263 completed, 112 unknown, 61 recruiting, 47 terminated. 183 Not applicable, 87 Phase 2, 49 Phase 1, 45 Phase 3, 12 Phase 4.
Follow Acute Respiratory Distress Syndrome: new trials by email Literature Review of Acute Respiratory Distress Syndrome trials Research Report on Acute Respiratory Distress Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| To Evaluate the Safety and Potential Therapeutic Activity of JadiCell™, an Investigational Umbilical Cord-Derived Mesenchymal Stem Cell Therapy, in Patients Diagnosed With Acute Respiratory Distress Syndrome (ARDS). Subjects in the UC-MSC treatment group will receive two intravenous infusions (at day 0 and 3) of 100 million UC-MSC., Controls will receive two infusions of vehicle solution. - Acute Respiratory Distress Syndrome | Phase 3 | Not yet recruiting | Breathe Biologics, Inc. | 128 | 2027-03-01 | 2026-10-01 |
| Fostamatinib for Treating Acute Respiratory Distress Syndrome (ARDS) in Hospitalized Adults Placebo, Fostamatinib - Acute Respiratory Distress Syndrome, ARDS | Phase 2 | Not yet recruiting | Inova Health Care Services | 40 | 2026-11-30 | 2026-10-27 |
| Development and Multicenter Validation of an Explainable System for Neonatal ARDS-Compatible Phenotyping Acute Respiratory Distress Syndrome | Not yet recruiting | Guangzhou Women and Children's Medical Center | 1600 | 2026-11-10 | 2026-11-06 | |
| Effect of Albumin Therapy in Mechanically Ventilated Patients With Sepsis-Associated ARDS Acute Respiratory Distress Syndrome, Sepsis | Not yet recruiting | The Second Affiliated Hospital of Hainan Medical University | 260 | 2026-10-10 | 2026-10-13 | |
| Effect of Spontaneous Breathing in APRV Mode on Respiratory Physiology of ARDS Patients APRV ventilation with low-level spontaneous breathing, APRV ventilation with high-level spontaneous breathing, APRV ventilation with fully suppressed spontaneous breathing - Acute Respiratory Distress Syndrome | Not applicable | Not yet recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 15 | 2026-10-01 | 2026-09-01 |
| Serum sRAGE, CC16, and Syndecan-1 as Predictors of ARDS and Mortality After Severe Chest Trauma No intervention - observational study - Acute Respiratory Distress Syndrome, Chest Trauma | Not yet recruiting | Assiut University | 85 | 2026-10-01 | 2026-08-19 | |
| Multimodal Physiologic State Intelligence Study OMNIPHYS Multimodal Ultrasound Imaging System - Heart Failure, Cardiomyopathies | Enrolling by invitation | Truway Health, Inc. | 25000 | 2026-09-02 | 2026-09-10 | |
| AI-Guided Mechanical Ventilation in Children: A Randomized Controlled Trial AI-generated recommendations for ventilator parameters. - Acute Respiratory Distress Syndrome, Pneumonia in Children | Not applicable | Not yet recruiting | Wu Rongzhou | 200 | 2026-09-01 | 2026-07-27 |
| Comparison of Different PEEP Strategies in Moderate-to-Severe ARDS Based on Various Bedside Assessment Tools Ventilation at different levels of PEP including a test involving a gradual decrease in PEP. - Acute Respiratory Distress Syndrome | Not applicable | Not yet recruiting | Centre Hospitalier Universitaire de Nice | 45 | 2026-09-01 | 2026-08-03 |
| R-3750 in Patients With Late-Stage Acute Respiratory Distress Syndrome (ARDS) R-3750 - Acute Respiratory Distress Syndrome | Phase 1 | Not yet recruiting | Rise Therapeutics LLC | 20 | 2026-09-01 | 2026-06-12 |
| Assessment of Acute Respiratory Distress in Children Presenting to the Emergency Department: Clinical, Epidemiological, and Etiological Insights Acute Respiratory Distress Syndrome | Not yet recruiting | Assiut University | 70 | 2026-08-30 | 2025-09-02 | |
| Vascular ARDS Recruitment After Inhaled Nitric Oxide Nitric Oxide - Acute Respiratory Distress Syndrome, Ventilation Perfusion Mismatch | Not applicable | Recruiting | Massachusetts General Hospital | 70 | 2026-07-10 | 2026-10-02 |
| Anti-CD14 Treatment With IC14 in Hospitalized ARDS Patients Atibuclimab, Placebo - Acute Respiratory Distress Syndrome, Adult Respiratory Distress Syndrome | Phase 2 | Recruiting | Implicit Bioscience | 56 | 2026-06-17 | 2026-07-29 |
| Full-Course ECMO Strategy for Moderate-to-Severe ARDS Full-Course ECMO Management Pathway, Usual Care - Acute Respiratory Distress Syndrome | Not applicable | Recruiting | Southeast University, China | 500 | 2026-06-16 | 2026-07-27 |
| Use of hUC-MSC Product (BX-U001) for the Treatment of COVID-19 With ARDS Human umbilical cord mesenchymal stem cells + best supportive care, Placebo control + best supportive care - COVID-19, ARDS | Phase 1 / Phase 2 | Withdrawn | Baylx Inc. | 2026-06-01 | 2025-12-29 | |
| Height Measurement Procedures Influence the Risk of Ventilator-induced Lung Injury in ARDS height measured - Acute Respiratory Distress Syndrome, Ventilator-Induced Lung Injury | Not applicable | Recruiting | Centre Hospitalier Universitaire, Amiens | 39 | 2026-05-20 | 2026-07-06 |
| Corticosteroids in Hyperinflammatory Phenotype of Critical Illness Methylprednisolone (MP), Placebo - Sepsis, Acute Respiratory Distress Syndrome | Phase 2 | Recruiting | Bin Du | 150 | 2026-04-15 | 2026-05-26 |
| Nogapendekin Alfa-Inbakicept and iNKT Cells for Critically Ill Adults With Severe Community-Acquired Pneumonia (With or Without Sepsis/ARDS) Nogapendekin Alfa-Inbakicept (NAI), Allogeneic invariant Natural Killer T (iNKT) Cells (AgenT-797) - Acute Respiratory Distress Syndrome, Severe Community-Acquired Pneum | Phase 2 | Withdrawn | ImmunityBio, Inc. | 2026-04-15 | 2026-05-08 | |
| EIT- Guided Lung Recruitment in pARDS Electrical Impedance Tomography (EIT)-Guided Lung Recruitment - Acute Respiratory Distress Syndrome | Not applicable | Not yet recruiting | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | 8 | 2026-03-01 | 2026-02-11 |
| Correlation Between EIT-based Pulse Wave Method for Pulmonary Perfusion Monitoring and Pulmonary Artery Catheter-based Stroke Volume Measurement Synchronous Data Acquisition of EIT and Pulmonary Artery Catheter - Shock, Acute Respiratory Distress Syndrome | Not yet recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 19 | 2026-02-02 | 2026-02-04 |
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Respiratory Distress Syndrome (551) · COVID-19 (78) · Acute Lung Injury (68) · Respiratory Insufficiency (41) · Sepsis (28) · Coronavirus Infections (27) · Critical Illness (16) · Pneumonia (16) · Lung Diseases (15) · Severe Acute Respiratory Syndrome (14) · Shock, Septic (13) · Heart Failure (11) · Cytokine Release Syndrome (10) · Ventilator-Induced Lung Injury (10) · Hypoxia (8)
Respiration Disorders (550) · Respiratory Tract Diseases (549) · Lung Diseases (536) · Infections (141) · Pathological Conditions, Signs and Symptoms (109) · Respiratory Tract Infections (98) · Virus Diseases (96) · RNA Virus Infections (95) · Coronaviridae Infections (92) · Nidovirales Infections (92) · Pathologic Processes (92) · Pneumonia (79) · Lung Injury (76) · Pneumonia, Viral (73) · Coronavirus Infections (65)
Prone Position (17) · Sodium Chloride (8) · Dexamethasone (7) · Saline Solution (7) · Continuous Positive Airway Pressure (6) · Respiration, Artificial (6) · Blood Specimen Collection (5) · Extracorporeal Membrane Oxygenation (5) · Positive-Pressure Respiration (5) · Propofol (5) · Sevoflurane (5) · Standard of Care (5) · Hydrocortisone (4) · Hydroxychloroquine (4) · Dexmedetomidine (3)
Southeast University, China (15) · Assistance Publique - Hôpitaux de Paris (12) · University Hospital, Clermont-Ferrand (12) · Hospices Civils de Lyon (9) · Bicetre Hospital (7) · University of Minnesota (7) · Beth Israel Deaconess Medical Center (6) · Massachusetts General Hospital (6) · Policlinico Hospital (6) · Beijing Chao Yang Hospital (5) · Boston Children's Hospital (5) · Daping Hospital and the Research Institute of Surgery of the Third Military Medical University (5) · National Taiwan University Hospital (5) · Peking Union Medical College Hospital (5) · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (5)
United States (122) · France (112) · China (81) · Italy (34) · Spain (30) · Canada (29) · United Kingdom (23) · Germany (20) · Turkey (Türkiye) (14) · Belgium (12) · Brazil (12) · Taiwan (11) · Netherlands (10) · Austria (8) · Egypt (8)
Davide Chiumello, MD (5) · Laurent Brochard, MD (4) · Leonard Hudson (3) · Rui Wang, Dr. (3) · Alan Morris (2) · Alexandre B Cavalcanti, MD, PhD (2) · Arthur Wheeler (2) · Bin Du (2) · Bin Du, MD (2) · Boyd Taylor Thompson, MD (2) · Christopher Tignanelli, MD (2) · Claude Guerin, Pr (2) · Daniel S Talmor, MD, MPH (2) · Daniel Talmor, MD MPH (2)
PMID 23688302, PMID 10793162, PMID 26903337, PMID 25693014, PMID 27620287, PMID 28422025, PMID 30624279, PMID 34425070, PMID 18270352, PMID 20843245, PMID 22340260, PMID 22797452, PMID 23050520, PMID 27611637, PMID 27757516, PMID 30291378, PMID 31112383, PMID 31577153, PMID 32658300, PMID 33177145, PMID 33204764, PMID 9476848, PMID 10434827, PMID 10446833, PMID 10470572, PMID 10485597, PMID 10793167, PMID 11103187, PMID 11371404, PMID 11395904, PMID 11445683, PMID 11575407, PMID 11742959, PMID 11748059, PMID 11867380, PMID 12091178, PMID 12163791, PMID 12412699, PMID 12423989, PMID 12651052, PMID 12702503, PMID 12907562, PMID 12950321, PMID 14650633, PMID 15030968, PMID 15269312, PMID 15276536, PMID 15343008, PMID 15738300, PMID 15995457
2019 (5), U01HL123009 (2), 1UG3HL166785 (1), 2018 (1), 5UL1TR001420-03 (1), K23HL112855 (1), K23HL118139 (1), KL2RR024151 (1), KL2TR003168 (1), P50HL050152 (1), P50HL073996 (1), R01HL036787 (1), R01HL043167 (1), R01HL052586 (1), R01HL060710 (1)