14 completed, 5 unknown, 3 recruiting, 3 withdrawn. 29 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 29 | Completed 14, Unknown 5, Recruiting 3, Withdrawn 3, Not yet recruiting 2, Active not recruiting 1, Enrolling by invitation 1 |
Follow Adrenal Insufficiency: new trials by email Literature Review of Adrenal Insufficiency trials Research Report on Adrenal Insufficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Hydrocortisone Versus Methylprednisolone for the Treatment of Glucocorticoid-Induced Adrenal Insufficiency Patients will receive 3 mg of methylprednisolone once daily. The dose is administered in the morning (1 ½ tablets of 2 mg Medrol after breakfast)., Patients will receive 15 mg of hydrocortisone daily. The dose is split into 10 mg in the morning after breakfast and 5 mg after 6-7 hours. - Adrenal Insufficiency | Phase 4 | Not yet recruiting | University Medical Centre Ljubljana | 66 | 2026-09-01 | 2026-07-14 |
| Combination Osilodrostat and Cabergoline in Cushing's Disease osilodrostat, osilodrostat and cabergoline - Cushing Disease Due to Increased ACTH Secretion | Phase 4 | Enrolling by invitation | University of Basrah | 50 | 2026-05-11 | 2026-05-22 |
| A Study to Investigate OCS Tapering in Adult Participants With Generalized Myasthenia Gravis Treated With Ravulizumab Oral Corticosteroid Tapering Schedule, Ravulizumab, Prednisone/Prednisolone - Generalized Myasthenia Gravis, gMG | Phase 4 | Recruiting | Alexion Pharmaceuticals, Inc. | 75 | 2026-03-04 | 2026-04-09 |
| Comparison of Glucocorticoid Tapering Schedules in Rheumatoid Arthritis Prednisolone - Rheumatoid Arthritis (RA) | Phase 4 | Not yet recruiting | Seoul National University Hospital | 206 | 2025-12-01 | 2025-11-25 |
| Tolerability and Acceptance of Two Oral Hydrocortisone Compounding Formulation for Pediatrics 3D printed chewable formulation of hydrocortisone, Oral suspension of hydrocortisone - Adrenal Insufficiency | Phase 4 | Unknown | Hospital Universitari Vall d'Hebron Research Institute | 35 | 2024-09-01 | 2024-05-30 |
| Treating Leg Symptoms in Women With X-linked Adrenoleukodystrophy Pramipexole, Placebo - Adrenoleukodystrophy, Restless Legs Syndrome | Phase 4 | Active not recruiting | Massachusetts General Hospital | 24 | 2023-04-01 | 2026-07-01 |
| Effect of Supplemental Hydrocortisone During Stress in Prednisolone-induced Adrenal Insufficiency Hydrocortisone, Placebo for hydrocortisone - Adrenal Insufficiency, Polymyalgia Rheumatica | Phase 4 | Recruiting | Marianne Christina Klose | 250 | 2022-06-07 | 2026-03-16 |
| The Effects of Two Brands of Hydrocortisone Injected Intramuscularly Into Deltoid and Thigh Muscles Solu-Cortef 100 MG Injection, Hydrocortisone 100mg/ml - Addison's Disease | Phase 4 | Unknown | The London Clinic | 8 | 2022-03-14 | 2022-04-27 |
| Hydrocortisone and Placebo in Patients With Symptoms of Adrenal Insufficiency After Cessation of Glucocorticoid Treatment Hydrocortisone, Placebo - Adrenal Insufficiency, Polymyalgia Rheumatica (PMR) | Phase 4 | Recruiting | Marianne Andersen | 100 | 2022-02-01 | 2025-12-22 |
| A Study of Markers of Glucocorticoid Effects in Patients With Addisons Disease (DOSCORT) Betamethasone - Addison Disease | Phase 4 | Completed | Göteborg University | 30 | 2021-03-02 | 2025-04-24 |
| Effects of High Intensity Statin Therapy on Steroid Hormones and Vitamin D in Type 2 Diabetic Men Atorvastatin 40 Mg Oral Tablet - Diabetes Mellitus, Type 2, Dyslipidemia Associated With Type II Diabetes Mellitus | Phase 4 | Completed | Hopital La Rabta | 104 | 2021-03-01 | 2023-04-10 |
| Salivary Cortisol Measurement in Corticotrope Deficiency Substitution With Hydrocortisone. Hydrocortisone (capsule) - Adrenal Insufficiency | Phase 4 | Completed | University Tunis El Manar | 40 | 2021-01-01 | 2022-07-13 |
| Comparison of Intramuscular and Intravenous ACTH Stimulation Test in Normal Volunteers Cosyntropin - Adrenal Insufficiency | Phase 4 | Withdrawn | Johns Hopkins University | 2019-07-01 | 2019-05-10 | |
| Optimising Steroid Replacement in Patients With Adrenal Insufficiency Modified release hydrocortisone - Adrenal Insufficiency | Phase 4 | Unknown | The Adelaide and Meath Hospital, incorporating The National Children's Hospital | 60 | 2017-09-05 | 2017-09-14 |
| Modified-release Compared to Conventional Hydrocortisone on Diurnal Fatigue in Secondary Hypoadrenalism Hydrocortisone, Plenadren - Adrenal Insufficiency | Phase 4 | Unknown | Ulla Feldt-Rasmussen | 30 | 2016-10-01 | 2017-02-23 |
| Steroid Use in Pediatric Fluid and Vasoactive Infusion Dependent Shock - Pilot Study Hydrocortisone, Placebo - Shock | Phase 4 | Completed | Children's Hospital of Eastern Ontario | 57 | 2014-07-01 | 2019-03-26 |
| Dual RElease Hydrocortisone Versus conventionAl Glucocorticoid replaceMent Therapy in Hypocortisolism (DREAM) Plenadren, Conventional glucocorticoid therapy - Primary Adrenal Insufficiency, Secondary Adrenal Insufficiency | Phase 4 | Completed | University of Roma La Sapienza | 89 | 2014-03-01 | 2019-04-25 |
| Evaluation of Efficacy and Hypothalamus-pituitary-adrenal Axis Suppression Due to Corticosteroids Intrabursal Injection methylprednisolone acetate, Triamcinolone Acetonide - Tendinopathy, Adrenal Insufficiency | Phase 4 | Completed | Istituto Ortopedico Rizzoli | 44 | 2012-03-01 | 2014-09-01 |
| Hydrocortisone Replacement in Patients With Secondary Adrenal Insufficiency (SUPREME CORT) Hydrocortisone - Adrenal Insufficiency | Phase 4 | Completed | University Medical Center Groningen | 63 | 2012-02-01 | 2014-07-14 |
| Revival of Stem Cells in Addison's Study depot tetracosactide - Adrenal Failure | Phase 4 | Completed | Newcastle University | 13 | 2010-09-01 | 2013-02-06 |
Showing 20 of 29. Sign in to see all of them.
Addison Disease (5) · Giant Cell Arteritis (2) · Hypopituitarism (2) · Polymyalgia Rheumatica (2) · Sepsis (2) · Adrenoleukodystrophy (1) · Arthritis, Rheumatoid (1) · Burns (1) · Coronary Artery Disease (1) · Diabetes Mellitus, Type 2 (1) · Eunuchism (1) · Fatigue (1) · Hyperandrogenism (1) · Hypertension (1)
Adrenal Gland Diseases (29) · Endocrine System Diseases (29) · Autoimmune Diseases (9) · Immune System Diseases (9) · Nervous System Diseases (7) · Brain Diseases (6) · Central Nervous System Diseases (6) · Pathological Conditions, Signs and Symptoms (5) · Cardiovascular Diseases (4) · Musculoskeletal Diseases (4) · Pathologic Processes (4) · Vascular Diseases (4) · Autoimmune Diseases of the Nervous System (3) · Connective Tissue Diseases (3)
Hydrocortisone (12) · Cosyntropin (3) · Prednisolone (3) · Etomidate (2) · Prednisone (2) · Propofol (2) · hydrocortisone hemisuccinate (2) · Atorvastatin (1) · Betamethasone (1) · Cabergoline (1) · Capsules (1) · Cortisone (1) · Dexamethasone (1) · Fludrocortisone (1) · Glucocorticoids (1)
Alexion Pharmaceuticals, Inc. (1) · CAMC Health System (1) · Cardiff University (1) · Centre Hospitalier Universitaire de Saint Etienne (1) · Children's Hospital of Eastern Ontario (1) · Göteborg University (1) · Hopital La Rabta (1) · Hospices Civils de Lyon (1) · Hospital Universitari Vall d'Hebron Research Institute (1) · Insel Gruppe AG, University Hospital Bern (1) · Istituto Ortopedico Rizzoli (1) · Johns Hopkins University (1) · Marianne Andersen (1) · Marianne Christina Klose (1) · Massachusetts General Hospital (1)
Italy (3) · United Kingdom (3) · Canada (2) · Denmark (2) · France (2) · Netherlands (2) · Switzerland (2) · Tunisia (2) · United States (2) · Germany (1) · Iraq (1) · Ireland (1) · Japan (1) · Slovenia (1) · Spain (1)
Abbas A Mansour (1) · Aled Rees, MB BCh, PhD (1) · Andrea M Isidori, MD, PhD (1) · Florian S Eichler, MD (1) · Gudmundur Johannsson, Prof., MD (1) · Haider A Alidrisi (1) · Hector Wong, MD (1) · Ibrahim H Hussein, MD (1) · James D McNally, MD, PhD (1) · Jill A Osborn, MD (1) · John A Bethea, Pharm.D. (1)
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