48 completed, 8 unknown, 7 recruiting, 4 active not recruiting. 77 Phase 3, 19 Phase 2.
Follow Type 1 Diabetes: new trials by email Literature Review of Type 1 Diabetes trials Research Report on Type 1 Diabetes
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Verapamil In Preclinical Type 1 Diabetes Verapamil 120 Mg/24 Hours Oral Capsule, Extended Release, Placebo, blood sampling - Type 1 Diabetes | Phase 2 / Phase 3 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 50 | 2027-01-01 | 2026-10-22 |
| Lean Mass Changes With Semaglutide in Adults With Type 1 Diabetes and Overweight/Obesity. Semaglutide, Placebo - Type 1 Diabetes, Overweight , Obesity | Phase 2 / Phase 3 | Recruiting | McGill University Health Centre/Research Institute of the McGill University Health Centre | 40 | 2026-10-13 | 2026-10-23 |
| A Clinical Trial Using Tirzepatide to Help Adults With Type 1 Diabetes Automatically Control Their Blood Sugar Tirzepatide, Tandem Control-IQ Automated Insulin Delivery System (with Dexcom G7 CGM), Carbohydrate Counting - Type 1 Diabetes, Type 1 Diabetes Mellitus | Phase 2 / Phase 3 | Recruiting | McGill University Health Centre/Research Institute of the McGill University Health Centre | 105 | 2026-05-19 | 2026-05-27 |
| Clinical Study for Dimethyl Fumarate in Preserving Islet β-Cell Function in Type 1 Diabetes Mellitus Dimethyl Fumarate Enteric-coated Capsules, Matching placebo capsules - Type 1 Diabetes | Phase 3 | Recruiting | Nanjing Medical University | 90 | 2026-01-27 | 2026-03-05 |
| A Long-Term Study of Tirzepatide (LY3298176) in Adults With Type 1 Diabetes and Obesity or Overweight Tirzepatide, Placebo - Type 1 Diabetes, Obesity | Phase 3 | Active not recruiting | Eli Lilly and Company | 465 | 2025-05-12 | 2026-02-17 |
| A Study of Tirzepatide (LY3298176) Compared With Placebo in Adults With Type 1 Diabetes and Obesity or Overweight Tirzepatide, Placebo - Type 1 Diabetes, Obesity | Phase 3 | Active not recruiting | Eli Lilly and Company | 905 | 2025-04-25 | 2026-05-12 |
| Insulin Producing Stem Cell Transplantation Clinical Trial in Type 1 Diabetes Insulin producing stem cells infusion - Stem Cells, Type 1 Diabetes | Phase 2 / Phase 3 | Recruiting | Ain Shams University | 20 | 2025-04-01 | 2025-04-30 |
| An Efficacy, Safety, and Tolerability Study of VX-880 in Participants With Type 1 Diabetes With a Kidney Transplant Biological/Vaccine - Type 1 Diabetes, Kidney Transplant | Phase 3 | Recruiting | Vertex Pharmaceuticals Incorporated | 10 | 2025-03-31 | 2026-03-23 |
| Automated Insulin Delivery for Inpatients With Dysglycemia AID system with Remote Real-Time CGM, Standard of Care Insulin Therapy + CGM - Type 1 Diabetes, Type 2 Diabetes | Phase 3 | Completed | Emory University | 130 | 2025-01-22 | 2025-11-14 |
| Alleviating Carbohydrate Counting for Patients with Type-1 Diabetes Using a Closed Loop System with Weekly Subcutaneous Semaglutide Semaglutide with 4 meal strategies, Placebo with 4 meal strategies - Type 1 Diabetes, Diabetes Mellitus | Phase 2 / Phase 3 | Recruiting | McGill University Health Centre/Research Institute of the McGill University Health Centre | 26 | 2024-12-01 | 2024-12-18 |
| SGLT2 Adjunct in T1D Empagliflozin (EMPA), Placebo - Type 1 Diabetes, Nephropathy, Diabetic | Phase 2 / Phase 3 | Completed | Ain Shams University | 86 | 2024-11-20 | 2026-05-18 |
| Multifactorial Intervention to Reduce Cardiovascular Disease in Type 1 Diabetes Aspirin tablet, Semaglutide, Sotagliflozin - Cardiovascular Diseases, Heart Failure | Phase 3 | Recruiting | Steno Diabetes Center Copenhagen | 2000 | 2024-07-01 | 2025-01-10 |
| Effects of Sitagliptin in Relatives of T1D Patients Sitagliptin, Professional CGM - Type 1 Diabetes | Phase 2 / Phase 3 | Not yet recruiting | University of Milan | 70 | 2023-07-01 | 2023-05-10 |
| A Study to Inv. Safety, Efficacy & PD of Dasiglucagon as Hypoglycemia Rescue Therapy in Children <6 Years With T1D Dasiglucagon - Hypoglycemia, Type 1 Diabetes | Phase 3 | Completed | Zealand Pharma | 8 | 2023-05-09 | 2025-07-20 |
| Alpha-lipoic Acid in Diabetic Nephropathy Thioctic Acid 333 MG Oral Capsule, Captopril 25Mg Tab - Type 1 Diabetes | Phase 3 | Unknown | Ain Shams University | 30 | 2023-01-01 | 2024-02-12 |
| Weekly Subcutaneous Semaglutide as Adjunct to Closed-loop Therapy in Type 1 Diabetes Care Outpatient therapy: 11 weeks of drug therapy with usual treatment + 4 weeks of closed-loop therapy - Type 1 Diabetes, Diabetes Mellitus, Type 1 | Phase 2 / Phase 3 | Completed | McGill University Health Centre/Research Institute of the McGill University Health Centre | 28 | 2022-10-02 | 2025-01-22 |
| Clinical Application of Stem Cell Educator Therapy in Type 1 Diabetes Stem Cell Educator therapy - Type 1 Diabetes | Phase 3 | Active not recruiting | Yong Zhao, MD, PhD | 80 | 2022-09-20 | 2026-10-30 |
| A Study of Insulin Efsitora Alfa (LY3209590) Compared With Insulin Degludec in Participants With Type 1 Diabetes Treated With Multiple Daily Injection Therapy Insulin Efsitora Alfa, Insulin Degludec - Type 1 Diabetes, Diabetes | Phase 3 | Completed | Eli Lilly and Company | 692 | 2022-08-12 | 2025-06-24 |
| Early High-Dose Vitamin D and Residual β-Cell Function in Pediatric Type 1 Diabetes Cholecalciferol (Vit D3) 400Unit Cap - Type 1 Diabetes | Phase 3 | Unknown | Shanghai Jiao Tong University School of Medicine | 198 | 2022-06-01 | 2022-05-23 |
| Efficacy and Safety of THDB0206 Compared to Insulin Lispro Injection in Participants With Type 1 Diabetes THDB0206, Insulin Lispro, Insulin Glargine - Type 1 Diabetes | Phase 3 | Completed | Tonghua Dongbao Pharmaceutical Co.,Ltd | 550 | 2022-04-13 | 2025-12-15 |
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Diabetes Mellitus, Type 1 (77) · Diabetes Mellitus (12) · Insulin Resistance (7) · Hypoglycemia (6) · Overweight (4) · Obesity (3) · Hyperglycemia (2) · Body Weight (1) · Cardiovascular Diseases (1) · Diabetes Mellitus, Type 2 (1) · Diabetic Nephropathies (1) · Health Education (1) · Heart Failure (1) · Inflammation (1) · Kidney Diseases (1)
Autoimmune Diseases (77) · Endocrine System Diseases (77) · Glucose Metabolism Disorders (77) · Immune System Diseases (77) · Metabolic Diseases (77) · Nutritional and Metabolic Diseases (77) · Diabetes Mellitus (65) · Hyperinsulinism (7) · Pathological Conditions, Signs and Symptoms (6) · Signs and Symptoms (6) · Body Weight (4) · Nutrition Disorders (4) · Overnutrition (4) · Female Urogenital Diseases (2) · Female Urogenital Diseases and Pregnancy Complications (2)
Liraglutide (7) · Insulin Glargine (4) · Metformin (4) · Tirzepatide (3) · semaglutide (3) · Angiotensin-Converting Enzyme Inhibitors (2) · Continuous Glucose Monitoring (2) · Cyclosporine (2) · Insulin (2) · Insulin Lispro (2) · Islets of Langerhans Transplantation (2) · Sitagliptin Phosphate (2) · candesartan cilexetil (2) · pramlintide (2) · (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(methylthio)tetrahydro-2H-pyran-3,4,5-triol (1)
University at Buffalo (5) · Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète (4) · Eli Lilly and Company (4) · Jaeb Center for Health Research (4) · McGill University Health Centre/Research Institute of the McGill University Health Centre (4) · Ain Shams University (3) · Andromeda Biotech Ltd. (3) · Assistance Publique - Hôpitaux de Paris (3) · Hvidovre University Hospital (3) · AstraZeneca (2) · Baylor College of Medicine (2) · Medtronic MiniMed, Inc. (2) · Northwestern University (2) · Perle Bioscience, Inc. (2) · Steno Diabetes Center Copenhagen (2)
United States (36) · France (12) · Canada (9) · Italy (7) · Denmark (6) · Spain (5) · Brazil (4) · China (4) · Czechia (4) · Germany (4) · Israel (4) · United Kingdom (4) · Argentina (3) · Egypt (3) · Switzerland (3)
Itamar Raz, MD (3) · Ingrid Libman, MD, PhD (2) · Kristen Nadeau, MD (2) · Melissa-Rosina Pasqua, MD, PhD (2) · Paolo Pozzilli, MD (2) · Paresh Dandona, MBBS, PhD (2) · Rubina Heptulla, MD (2) · Ahmad Haidar, PhD (1) · Alfonso Galderisi, Phd (1)
PMID 18823656, PMID 19451554, PMID 21225239, PMID 21309844, PMID 38682786, PMID 10752702, PMID 15793249, PMID 18779236, PMID 18814906, PMID 19073764, PMID 19429875, PMID 19675193, PMID 19675206, PMID 19689275, PMID 19752173, PMID 19821755, PMID 19837791, PMID 20200306, PMID 21266647, PMID 21266648, PMID 21266651, PMID 21299401, PMID 21505208, PMID 21636800, PMID 22233865, PMID 22237062, PMID 22274724, PMID 22416821, PMID 22761275, PMID 22833322, PMID 22960587, PMID 23562090, PMID 23570538, PMID 23579179, PMID 23780460, PMID 23789889, PMID 23911183, PMID 24163439, PMID 24408401, PMID 24432999, PMID 24550217, PMID 24757230, PMID 25229125, PMID 25392936, PMID 25986629, PMID 26237308, PMID 26246593, PMID 26404926, PMID 26624824, PMID 26844283
2014 (1), 2015 (1), 2018 (1), 2025 (1), R01DK092653 (1), R01DK138366 (1), R01NR004009 (1), R21DK113353 (1), R56DK078645 (1), U01DK071733 (1)