administered by electroporation, Placebo administered by electroporation - High-grade Squamous Intraepithelial Lesion (HSIL) | Phase 2 | Recruiting | Newish Biotech (Wuxi) Co., Ltd. | 150 | 2025-11-11 | 2026-02-17 |
| Screening for Anal Cancer in Men Who Have Sex With Men Using Pre-Exposure Prophylaxis Anal smear, Self-administered questionnaire, EQ-5D-5L questionnaire - Anal Cancer, Squamous Intraepithelial Lesions | Not applicable | Recruiting | Universitair Ziekenhuis Brussel | 296 | 2025-09-23 | 2026-05-01 |
| A Clinical Study on the Evaluation of BD114 for the Treatment HPV-16-Related Cervical HSIL BD114VLP, or BD114 - High-grade Squamous Intraepithelial Lesions (HSIL) | Early Phase 1 | Terminated | Shanghai BDgene Co., Ltd. | 2 | 2025-09-15 | 2026-09-04 |
| NWRD09 for HPV-16 Related Cervical HSIL NWRD09 injection - High-grade Squamous Intraepithelial Lesion (HSIL) | Phase 1 | Recruiting | Newish Biotech (Wuxi) Co., Ltd. | 9 | 2025-06-12 | 2025-07-02 |
| Predicting Treatment Failure in HSIL Patients with Positive Margins After Conization Via Detection of PAX1 Methylation High-grade Squamous Intraepithelial Lesions (HSIL), Cervical Conization | Not yet recruiting | Women's Hospital School Of Medicine Zhejiang University | 800 | 2024-12-01 | 2024-12-06 | |
| Anal High-risk HPV, HSIL, and Microbiome Among Hispanic Peoples Living With HIV (PLWH) Biospecimen Collection, Questionnaires - Human Immunodeficiency Virus, Human Papillomavirus-Related Anal Squamous Cell Carcinoma | Active not recruiting | University of California, San Francisco | 217 | 2024-10-31 | 2026-08-20 |
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Uterine Cervical Dysplasia (28) · Papillomavirus Infections (27) · Uterine Cervical Neoplasms (20) · Anus Neoplasms (12) · Atypical Squamous Cells of the Cervix (11) · Precancerous Conditions (8) · Carcinoma, Squamous Cell (7) · Acquired Immunodeficiency Syndrome (6) · HIV Infections (6) · Squamous Intraepithelial Lesions of the Cervix (5) · Adenocarcinoma in Situ (4) · Homosexuality (3) · Infections (3) · Carcinoma, Basal Cell (2)
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PMID 35288319, PMID 18630456, PMID 19524035, PMID 20812850, PMID 20852198, PMID 23032420, PMID 23618600, PMID 24118526, PMID 24458427, PMID 26083247, PMID 26687616, PMID 27526956, PMID 28857936, PMID 29851256, PMID 30048762, PMID 30060087, PMID 30098677, PMID 30122563, PMID 30989655, PMID 31490545, PMID 32408396, PMID 32745170, PMID 32835877, PMID 33394202, PMID 33538338, PMID 33594934, PMID 34536311, PMID 34907980, PMID 35266975, PMID 35416975, PMID 35545433, PMID 35689493, PMID 35704479, PMID 35781093, PMID 36650011, PMID 36894985, PMID 37047452, PMID 37294390, PMID 37894462, PMID 38572751, PMID 38768231, PMID 38794347, PMID 39639322, PMID 40295124, PMID 40801169, PMID 42171389
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