105 completed, 20 terminated, 15 unknown, 7 withdrawn. 54 Phase 4, 52 Phase 3, 20 Phase 2, 13 Phase 1, 10 Not applicable.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Non-Inferiority Study of Aliskiren vs Losartan in the Treatment of Hypertension With Hyperuricemia Aliskiren, Losartan - Hypertension,Essential, Hyperuricemia | Phase 4 | Completed | Hansung University | 66 | 2021-05-01 | 2024-12-05 |
| Evaluation of a Renin Inhibitor, Aliskiren, Compared to Enalapril, in C3 Glomerulopathy Aliskiren, Enalapril - C3 Glomerulopathy, Membranoproliferative Glomerulonephritis | Phase 2 | Recruiting | Region Skane | 30 | 2020-10-01 | 2025-06-22 |
| ACEI or ARB and COVID-19 Severity and Mortality in US Veterans ACEI/ARB, Non-ACEI/ARB, ACEI - Hypertension, COVID | Completed | University of Utah | 22213 | 2020-01-19 | 2021-04-28 | |
| Aliskiren Study of Safety and Efficacy in Senior Hypertensives Aliskiren, Amlodipine, Ramipril - Hypertension | Phase 4 | Withdrawn | Novartis Pharmaceuticals | 2015-05-01 | 2015-04-16 | |
| Eplerenone and Aliskiren Research Targeting Hypertensive Patients With Left Ventricular Hypertrophy Aliskiren, Eplerenone - Hypertensive Left Ventricular Hypertrophy | Phase 4 | Unknown | Nagoya University | 100 | 2013-04-01 | 2013-07-22 |
| Influence of Aliskiren on Albuminuria After Kidney Transplantation aliskiren, losartan, Placebo - Albuminuria | Not applicable | Completed | Medical University of Gdansk | 18 | 2013-03-01 | 2015-05-18 |
| RAS Quantification in Patients With Aliskiren or Candesartan RAS blockade discontinuation, Aliskiren, Candesartan - Hypertension, Chronic Kidney Disease | Phase 4 | Completed | Medical University of Vienna | 24 | 2012-12-01 | 2016-03-16 |
| 8-week Randomized, Open-label Study to Evaluate Food Effect on Efficacy and Safety of Oral Aliskiren 300 mg in Patients With Hypertension Aliskiren - Hypertension | Phase 4 | Completed | Novartis Pharmaceuticals | 589 | 2012-04-01 | 2014-01-22 |
| Role of ALiskiren, a Direct Renin Inhibitor, in Preventing Atrial Fibrillation in Patients With a Pacemaker; RALF. aliskiren - Atrial Fibrillation | Phase 3 | Unknown | Mika Lehto | 70 | 2012-01-01 | 2016-09-21 |
| Aliskiren vs Hydrochlorothiazide in Hypertensive Type II Diabetic Patients on Resistance Arteries Aliskiren vs. hydrochlorothiazide, Hydrochlorothiazide - Hypertension, Diabetes | Phase 2 | Withdrawn | Sir Mortimer B. Davis - Jewish General Hospital | 2012-01-01 | 2015-05-19 | |
| Effect of Aliskiren and Hydrochlorothiazide on Kidney Oxygenation in Patients With Hypertension Aliskiren, Hydrochlorothiazide - Hypertension | Phase 4 | Completed | Centre Hospitalier Universitaire Vaudois | 24 | 2011-10-01 | 2020-03-17 |
| Shiga Microalbuminuria Reduction Trial-2 Aliskiren, any angiotensin receptor blockers - Type 2 Diabetes Mellitus, Hypertension | Phase 4 | Completed | Shiga University | 237 | 2011-10-01 | 2018-02-19 |
| Study on Anti-inflammatory Effect of Anti-hypertensive Treatment in Patients With Small AAA's and Mild Hypertension Aliskiren, Amlodipine - Hypertension, Abdominal Aortic Aneurysm | Not applicable | Terminated | Amsterdam UMC, location VUmc | 3 | 2011-09-01 | 2014-12-09 |
| 52-104 Week Off-therapy Second Extension to Study CSPP100A2365 SPP100 - Hypertension | Completed | LXO Group | 106 | 2011-08-19 | 2019-03-19 | |
| Vitamin D Augmentation of Tekturna (Aliskiren) in Hypertension Vitamin D (cholecalciferol), Tekturna(Aliskiren) plus placebo - Hypertension | Phase 4 | Unknown | Wayne State University | 92 | 2011-07-01 | 2011-11-16 |
| Effect of the Direct Renin Inhibitor Aliskiren on Endothelial Function and Arterial Stiffness in Diabetic Subjects aliskiren 300 mg once daily, Placebo/sugar pill - Diabetes, Pre-hypertension | Phase 4 | Terminated | University of Alabama at Birmingham | 21 | 2011-06-01 | 2017-05-11 |
| Clinical Pharmacology of Aliskiren in Combination With Cyclosporine in Cardiac Transplantation Aliskiren - Hypertension, Cardiac Transplantation | Phase 4 | Terminated | University of Colorado, Denver | 1 | 2011-05-01 | 2018-06-29 |
| Comparison of Amlodipine and Aliskiren in Diabetic Hypertensive Patient With Blood Pressure Not Controlled by Losartan Aliskiren, Amlodipine - Hypertension, Diabetes Mellitus | Phase 4 | Withdrawn | Hospital Universitario Pedro Ernesto | 2011-04-01 | 2012-03-06 | |
| Effects of Aliskiren in Elderly Hypertensive Chronic Kidney Disease (CKD) Patients Aliskiren - Hypertension, Chronic Kidney Disease | Phase 4 | Completed | Jichi Medical University | 23 | 2011-02-01 | 2012-10-22 |
| The Study of Novel Dual Renin Angiotensin Aldosterone System (RAAS) Blockade; Valsartan/Aliskiren in African American Patients With Hypertension and the Metabolic Syndrome Aliskerin/Valsartan and Rampiril - Hypertension, Metabolic Syndrome | Phase 1 | Withdrawn | University of Michigan | 2011-02-01 | 2013-11-18 |
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Hypertension (100) · Diabetes Mellitus (14) · Essential Hypertension (12) · Diabetes Mellitus, Type 2 (11) · Heart Failure (10) · Proteinuria (8) · Metabolic Syndrome (5) · Renal Insufficiency, Chronic (5) · Albuminuria (4) · Atherosclerosis (4) · Cardiovascular Diseases (4) · Glomerulonephritis, IGA (4) · Kidney Diseases (4) · Insulin Resistance (3) · Kidney Failure, Chronic (3)
Novartis (65) · Novartis Pharmaceuticals (22) · Medical University of Gdansk (3) · Brigham and Women's Hospital (2) · Mayo Clinic (2) · Taipei Veterans General Hospital, Taiwan (2) · Texas Tech University Health Sciences Center (2) · The University of Hong Kong (2) · UMC Utrecht (2) · University of Campania Luigi Vanvitelli (2) · Vanderbilt University Medical Center (2) · Amsterdam UMC, location VUmc (1) · Assaf-Harofeh Medical Center (1) · Beth Israel Deaconess Medical Center (1) · Centre Hospitalier Universitaire Vaudois (1)
United States (74) · Germany (42) · Spain (20) · Canada (16) · Italy (16) · Netherlands (15) · Switzerland (14) · Hungary (13) · Poland (13) · Japan (12) · Slovakia (12) · Argentina (11) · Belgium (11) · Denmark (11) · Russia (11)
Sydney CW Tang, MD (2) · Adam P Bress, PharmD, MS (1) · Amir Lerman, MD (1) · Anil Chandraker, MD (1) · Aristidis Veves, MD (1) · Boleslaw Rutkowski, Prof. (1) · Brian K Irons, PharmD (1) · Christina L Aquilante, Pharm.D. (1) · Dalane W Kitzman, MD (1)
PMID 33089502, PMID 40013543, PMID 17658393, PMID 19139391, PMID 21659626, PMID 22035463, PMID 10342782, PMID 10851208, PMID 11799102, PMID 11927799, PMID 12119802, PMID 12923400, PMID 15738343, PMID 16391172, PMID 16533484, PMID 17353513, PMID 17485026, PMID 18058456, PMID 18205098, PMID 18300872, PMID 18426998, PMID 18525041, PMID 18559696, PMID 18957387, PMID 19047577, PMID 19257800, PMID 19458624, PMID 19527323, PMID 19587362, PMID 19727007, PMID 19738158, PMID 19808266, PMID 19927154, PMID 20110023, PMID 20480132, PMID 20693353, PMID 20876343, PMID 21062137, PMID 21123186, PMID 21236483, PMID 21317148, PMID 21414565, PMID 21459891, PMID 21467128, PMID 21680850, PMID 21746765, PMID 21846154, PMID 21925996, PMID 22002336, PMID 22303910
2009 (9), 2008 (3), 2019 (1), R01AG031750 (1), R01HL092954 (1)