40 completed. 40 Phase 3, 11 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 40 | Completed 40 |
| Phase 2 | 11 | Completed 11 |
Follow Alcohol Dependence: new trials by email Literature Review of Alcohol Dependence trials Research Report on Alcohol Dependence
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Interdisciplinary Study of A Novel Anticonvulsant in Alcoholism Zonisamide, Take Control, Placebo (for Zonisamide) - Alcohol Dependence | Phase 3 | Completed | Boston University Charles River Campus | 81 | 2017-09-21 | 2023-06-18 |
| Progesterone Effect on Individuals Diagnoses With AD and PTSD. Progesterone, Placebo (for Progesterone) - Alcohol Dependence, Post-Traumatic Stress Disorder (PTSD) | Phase 2 / Phase 3 | Completed | Yale University | 13 | 2016-09-01 | 2023-04-26 |
| A Long-term Extension Study for the Phase 3 Study of Nalmefene (339-14-001) in Patients With Alcohol Dependence Nalmefene hydrochloride - Alcohol Dependence | Phase 3 | Completed | Otsuka Pharmaceutical Co., Ltd. | 405 | 2015-07-13 | 2020-07-20 |
| Glutamatergic Modulation of Disordered Alcohol Use CI-581a, CI-581b, Motivational Enhancement Therapy (MET) - Alcohol Dependence | Phase 2 / Phase 3 | Completed | New York State Psychiatric Institute | 50 | 2015-07-01 | 2020-02-11 |
| A Multicenter, Randomized, Double-blind, Placebo-controlled, 3-parallel-group Comparison Trial to Investigate the Effect of Nalmefene on Alcohol Consumption Reduction in Patients With Alcohol Dependence (Phase 3 Trial) Nalmefene hydrochloride, Placebo - Alcohol Dependence | Phase 3 | Completed | Otsuka Pharmaceutical Co., Ltd. | 678 | 2015-02-09 | 2019-09-30 |
| Efficacy and Safety Evaluating Study of Odelepran for the Use in Patient With Alcohol Dependence Odelepan, Placebo - Alcohol Dependence | Phase 3 | Completed | R-Pharm | 644 | 2014-11-18 | 2019-05-22 |
| Oral vs. Injectable Naltrexone for Hospitalized Veterans With Alcohol Dependence Naltrexone - Alcohol Dependence | Phase 3 | Completed | University of Wisconsin, Madison | 54 | 2013-05-01 | 2019-03-05 |
| Baclofen in the Treatment of Alcohol Dependence With or Without Alcoholic Liver Disease Baclofen 30mg/day, Baclofen 75mg/day, Placebo - Alcoholic Liver Disease, Alcohol Dependence | Phase 3 | Completed | South West Sydney Local Health District | 104 | 2013-03-01 | 2017-08-08 |
| Efficacy and Safety of Baclofen for Maintenance of Abstinence in Alcohol Dependent Patients Baclofen, Placebo (for baclofen) - Alcohol Dependence | Phase 3 | Completed | Ethypharm | 316 | 2012-12-01 | 2014-07-30 |
| Changing the Vulnerable Brain: A Neuromodulation Study in Alcohol Dependence Repetitive Transcranial Magnetic Stimulation - Alcohol Dependence | Phase 3 | Completed | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 80 | 2012-02-01 | 2015-09-23 |
| New Treatment for Alcohol and Nicotine Dependence Low-Dose Topiramate, Placebo, High-Dose Topiramate - Alcohol Dependence, Nicotine Dependence | Phase 2 / Phase 3 | Completed | University of Virginia | 236 | 2011-11-01 | 2025-10-31 |
| Treatment Strategy for Alcohol Use Disorders in Veterans With TBI Valproate, Naltrexone - Alcohol Dependence | Phase 3 | Completed | VA Office of Research and Development | 62 | 2011-09-01 | 2016-06-09 |
| Varenicline Treatment for Active Alcoholic Smokers Varenicline, placebo - Smoking, Tobacco Dependence | Phase 2 / Phase 3 | Completed | Mayo Clinic | 33 | 2011-06-01 | 2018-02-05 |
| Baclofen for the Treatment of Alcohol Dependence Baclofen, Placebo - Alcohol Dependence | Phase 2 / Phase 3 | Completed | Charite University, Berlin, Germany | 56 | 2011-02-01 | 2014-09-05 |
| Aripiprazole Effects on Alcohol Drinking and Craving Aripiprazole, Placebo - Alcohol Dependence | Phase 3 | Completed | Medical University of South Carolina | 99 | 2011-02-01 | 2017-08-08 |
| Gabapentin for Abstinence Initiation in Alcohol Dependence Gabapentin, Placebo - Alcohol Dependence | Phase 2 / Phase 3 | Completed | New York State Psychiatric Institute | 40 | 2010-08-01 | 2019-04-24 |
| Efficacy of Topiramate for Hospitalized Patients With Alcoholism Topiramate - Alcohol Dependence | Phase 2 / Phase 3 | Completed | Chiang Mai University | 90 | 2010-06-01 | 2011-06-23 |
| Safety and Efficacy of Nalmefene in Patients With Alcohol Dependence Placebo, Nalmefene - Alcohol Dependence | Phase 3 | Completed | H. Lundbeck A/S | 665 | 2009-03-01 | 2013-08-07 |
| Efficacy of Nalmefene in Patients With Alcohol Dependence Placebo, Nalmefene - Alcohol Dependence | Phase 3 | Completed | H. Lundbeck A/S | 678 | 2009-03-01 | 2013-07-22 |
| Prazosin for Treatment of Patients With Alcohol Dependence (AD) and Post Traumatic Stress Disorder (PTSD). Prazosin, Placebo - Alcohol Dependence, Stress Disorders, Post-Traumatic | Phase 3 | Completed | Yale University | 96 | 2009-01-01 | 2020-03-19 |
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Alcoholism (40) · Alcohol-Related Disorders (3) · Mental Disorders (3) · Stress Disorders, Post-Traumatic (3) · Alcohol Drinking (2) · Patient Acceptance of Health Care (2) · Substance-Related Disorders (2) · Tobacco Use Disorder (2) · Anxiety Disorders (1) · Behavior, Addictive (1) · Brain Injuries, Traumatic (1) · Depression (1) · Emotional Regulation (1) · Impulsive Behavior (1) · Liver Diseases, Alcoholic (1)
Chemically-Induced Disorders (40) · Substance-Related Disorders (38) · Alcohol-Related Disorders (37) · Mental Disorders (37) · Behavior (7) · Stress Disorders, Traumatic (3) · Trauma and Stressor Related Disorders (3) · Drinking Behavior (2) · Health Behavior (2) · Treatment Adherence and Compliance (2) · Alcohol-Induced Disorders (1) · Behavioral Symptoms (1) · Brain Diseases (1) · Brain Injuries (1) · Central Nervous System Diseases (1)
Naltrexone (5) · nalmefene (5) · Baclofen (4) · Gabapentin (3) · Sugars (3) · Topiramate (3) · vivitrol (3) · Aripiprazole (2) · Valproic Acid (2) · Acamprosate (1) · Cognitive Behavioral Therapy (1) · Counseling (1) · Crisis Intervention (1) · Flumazenil (1) · LY2196044 (1)
Yale University (5) · H. Lundbeck A/S (3) · Medical University of South Carolina (3) · Alkermes, Inc. (2) · Boston Medical Center (2) · Charite University, Berlin, Germany (2) · New York State Psychiatric Institute (2) · Otsuka Pharmaceutical Co., Ltd. (2) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Alcohol Research Group (1) · AstraZeneca (1) · Bankole Johnson (1) · Boston University Charles River Campus (1) · Brown University (1) · Chiang Mai University (1)
United States (25) · Germany (3) · Czechia (2) · France (2) · Japan (2) · Poland (2) · Russia (2) · Australia (1) · Austria (1) · Belgium (1) · Brazil (1) · Estonia (1) · Finland (1) · Hungary (1) · Italy (1)
Elizabeth Ralevski, Ph.D. (2) · Ismene L Petrakis, MD (2) · Andreas Heinz, Prof., M.D. (1) · Andrew Baillie, PhD (1) · Anneke E Goudriaan, Prof dr. (1) · Bankole A Johnson, MD (1) · Bankole Johnson, M.D., Ph.D. (1) · Bernard L Silverman, MD (1) · Bernard L. Silverman, MD (1) · David H Barlow, PhD (1) · Elias Dakwar, MD (1) · Ismene Petrakis, MD (1) · James C Garbutt, MD (1)
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P60AA013759 (2), P50AA010761 (1), R01AA009568 (1), R01AA009892 (1), R01AA010522 (1), R01AA014850 (1), R01AA019720 (1), R21AA023010 (1)