104 completed. 104 Phase 2, 24 Phase 1, 10 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 104 | Completed 104 |
| Phase 1 | 24 | Completed 24 |
| Phase 3 | 10 | Completed 10 |
Follow Type 1 Diabetes: new trials by email Literature Review of Type 1 Diabetes trials Research Report on Type 1 Diabetes
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| SGLT2 Adjunct in T1D Empagliflozin (EMPA), Placebo - Type 1 Diabetes, Nephropathy, Diabetic | Phase 2 / Phase 3 | Completed | Ain Shams University | 86 | 2024-11-20 | 2026-05-18 |
| ADJUnct Semaglutide Treatment in Type 1 Diabetes Semaglutide, Placebo - Type 1 Diabetes, Obesity | Phase 2 | Completed | Viral N. Shah | 115 | 2023-04-11 | 2025-09-03 |
| Acetazolamide in Persons With Type 1 Diabetes - Dose Finding Acetazolamide - Type 1 Diabetes | Phase 1 / Phase 2 | Completed | University of California, San Diego | 12 | 2023-03-20 | 2025-05-15 |
| Insulin and Abatacept in Recently-diagnosed Type 1 Diabetes Abatacept (CTLA4-Ig) and nasal insulin (Humulin R®), Abatacept (CTLA4-Ig) and nasal placebo (0.9% sodium chloride) - Type 1 Diabetes, Diabetes Mellitus, Type 1 | Phase 2 | Completed | Melbourne Health | 68 | 2023-02-13 | 2025-12-24 |
| Weekly Subcutaneous Semaglutide as Adjunct to Closed-loop Therapy in Type 1 Diabetes Care Outpatient therapy: 11 weeks of drug therapy with usual treatment + 4 weeks of closed-loop therapy - Type 1 Diabetes, Diabetes Mellitus, Type 1 | Phase 2 / Phase 3 | Completed | McGill University Health Centre/Research Institute of the McGill University Health Centre | 28 | 2022-10-02 | 2025-01-22 |
| Oral Hypoglycemic Therapy for Monogenic Variant Carriers of the Joslin Medalist Study Metformin Extended Release Oral Tablet, Sitagliptin - Type 1 Diabetes, Monogenic Diabetes | Phase 2 / Phase 3 | Completed | Joslin Diabetes Center | 3 | 2021-08-26 | 2025-02-24 |
| Pen-Administered Low-Dose Dasiglucagon for Prevention and Treatment of Hypoglycemia in People With Type 1 Diabetes Dasiglucagon - Type 1 Diabetes, Hypoglycemia | Phase 2 | Completed | Steno Diabetes Center Copenhagen | 24 | 2021-04-27 | 2022-09-07 |
| Combination GRA and SGLT-2i Treatment in Type 1 Diabetes Dapagliflozin 10 MG [Farxiga], REMD-477, Placebo - Type 1 Diabetes | Phase 1 / Phase 2 | Completed | University of California, San Diego | 12 | 2021-02-22 | 2023-01-23 |
| DiaBetter Together for Young Adults With Type 1 Diabetes DiaBetter Together, Peer Mentor Delivery - Type 1 Diabetes | Phase 2 | Completed | Baylor College of Medicine | 144 | 2020-12-15 | 2025-12-16 |
| Baricitinib in New-onset Type 1 Diabetes Baricitinib, Placebo - Type 1 Diabetes | Phase 2 | Completed | St Vincent's Institute of Medical Research | 91 | 2020-10-30 | 2024-12-03 |
| A Study of LY900014 and Insulin Degludec in Participants With Type 1 Diabetes LY900014, Insulin Degludec - Type 1 Diabetes | Phase 2 | Completed | Eli Lilly and Company | 31 | 2020-10-30 | 2022-06-03 |
| Low-dose Dasiglucagon for Prevention of Insulin-Induced Hypoglycemia in People With Type 1 Diabetes Dasiglucagon, Carbohydrate (dextrose tablets) - Type 1 Diabetes, Hypoglycemia | Phase 2 | Completed | Steno Diabetes Center Copenhagen | 20 | 2020-07-02 | 2021-02-09 |
| A Study to Compare ORMD-0801 Once Daily to ORMD-0801 Three Times Daily in Subjects With Type 1 Diabetes ORMD-0801 Treatment A, ORMD-0801 Treatment B, Placebo - Type 1 Diabetes | Phase 2 | Completed | Oramed, Ltd. | 30 | 2019-10-17 | 2022-06-02 |
| Pancreatic Islets and Parathyroid Gland Co-transplantation for Treatment of Type 1 Diabetes Co-transplantation of PTG with pancreatic islets - Type 1 Diabetes | Phase 1 / Phase 2 | Completed | Peter Stock | 4 | 2019-07-01 | 2026-03-06 |
| Closed-loop Control of Glucose Levels (Artificial Pancreas) for 12 Days in Adults With Type 1 Diabetes 12-day intervention with sensor-augmented pump therapy, 12-day intervention with single-hormone closed-loop strategy, Insulin pump - Type 1 Diabetes | Phase 2 | Completed | Institut de Recherches Cliniques de Montreal | 36 | 2019-01-24 | 2020-06-11 |
| Vitamin D and Residual Beta-Cell Function in Type 1 Diabetes Ergocalciferol, Placebo - Type 1 Diabetes | Phase 2 / Phase 3 | Completed | Benjamin U. Nwosu, MD | 48 | 2017-10-19 | 2024-07-10 |
| Multicenter Trial of the Effect of AAT on Islet Transplant Engraftment and Durability After Renal Transplant Alpha 1-Antitrypsin, Islet Transplantation, Thymoglobulin - Kidney Transplant, Type 1 Diabetes | Phase 2 | Completed | Massachusetts General Hospital | 2 | 2017-01-01 | 2023-12-22 |
| Targeting Inflammation With Salsalate in Type 1 Diabetes Neuropathy Salsalate, PLACEBO - Type 1 Diabetes, Peripheral Neuropathy | Phase 2 / Phase 3 | Completed | University of Michigan | 61 | 2016-10-01 | 2025-05-16 |
| Closed-loop Control of Glucose Levels (Artificial Pancreas) During Postprandial Exercise in Adults With Type 1 Diabetes 60-minute exercise, Insulin pump, Dexcom G4 Platinum glucose sensor - Type 1 Diabetes | Phase 2 | Completed | Institut de Recherches Cliniques de Montreal | 37 | 2016-09-01 | 2019-02-11 |
| MMPPC Outpatient Clinical Protocol 2016 MMPPC algorithm artificial pancreas - Type 1 Diabetes | Phase 2 | Completed | Rensselaer Polytechnic Institute | 10 | 2016-07-01 | 2018-01-30 |
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Diabetes Mellitus, Type 1 (104) · Hypoglycemia (26) · Insulin Resistance (21) · Diabetes Mellitus (15) · Autoimmune Diseases (2) · Inflammation (2) · Kidney Diseases (2) · Pain (2) · Peripheral Nervous System Diseases (2) · Depression (1) · Diabetic Nephropathies (1) · Disease (1) · Glucose Intolerance (1) · Hyperglycemia (1) · Ichthyosis prematurity syndrome (1)
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Insulin (13) · Liraglutide (6) · Glucagon (4) · Insulin Aspart (4) · Methods (4) · Sirolimus (4) · Sitagliptin Phosphate (4) · Sodium Chloride (4) · Abatacept (3) · Etanercept (3) · Exercise (3) · Mycophenolic Acid (3) · Tacrolimus (3) · aldesleukin (3) · thymoglobulin (3)
Institut de Recherches Cliniques de Montreal (14) · University of Cambridge (5) · University of Minnesota (5) · Assistance Publique - Hôpitaux de Paris (4) · University of Alberta (4) · Jaeb Center for Health Research (3) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (3) · Steno Diabetes Center Copenhagen (3) · Cambridge University Hospitals NHS Foundation Trust (2) · Diatranz Otsuka Limited (2) · Massachusetts General Hospital (2) · Melbourne Health (2) · Ospedale San Raffaele (2) · University Hospital, Montpellier (2) · University of California, San Diego (2)
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Roman Hovorka, PhD (4) · John Lum, MS (3) · Remi Rabasa-Lhoret (3) · A.M. James Shapiro, MD, PhD (2) · Bernhard J. Hering, M.D. (2) · Bruce A Buckingham, MD (2) · Christian Laugesen, MD (2) · Elizabeth R Seaquist, MD (2) · Lorenzo Piemonti, MD (2) · Riitta Veijola, MD (2) · Rodica Pop-Busui, MD, PhD (2) · Roy W Beck, MD, PhD (2)
PMID 23438305, PMID 23562090, PMID 26241693, PMID 34091488, PMID 35797241, PMID 12176626, PMID 12176628, PMID 14961992, PMID 15233820, PMID 15713772, PMID 18843118, PMID 19366957, PMID 19571282, PMID 20142543, PMID 20332358, PMID 20357369, PMID 21084848, PMID 21116604, PMID 21715517, PMID 22419704, PMID 22943030, PMID 22946986, PMID 22996144, PMID 23274902, PMID 23359039, PMID 23469940, PMID 23883408, PMID 24050942, PMID 24302596, PMID 24432999, PMID 24622415, PMID 24757227, PMID 24804697, PMID 24963110, PMID 24997559, PMID 25286053, PMID 25381193, PMID 25393157, PMID 25434967, PMID 25761202, PMID 25881192, PMID 25898052, PMID 26049549, PMID 26066705, PMID 26072052, PMID 26312919, PMID 26345338, PMID 26523526, PMID 27087519, PMID 27704167
2014 (3), R01DK085591 (3), UC4DK106993 (2), UC4DK117009 (2), R01DK062440 (1), R01DK119246 (1), R21DK113353 (1), UC4DK097835 (1), UL1TR001082 (1)