17 completed, 8 recruiting, 5 unknown, 3 active not recruiting. 28 Not applicable, 2 Early Phase 1, 1 Phase 2.
Follow Adverse Childhood Experiences: new trials by email Literature Review of Adverse Childhood Experiences trials Research Report on Adverse Childhood Experiences
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Early Life Exposures Among Children With Sickle Cell Disease Breastfeeding support group, Observation - Sickle Cell Disease, Adverse Childhood Experiences | Not applicable | Recruiting | University of Alabama at Birmingham | 20 | 2026-08-01 | 2026-07-15 |
| Effects of Online Mindfulness Therapy on Pain and Stress in Adults With Chronic Migraine and Adverse Childhood Experiences Online Mindfulness-Based Cognitive Therapy - Chronic Migraine, Adverse Childhood Experiences | Not applicable | Not yet recruiting | Fundación Cardiovascular de Colombia | 60 | 2025-07-01 | 2025-06-26 |
| The THRIVE Study: Teaching Healthy Regulation in Individuals & Vulnerable Environments Garnering Resilience in Traumatized youth and families (GRIT), Digital Citizenship Curriculum (DCC) - Adverse Childhood Experiences, Family Functioning | Not applicable | Recruiting | University of California, Irvine | 210 | 2025-04-17 | 2026-03-18 |
| Brief Intervention for Chronic Pain and History of Stressful Experiences Trauma Focused Emotional Awareness and Expression Therapy (EAET) - Chronic Pain, Trauma | Not applicable | Completed | Brigham and Women's Hospital | 50 | 2025-04-14 | 2026-03-10 |
| ACEs, SIRT1, and Premature Vascular Aging in Humans Nicotinamide Riboside, Placebo - Adverse Childhood Experiences, Endothelial Dysfunction | Not applicable | Recruiting | University of Wisconsin, Madison | 30 | 2025-03-27 | 2026-08-19 |
| Study of Transition in Real-life Experiences Affecting Micturition and Well-being in Adolescent Years Semi-structured in-depth interviews with standardized validated questionnaires, Completion of a urological time-line - Lower Urinary Tract Symptoms (LUTS), Transition Care | Enrolling by invitation | University Hospital, Ghent | 20 | 2025-02-28 | 2026-01-14 | |
| ACEs Referral From PED In-person therapy, Telehealth therapy - Adverse Childhood Experiences | Not applicable | Completed | Emory University | 62 | 2024-10-03 | 2025-04-25 |
| Effects of Parent-Adolescent Joint Interventions for Adolescents With Adverse Childhood Experiences Emotiaonl skill enhancement, PCE promotion, Psychoeducation - Stress, Emotional, Stress-related Mental Disorders | Not applicable | Active not recruiting | Peking University | 3000 | 2024-09-27 | 2024-12-04 |
| Growing Up in Multifactorial Risk Conditions Home visiting programme - Adverse Childhood Experiences, Developmental Risk | Not applicable | Enrolling by invitation | IRCCS Eugenio Medea | 352 | 2024-06-26 | 2026-03-23 |
| The ACCEPT Study: Improving the Process of Disclosing Adverse Childhood Experiences in Community Mental Health ACCEPT intervention - Adverse Childhood Experiences | Not applicable | Unknown | King's College London | 20 | 2024-06-01 | 2024-06-27 |
| The Iowa ACEs and Sleep Cohort and Manipulating Sleep in Young Adults With ACEs Studies Cognitive Behavioral Therapy for Insomnia (CBT-i) - Adverse Childhood Experiences, Vascular Dilatation | Not applicable | Suspended | University of Wisconsin, Madison | 70 | 2024-05-01 | 2026-10-29 |
| School Violence Exposure as an Adverse Childhood Experience School shooting incident - Mental Health Outcomes, Adverse Childhood Experiences | Recruiting | Teachers College, Columbia University | 2500 | 2024-04-26 | 2025-09-16 | |
| CEDARS Intervention: A Coping, Emotional Development, & Stress Reduction Intervention CEDARS - Adolescent Behavior, Stress Reduction | Not applicable | Completed | Ann & Robert H Lurie Children's Hospital of Chicago | 36 | 2024-02-29 | 2026-08-17 |
| Neurobehavioral Mechanisms Linking Childhood Adversity to Increased Risk for Smoking Nicotine nasal spray 0.5 mg, Placebo - Adverse Childhood Experiences, Nicotine Dependence, Cigarettes | Early Phase 1 | Recruiting | Duke University | 150 | 2024-01-19 | 2026-04-02 |
| Evaluating an Adverse Childhood Experience-Targeting Advocate Model of a Substance Use Prevention Program Strengthening Families Program + Family Advocate, Strengthening Families Program - Substance-Related Disorders, Adverse Childhood Experiences | Not applicable | Recruiting | RTI International | 360 | 2023-11-29 | 2026-05-05 |
| Childhood Trauma, Exercise, and Cognition Moderate Intensity Exercise (one day), Placebo - Light Intensity Exercise (one day), Moderate Intensity Exercise (9 wks) - Adverse Childhood Experiences | Not applicable | Recruiting | University of Texas at Austin | 34 | 2023-11-27 | 2026-07-17 |
| BLOOM: Boldly Living outdOOrs for Mental Health Group Nature Outings, Family Outings - Anxiety, Stress Disorder, Posttraumatic | Not applicable | Withdrawn | University of California, San Francisco | 2023-07-18 | 2026-08-14 | |
| The FACE Self-help App for Fostering Resilience FACE self-help App - Adverse Childhood Experiences | Not applicable | Completed | Jeannette Brodbeck | 167 | 2023-05-31 | 2025-12-24 |
| Traumatic Events in Childhood, Attachment, Pain Perception, Epigenetic Marks, Quality of Life and Resilience. Biological samples - Chronic Pain, Adverse Childhood Experiences | Completed | University of Lorraine | 100 | 2023-04-12 | 2025-07-25 | |
| Playing Playfully to Overcome Adversity Playing Playfully to Overcome Adversity - Adverse Childhood Experiences | Not applicable | Active not recruiting | Sacred Heart University | 12 | 2023-03-01 | 2025-05-22 |
Showing 20 of 39. Sign in to see all of them.
Depression (4) · Anxiety Disorders (3) · Chronic Pain (3) · Emotional Regulation (3) · Pain (2) · Psychological Well-Being (2) · Stress Disorders, Post-Traumatic (2) · Wounds and Injuries (2) · Adolescent Behavior (1) · Anemia, Sickle Cell (1) · Aneurysm (1) · Autism Spectrum Disorder (1) · Breast Feeding (1) · Breast Neoplasms (1) · Constipation (1)
Behavior (13) · Mental Disorders (9) · Pathological Conditions, Signs and Symptoms (7) · Behavioral Symptoms (5) · Signs and Symptoms (5) · Nervous System Diseases (4) · Neurologic Manifestations (4) · Social Behavior (4) · Self-Control (3) · Stress Disorders, Traumatic (3) · Trauma and Stressor Related Disorders (3) · Cardiovascular Diseases (2) · Chemically-Induced Disorders (2) · Pain (2) · Pathologic Processes (2)
Biological Products (1) · Cognitive Behavioral Therapy (1) · Focus Groups (1) · Influenza Vaccines (1) · Insemination, Artificial, Heterologous (1) · Mass Screening (1) · Neuropsychological Tests (1) · Nicotine (1) · Observation (1) · Probiotics (1) · Therapeutics (1) · Tobacco Use Cessation Devices (1) · nicotinamide-beta-riboside (1)
University of Pittsburgh (3) · University of Wisconsin, Madison (3) · University of Lorraine (2) · Ann & Robert H Lurie Children's Hospital of Chicago (1) · Brigham and Women's Hospital (1) · Dalhousie University (1) · Duke University (1) · Emory University (1) · Fundación Cardiovascular de Colombia (1) · Gia Mudd (1) · IRCCS Eugenio Medea (1) · Jeannette Brodbeck (1) · King's College London (1) · Le Bonheur Children's Hospital (1) · Loma Linda University (1)
United States (26) · Canada (2) · France (2) · Switzerland (2) · Belgium (1) · China (1) · Colombia (1) · Italy (1) · Jamaica (1) · South Africa (1) · United Kingdom (1)
Nathaniel Jenkins, PhD (2) · Rachel A Vaughn-Coaxum, Ph.D. (2) · Amiya Waldman-Levi, PhD (1) · Ariane Marie-Mitchell, MD, PhD, MPH (1) · Brandi M Pernell, DNP, MSPH (1) · Christine Lay, MD (1) · Claudia Frankfurter, MD (1) · Dallas J Elgin, PhD (1) · Dawn T. Bounds, Ph.D. (1) · Elkin Rene Llanez Anaya, MD, Psychiatrist. (1) · Erin Logue, PhD (1) · Gesulla Cavanaugh, PhD (1) · Gia Mudd-Martin, PhD (1) · Hsiao-wei M Banks (1)
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K01HL147995 (1), K23HL159280 (1), K23MH123685 (1), R01DA054972 (1), R01DA060784 (1), R01HL167788 (1), R21MH123835 (1), R24AG065174 (1)