185 completed, 36 unknown, 30 terminated, 20 recruiting. 58 Phase 3, 44 Phase 2, 42 Not applicable, 38 Phase 4, 20 Phase 1.
Follow Hypopituitarism: new trials by email Literature Review of Hypopituitarism trials Research Report on Hypopituitarism
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The AgRP and GH/IGF-1 Axis in Children Growth Hormone Deficiency | Not yet recruiting | Columbia University | 156 | 2027-06-10 | 2026-09-25 | |
| Phase 3 Long Term Safety Extension Study of LUM-201 in Children With Growth Hormone Deficiency LUM-201 - Growth Hormone Deficiency (GHD) | Phase 3 | Not yet recruiting | Lumos Pharma | 150 | 2027-02-01 | 2026-07-08 |
| Identifying Oxytocin Deficiency in Pediatric Patients With Pituitary Disease Norethindrone Acetate-Ethinyl Estradiol - Arginine Vasopressin Deficiency, Oxytocin Deficiency | Early Phase 1 | Recruiting | Massachusetts General Hospital | 20 | 2026-08-17 | 2026-10-26 |
| Evaluation of (Cardio)Metabolic and Auxological Outcomes of GHD Patients Under rhGH or LAGH With Stratification According to IGF-1 Levels metabolic and auxological outcomes - Growth Hormone Deficiency | Not applicable | Not yet recruiting | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | 300 | 2026-07-01 | 2026-05-11 |
| Safety, Pharmacokinetic (PK) Profile and Efficacy of Inpegsomatropin Injection in Adults With Growth Hormone Deficiency Inpegsomatropin Injection, Placebo for Inpegsomatropin Injection - Adult Growth Hormone Deficiency | Phase 2 | Recruiting | Xiamen Amoytop Biotech Co., Ltd. | 36 | 2026-06-10 | 2026-07-22 |
| GB06 Phase III Trial for Pediatric Growth Hormone Deficiency GB06, Norditropin®FlexProTM - Growth Hormone Deficiency (GHD), Growth Hormone Deficiency in Children | Phase 3 | Recruiting | Kexing Biopharm Co., Ltd. | 192 | 2026-06-06 | 2026-06-10 |
| Phase 3 Study of LUM-201 in Children With Growth Hormone Deficiency LUM-201, Matched Placebo (Capsules) - Growth Hormone Deficiency (GHD) | Phase 3 | Recruiting | Lumos Pharma | 150 | 2026-05-20 | 2026-10-19 |
| A Study of GS3-007a for Oral Suspension in the Diagnosis of Adult Growth Hormone Deficiency (AGHD) GS3-007a dry suspension, Insulin - Adult Growth Hormone Deficiency (AGHD) | Phase 2 | Terminated | Changchun GeneScience Pharmaceutical Co., Ltd. | 120 | 2025-12-19 | 2026-05-22 |
| REMS25: Study on the Use of REMS Technology in Diseases Commonly Associated With Reduced Bone Mineral Density (BMD) REMS - Osteogenesis Imperfecta, Osteoporosis | Not applicable | Recruiting | Meyer Children's Hospital IRCCS | 100 | 2025-12-04 | 2026-02-17 |
| Effects of Intranasal Oxytocin in Patients With Arginine-vasopressin Deficiency Intranasal Oxytocin (IN-OXT) 6 IU single dose, Intranasal Oxytocin (IN-OXT) 6 IU repeat dose, Placebo repeat dose - Vasopressin Deficiency | Phase 1 | Recruiting | Elizabeth Austen Lawson | 40 | 2025-09-10 | 2026-10-26 |
| Sleep Disorders in Hypothalamic and Pituitary Damage This is an observational study. No drugs will be administered - Hypopituitarism, Sleep Wake Disorders | Recruiting | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 60 | 2025-09-01 | 2025-11-18 | |
| Evaluating the Efficacy and Safety of GB08 Injection in Pediatric Patients With Growth Hormone Deficiency GB08, Norditropin NordiFlex - Growth Hormone Deficiency in Children, Growth Hormone Deficiency (GHD) | Phase 2 / Phase 3 | Not yet recruiting | Shenzhen Kexing Pharmaceutical Co., Ltd. | 268 | 2025-08-31 | 2025-08-22 |
| A Clinical Study of GenSci134 in Healthy Adults and Adult Growth Hormone Deficiency(AGHD) GenSci134, Placebo, Recombinant Human Growth Hormone Injection (Norditropin®) - Safety, Tolerability | Phase 1 | Recruiting | Changchun GeneScience Pharmaceutical Co., Ltd. | 64 | 2025-06-09 | 2026-04-14 |
| BELux Children OutcoME During A(@)Dulthood With GHD Biological Sample - Growth Hormone Deficiency, Adult Growth Hormone Deficiency | Not applicable | Recruiting | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | 200 | 2025-05-21 | 2026-09-21 |
| Development of a Personalized Growth Hormone Treatment Profile (PGTP) Report for Pediatric Endocrinology ACDP® and growth hormone treatment - Growth Hormone Deficiency (GHD) | Completed | Luis Fernandez Luque | 40 | 2025-05-19 | 2025-12-01 | |
| A Study to Learn About Somatrogon in Patients With Pediatric Growth Hormone Deficiency (p GHD) in India. Somatrogon - Dwarfism, Pituitary | Recruiting | Pfizer | 50 | 2025-01-30 | 2026-11-12 | |
| Growth Hormone Replacement Therapy in Veterans With Mild Traumatic Brain Injury (mTBI) and Adult Growth Hormone Deficiency (AGHD) Somatropin, Placebo - Adult Growth Hormone Deficiency, Mild Traumatic Brain Injury | Phase 3 | Recruiting | VA Office of Research and Development | 172 | 2025-01-13 | 2026-10-13 |
| A Study to Follow Paediatric Participants With Growth Hormone Deficiency Treated With Somapacitan for Long Term Safety Information and Clinical Parameters Somapacitan - Growth Hormone Deficiency, Neoplasms | Enrolling by invitation | Novo Nordisk A/S | 500 | 2024-12-13 | 2026-04-06 | |
| Growing up With the Young Endocrine Support System (YESS!) YESS! game, Snake '97, Transition-toolkit - Congenital Adrenal Hyperplasia, Hypogonadotropic Hypogonadism | Not applicable | Not yet recruiting | dr. Laura C. G. de Graaff-Herder | 160 | 2024-12-01 | 2023-09-07 |
| Neuroendocrine Mechanisms in Adiposity: An Integrated Approach to the Characterization of Potential Pharmacological Novel Targets Based on Experimental and Clinical Models Endocrine Disorders, Adiposity | Not yet recruiting | IRCCS San Raffaele | 200 | 2024-07-01 | 2024-06-11 |
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Dwarfism, Pituitary (252) · Dwarfism (14) · Pituitary Diseases (13) · Turner Syndrome (13) · Endocrine System Diseases (11) · Insulin Resistance (11) · Brain Injuries, Traumatic (8) · Acromegaly (7) · Failure to Thrive (7) · Obesity (7) · Diabetes Insipidus, Neurogenic (6) · Hypogonadism (6) · Kidney Failure, Chronic (5) · Pituitary Neoplasms (5)
Central Nervous System Diseases (289) · Nervous System Diseases (289) · Brain Diseases (287) · Hypothalamic Diseases (286) · Endocrine System Diseases (278) · Pituitary Diseases (276) · Bone Diseases (253) · Musculoskeletal Diseases (253) · Bone Diseases, Endocrine (252) · Bone Diseases, Developmental (251) · Dwarfism (238) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (35) · Genetic Diseases, Inborn (33) · Pathological Conditions, Signs and Symptoms (33)
Human Growth Hormone (82) · Growth Hormone (44) · somapacitan (11) · Blood Specimen Collection (6) · Growth Hormone-Releasing Hormone (6) · Injections (5) · MOD-4023 (5) · albusomatropin (4) · somatrogon (4) · Arginine (3) · NNC0195-0092 (3) · Sodium Chloride (3) · Surveys and Questionnaires (3) · Thyroxine (3) · lonapegsomatropin (3)
Novo Nordisk A/S (27) · Pfizer (17) · Changchun GeneScience Pharmaceutical Co., Ltd. (13) · Merck KGaA, Darmstadt, Germany (9) · University of Aarhus (9) · Columbia University (8) · Federico II University (8) · Massachusetts General Hospital (7) · Versartis Inc. (7) · Ascendis Pharma Endocrinology Division A/S (6) · Lumos Pharma (6) · Eli Lilly and Company (5) · Ferring Pharmaceuticals (5) · LG Life Sciences (5) · OPKO Health, Inc. (5)
United States (96) · Germany (34) · Italy (31) · France (28) · United Kingdom (28) · Spain (20) · Denmark (18) · China (16) · Israel (16) · Sweden (15) · Japan (14) · Poland (14) · Australia (13) · Greece (13) · Hungary (12)
Will Charlton, MD (4) · Anna Aulinas, MD PhD (3) · Pamela U. Freda, MD (3) · Philippe Lysy, MD, PhD (3) · Antonio Cittadini, MD (2) · Barbara Lippe, M.D. (2) · Dariush Elahi, PhD (2)
PMID 36380045, PMID 18395480, PMID 22508317, PMID 22788856, PMID 23658497, PMID 24291224, PMID 28566441, PMID 29671202, PMID 31305924, PMID 31972476, PMID 33571362, PMID 33709288, PMID 33754315, PMID 36947589, PMID 40919719, PMID 10022400, PMID 10199767, PMID 10199774, PMID 10372687, PMID 10405442, PMID 10453734, PMID 10598807, PMID 11134092, PMID 11203878, PMID 11207626, PMID 11273062, PMID 11344175, PMID 11531927, PMID 11839953, PMID 11889170, PMID 12794705, PMID 12924350, PMID 14556926, PMID 15126541, PMID 15355453, PMID 15540176, PMID 15579750, PMID 15585563, PMID 15671089, PMID 15671099, PMID 15704090, PMID 15760848, PMID 15985481, PMID 16007630, PMID 16394080, PMID 16522693, PMID 16675931, PMID 16690338, PMID 16840832, PMID 17164301
2016 (4), 2018 (4), 2008 (3), 2014 (2), R01DK110771 (2), R01HL085268 (2), 2004 (1), 2015 (1), 2017 (1), M01RR001346 (1), P01AG000599 (1), R01AR050618 (1), R21HD078864 (1), U10HD045934 (1)