68 completed, 26 recruiting, 18 unknown, 9 not yet recruiting. 50 Not applicable, 16 Phase 4, 13 Phase 2, 11 Phase 3, 3 Phase 1.
Follow Syphilis: new trials by email Literature Review of Syphilis trials Research Report on Syphilis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Integrated Care Versus Usual Care for Opioid Use Disorder and Infectious Diseases in Veterans Integrated care - Opioid Use Disorder, HIV | Not applicable | Not yet recruiting | VA Office of Research and Development | 60 | 2028-04-03 | 2026-04-24 |
| A Clinical Study to Assess the Efficacy of Weekly Doxycycline Prophylaxis to Reduce Bacterial Sexually Transmitted Infections (STI) in Young African Women Doxycycline hyclate, Standard of Care for STI prevention - Sexually Transmitted Infection (STI), Gonorrhea | Phase 3 | Not yet recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 580 | 2026-11-30 | 2026-10-20 |
| Congenital Syphilis Treatment Trial (CONSISTENT) in Neonates Benzathine Penicillin, Amoxicillin - Syphilis, Congenital | Phase 4 | Not yet recruiting | University of Alabama at Birmingham | 374 | 2026-11-01 | 2026-09-02 |
| Pilot HIV Self-Testing And Self-collected STI Testing Strategy for Sex Worker Empowerment Study Venue-based, peer-enhanced strategy for integrated HIV self-testing (and self-collected STI testing - HIV, Syphilis | Not applicable | Not yet recruiting | University of North Carolina, Chapel Hill | 232 | 2026-10-01 | 2026-09-18 |
| Strengthening, Guidance, Health, Empowerment Self-sampling for six sexually transmitted infections - HIV Infection, Syphilis | Not applicable | Not yet recruiting | University Hospital, Montpellier | 200 | 2026-09-01 | 2026-08-26 |
| Improving Maternal and Child Health Through Point-of-care STI Testing Point-of-care STI tests, Standard of care STI testing - Treponema Pallidum Infection, Chlamydia Trachomatis Infection | Not applicable | Recruiting | Emory University | 756 | 2026-08-11 | 2026-08-19 |
| Evaluating VM100 Nutritional Supplement for Improving Quality of Life in Duchenne Muscular Dystrophy Patients VM100 Nutritional Supplement - Duchenne Muscular Dystrophy, Duchenne Disease | Phase 2 | Recruiting | University of Florida | 20 | 2026-07-27 | 2026-10-08 |
| Comprehensive Ambulatory Antibiotics for the Treatment of Congenital Syphilis Linezolid (LZD), Amoxicillin, Benzathine Penicillin G - Syphilis, Congenital | Phase 2 | Recruiting | London School of Hygiene and Tropical Medicine | 90 | 2026-05-04 | 2026-10-22 |
| Ultrasound-Guided Long vs Short Peripheral IV Catheters in Neonates With Congenital Syphilis Receiving Antibiotics Ultrasound-Guided Long Peripheral Intravenous Catheter, Short Peripheral Intravenous Catheter (Conventional Technique) - Infant, Newborn, Syphilis, Congenital | Not applicable | Not yet recruiting | Hospital de Clinicas de Porto Alegre | 104 | 2026-05-01 | 2026-05-11 |
| Evaluation of Free STI Testing Pilot Projects in Lucerne and Zurich, Switzerland HIV (Human Immunodeficiency Virus), Chlamydia | Not yet recruiting | University of Zurich | 1800 | 2026-04-07 | 2026-04-08 | |
| MAGIA H3S Point of Care Test Performance for HIV, HBV, HCV, and Syphilis Screening in Pregnant Women in DR Congo MAGIA H3S - HIV - Human Immunodeficiency Virus, HBV (Hepatitis B Virus) | Not yet recruiting | Gardiens de Vies | 7500 | 2026-03-01 | 2026-02-05 | |
| Doxycycline Prophylaxis for Prevention of Sexually Transmitted Infections Doxycycline hyclate delayed released 200 mg, Doxycycline hyclate delayed released 200 mg weekly, Per standard of care with quarterly STI testing/treatment and sexual health counseling - Gonorrhea, Chlamydia | Phase 4 | Recruiting | Westat | 760 | 2026-02-27 | 2026-10-16 |
| Study of Ceftriaxone and Benzathine Penicillin G During Pregnancy Ceftriaxon, Benzathine penicillin G - Pregnancy | Recruiting | International Maternal Pediatric Adolescent AIDS Clinical Trials Group | 110 | 2026-02-16 | 2026-08-06 | |
| Rapid HIV, Hep C, and Syphilis Screening in a Rural Street Medicine Clinic Rapid Fingerstick Test, Blood Draw for lab test - HIV Testing, HEPATITIS C (HCV) | Recruiting | West Virginia University | 200 | 2026-01-21 | 2026-08-13 | |
| This Study Evaluates the ALPCO Syphilis-T and Syphilis-NT CLIA Kits for Detecting Syphilis Antibodies in Serum and Plasma. Samples From At-risk, HIV-positive, Pregnant, and Healthy Individuals Will Assess Assay Performance Versus Established Comparator Tests. ALPCO Syphilis-T, ALPCO Syphilis-NT CLIA Kits - Treponema Pallidum, Treponema Pallidum Infection | Recruiting | American Laboratory Products Company | 1000 | 2025-12-10 | 2026-09-16 | |
| Treponemal Shedding, Load, and Viability, in Women and Men-who-have-sex-with-women-only With Early Infectious Syphilis: Implications for Transmission No Intervention: Observational Cohort - Syphilis | Recruiting | Monash University | 480 | 2025-12-02 | 2026-04-03 | |
| Periodic Presumptive Treatment vs. doxyPEP for STI Control in Kenyan MSM WHO-recommended periodic presumptive treatment, Doxycycline post-exposure prophylaxis - Gonorrhea Male, Chlamydia (Male) | Phase 4 | Recruiting | University of Washington | 2900 | 2025-10-29 | 2025-11-19 |
| Doxi-Rio: Study on the Use of Doxycycline to Prevent Sexually Transmitted Infections in Rio de Janeiro Doxycycline - Sexually Transmitted Diseases, Syphilis | Not applicable | Recruiting | Oswaldo Cruz Foundation | 200 | 2025-10-28 | 2026-03-30 |
| Validation of Self Testing Using the INSTI Multiplex HIV1/2 Syphilis Antibody Test INSTI HIV/syphilis Point of Care Self-Test Administration - Hiv, Syphilis | Not applicable | Terminated | Nova Scotia Health Authority | 35 | 2025-10-06 | 2026-10-01 |
| The Efficacy of Doxycycline Post Exposure Prophylaxis for Preventing STIs Among MSM in Bangkok, Thailand. Doxycycline (200mg/day) - Syphilis Infection, Gonorrhea | Phase 4 | Recruiting | Bangrak STIs Center | 400 | 2025-10-06 | 2026-02-09 |
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Sexually Transmitted Diseases (33) · Gonorrhea (31) · Chlamydia Infections (30) · HIV Infections (28) · Acquired Immunodeficiency Syndrome (15) · Hepatitis B (10) · Hepatitis C (10) · Syphilis, Congenital (10) · Homosexuality (8) · Treponemal Infections (8) · Neurosyphilis (6) · Trichomonas Infections (4) · Trichomonas Vaginitis (4) · Herpes Simplex (3)
Bacterial Infections (135) · Bacterial Infections and Mycoses (135) · Gram-Negative Bacterial Infections (135) · Spirochaetales Infections (135) · Infections (134) · Treponemal Infections (127) · Genital Diseases (120) · Urogenital Diseases (120) · Communicable Diseases (119) · Sexually Transmitted Diseases, Bacterial (117) · Sexually Transmitted Diseases (87) · Virus Diseases (50) · Blood-Borne Infections (48) · RNA Virus Infections (48) · Immune System Diseases (44)
Doxycycline (11) · Penicillin G (8) · Penicillin G Benzathine (6) · Cefixime (4) · Ceftriaxone (3) · Linezolid (3) · Methods (3) · Amoxicillin (2) · Circumcision, Male (2) · Counseling (2) · Standard of Care (2) · Syphilis Serodiagnosis (2) · Antiretroviral Therapy, Highly Active (1) · Azithromycin (1) · Blood Specimen Collection (1)
National Institute of Allergy and Infectious Diseases (NIAID) (7) · London School of Hygiene and Tropical Medicine (5) · University of Washington (4) · Centers for Disease Control and Prevention (3) · Institute of Tropical Medicine, Belgium (3) · National Taiwan University Hospital (3) · Peking Union Medical College Hospital (3) · Population Council (3) · The University of Texas Health Science Center, Houston (3) · University of California, Los Angeles (3) · University of North Carolina, Chapel Hill (3) · British Columbia Centre for Disease Control (2) · Columbia University (2) · Hospital de Niños R. Gutierrez de Buenos Aires (2) · Jacobi Medical Center (2)
United States (42) · Canada (12) · China (11) · South Africa (5) · Uganda (5) · France (4) · Taiwan (4) · United Kingdom (4) · Argentina (3) · Brazil (3) · Kenya (3) · Malawi (3) · Thailand (3) · Zambia (3) · Zimbabwe (3)
Jeffrey D Klausner, MD MPH (3) · Chris Kenyon, MD (2) · Irene Stafford, MD (2) · Troy Grennan, MD (2) · Zunyou Wu, MD, PHD (2) · Akshay Sharma, PhD (1) · Ann N Burchell, PhD (1) · Anne Luetkemeyer, MD (1) · Anthony LaMarca, M.D. (1) · Audun J Lier, MD (1) · Barbara A Castelnuovo, MD, MPH. PhD (1) · Bridget Freyne (1) · Bridget Haire, PhD (1) · Caroline DeSchacht, MD, MSc (1) · Charlotte E. Ellertson, MPA, Ph.D. (1)
PMID 18532873, PMID 19220138, PMID 19321868, PMID 19389002, PMID 19936044, PMID 21216000, PMID 37018493, PMID 15075545, PMID 17321311, PMID 17545184, PMID 18032943, PMID 18086100, PMID 19571722, PMID 19616720, PMID 19693024, PMID 20095074, PMID 20336078, PMID 20370481, PMID 20370483, PMID 20402591, PMID 20678190, PMID 21173675, PMID 21482866, PMID 21489882, PMID 21998287, PMID 22082722, PMID 22210632, PMID 23107285, PMID 23759262, PMID 23949590, PMID 24236175, PMID 24325737, PMID 24431188, PMID 25053721, PMID 25262105, PMID 25560566, PMID 25585069, PMID 25870333, PMID 26094162, PMID 26741583, PMID 26772390, PMID 26879979, PMID 27124895, PMID 27375613, PMID 28200045, PMID 28495681, PMID 29065149, PMID 29191814, PMID 29229440, PMID 29970355
1IK2CX002822-01A1 (1), 2019 (1), D43TW009340 (1), K23MH084611 (1), K24NR018621 (1), R01AI045468 (1), R01AI143439 (1), R01AI179838 (1), R01AI187414 (1), R01DA029910 (1), R01DA030234 (1), R01HD108201 (1), R01MD020754 (1), R01MH087054 (1), R01MH092226 (1)