12 completed, 7 unknown, 5 recruiting, 2 terminated. 5 Not applicable, 3 Phase 1, 2 Phase 2, 1 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 5 | Recruiting 2, Active not recruiting 1, Completed 1, Unknown 1 |
| Phase 1 | 3 | Completed 2, Withdrawn 1 |
| Phase 2 | 2 | Completed 2 |
| Phase 3 | 1 | Not yet recruiting 1 |
| Phase 4 | 1 | Completed 1 |
Follow Microbiota: new trials by email Literature Review of Microbiota trials Research Report on Microbiota
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy of Temocillin Compared to Standard of Care in the Treatment of Neisseria Gonorrhoeae Infections Temocillin (NEGABAN®) 2 g intravenous with lidocaine (3ml), Rectal swab for ESBL-E and microbiota (Eswab), Temocillin (NEGABAN®) 2 g intramuscular single dose with lidocaine (3ml) - Neisseria Gonorrhoeae (Ng) Infections | Phase 3 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 360 | 2026-09-01 | 2026-06-22 |
| Systemic Sclerosis DIet for GastrointESTinal Symptoms Diet 1: Restriction of fermentable carbohydrates, Diet 2: Elimination of foods harmful to gut barrier and microbiome, Diet 3: Regular meal patterns, soluble fiber, and portion control - Systemic Sclerosis (SSc) | Not applicable | Recruiting | University of Michigan | 60 | 2026-03-16 | 2026-07-01 |
| Assessment of the Efficacy and Safety of Fecal Microbiota Transplantation (FMT) in Patients With Major Depressive Disorder FMT capsule, Escitalopram (Lexapro), Corn Starch capsules - Major Depressive Disorder (MDD), Depression - Major Depressive Disorder | Not applicable | Recruiting | Gang Wang | 214 | 2025-01-01 | 2025-12-02 |
| A Phase 1b Proof-of-concept Trial Exploring the Effects of FE 999322 and FE 999324 in Adults With Mild to Moderate Ulcerative Colitis Microbiota suspension, Microbiota capsule, Placebo suspension - Ulcerative Colitis | Phase 1 | Withdrawn | Ferring Pharmaceuticals | 2024-03-12 | 2024-10-18 | |
| Assess Diversity of Gut Microbiome in Met NSCLC in Correlation to Tx & Adverse Effects Microbiome - Non Small Cell Lung Cancer | Recruiting | University of California, Irvine | 82 | 2024-01-31 | 2026-02-05 | |
| A Multicenter Study Based on Multi-omics Analysis to Predict the Early Prognosis and Recurrence Risk of Acute Ischemic Stroke microbiome; metabolomics; proteomics - Ischemic Stroke, Acute | Recruiting | Nanfang Hospital, Southern Medical University | 400 | 2024-01-30 | 2024-09-05 | |
| Clinical and Microbiological Approach in Orthopedic Treatment of Patients When Choosing a Structural Material dental prosthetics, biofilm response and oral microbiota - Oral Microbiota | Not applicable | Completed | Samara State Medical University | 80 | 2023-06-01 | 2026-10-16 |
| The Efficacy of Beneficial Intestinal Microbiota in the Treatment of Migraine and Its Mechanism: Basic and Clinical Studies microbiota - Pediatric Migraine | Not applicable | Active not recruiting | National Taiwan University Hospital | 30 | 2023-01-01 | 2025-07-29 |
| To Evaluate the Short-term and Long Term Efficacy of Acupuncture in Ocular and Oral Dryness Symptoms of Dry Eye Syndrome Acupuncture, Oral microbiota, Schirmer's test - Dry Eye Syndrome, Xerophthalmia | Not applicable | Unknown | Taipei Veterans General Hospital, Taiwan | 120 | 2022-12-06 | 2022-12-13 |
| Clinical Characteristics, Lifestyle and Multi-omics Analysis in Autoimmune Gastritis Microbiome, metabolome, transcriptome, genome - Autoimmune Gastritis | Unknown | Shanghai Jiao Tong University School of Medicine | 450 | 2022-06-19 | 2023-04-19 | |
| Effect of Oral Microbiota on MDRO Decolonization Microbiota capsule, Placebo - Clostridioides Difficile Infection, Drug Resistance, Bacterial | Phase 1 / Phase 2 | Completed | Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran | 42 | 2022-03-31 | 2026-03-27 |
| Impact of Gut Microbiota and Tryptophan Metabolites on Acute Pain in Lumbar Disc Herniation Surgery Patients Pain Perception in Patients Undergoing Lumbar Disc Herniation Surgery - Microbial Substitution, Tryptophan Metabolism Alterations | Completed | Dokuz Eylul University | 37 | 2022-01-12 | 2024-07-16 | |
| Association Between Cell-free Nucleic Acid in Blood, Urine and Microbiome in Stool With Pancreatobiliary Cancer cell free DNA in blood and urine, metabolite/microbiome in urine and stool - Pancreatic Cancer, Cholangiocarcinoma | Unknown | Seoul National University Hospital | 150 | 2022-01-06 | 2022-11-07 | |
| Airway Microbiota Based Treatment of Asthma in Preschool Children Microbiota and eosinophils based therapy, Clinical guidelines based therapy - Asthma in Children | Phase 4 | Completed | Children's Hospital of Fudan University | 120 | 2021-10-18 | 2024-07-10 |
| Biomarkers for Ventilator-associated Pneumonia Heparin-binding protein, Interleukin-26, Microbiome - Pneumonia, Ventilator-Associated | Recruiting | Region Skane | 1000 | 2021-10-15 | 2026-06-26 | |
| Dietary Habits, Metabolome, Immune Profile and Microbiota in Patients With Bone Sarcoma EPIC-COS Food Frequency Questionnaire diet Evaluation, Metabolome, Microbiota, Lymphocytes subpopulations - Osteosarcoma, Ewing Sarcoma | Unknown | Istituto Ortopedico Rizzoli | 810 | 2021-03-10 | 2023-08-04 | |
| Microbiome in Immunotherapy naïve NSCLC Patients Receiving PD-1/L1 Blockade (MIP_NSCLC) Microbiome - NSCLC Stage IV, NSCLC, Recurrent | Unknown | Jun Zhang, MD, PhD | 46 | 2020-07-29 | 2023-12-11 | |
| MTT for Children With Both Pitt Hopkins Syndrome and Gastrointestinal Disorders vancomycin, magnesium citrate, microbiota, placebo vancomycin, real magnesium citrate, placebo microbiota - Pitt Hopkins Syndrome | Phase 2 | Completed | Arizona State University | 6 | 2019-09-30 | 2024-08-26 |
| Multiomics Targeting Microbiome Associated Changes in Stroke Patients (StrokeMicroBiomics) Microbiome and Plasma Characterisation - Ischemic Stroke, Transient Ischemic Attack | Completed | Ludwig-Maximilians - University of Munich | 10 | 2019-06-16 | 2024-10-15 | |
| Comparison of Scalp Microbiota of the Psoriasis and Seborrheic Dermatitis Patients Microbiota - Psoriasis Vulgaris, Seborrheic Dermatitis | Completed | Istanbul Medeniyet University | 30 | 2019-04-25 | 2020-09-10 |
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Inflammatory Bowel Diseases (3) · Carcinoma, Non-Small-Cell Lung (2) · Ischemic Stroke (2) · Acute Pain (1) · Autism Spectrum Disorder (1) · Autistic Disorder (1) · Bone Neoplasms (1) · Cholangiocarcinoma (1) · Clostridium Infections (1) · Colitis (1) · Colitis, Ulcerative (1) · Communicable Diseases (1) · Crohn Disease (1) · Depressive Disorder, Major (1) · Dermatitis, Seborrheic (1)
Taipei Veterans General Hospital, Taiwan (2) · Arizona State University (1) · Assistance Publique - Hôpitaux de Paris (1) · Centre Hospitalier Universitaire de Nīmes (1) · Chang Gung Memorial Hospital (1) · Children's Hospital of Fudan University (1) · Connecticut Children's Medical Center (1) · Dokuz Eylul University (1) · Ferring Pharmaceuticals (1) · Gang Wang (1) · Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran (1) · Istanbul Medeniyet University (1) · Istituto Ortopedico Rizzoli (1) · Johns Hopkins University (1) · Jun Zhang, MD, PhD (1)
United States (9) · China (5) · Taiwan (3) · France (2) · Turkey (Türkiye) (2) · Canada (1) · Germany (1) · Italy (1) · Mexico (1) · Norway (1) · Portugal (1) · Russia (1) · South Korea (1) · Sweden (1)
Alessandra Longhi, MD (1) · Amy E Millen, PhD (1) · Chang Ching-Mao, M.D., Ph.D. (1) · Ching-Mao Chang, M.D., Ph.D. (1) · Dinesh Khanna, MD, MSc (1) · Jean-Philippe Lavigne (1) · Jiande Chen, PhD (1) · Jingyuan Fang, MD, Ph.D (1) · Jun Zhang, MD, PhD (1) · Lei Li, MD (1) · Magnus Paulsson, PhD MD (1) · Misako Nagasaka, MD,PhD (1)
PMID 25838377, PMID 26331920, PMID 27974040, PMID 28934351, PMID 29558948, PMID 31627210, PMID 31784432, PMID 32471029, PMID 40760513
2025 (1)