41 completed, 9 terminated, 9 unknown, 5 active not recruiting. 24 Phase 2, 22 Phase 1, 16 Not applicable, 6 Phase 3, 6 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| PDT vs Peels for Treatment of Actinic Keratoses Photodynamic Therapy, Chemical Peels - Actinic Keratoses | Phase 2 | Not yet recruiting | Northwestern University | 60 | 2026-08-01 | 2026-07-01 |
| Clinical Comparative Evaluation of the Use of Photodynamic Therapy in Conjunction With the Use of Vitamin D in Management Stage II Grade B Periodontitis Patients non-surgical periodontal therapy (SRP) and Photodynamic therapy (PDT) with systemic vitamin D - Vitamin D Deficiency | Not applicable | Completed | Cairo University | 24 | 2025-03-01 | 2026-05-26 |
| Photoradiation With Verteporfin to Facilitate Immunologic Activity of Pembrolizumab in Unresectable, Locally Advanced or Metastatic Pancreatic Cancer Biopsy, Biospecimen Collection, Computed Tomography - Locally Advanced Pancreatic Adenocarcinoma, Metastatic Pancreatic Adenocarcinoma | Phase 2 | Active not recruiting | Mayo Clinic | 24 | 2024-12-06 | 2026-06-18 |
| Fluorescence Image Guided Surgery Followed by Intraoperative Photodynamic Therapy for Improving Local Tumor Control in Patients With Locally Advanced or Recurrent Colorectal Cancer Aminolevulinic Acid, Biospecimen Collection, Computed Tomography - Locally Advanced Colorectal Carcinoma, Recurrent Colorectal Carcinoma | Phase 1 / Phase 2 | Recruiting | Roswell Park Cancer Institute | 21 | 2024-07-30 | 2026-10-15 |
| A Dose-escalation Clinical Study of Intraoperative Photodynamic Therapy of Glioblastoma 5-ALA HCl intraoperative Photodynamic Therapy (PDT) at 200 J/cm^2, 5-ALA HCl intraoperative Photodynamic Therapy (PDT) at 400 J/cm^2 - Primary Glioblastoma | Phase 1 / Phase 2 | Active not recruiting | Hemerion Therapeutics | 12 | 2024-02-20 | 2026-05-22 |
| Aftificial Inteligence in Assisted Reproductive Techniques to Assess Oocyte Quality and Embryo Ploidy arteficial inteligence evaluation of oocyte and embryo development - Infertility, Infertility, Female | Recruiting | Charles University, Czech Republic | 1000 | 2024-01-05 | 2025-01-22 | |
| COMPARİSON OF EARLY COMPLİCATİONS İN PERCUTANEOUS TRACHEOSTOMİES PERFORMED VİA VERTİCAL AND HORİZONTAL SKİN INCİSİONS percutaneous dilatational tracheostomy (PDT) via the Griggs technique -Horizontal incision, percutaneous dilatational tracheostomy (PDT) via the Griggs technique -Vertical incision - Percutaneous Dilatational Tracheostomy Early Complications | Completed | Bursa Yuksek Ihtisas Training and Research Hospital | 74 | 2023-09-01 | 2026-06-23 | |
| Safety and Efficacy of PDT vs RFA vs PDT+RFA for the Treatment of Extrahepatic Cholangiocarcinoma RFA, PDT, RFA combined with PDT - Extrahepatic Cholangiocarcinoma, Bile Duct Cancer | Not applicable | Unknown | First People's Hospital of Hangzhou | 70 | 2023-01-01 | 2023-02-21 |
| Pembrolizumab and Photodynamic Therapy in Previously Treated Metastatic Esophageal Squamous Cell Carcinoma Pembrolizumab, Sinoporphyrin Sodium, Photodynamic therapy - Esophageal Squamous Cell Carcinoma | Phase 2 | Not yet recruiting | Peking University | 54 | 2022-12-01 | 2022-11-28 |
| Photodynamic Therapy to Amplify the Response to Immunotherapy in Patients With Non-small Cell Lung Cancer With Pleural Disease Porfimer Sodium, Video-Assisted Thoracic Surgery, Photodynamic Therapy - Lung Non-Small Cell Carcinoma, Pleural Disorder | Phase 1 | Terminated | Roswell Park Cancer Institute | 5 | 2022-03-10 | 2026-02-04 |
| A Comparative Study of Endoscopic Submucosal Dissection and Photodynamic Therapy for Early Esophageal Cancer PDT, ESD - Esophageal Carcinoma in Situ AJCC V7 | Not applicable | Unknown | The First Affiliated Hospital of Henan University of Science and Technology | 46 | 2022-03-01 | 2022-01-26 |
| Nasal Photodisinfection in All Patients Presenting for Surgery for a Wide Range of Surgical Procedures methylene blue 0.01%/chlorhexidine gluconate 0.25% + light activation - Surgical Site Infections, Nosocomial Infection | Phase 2 | Completed | Ondine Biomedical Inc. | 322 | 2022-02-04 | 2022-08-22 |
| Alteration of the Immune Microenvironment in Basal Cell Carcinoma Following Photodynamic Therapy ALA, PDT - Basal Cell Carcinoma | Phase 2 | Active not recruiting | Case Comprehensive Cancer Center | 18 | 2021-12-13 | 2026-06-01 |
| Study to Evaluate the Safety and Efficacy of BF-200 ALA (Ameluz®) and BF-RhodoLED® in the Treatment of Moderate to Severe Acne Vulgaris With Photodynamic Therapy in Adults 1h Incubation Photodynamic therapy (PDT) (ALA-PDT, Ameluz®-PDT), 1h Incubation Photodynamic therapy (PDT) (vehicle to BF-200 ALA containing no active ingredient), 3h Incubation Photodynamic therapy (PDT) (ALA-PDT, Ameluz®-PDT) - Acne Vulgaris | Phase 2 | Completed | Biofrontera Inc. | 120 | 2021-12-10 | 2026-10-01 |
| Light Dosimetry for Photodynamic Therapy With Porfimer Sodium in Treating Participants With Malignant Mesothelioma or Non-Small Cell Lung Cancer With Pleural Disease Undergoing Surgery Light Dosimetry for Intranoperative Therapy, Photodynamic Therapy, Porfimer Sodium - Malignant Mesothelioma, Non-Small Cell Lung Carcinoma | Phase 1 | Completed | Roswell Park Cancer Institute | 9 | 2021-09-17 | 2026-03-27 |
| Comparison of Clinical Efficiency of Photodynamic Therapy and Topical Corticosteroid in Treatment of Oral Lichen Planus Triamcinolone Acetonide, Photodynamic Therapy - Lichen Planus, Oral | Phase 2 | Completed | Wroclaw Medical University | 30 | 2020-12-10 | 2021-08-02 |
| Photodynamic Therapy in Patients With Gingivitis scaling and root planing (SRP) + PDT placebo, scaling and root planing (SRP) + PDT - Gingivitis, Orthodontic Appliance Complication | Not applicable | Completed | University of Nove de Julho | 20 | 2020-11-09 | 2023-10-11 |
| St. John's Wort Photodynamic Therapy PDT - Acne | Not applicable | Completed | Seoul National University Bundang Hospital | 31 | 2020-06-01 | 2021-10-11 |
| Clinical Effect and Safety of PDT and RFA for Unresectable EHCC Photodynamic therapy, radiofrequency ablation - Cholangiocarcinoma | Not applicable | Completed | First People's Hospital of Hangzhou | 67 | 2020-03-01 | 2021-09-01 |
| Evaluation of Photodynamic Therapy in Pericoronitis irrigation /sterile saline, Conventional methylene blue as photosensitizer, Methylene blue for oral use as photosensitizer - Pericoronitis | Not applicable | Completed | University of Nove de Julho | 34 | 2019-12-01 | 2026-07-29 |
Showing 20 of 73. Sign in to see all of them.
Acne Vulgaris (7) · Carcinoma, Basal Cell (7) · Carcinoma, Non-Small-Cell Lung (5) · Macular Degeneration (4) · Squamous Cell Carcinoma of Head and Neck (4) · Cholangiocarcinoma (3) · Keratosis, Actinic (3) · Pancreatic Neoplasms (3) · Basal Cell Nevus Syndrome (2) · Bile Duct Neoplasms (2) · Carcinoma, Transitional Cell (2) · Mesothelioma, Malignant (2) · Mycosis Fungoides (2) · Non-Muscle Invasive Bladder Neoplasms (2) · Pleural Diseases (2)
Roswell Park Cancer Institute (10) · University of Nove de Julho (5) · Photocure (4) · Mayo Clinic (3) · National Cancer Institute (NCI) (3) · Shahid Beheshti University of Medical Sciences (3) · Abramson Cancer Center at Penn Medicine (2) · Biofrontera Inc. (2) · Case Comprehensive Cancer Center (2) · First People's Hospital of Hangzhou (2) · Theralase® Technologies Inc. (2) · Weill Medical College of Cornell University (2) · Biofrontera Bioscience GmbH (1) · Bursa Yuksek Ihtisas Training and Research Hospital (1) · Cairo University (1)
United States (40) · Brazil (7) · China (4) · Canada (3) · Australia (1) · Chile (1) · Czechia (1) · Egypt (1) · France (1) · Germany (1) · Poland (1) · Serbia (1) · South Korea (1) · Sweden (1) · Switzerland (1)
David Pariser, MD (2) · Edward V. Maytin, MD, PhD (2) · Hassan Arshad (2) · Keith Cengel, MD, PhD (2) · Zohreh Tehranchi-nia, assist.prof. (2) · Aaron Mangold (1) · Anna Carolina R Horliana, Phd (1) · Anthony S Dakwar (1) · Ariel Hasson, MD (1) · Ashish C Bhatia, MD (1) · Caihong Dong, MD，PhD (1) · Chukwumere Nwogu (1) · Cristiane M Franca, PhD (1) · Daniela FT Silva, PhD (1)
PMID 10423050, PMID 16862549, PMID 18754720, PMID 19125084, PMID 21394411, PMID 21473845, PMID 21537592, PMID 21911312, PMID 22057503, PMID 23868427, PMID 24119379, PMID 25161649, PMID 25198431, PMID 25394474, PMID 25555191, PMID 26013003, PMID 26160556, PMID 26510574, PMID 26862179, PMID 27248838, PMID 28793884, PMID 29342492, PMID 29926944, PMID 30222972, PMID 30399455, PMID 30985667, PMID 31027098, PMID 32243363, PMID 33104917, PMID 33647286, PMID 34261044, PMID 34995788, PMID 36946749, PMID 39666443, PMID 39838651, PMID 40522203, PMID 40846240
P01CA084203 (2), P30CA016056 (2), 2019 (1), 2025 (1), P30CA060553 (1), R21CA153594 (1), U01CA099168 (1), UL1TR001412 (1)