75 completed, 11 terminated, 9 recruiting, 6 unknown. 109 Phase 1, 40 Phase 2.
Follow Type 1 Diabetes: new trials by email Literature Review of Type 1 Diabetes trials Research Report on Type 1 Diabetes
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| ENCRT-103-hPI: Evaluation of an Immune-protected ENCRT-103-hPI Containing Primary Human Islets in Adults With Type 1 Diabetes, With and Without Standard-of-care Portal Vein Islet Infusion. ENCRT-103-hPI encompasses the ENC-103 device, which will be implanted once loaded with primary islet cargo. - Type 1 Diabetes | Phase 1 | Not yet recruiting | Encellin | 10 | 2027-01-06 | 2026-08-20 |
| Study of IMC-S118AI in Type 1 Diabetes IMC-S118AI - Type 1 Diabetes, Type 1 Diabetes (T1D) | Phase 1 | Not yet recruiting | Immunocore Ltd | 154 | 2026-04-01 | 2026-03-25 |
| A Randomized Phase 1/2 Trial of Low Dose Anti-thymocyte Globulin (ATG) With Subsequent Adalimumab or Verapamil in New Onset Type 1 Diabetes Anti-thymocyte globulin (ATG), verapamil extended-release capsule, Adalimumab - Type 1 Diabetes, New Onset | Phase 1 / Phase 2 | Recruiting | City of Hope Medical Center | 120 | 2026-03-10 | 2026-10-16 |
| A Single Bolus, 12-hour Euglycemic Clamp Study of the Safety, Pharmacokinetics (PK) and Glucodynamics (GD) of Intraperitoneal (IP) Portal Insulin U-500 Portal Insulin U-500, Humulin R U-500, Lyumjev U-100 Insulin - Type 1 Diabetes | Phase 1 | Recruiting | Portal Diabetes, Inc. | 25 | 2026-02-10 | 2026-04-28 |
| A Phase I/II Trial to Preserve Residual Insulin Secretion in Children With Recent Onset Type 1 Diabetes by Giving Verapamil Verapamil (Part A), Placebo - Type 1 Diabetes | Phase 1 / Phase 2 | Recruiting | Johnny Ludvigsson | 36 | 2025-08-06 | 2025-09-30 |
| A Study to Investigate Safety and Effectiveness of Porcine Pancreatic Cells (OPF-310) in Patients With Type 1 Diabetes Mellitus OPF-310 - Diabetes Mellitus, Type 1, Hypoglycemia | Phase 1 / Phase 2 | Recruiting | Otsuka Pharmaceutical Factory, Inc. | 13 | 2025-06-10 | 2026-08-21 |
| CNP-103 in Adolescent and Adult Subjects Ages 12-35 With Recently Diagnosed (Within 6 Months) Stage 3 Type 1 Diabetes (T1D) CNP-103, Placebo - Type 1 Diabetes Mellitus, T1D | Phase 1 / Phase 2 | Recruiting | COUR Pharmaceutical Development Company, Inc. | 72 | 2025-05-12 | 2026-09-11 |
| Denosumab for Type 1 Diabetes Denosumab, Placebo - Type 1 Diabetes | Phase 1 / Phase 2 | Recruiting | City of Hope Medical Center | 45 | 2025-05-05 | 2026-10-20 |
| Premixed Glucagon/Insulin Solution for Faster Insulin Absorption in Type 1 Diabetes Lyumjev 100 UNT/ML Injectable Solution, Premixed Lyumjev - Type 1 Diabetes | Phase 1 / Phase 2 | Terminated | St. Olavs Hospital | 9 | 2025-04-01 | 2026-10-19 |
| Suppression of Endogenous Glucose Production by Injectable HDV-Insulin Lispro: A Dose Response Study in Human Subjects With Type 1 Diabetes HDV-Insulin Lispro - Type 1 Diabetes | Phase 1 | Not yet recruiting | University of California, San Diego | 18 | 2025-02-01 | 2024-10-10 |
| Combination Adjunctive Therapy to Address Multiple Metabolic Imbalances in Type 1 Diabetes Sotagliflozin, Volagidemab - Type 1 Diabetes | Phase 1 / Phase 2 | Active not recruiting | University of California, San Diego | 24 | 2024-09-09 | 2026-06-15 |
| Safety, Pharmacokinetics, and Pharmacodynamics of MTX-101 in Healthy Adults and Patients Placebo, MTX-101 - Healthy Volunteers, Type 1 Diabetes | Phase 1 | Recruiting | Mozart Therapeutics Australia Pty Ltd | 96 | 2024-06-13 | 2026-05-18 |
| Semaglutide GLP1 Agonists With Degludec Basal-bolus Insulin in Early Type 1 Diabetes to Basal-bolus Semaglutide weekly injection - Type 1 Diabetes | Phase 1 / Phase 2 | Unknown | Ministry of Health, Saudi Arabia | 120 | 2024-01-01 | 2023-09-28 |
| R-5280 in Newly Diagnosed Patients With Type 1 Diabetes R-5280, Placebo - Type 1 Diabetes, Type 1 Diabetes (Juvenile Onset) | Phase 1 | Completed | Rise Therapeutics LLC | 9 | 2023-12-05 | 2025-11-10 |
| A Safety, Tolerability, and Efficacy Study of VX-264 in Participants With Type 1 Diabetes VX-264 - Type 1 Diabetes | Phase 1 / Phase 2 | Active not recruiting | Vertex Pharmaceuticals Incorporated | 7 | 2023-05-16 | 2026-10-09 |
| Safety and Efficacy of CELZ-201 in Patients With Recent Onset Type 1 Diabetes CELZ-201 Administration, Control Group - Type 1 Diabetes, Diabetes Mellitus, Type 1 | Phase 1 / Phase 2 | Recruiting | Creative Medical Technology Holdings Inc | 18 | 2023-04-07 | 2026-02-19 |
| A Study to Assess the Effects of CT-868 Treatment on Glucose Homeostasis in Participants with Type 1 Diabetes CT-868, Placebo, Victoza - Type 1 Diabetes | Phase 1 | Completed | Carmot Therapeutics, Inc. | 32 | 2023-03-21 | 2024-12-27 |
| Acetazolamide in Persons With Type 1 Diabetes - Dose Finding Acetazolamide - Type 1 Diabetes | Phase 1 / Phase 2 | Completed | University of California, San Diego | 12 | 2023-03-20 | 2025-05-15 |
| MANATEE-T1D: Metformin ANd AutomaTEd Insulin Delivery System Effects on Renal Vascular Resistance, Insulin Sensitivity, and Cardiometabolic Function in Youth With Type 1 Diabetes Metformin Hcl 1000Mg Tab, Aminohippurate Sodium 20 % Injection, Iohexol 300 Mg/mL Injectable Solution - Type 1 Diabetes, Diabetic Kidney Disease | Phase 1 | Recruiting | Kalie Tommerdahl | 60 | 2022-07-01 | 2025-06-13 |
| Study to Explore the Effect of Dapagliflozin and Stress in Adolescent and Adult Subjects With Type 1 Diabetes (T1D) Dapagliflozin, Placebo oral tablet, Stress - Type 1 Diabetes, Diabetic Ketoacidosis | Phase 1 | Terminated | Kinderkrankenhaus auf der Bult | 2 | 2022-05-18 | 2024-12-09 |
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Diabetes Mellitus, Type 1 (109) · Diabetes Mellitus (22) · Hypoglycemia (13) · Insulin Resistance (6) · Hyperglycemia (4) · Diabetes Mellitus, Type 2 (2) · Autoimmune Diseases (1) · Cardiovascular Diseases (1) · Diabetic Ketoacidosis (1) · Diabetic Nephropathies (1) · Enterovirus Infections (1) · Glucose Metabolism Disorders (1) · Immune System Diseases (1) · Metabolic Diseases (1) · Obesity (1)
Endocrine System Diseases (109) · Nutritional and Metabolic Diseases (109) · Autoimmune Diseases (108) · Glucose Metabolism Disorders (108) · Immune System Diseases (108) · Metabolic Diseases (108) · Diabetes Mellitus (87) · Hyperinsulinism (6) · Pathological Conditions, Signs and Symptoms (3) · Diabetes Complications (2) · Signs and Symptoms (2) · Acid-Base Imbalance (1) · Acidosis (1) · Body Weight (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1)
Insulin Lispro (6) · Insulin (4) · Insulin Aspart (3) · Islets of Langerhans Transplantation (3) · Sodium Chloride (3) · aldesleukin (3) · dapagliflozin (3) · thymoglobulin (3) · Antilymphocyte Serum (2) · Continuous Glucose Monitoring (2) · Etanercept (2) · Hematologic Tests (2) · Interleukin-2 (2) · Mycophenolic Acid (2) · Sirolimus (2)
University of Minnesota (5) · Sanofi (4) · University of California, San Diego (4) · Baylor Research Institute (3) · Medical University of Graz (3) · University of Alberta (3) · Adocia (2) · AstraZeneca (2) · Cambridge University Hospitals NHS Foundation Trust (2) · Cardiff University (2) · City of Hope Medical Center (2) · Diatranz Otsuka Limited (2) · Indiana University (2) · Jaeb Center for Health Research (2) · Kinderkrankenhaus auf der Bult (2)
United States (60) · Germany (11) · Canada (10) · United Kingdom (7) · Austria (4) · Israel (4) · Italy (4) · China (2) · France (2) · Switzerland (2) · Argentina (1) · Australia (1) · Belgium (1) · Netherlands (1) · New Zealand (1)
Bernhard J. Hering, M.D. (2) · Howard Zisser, MD (2) · Lorenzo Piemonti, MD (2) · Michael J Haller, MD (2) · Moshe Phillip, Prof (2) · Roy W Beck, MD, PhD (2) · Thomas R Pieber, MD (2) · Abhimanyu Garg, M.D. (1) · Ahmad Haidar, PhD (1) · Alberto Pugliese, MD (1) · Aleksandra Pastrak, M.D. (1) · Amer Rajab, MD, PhD (1) · Amir Moheet, MD (1)
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