217 completed, 74 unknown, 36 recruiting, 26 terminated. 143 Not applicable, 69 Phase 2, 39 Phase 3, 38 Phase 1, 12 Phase 4.
Follow Uterine Cervical Dysplasia: new trials by email Literature Review of Uterine Cervical Dysplasia trials Research Report on Uterine Cervical Dysplasia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Papilozumib Vaginal Gel for Exocervical Mucosal Restoration in Women With Human Papillomavirus (HPV) Papilozumib vaginal gel, Papilozumib oral supplement - Human Papillomavirus Infection, Human Papillomavirus Infections | Not applicable | Not yet recruiting | Hifas da Terra S.L. | 81 | 2027-07-01 | 2026-10-05 |
| C-3002: Enhancing Cervical Cancer Screening Access and Follow-up Care at 'CASCADE' Clinical Sites in the United States Qualitative interviews, Focus groups - Human Immunodeficiency Virus (HIV), Human Papillomavirus (HPV) | Not yet recruiting | UNC Lineberger Comprehensive Cancer Center | 3500 | 2026-11-10 | 2026-10-20 | |
| Exploratory Study of the Efficacy of HAL-PDT in CIN 3 Hexaminolevulinate (HAL) - Cervical Intraepithelial Neoplasia Grade 3 | Phase 2 | Not yet recruiting | Tongji Hospital | 260 | 2026-11-01 | 2026-10-23 |
| Clinical Audit of Cervical Cytology Services in an Early Cancer Detection Unit Cervical Intraepithelial Neoplasia, Uterine Cervical Neoplasms | Not yet recruiting | Assiut University | 500 | 2026-11-01 | 2026-10-27 | |
| Feasibility Study Comparing One vs Two Probes for Thermal Ablation Among Cervical Cancer Screen Positive Women Living With HIV in C1001P-CS7 Zimbabwe Thermal ablation (TA) with 1 probe, Thermal ablation (TA) with 2 probes - HIV (Human Immunodeficiency Virus), HPV | Not applicable | Recruiting | Fred Hutchinson Cancer Center | 300 | 2026-10-15 | 2026-10-19 |
| Feasibility Study Comparing One vs Two Probes for TA Among Cervical Cancer Screen Positive WLWH in C1001P-CS5 Rwanda Thermal ablation (TA) with 1 probe, Thermal ablation (TA) with 2 probes - HIV (Human Immunodeficiency Virus), HPV | Not applicable | Recruiting | Fred Hutchinson Cancer Center | 300 | 2026-10-15 | 2026-10-19 |
| Feasibility Study Comparing One vs Two Probes for Thermal Ablation Among Cervical Cancer Screen Positive WLWH in C1001P-CS9 South Africa Thermal ablation (TA) with 1 probe, Thermal ablation (TA) with 2 probes - HIV (Human Immunodeficiency Virus), HPV | Not applicable | Recruiting | Fred Hutchinson Cancer Center | 200 | 2026-10-15 | 2026-10-20 |
| Feasibility Study Comparing Use of One Or Two Probes for Thermal Ablation Among Screen Positive Women Living With HIV in C1001P-CS2 Kenya Thermal ablation (TA) with 1 probe, Thermal ablation (TA) with 2 probes - HIV (Human Immunodeficiency Virus), HPV | Not applicable | Recruiting | Fred Hutchinson Cancer Center | 300 | 2026-10-12 | 2026-10-20 |
| Predictive Biomarkers for Precision Management of Pre-cancerous Cervical Neoplasia DNA methylation - HSIL, High Grade Squamous Intraepithelial Lesion, DNA Methylation | Active not recruiting | Lund University | 199 | 2026-09-19 | 2026-10-26 | |
| Adjuvant 5-Fluorouracil Following Thermal Ablation to Improve HPV Treatment Outcomes in Women With HIV in Kenya 5% 5-fluorouracil Topical Cream, Placebo Cream - HIV Infections, HPV Infection | Phase 2 | Not yet recruiting | UNC Lineberger Comprehensive Cancer Center | 140 | 2026-09-01 | 2026-08-27 |
| VIA Versus Colposcopy VIA - Cervical Intraepithelial Neoplasia (CIN), Cervicitis | Not yet recruiting | Sohag University | 200 | 2026-08-01 | 2026-07-09 | |
| Hexaminolevulinate Photodynamic Therapy (HAL-PDT) With Deferred Surgery Versus Surgery for High-grade Squamous Intraepithelial Lesions (HSIL) Loop Electrosurgical Excision Procedure (LEEP) or Cold Knife Conization (CKC), HAL 5% with illumination - Cervical Intraepithelial Neoplasia, Papillomavirus Infections | Phase 2 | Not yet recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 230 | 2026-07-01 | 2026-07-09 |
| PRIORITY Study in Cervical Cancer Cervical Cancer, Cervical Intraepithelial Neoplasia | Not yet recruiting | Pontificia Universidad Catolica de Chile | 700 | 2026-06-30 | 2026-05-18 | |
| Effectiveness of a Vaginal Gel on CIN1/2 Regression and HPV Clearance. Papilocare Vaginal Gel - Womens Health, Cervical Dysplasia | Not applicable | Recruiting | University of Aarhus | 70 | 2026-06-09 | 2026-08-03 |
| Testing the Feasibility of Different HPV Screening and Care Strategies for Women Living With HIV HPV DNA Testing (Abbott Alinity m HPV Assay), Visual Inspection with Acetic Acid, Cervical Histology (Biopsy Procedures) - Human Papillomavirus (HPV), HPV Associated Cancers | Not applicable | Not yet recruiting | University of California, San Diego | 750 | 2026-06-01 | 2026-05-08 |
| Peripheral Blood CyTOF Immune Model for Cervical Lesion Detection in HPV16/18+ Women CIN 2/3, Cervical Cancer (Early Detection) | Not yet recruiting | Women's Hospital School Of Medicine Zhejiang University | 1465 | 2026-05-15 | 2026-05-26 | |
| Phase II Study of Dysplasix™ Intravaginal Suppositories in Patients Patients With High-Risk HPV and Mild Cervical Cytologic Abnormalities EGCG and Quinine Sulfate Vaginal Suppository, Placebo - High-risk HPV (Any Strain), LSIL, Low Grade Squamous Intraepithelial Lesion | Phase 2 | Recruiting | Amplexd Therapeutics, Inc. | 45 | 2026-04-30 | 2026-05-14 |
| Dual-Modality Immunotherapy for HPV Clearance (DUAL-HPV) Oral Immunomodulator, Vaginal Ovule, Standard Supportive Care - Human Papillomavirus Infection, Cervical Intraepithelial Neoplasia (CIN) | Not applicable | Active not recruiting | Dr. Lutfi Kirdar Kartal Training and Research Hospital | 76 | 2026-04-28 | 2026-07-29 |
| PVX4 for the Treatment of Human Papilloma Virus (HPV)16+ Cervical Dysplasia PVX4 Combination Product, Placebo Control - Cervical Intraepithelial Neoplasia Grade 2/3, Human Papilloma Virus Infection Type 16 | Phase 2 | Recruiting | PapiVax Biotech, Inc. | 138 | 2026-04-01 | 2026-05-06 |
| A Clinical Trial to Investigate the Safety and Efficacy of Papillex® on Abnormal Cervical Cells Caused by HPV. Papillex®, Placebo - CIN - Cervical Intraepithelial Neoplasia, CIN 1 | Not applicable | Recruiting | Papillex Inc. | 60 | 2026-03-01 | 2026-07-08 |
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Uterine Cervical Neoplasms (181) · Papillomavirus Infections (65) · Precancerous Conditions (30) · Squamous Intraepithelial Lesions (30) · Atypical Squamous Cells of the Cervix (28) · Acquired Immunodeficiency Syndrome (17) · Neoplasms (12) · Persistent Infection (9) · HIV Infections (7) · Uterine Cervical Diseases (7) · Vulvar Neoplasms (7) · Carcinoma in Situ (6) · Infections (6) · Adenocarcinoma in Situ (5)
Female Urogenital Diseases (403) · Female Urogenital Diseases and Pregnancy Complications (402) · Genital Diseases (402) · Urogenital Diseases (402) · Genital Diseases, Female (400) · Uterine Diseases (400) · Uterine Cervical Diseases (396) · Neoplasms (391) · Precancerous Conditions (373) · Neoplasms by Site (184) · Urogenital Neoplasms (181) · Genital Neoplasms, Female (180) · Uterine Neoplasms (179) · Pathological Conditions, Signs and Symptoms (128) · Infections (86)
Colposcopy (18) · Imiquimod (15) · Conization (13) · Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18 (9) · Papillomavirus Vaccines (9) · Vaccines (8) · Cryotherapy (7) · Acetic Acid (6) · Biopsy (6) · Blood Specimen Collection (5) · Human Papillomavirus DNA Tests (5) · Papanicolaou Test (5) · Vaginal Smears (5) · human papillomavirus vaccine, L1 type 16, 18 (5) · GX-188 vaccine (4)
M.D. Anderson Cancer Center (14) · National Cancer Institute (NCI) (13) · GlaxoSmithKline (12) · Zydolab - Institute of Cytology and Immune Cytochemistry (9) · British Columbia Cancer Agency (8) · University of Aarhus (8) · Ruhr University of Bochum (7) · Barretos Cancer Hospital (6) · Universiteit Antwerpen (6) · Genexine, Inc. (5) · Huazhong University of Science and Technology (5) · Jun Zhang (5) · Lei Li (5) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (5) · UNC Lineberger Comprehensive Cancer Center (5)
United States (114) · China (53) · Germany (25) · Canada (21) · France (13) · Belgium (12) · Denmark (12) · South Korea (12) · Brazil (11) · Kenya (10) · South Africa (9) · Taiwan (9) · Italy (7) · Puerto Rico (7) · Spain (7)
Michele Follen, MD, PhD (9) · Rachel L Winer, PhD, MPH (6) · Ting Wu, Ph. D. (6) · Ziad Hilal, M.D. (6) · Lei Li, M.D. (5) · Leeya Pinder, MD, MPH (4) · Margaret M Madeleine, PhD, MPH (4) · Pierre Van Damme, MD, PhD (4) · Clemens B Tempfer, MD, MBA (3) · Jerome L Belinson, MD (3) · Lisa Rahangdale, MD, MPH (3) · Miriam Cremer, MD (3) · Yuemei Hu, Bachelor (3)
PMID 19586656, PMID 22914404, PMID 24435414, PMID 28173776, PMID 30195193, PMID 10451482, PMID 10764464, PMID 10796771, PMID 10880770, PMID 11229684, PMID 12544628, PMID 12807941, PMID 1305466, PMID 14990651, PMID 14992310, PMID 1550088, PMID 15668895, PMID 15888991, PMID 15944071, PMID 15986031, PMID 16150255, PMID 16152582, PMID 16232104, PMID 16264158, PMID 16264159, PMID 16284376, PMID 17177902, PMID 17204311, PMID 1731281, PMID 17335880, PMID 17354241, PMID 17393618, PMID 17494925, PMID 17505218, PMID 17586030, PMID 17699008, PMID 17919718, PMID 17942872, PMID 17959735, PMID 18085153, PMID 18322812, PMID 18348589, PMID 18630456, PMID 18798072, PMID 18948732, PMID 19118066, PMID 19531227, PMID 19552597, PMID 19638646, PMID 19716561
U24CA275417 (6), P01CA082710 (4), UG1CA275402 (4), 2018 (3), P30CA016672 (3), U10CA101165 (3), 2008 (2), 2015 (2), P50CA098252 (2), R01CA103830 (2), U01CA121947 (2), 2009 (1), 2014 (1), 2016 (1), 2017 (1)