45 completed, 30 unknown, 10 recruiting, 2 active not recruiting. 31 Not applicable, 3 Phase 4, 2 Phase 3, 1 Phase 1, 1 Phase 2.
Follow Weaning Failure: new trials by email Literature Review of Weaning Failure trials Research Report on Weaning Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Characterization of Weaning Practices in ICUs of Global South Countries Weaning From Mechanical Ventilation, Weaning Failure | Recruiting | Hospital do Coracao | 900 | 2026-05-25 | 2026-09-23 | |
| Quantification of Systemic Congestion by Ultrasound As a Predictor of Weaning Failure From Mechanical Ventilation point of care ultrasound - Weaning Failure, Pulmonary Edema - Acute | Not applicable | Not yet recruiting | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 350 | 2026-04-01 | 2026-01-21 |
| Shorter Weaning From Invasive Ventilation With Levosimendan levosimendan, Soluvit, Standard care - Mechanical Ventilation, Weaning Failure | Phase 4 | Recruiting | Radboud University Medical Center | 250 | 2025-09-17 | 2026-01-09 |
| Temporal Change in Parasternal Thickening Fraction as a Predictor for Weaning Parasternal intercostal thickening - Mechanical Ventilation, Weaning From Mechanical Ventilation | Completed | Cairo University | 64 | 2025-07-13 | 2026-03-25 | |
| Surface Electrical Myography, Oxygen Consumption, Effort, and Weaning in the Mechanically Ventilated Patient in the Intensive Care Unit Critical Illness, Intensive Care Units (ICUs) | Recruiting | Leiden University Medical Center | 60 | 2025-07-08 | 2025-11-26 | |
| PREdicting Failure of Non-inVasIve Ventilatory Support Using Non-invaSIve mONitoring in Non-intubated Patients With Acute Hypoxemic Respiratory Failure or Post-extubation Failure. The PREVISION Study Ventilatory Failure, Hypoxemic Respiratory Failure | Active not recruiting | Unity Health Toronto | 80 | 2025-01-27 | 2026-11-10 | |
| Role of Regional Lung Compliance and Dynamic Transpulmonary Driving Pressure in the Liberation Difficulty in Tracheostomized Patients Receiving Prolonged Mechanical Ventilation Weaning Failure | Recruiting | National Taiwan University Hospital | 120 | 2025-01-16 | 2025-06-04 | |
| Can Total Mechanical Power Be a Determinant of Weaning Failure in Chronic Obstructive Pulmonary Disease (COPD)? COPD (Chronic Obstructive Pulmonary Disease), ARDS (Acute Respiratory Distress Syndrome) | Completed | Bakirkoy Dr. Sadi Konuk Research and Training Hospital | 1000 | 2024-12-06 | 2024-12-30 | |
| Evaluation of heepSync, a Novel Algorithm for Transcutaneous Electrical Stimulation of Respiratory Muscles in Mechanically Ventilated Patients. Heecap - Ventilator-induced Diaphragm Dysfunction, VIDD | Not applicable | Recruiting | Tesai Care SL | 20 | 2024-12-01 | 2026-09-21 |
| Ventilatory Settings and Monitoring Variables Associated With Weaning Failure in Critically Ill Patients Mechanical Ventilation, Weaning Failure | Recruiting | Hospital Italiano de Buenos Aires | 1077 | 2024-12-01 | 2025-03-17 | |
| Role of Spectrophotometer in Early Prediction of Weaning Induced Cardiac Dysfunction massimo - Weaning Failure | Completed | Ain Shams University | 55 | 2024-10-25 | 2025-08-05 | |
| Effect of Hypophosphatemia on Neuro-excursion Efficiency During Mechanical Ventilator Weaning Sodium Glycerophosphate 216 MG/ML - Mechanical Ventilation, Weaning Failure | Recruiting | Peking Union Medical College | 70 | 2024-10-01 | 2025-05-31 | |
| TESTO-TRIAL: Use of Testosterone in Critically Ill Patients Testosterone cypionate (200mg/3ml), Sesame oil (3ml) - Weaning Failure, Muscle Weakness | Phase 4 | Active not recruiting | Leticia Maria Defendi Barboza Marson | 94 | 2024-09-09 | 2024-12-18 |
| Exploration of Mechanisms for Weaning Failure Monitoring of respiratory mechanics parameters - Weaning Failure, Central Respiratory Depression | Unknown | The First Affiliated Hospital of Guangzhou Medical University | 30 | 2024-07-09 | 2024-07-09 | |
| Preventing Celiac Disease by Weaning With Mediterranean Diet Weaning by Mediterranean Diet - Weaning Failure | Phase 3 | Not yet recruiting | University of Naples | 3200 | 2024-06-15 | 2024-05-08 |
| The Effect of Quantitative EEG Combined With Ultrasound and Sputum Volume on Predicting Weaning Failure Quantitative EEG monitoring and beside ultrasound evaluation - Weaning Failure | Unknown | Qingdao University | 50 | 2024-04-15 | 2024-04-11 | |
| Extremes of Respiratory Effort in Weaning Failure From Mechanical Ventilation: a Prospective Observational Study low respiratory effort, high respiratory effort - Mechanical Ventilation Pressure High, Weaning Failure | Unknown | Universidade Federal do Rio de Janeiro | 1 | 2024-04-01 | 2024-07-23 | |
| Preventing Failed Extubations Plateau Pressure - Mechanical Ventilation Complication, Weaning Failure | Completed | Duke University | 248 | 2024-03-01 | 2024-11-21 | |
| Oxygen Consumption (VO2), Effort, and Weaning in the Mechanically Ventilated Patient in the Intensive Care Unit (ICU) Spontaneous Breathing Trial - Critical Illness, Intensive Care Unit | Unknown | Leiden University Medical Center | 60 | 2024-01-01 | 2024-09-19 | |
| Monitoring of Breathing Effort Through Pressure Time Product Measurement Using Airway Occlusion Pressure End expiratory occlusion maneuver - Respiratory Failure, Weaning Failure | Unknown | Hospital Italiano de Buenos Aires | 50 | 2023-10-01 | 2024-03-12 |
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Respiratory Insufficiency (9) · Critical Illness (6) · Respiratory Aspiration (4) · Muscle Weakness (3) · Pulmonary Disease, Chronic Obstructive (3) · Respiration Disorders (3) · Respiratory Distress Syndrome (3) · COVID-19 (2) · Pulmonary Atelectasis (2) · Pulmonary Edema (2) · Acute Lung Injury (1) · Airway Obstruction (1) · Brain Injuries (1) · Brain Injuries, Traumatic (1) · Celiac Disease (1)
Respiratory Tract Diseases (23) · Pathological Conditions, Signs and Symptoms (20) · Pathologic Processes (15) · Respiration Disorders (14) · Lung Diseases (11) · Disease Attributes (9) · Signs and Symptoms (8) · Nervous System Diseases (6) · Infections (4) · Neurologic Manifestations (4) · Cardiovascular Diseases (3) · Chronic Disease (3) · Heart Diseases (3) · Lung Diseases, Obstructive (3) · Muscular Diseases (3)
Simendan (2) · Blood Gas Analysis (1) · Clinical Protocols (1) · Diagnostic Tests, Routine (1) · Doxapram (1) · Echocardiography (1) · Electroencephalography (1) · Endurance Training (1) · High-Energy Shock Waves (1) · Maximal Respiratory Pressures (1) · Sesame Oil (1) · Standard of Care (1) · Theophylline (1) · Ultrasonography (1) · Weaning (1)
Ain Shams University (4) · Althaia Xarxa Assistencial Universitària de Manresa (3) · Assiut University (2) · Cairo University (2) · Federal University of Uberlandia (2) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (2) · Henrik Endeman (2) · Hospital Italiano de Buenos Aires (2) · KU Leuven (2) · Leiden University Medical Center (2) · National Taiwan University Hospital (2) · Università degli Studi di Ferrara (2) · Alexandria University (1) · Amsterdam UMC, location VUmc (1) · Antalya Training and Research Hospital (1)
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Leo Heunks, MD, PhD (2) · Abraham Schoe, MD PhD (1) · Alaa M Taghyan, Ass.Lecturer (1) · Ali Rashad, MBBCH (1) · Antonio Messina, PhD (1) · Begum Ergan (1) · Bernat Planas Pascual, PT,MSc (1) · Camila Marques Dias (1)
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