11 not yet recruiting, 7 recruiting, 6 completed, 6 unknown. 16 Not applicable, 3 Phase 4, 1 Phase 1, 1 Phase 2.
Follow Advanced Heart Failure: new trials by email Literature Review of Advanced Heart Failure trials Research Report on Advanced Heart Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| TORCH-LATAM-002: Regional Pathway for Adult Heart Transplant Evaluation and Candidacy TORCH Adult Heart Transplant Evaluation and Candidacy Pathway - Advanced Heart Failure, Heart Transplantation | Not applicable | Not yet recruiting | CardioVision International Tech, S.A.S. de C.V. | 360 | 2027-03-30 | 2026-10-13 |
| TORCH-LATAM-004: Regional Advanced-Therapy Pathways for Adults With Acquired or Structural Heart Disease TORCH Adult Advanced Therapies Pathway (TORCH-AATP) - Advanced Heart Failure, Acquired Heart Disease | Not applicable | Not yet recruiting | CardioVision International Tech, S.A.S. de C.V. | 360 | 2027-03-30 | 2026-10-13 |
| TORCH-LATAM-003: Regional Advanced-Therapy Pathways for Congenital Heart Disease TORCH Congenital Advanced Therapies Pathway (TORCH-CATP) - Congenital Heart Disease, Advanced Heart Failure | Not applicable | Not yet recruiting | CardioVision International Tech, S.A.S. de C.V. | 360 | 2027-03-30 | 2026-10-13 |
| A Prospective, Multicenter,Single-arm Study of DuoCor 2 Ventricular Assist System for the Treatment of Advanced Biventricular Heart Failure DuoCor 2 Ventricular Assist System (DuoCor 2 VAS) - Advanced Heart Failure | Not applicable | Not yet recruiting | Shenzhen Core Medical Technology CO.,LTD. | 64 | 2026-10-01 | 2026-08-11 |
| HiCM-188 Cell Therapy in Adults With Advanced Heart Failure Undergoing Heart Bypass Surgery HiCM-188 Cells - Advanced Heart Failure, Ischemic Heart Failure | Phase 1 / Phase 2 | Not yet recruiting | HELP Therapeutics Co., Ltd. | 12 | 2026-09-01 | 2026-06-29 |
| Cardiorenal Syndrome: Characteristics and Prognostic Impact in Advanced Heart Failure Cardiorenal syndrome follow-up - Advanced Heart Failure, Cardiorenal Syndrome | Not applicable | Not yet recruiting | Hospices Civils de Lyon | 100 | 2026-09-01 | 2026-07-01 |
| Tier Palliative Care For Patients With Advanced Heart Failure or Cancer Tier-Palliative Care, Community Health Worker - Advanced Heart Failure, Advanced Non-Colorectal Gastrointestinal Cancer | Not applicable | Recruiting | Icahn School of Medicine at Mount Sinai | 400 | 2026-07-10 | 2026-09-14 |
| REACTION-VAD Trial: Remote Exercise Training Via Telemedicine in Patients With Long-Term Ventricular Assist Devices Remote Physical Conditioning Program (Telerehabilitation), Usual care. No Remote Monitoring. - Heart Failure, Advanced Heart Failure | Not applicable | Not yet recruiting | Puerta de Hierro University Hospital | 78 | 2026-05-01 | 2026-05-28 |
| DuoCor 2 DOMINATE Study DuoCor Ventricular Assist System - Advanced Heart Failure | Not applicable | Not yet recruiting | Shenzhen Core Medical Technology CO.,LTD. | 50 | 2026-04-01 | 2026-04-24 |
| Palliative Care Intervention to Improve Health Related Quality of Life for Patients on Long-Term LVAD Support Palliative care intervention - Advanced Heart Failure, Mechanical Circulatory Support | Not applicable | Not yet recruiting | Medstar Health Research Institute | 90 | 2026-03-01 | 2026-03-03 |
| GDF-15 and Early Outcomes After LVAD Implantation Advanced Heart Failure, Left Ventricular Assist Device Implantation | Recruiting | Akdeniz University | 48 | 2026-02-04 | 2026-03-27 | |
| Trial of Low-intensity Anticoagulation to Reduce GI or Other Bleeding Complications With Equivalent Therapeutic Efficacy in HeartMate 3 LVAD Patients Warfarin (low-intensity anticoagulation), Warfarin (standard anticoagulation) - Advanced Heart Failure, Left Ventricular Assist Devices | Phase 4 | Not yet recruiting | Asan Medical Center | 94 | 2025-10-01 | 2025-07-23 |
| Multi-Site Feasibility Testing of the Ventricular Assist Device Anticipatory Guidance Tool Ventricular Assist Device, Advanced Heart Failure | Recruiting | Bryan Heart | 10 | 2025-08-17 | 2025-09-19 | |
| Wearables and Artificial Intelligence in Advanced Heart Failure Care Advanced Heart Failure | Not yet recruiting | UMC Utrecht | 200 | 2025-07-01 | 2025-07-04 | |
| CorWave LVAS FIH Study LVAS - Advanced Heart Failure | Not applicable | Recruiting | CorWave | 20 | 2025-05-06 | 2026-08-03 |
| Tier - Palliative Care For Patients With Advanced Heart Failure or Cancer Tier-Palliative Care - Advanced Heart Failure, Advanced Non-Colorectal Gastointestinal Cancer | Not applicable | Recruiting | Icahn School of Medicine at Mount Sinai | 60 | 2025-01-31 | 2026-10-13 |
| Cardiac Cachexia in Advanced Heart Failure Advanced Heart Failure, Cardiac Cachexia | Completed | Royal Brompton & Harefield NHS Foundation Trust | 261 | 2024-02-25 | 2026-06-04 | |
| First in Human Study of the Icoms Flowmaker Cardiac assist device implantation during surgical intervention - Advanced Heart Failure | Not applicable | Recruiting | FineHeart | 10 | 2023-12-19 | 2026-06-08 |
| Screening for Advanced Heart Failure IN Stable outPatientS - The SAINTS Study (SAINTS B) CardioMEMS HF System, Standard heart failure medical therapy - Advanced Heart Failure, Heart Failure With Reduced Ejection Fraction | Phase 4 | Unknown | Finn Gustafsson | 60 | 2023-03-02 | 2023-03-20 |
| Carmat Total Artificial Heart as a Bridge to Transplant in Patients With Advanced Heart Failure Carmat Total Artificial Heart, Standard therapy for heart failure - Advanced Heart Failure | Not applicable | Active not recruiting | Carmat SAS | 104 | 2022-12-12 | 2026-04-28 |
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Heart Failure (7) · Cachexia (1) · Cardio-Renal Syndrome (1) · Frailty (1) · Gastrointestinal Hemorrhage (1) · Heart Defects, Congenital (1) · Hyperemia (1) · Hypertension (1) · Hypotension (1) · Reperfusion Injury (1) · Respiratory Insufficiency (1) · Stroke (1) · Thromboembolism (1) · Weight Loss (1)
Cardiovascular Diseases (11) · Heart Diseases (9) · Vascular Diseases (4) · Pathologic Processes (3) · Pathological Conditions, Signs and Symptoms (3) · Body Weight (1) · Body Weight Changes (1) · Brain Diseases (1) · Cardiovascular Abnormalities (1) · Central Nervous System Diseases (1) · Cerebrovascular Disorders (1) · Congenital Abnormalities (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1) · Digestive System Diseases (1) · Embolism and Thrombosis (1)
Cardiac Resynchronization Therapy Devices (1) · Community Health Workers (1) · Simendan (1) · Standard of Care (1) · Surgical Procedures, Operative (1) · Telerehabilitation (1) · Warfarin (1)
Abbott Medical Devices (3) · CardioVision International Tech, S.A.S. de C.V. (3) · Carmat SAS (2) · Icahn School of Medicine at Mount Sinai (2) · Shenzhen Core Medical Technology CO.,LTD. (2) · University of Minnesota (2) · Akdeniz University (1) · Asan Medical Center (1) · Bryan Heart (1) · Cedars-Sinai Medical Center (1) · Copenhagen University Hospital, Rigshospitalet (1) · CorWave (1) · FineHeart (1) · Finn Gustafsson (1) · HELP Therapeutics Co., Ltd. (1)
United States (9) · France (4) · Denmark (3) · Netherlands (3) · Germany (2) · Kazakhstan (2) · South Korea (2) · Spain (2) · Taiwan (2) · United Kingdom (2) · Australia (1) · China (1) · Czechia (1) · Hong Kong (1) · Israel (1)
Peter M Eckman, MD (2) · Aldona Browarek, MD, PhD (1) · Andrea Garascia, MD (1) · Carlo Gazzola (1) · Carlo Gazzola, B. Sc. (1) · Davide Marchetti, MD (1) · Demitri Yannopoulos, MD (1) · Enrico Ammirati, MD, PhD (1) · Fabrizio Oliva, MD (1) · Finn Gustafsson, MD, professor, PhD, DMSci (1) · Finn Gustafsson, MD,PhD,DMSci (1) · Frederic C Daoud, MD, PhD (1) · Gabriel Sayer, MD (1) · Giada Colombo (1)
PMID 19755203, PMID 19857702, PMID 19857703, PMID 19950084, PMID 27959709, PMID 28146651, PMID 28736110, PMID 29526139, PMID 29655662, PMID 32758387, PMID 34391745, PMID 35171213, PMID 37659882, PMID 38299348
R56NR020624 (1)