55 completed, 9 recruiting, 8 unknown, 3 terminated. 21 Phase 2, 17 Phase 3, 15 Not applicable, 9 Phase 4, 8 Phase 1.
Follow Vibrio Infections: new trials by email Literature Review of Vibrio Infections trials Research Report on Vibrio Infections
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ondansetron to Prevent Oral Rehydration Failure in Children With Cholera Ondansetron, Standard Cholera Care - Cholera (Disorder) | Phase 2 | Not yet recruiting | Public Interest Science Center | 120 | 2026-10-20 | 2026-10-19 |
| Phase 1b Ascending Dose Study of PanChol in Healthy Volunteers PanChol - Cholera Vaccination Reaction | Phase 1 | Recruiting | Centre for Infectious Disease Research in Zambia | 32 | 2026-05-20 | 2026-10-06 |
| Extended Dosing Intervals Trial for Oral Cholera Vaccine, Kenya Euvichol-S Oral Cholera Vaccine - Cholera Vaccination | Phase 4 | Recruiting | Albert B. Sabin Vaccine Institute | 1071 | 2025-10-31 | 2026-03-23 |
| Vaccine- and Infection-derived Correlates of Protection for Cholera oral cholera vaccine or typhoid conjugate vaccine - Cholera | Not applicable | Recruiting | Massachusetts General Hospital | 1221 | 2025-03-02 | 2026-04-08 |
| Cholera Control by Case-area Targeted Interventions (CATIs) Cholvax - Cholera, Methodology Study | Not applicable | Recruiting | International Centre for Diarrhoeal Disease Research, Bangladesh | 68400 | 2024-09-05 | 2026-07-06 |
| Testing a Scalable Model of the Cholera Hospital-Based Intervention for 7 Days (CHoBI7) Standard Recommendation, CHoBI7 Scale-Up Program - Diarrhea Infectious, Cholera | Not applicable | Recruiting | Johns Hopkins Bloomberg School of Public Health | 1600 | 2024-08-19 | 2026-04-15 |
| Simulation Based Training In Medical Students Tabletop simulation based teaching, conventional class room teaching - Cholera | Not applicable | Completed | CMH Lahore Medical College and Institute of Dentistry | 87 | 2024-07-08 | 2025-07-31 |
| Assessment of a Novel Fixed-dose Combination (FDC) Drug VR-AD-1005 for the Treatment of Acute Watery Diarrhea in Cholera VR-AD-1005, Placebo - Cholera | Phase 2 | Completed | Hunazine Biotech S.L. | 150 | 2024-02-11 | 2026-06-02 |
| Immune Response Elicited by Concomitant Administration of Oral Typhoid Fever (Vivotif®) and Cholera (Dukoral®) Vaccines Oral typhoid fever vaccine, Oral cholera vaccine - Vaccine-Preventable Diseases, Typhoid Fever | Phase 4 | Completed | Helsinki University Central Hospital | 65 | 2023-10-25 | 2024-12-05 |
| Cholera-Hospital-Based-Intervention-for-7-Days (CHoBI7) Water, Sanitation, and Hygiene (WASH) Case Area Targeted Intervention (CATI) Cholera-Hospital-Based-Intervention-for-7-Days (CHoBI7) CATI, Standard message - Cholera, Diarrhea | Not applicable | Recruiting | Johns Hopkins Bloomberg School of Public Health | 3140 | 2023-10-18 | 2025-12-02 |
| Co-administration Study of OCV, TCV and MR Oral Cholera Vaccine (OCV), Typhoid Conjugate Vaccine (TCV), Measles and Rubella (MR) - Typhoid, Cholera | Phase 3 | Unknown | International Centre for Diarrhoeal Disease Research, Bangladesh | 2117 | 2023-10-14 | 2023-10-13 |
| Next Generation ORS: Comparing ORS With Calcium vs Standard ORS in Reducing Severity of Acute Watery Diarrhea Next Generation ORS (oral rehydration solution) (including placebo, Current standard control ORS (oral rehydration solution) - Diarrhea, Cholera | Phase 2 / Phase 3 | Completed | University of Florida | 396 | 2023-08-21 | 2026-04-14 |
| To Evaluate Safety of Oral Cholera Vaccine Hillchol® (BBV131) Hillchol vaccine - Cholera | Phase 3 | Unknown | Bharat Biotech International Limited | 1800 | 2023-02-04 | 2023-02-17 |
| First in Human Phase 1 Ascending Dose Study of PanChol in Healthy Volunteers PanChol - Cholera, Cholera Vaccine Toxicity | Phase 1 | Unknown | Brigham and Women's Hospital | 53 | 2022-12-12 | 2022-12-20 |
| Immune Response to a Delayed Second Dose of Oral Cholera Vaccine Delayed second dose of oral cholera vaccine, Euvichol-Plus, Oral cholera vaccine, Euvichol-Plus, according to manufacturer notice - Cholera, Vibrio Cholerae Infection | Phase 4 | Unknown | Epicentre | 456 | 2022-07-20 | 2023-03-07 |
| A Phase III Randomized, Modified Double-blind, Multi-centric, Comparative Study, to Evaluate the Non-inferiority of Immunogenicity and Safety of Hillchol® (BBV131)to Shanchol™ Along With Lot-to-lot Consistency of Hillchol®(BBV131). Hillchol vaccine, Shanchol Vaccine - Cholera | Phase 3 | Unknown | Bharat Biotech International Limited | 1800 | 2022-02-22 | 2022-08-18 |
| Preventative Intervention for Cholera for 7 Days PICHA7 mHealth program, Standard Arm - Cholera, Water-Related Diseases | Not applicable | Recruiting | Johns Hopkins Bloomberg School of Public Health | 2900 | 2021-12-22 | 2025-12-17 |
| Single Dose Azithromycin to Prevent Cholera in Children Azithromycin, Placebo - Cholera | Phase 2 | Completed | Massachusetts General Hospital | 2475 | 2021-10-31 | 2026-08-07 |
| Immune Non-Inferiority, Safety and Lot-to-Lot Consistency of Oral Cholera Vaccine-Simplified Compared to Shanchol™ Oral Cholera Vaccine Simplified (OCV-S), Shanchol™ - Cholera | Phase 3 | Completed | International Vaccine Institute | 2530 | 2021-10-06 | 2023-06-22 |
| Impact Study of Cholera Vaccination in Endemic Areas - Seroprevalence Cholera | Completed | Epicentre | 7000 | 2021-09-20 | 2024-09-19 |
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Cholera (76) · Diarrhea (18) · Typhoid Fever (3) · Dehydration (2) · Dysentery (2) · Osteoarthritis (2) · Abortion, Spontaneous (1) · Communicable Diseases (1) · Escherichia coli Infections (1) · Growth Disorders (1) · Inflammatory Bowel Diseases (1) · Malnutrition (1) · Measles (1) · Rubella (1)
Bacterial Infections (77) · Bacterial Infections and Mycoses (77) · Gram-Negative Bacterial Infections (77) · Infections (77) · Pathological Conditions, Signs and Symptoms (22) · Signs and Symptoms (20) · Signs and Symptoms, Digestive (19) · Pathologic Processes (6) · Enterobacteriaceae Infections (4) · Digestive System Diseases (3) · Gastroenteritis (3) · Gastrointestinal Diseases (3) · Intestinal Diseases (3) · Nutritional and Metabolic Diseases (3)
shanchol (15) · Cholera Vaccines (7) · Azithromycin (3) · Ciprofloxacin (3) · IOWH-032 (3) · Dukoral (2) · Peru 15 (2) · Vaxchora (2) · Albendazole (1) · Anti-Bacterial Agents (1) · Arsenic (1) · Blood Specimen Collection (1) · Calcium (1) · Dopamine (1) · Epinephrine (1)
International Centre for Diarrhoeal Disease Research, Bangladesh (17) · International Vaccine Institute (15) · Johns Hopkins Bloomberg School of Public Health (8) · Bavarian Nordic (5) · PATH (4) · Epicentre (3) · National Institute of Allergy and Infectious Diseases (NIAID) (3) · Bharat Biotech International Limited (2) · Brigham and Women's Hospital (2) · Massachusetts General Hospital (2) · Sanofi Pasteur, a Sanofi Company (2) · Albert B. Sabin Vaccine Institute (1) · CMH Lahore Medical College and Institute of Dentistry (1) · Centre for Infectious Disease Research in Zambia (1) · Emory University (1)
Bangladesh (29) · India (12) · United States (10) · Democratic Republic of the Congo (4) · Zambia (2) · Australia (1) · Cameroon (1) · Dominican Republic (1) · Ethiopia (1) · Finland (1) · France (1) · Guinea (1) · Haiti (1) · Kenya (1) · Mali (1)
Christine Marie George, PhD (5) · James McCarty, MD (3) · Debasish Saha, MBBS,MS (2) · Firdausi Qadri, Dr. (2) · Firdausi Qadri, PhD (2) · Shantanu K Kar, MD (2) · Ahmed Khatib, MD (1) · Aleksandra Banaszkiewicz, MD, PhD (1) · Alok K Deb, PhD, MDDS (1) · Amanda K Debes, PhD (1) · Anu Kantele, MD, PhD (1) · Armel Landry Batchi-Bouyou, MD, PhD, MPH (1) · Dang Duc Anh, PhD (1) · David Sack, MD (1)
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R01AI099243 (1), R01AI137127 (1), R01AI148332 (1), R01HD102540 (1), R21AI169282 (1), U01AI058935 (1)