60 completed, 36 recruiting, 16 unknown, 13 terminated. 22 Phase 2, 19 Phase 3, 12 Not applicable, 8 Phase 1, 6 Phase 4.
Follow Giant Cell Arteritis: new trials by email Literature Review of Giant Cell Arteritis trials Research Report on Giant Cell Arteritis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Long-Axial Field of View (LAFOV) [18F]FDG PET/CT Imaging in Large Vessel Vasculitis (LVV): Protocol Optimisation Study. [18F]FDG Long-Axial Field of View (LAFOV)-PET/CT, CT Angiogram, MR Angiogram - Large Vessel Vasculitis, Takayasu Arteritis | Not applicable | Not yet recruiting | Imperial College London | 18 | 2026-12-01 | 2026-10-16 |
| Mapping B-cell Biology Across the Cardiovascular Territories of Giant Cell Arteritis: Towards a New Therapeutic Approach (RituxiMAP GCA) Zirconium Zr 89 labelled rituximab - Giant Cell Arteritis (GCA) | Not yet recruiting | University of Edinburgh | 30 | 2026-10-01 | 2026-06-16 | |
| Inflammatory Disease Biobank for Immunophenotyping and Cardiovascular Research Pericarditis, Tako-TSUBO Cardiomyopathy | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 300 | 2026-09-01 | 2026-08-10 | |
| Treatment for Giant Cell Arteritis With Tocilizumab and 8 as Compared to 26 Weeks of Prednisone Prednisone - Giant Cell Arteritis (GCA) | Phase 3 | Not yet recruiting | Insel Gruppe AG, University Hospital Bern | 178 | 2026-07-01 | 2026-05-01 |
| Kinetics of C-Reactive Protein in Giant Cell Arteritis Following Glucocorticoid Initiation: A Pilot Study (GIDEON) Blood tests to measure CRP - Giant Cell Arteritis (GCA) | Not applicable | Not yet recruiting | University Hospital, Limoges | 40 | 2026-06-22 | 2026-07-22 |
| Bosentan in the Treatment of Giant Cell Arteritis Bosentan, Glucocorticoids - Giant Cell Arteritis (GCA) | Phase 2 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 40 | 2026-06-01 | 2026-05-06 |
| Disease Activity Monitoring in Patients With Giant Cell Arteritis Study Giant Cell Arteritis (GCA) | Recruiting | University of Aarhus | 175 | 2026-05-06 | 2026-08-31 | |
| Early Temporal Dynamics of Optic Nerve Sheath Diameter After Therapy in GCA Optic Nerve Sheath Ultrasound, Temporal artery ultrasound, Bloodwork : CRP and ESR - Giant Cell Arteritis, Temporal Arteritis | Recruiting | Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal | 60 | 2026-05-01 | 2026-10-21 | |
| The VGR GCA Cohort: Ultrasound, Biopsy and Biomarkers - Novel Methods for Diagnosis, Monitoring and Prognosis in Giant Cell Arteritis. Giant Cell Arteritis (GCA) | Recruiting | Vastra Gotaland Region | 340 | 2026-03-01 | 2026-04-15 | |
| Upadacitinib in Giant Cell Arteritis (GCA) With Active Large-vessel Involvement. Giant Cell Arteritis (GCA) | Not yet recruiting | Groupe français d'étude des Maladies Inflammatoires de loeil | 80 | 2026-03-01 | 2026-01-21 | |
| Halo Sign Vanishing Time After Steroids Outbreak in GCA Patients Doppler Ultrasound - Giant Cell Arteritis (GCA), Doppler Ultrasound | Not applicable | Recruiting | Centre Hospitalier le Mans | 64 | 2026-02-27 | 2026-07-17 |
| Study of the Association Between Sacroiliitis/Axial Spondylarthritis and Giant Cell Arteritis/ Polymyalgia Rheumatica Description of population - Giant Cell Arteritis (GCA), Spondylarthritis | Not yet recruiting | Hôpital NOVO | 10 | 2026-02-01 | 2026-02-06 | |
| Orbital Vascular Inflammation in Ischemic Optic Neuropathy and Giant Cell Arteritis Positron Emission Tomography / Magnetic Resonance Imaging - Giant Cell Arteritis (GCA), Ischemic Optic Neuropathy | Recruiting | Copenhagen University Hospital, Rigshospitalet | 122 | 2026-01-14 | 2026-05-07 | |
| Tocilizumab Discontinuation Versus Dose Reduction for Patients With Well-Controlled Giant Cell Arteritis Tocilizumab, Discontinue Tocilizumab - Giant Cell Arteritis (GCA) | Phase 2 | Recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 78 | 2026-01-05 | 2026-08-10 |
| Immunosuppressant Management in Rheumatology Patients Undergoing Elective Total Shoulder Arthroplasty Methotrexate, Sulfasalazine, Hydroxychloroquine - Rheumatic Disease | Phase 2 | Recruiting | NYU Langone Health | 80 | 2025-12-12 | 2026-07-09 |
| Giant Cell Arteritis - Ways to Precision Medicine Giant Cell Arteritis, Polymyalgia Rheumatic (PMR) | Recruiting | Wuerzburg University Hospital | 400 | 2025-11-14 | 2025-12-22 | |
| oPtic Nerve Sheath Evaluation in gianT Cell aRtheritis by UltraSound orbital ultrasound - Giant Cell Arteritis (GCA) | Not applicable | Recruiting | Hôpital NOVO | 190 | 2025-09-04 | 2025-09-12 |
| Optic Nerve Sheath Ultrasound in Giant Cell Arteritis Optic nerve sheath ultrasound, Standardized GCA assessment - Giant Cell Arteritis, Anterior Ischemic Optic Neuropathy | Recruiting | Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal | 285 | 2025-08-09 | 2026-10-21 | |
| Association of Ultrasonographic Temporal Artery Lesions and Relapse in Patients With Giant Cell Arteritis Giant Cell Arteritis | Recruiting | University Hospital, Brest | 100 | 2025-08-05 | 2026-03-20 | |
| The Applanation Tonometry in GCA Pilot Applanation tonometry, Standardized GCA assessment, Repeat applanation tonometry (optional) - Giant Cell Arteritis | Active not recruiting | Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal | 146 | 2025-07-30 | 2026-10-21 |
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Polymyalgia Rheumatica (24) · Takayasu Arteritis (22) · Vasculitis (20) · Arthritis, Rheumatoid (15) · Granulomatosis with Polyangiitis (14) · Polyarteritis Nodosa (13) · Churg-Strauss Syndrome (10) · Microscopic Polyangiitis (10) · Arthritis, Psoriatic (9) · Behcet Syndrome (9) · IgA Vasculitis (8) · Arthritis, Juvenile (7) · Lupus Erythematosus, Systemic (7) · Rheumatic Diseases (6)
Autoimmune Diseases of the Nervous System (145) · Brain Diseases (145) · Central Nervous System Diseases (145) · Nervous System Diseases (145) · Skin Diseases (145) · Skin and Connective Tissue Diseases (145) · Cerebrovascular Disorders (144) · Skin Diseases, Vascular (144) · Cardiovascular Diseases (143) · Vascular Diseases (143) · Immune System Diseases (142) · Autoimmune Diseases (141) · Arteritis (140) · Vasculitis, Central Nervous System (140) · Vasculitis (125)
tocilizumab (13) · Prednisone (9) · Blood Specimen Collection (5) · secukinumab (5) · Abatacept (4) · Adrenal Cortex Hormones (4) · Glucocorticoids (4) · Methotrexate (4) · Infliximab (3) · Surveys and Questionnaires (3) · Ultrasonography (3) · upadacitinib (3) · Adalimumab (2) · Bosentan (2) · Cyclosporine (2)
Centre Hospitalier Universitaire Dijon (10) · University of Pennsylvania (7) · University of Bonn (5) · University of South Florida (5) · Assistance Publique - Hôpitaux de Paris (4) · Insel Gruppe AG, University Hospital Bern (4) · Novartis Pharmaceuticals (4) · University Hospital, Brest (4) · University Hospital, Caen (4) · University of Aarhus (4) · University of Oxford (4) · Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal (3) · Fondation Ophtalmologique Adolphe de Rothschild (3) · Groupe français d'étude des Maladies Inflammatoires de loeil (3) · Hoffmann-La Roche (3)
France (53) · United States (35) · Germany (22) · Canada (20) · Denmark (18) · United Kingdom (16) · Switzerland (13) · Italy (12) · Spain (11) · Belgium (10) · Australia (9) · Netherlands (9) · Sweden (8) · Poland (7) · Portugal (7)
Peter A. Merkel, MD, MPH (5) · Peter A Merkel, MD, MPH (4) · Amanda M. Terry, MA (3) · Raashid A Luqmani, DM FRCP (3) · Ann Morgan (2) · Peter C. Grayson, MD (2) · Peter Merkel, MD, MPH (2) · Salome Kristensen, MD, PhD (2) · Alessandro Invernizzi, Prof. (1) · Alexander Isaak, PD Dr. (1)
PMID 26952547, PMID 28745999, PMID 32866179, PMID 14558057, PMID 16914703, PMID 17407214, PMID 17470830, PMID 17557758, PMID 19955046, PMID 21743987, PMID 21873264, PMID 22674883, PMID 23528439, PMID 23653652, PMID 23897775, PMID 24046471, PMID 24106211, PMID 24189842, PMID 24529335, PMID 24574239, PMID 24891881, PMID 25396066, PMID 25592534, PMID 25697557, PMID 25902790, PMID 26090367, PMID 27236507, PMID 27940595, PMID 27980877, PMID 28133925, PMID 28133931, PMID 28405470, PMID 28756037, PMID 29961816, PMID 30054122, PMID 30392702, PMID 30786937, PMID 30835950, PMID 30848549, PMID 31270110, PMID 31649025, PMID 31785185, PMID 32248659, PMID 32844378, PMID 33544969, PMID 33942031, PMID 34049857, PMID 34117737, PMID 34404463, PMID 34532040
2018 (4), 2023 (3), U54AR057319 (3), 2016 (2), 2017 (2), 2019 (2), 2008 (1), 2015 (1), 2025 (1), 268200700036C-5-0-1 (1), R01AR084199 (1)