89 completed, 27 recruiting, 27 unknown, 12 terminated. 105 Not applicable, 20 Phase 3, 10 Phase 1, 9 Phase 2, 2 Phase 4.
Follow Amblyopia: new trials by email Literature Review of Amblyopia trials Research Report on Amblyopia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Attention-based Binocular Training for Impaired Stereopsis (BRAVE) Attention-Guided Dichoptic Visual Search Training, Zero-Disparity Dichoptic Visual Search Task - Amblyopia, Strabismus | Not applicable | Not yet recruiting | Centre for Eye and Vision Research | 56 | 2026-11-01 | 2026-09-03 |
| Non-invasive Induction of Metaplasticity for Amblyopia Flicker - Amblyopia, Amblyopia Unilateral | Not applicable | Not yet recruiting | Boston Children's Hospital | 10 | 2026-11-01 | 2026-09-29 |
| A Randomized Controlled Trial of Autostereoscopic 3D Vision Therapy for Amblyopia Autostereoscopic 3D Training, Conventional Patching - Amblyopia, Visual Training | Not applicable | Not yet recruiting | Beijing Tongren Hospital | 34 | 2026-07-31 | 2026-07-17 |
| Valproate for the Treatment of Residual Amblyopia Valproate, Placebo, Patch - Amblyopia, Amblyopia Unilateral | Phase 1 / Phase 2 | Recruiting | Boston Children's Hospital | 28 | 2026-07-01 | 2026-07-30 |
| Augmented Reality Training for Amblyopia After Congenital Cataract Surgery Augmented Reality Amblyopia Training, Conventional Patching - Deprivation Amblyopia, Congenital Cataract | Not applicable | Not yet recruiting | Zhongshan Ophthalmic Center, Sun Yat-sen University | 88 | 2026-07-01 | 2026-07-09 |
| Evaluation of Echothiophate in Pediatric Patients With Refractory Amblyopia Echothiophate Iodide 0.125% Ophthalmic Solution - Refractory Amblyopia | Phase 2 | Not yet recruiting | University of Oklahoma | 20 | 2026-06-01 | 2026-04-28 |
| A Comparative Study of the Efficacy of AR Based Amblyopia Training Therapy and Occlusion Therapy in Older Children and Adults With Amblyopia Augmented Reality glasses, Eye patch - Amblyopia, Amblyopia Unilateral | Not applicable | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 60 | 2026-06-01 | 2026-06-03 |
| Effectiveness of tDCS in Paediatric Amblyopia. tDCS - Amblyopia, Amblyopia Strabismic | Not applicable | Recruiting | Universidad de Murcia | 100 | 2026-05-02 | 2026-07-28 |
| A Study on the Efficacy and User Experience of Gamified Intervention for Children With Anisometropic Amblyopia Serious touchscreen game combined with occlusion, Augmented reality game combined with occlusion, Occlusion therapy - Amblyopia | Not applicable | Recruiting | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | 66 | 2026-05-01 | 2026-07-30 |
| 3D Movie Viewing vs Occlusion for Treating Amblyopia in Children 3D Movie Viewing, Occlusion Therapy - Anisometropic Amblyopia, Strabismic Amblyopia | Not applicable | Not yet recruiting | Universitat Politècnica de Catalunya | 56 | 2026-05-01 | 2026-05-04 |
| Augmented Reality-Based Binocular Therapy for Visual Rehabilitation in Adults With Amblyopia Active Augmented Reality-Based Binocular Therapy, Placebo Augmented Reality-Based Visual Training - Amblyopia, Anisometropic Amblyopia | Not applicable | Recruiting | Polytechnic Institute of Porto | 60 | 2026-05-01 | 2026-09-18 |
| Evaluation of AmblyoFix for the Treatment of Unilateral Amblyopia in Children AmblyoFix binocular digital therapy - Amblyopia | Not applicable | Recruiting | Eyesight Electronics | 33 | 2026-03-16 | 2026-09-23 |
| VISION-3D: Visual Skills Improvement With On-screen 3D Movies. Stereoscopic (3D) Movie Viewing, 2D Movie Viewing - Amblyopia, Strabismus | Not applicable | Not yet recruiting | Universitat Politècnica de Catalunya | 40 | 2026-01-15 | 2025-12-24 |
| Morning Versus Evening Patching in Childhood Amblyopia eye-patching - Amblyopia | Not applicable | Completed | Yarmouk University | 84 | 2025-12-14 | 2026-08-04 |
| Interactive Binocular Treatment (I- BiT) in Adult Patients With Anisometropic Amblyopia Interactive Binocular Treatment - Amblyopia | Not applicable | Not yet recruiting | Shahid Beheshti University of Medical Sciences | 15 | 2025-12-10 | 2025-08-05 |
| Early Detection and Prevention of Amblyopia and Visual Impairment Through Systematic Pediatric Vision Screening Standard screening procedure for amblyopia, New amblyopia screening method using a virtual reality headset. - Amblyopia | Not yet recruiting | University Hospital, Strasbourg, France | 40 | 2025-09-01 | 2025-08-08 | |
| Evaluation of AmblyoFix for the Treatment of Unilateral Amblyopia AmblyoFix binocular digital therapy, Occlusion therapy (Patching) - Amblyopia | Not applicable | Terminated | Eyesight Electronics | 40 | 2025-09-01 | 2026-04-06 |
| A Randomized Controlled Trial of Gabor-Based Perceptual Learning for Adult Amblyopia Gabor training - Amblyopia, Anisometropia | Not applicable | Recruiting | Jiannan Huang | 80 | 2025-05-25 | 2026-08-13 |
| Combining Noninvasive Brain Stimulation and Augmented Reality-based Dichoptic Therapy for Treating Amblyopic Adults Active High-Definition Transcranial Direct Current Stimulation, Sham High-Definition Transcranial Direct Current Stimulation, Augmented Reality-Based Dichoptic Therapy - Amblyopia, Anisometropic Amblyopia | Not applicable | Recruiting | Polytechnic Institute of Porto | 80 | 2025-05-01 | 2026-09-18 |
| Ocular Characteristics in Patients With Craniosynostosis Craniosynostosis, Strabismus | Recruiting | Centre Hospitalier Universitaire, Amiens | 65 | 2025-04-04 | 2026-02-12 |
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Strabismus (32) · Anisometropia (18) · Refractive Errors (11) · Vision Disorders (7) · Myopia (6) · Hyperopia (5) · Bites and Stings (3) · Ocular Motility Disorders (3) · Alzheimer Disease (2) · Astigmatism (2) · Crowding (2) · Esotropia (2) · Motor Activity (2) · Nystagmus, Pathologic (2)
Central Nervous System Diseases (182) · Nervous System Diseases (182) · Neurologic Manifestations (182) · Pathological Conditions, Signs and Symptoms (182) · Sensation Disorders (182) · Signs and Symptoms (182) · Brain Diseases (181) · Eye Diseases (181) · Vision Disorders (175) · Cranial Nerve Diseases (35) · Ocular Motility Disorders (32) · Refractive Errors (21) · Behavior (6) · Wounds and Injuries (4) · Chemically-Induced Disorders (3)
Atropine (9) · Eyeglasses (8) · Transdermal Patch (4) · Transcranial Direct Current Stimulation (3) · Dental Occlusion (2) · Donepezil (2) · Flicker Fusion (2) · Low-Level Light Therapy (2) · Tomography, Optical Coherence (2) · carbidopa, levodopa drug combination (2) · Caffeine (1) · Color Vision (1) · Control Groups (1) · Crossing Over, Genetic (1) · Docosahexaenoic Acids (1)
Jaeb Center for Health Research (24) · Retina Foundation of the Southwest (6) · Alaska Blind Child Discovery (5) · Boston Children's Hospital (5) · National Eye Institute (NEI) (5) · Rebiscan, Inc. (5) · Erasmus Medical Center (4) · Shahid Beheshti University of Medical Sciences (4) · Universitat Politècnica de Catalunya (4) · Luminopia (3) · NovaSight (3) · Salus University (3) · Amany Refaat Mohamed Abdel Wahid (2) · Beijing Airdoc Technology Co., Ltd. (2) · Cairo University (2)
United States (80) · China (16) · United Kingdom (11) · Egypt (8) · Canada (6) · Iran (5) · Spain (5) · France (4) · Hong Kong (4) · Netherlands (4) · Turkey (Türkiye) (4) · Israel (3) · Pakistan (3) · Australia (2) · Belgium (2)
David K. Wallace, M.D. (5) · Dennis M Levi, OD, PhD (3) · Huibert J Simonsz, MD, PhD (3) · Robert W Arnold, MD (3) · Roger W Li, OD, PhD (3) · Sean Donahue, MD, PhD (3) · Burcin Cakir, MD (2) · Eileen Birch, PhD (2) · Erick Bothun, MD (2) · Jonathan Holmes, MD (2) · Laura Asensio Jurado, MsC (2) · Michael X Repka, M.D. (2)
PMID 20451898, PMID 22108357, PMID 37619861, PMID 15824215, PMID 19109504, PMID 21912514, PMID 18824189, PMID 19008199, PMID 22558234, PMID 23882695, PMID 25715870, PMID 26909178, PMID 28824369, PMID 35129211, PMID 38917142, PMID 10360300, PMID 12742836, PMID 14597512, PMID 15330715, PMID 15522375, PMID 16123415, PMID 16751032, PMID 16751033, PMID 16930666, PMID 17502505, PMID 17707330, PMID 17855283, PMID 17962456, PMID 18789533, PMID 19064841, PMID 19139333, PMID 19250947, PMID 19503473, PMID 19541265, PMID 20163869, PMID 20212198, PMID 20714361, PMID 20837811, PMID 20974292, PMID 21209494, PMID 21419678, PMID 21683635, PMID 21730344, PMID 21746992, PMID 21870914, PMID 21907115, PMID 21959371, PMID 22144947, PMID 22336120, PMID 22633344
U10EY011751 (21), 2UG1EY011751 (3), R01EY022313 (3), R01EY001728 (2), 2023 (1), R21EY025398 (1), R44EY025902 (1)