Spirochaetales Infections: Clinical Trials

143 completed, 55 recruiting, 40 unknown, 24 not yet recruiting. 95 Not applicable, 35 Phase 2, 34 Phase 3, 24 Phase 4, 14 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	95	Completed 43, Recruiting 17, Unknown 14, Not yet recruiting 10, Terminated 6, Active not recruiting 2, Withdrawn 2, Suspended 1
Phase 2	35	Completed 21, Recruiting 8, Active not recruiting 2, Enrolling by invitation 1, Terminated 1, Unknown 1, Withdrawn 1
Phase 3	34	Completed 21, Recruiting 4, Terminated 3, Unknown 3, Not yet recruiting 2, Active not recruiting 1
Phase 4	24	Completed 11, Not yet recruiting 3, Recruiting 3, Unknown 3, Active not recruiting 2, Terminated 2
Phase 1	14	Completed 10, Recruiting 2, Unknown 1, Withdrawn 1
Early Phase 1	2	Completed 1, Recruiting 1

Follow Spirochaetales Infections: new trials by email Literature Review of Spirochaetales Infections trials Research Report on Spirochaetales Infections

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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Integrated Care Versus Usual Care for Opioid Use Disorder and Infectious Diseases in Veterans Integrated care - Opioid Use Disorder, HIV	Not applicable	Not yet recruiting	VA Office of Research and Development	60	2028-04-03	2026-04-24
Doxycycline Boosted Therapy in Lyme Borreliosis: DoBo Study. Hydroxychloroquin, Placebo, Doxycycline - Lyme Borreliosis, Nervous System	Phase 4	Not yet recruiting	Radboud University Medical Center	50	2027-03-01	2026-08-27
Ex Vivo Study of Leukocyte Responses in the Blood of Patients With Leptospirosis and ex Vivo Testing of a New Host-targeted Therapeutic Strategy to Restore Phagocytosis of Leptospira 24 ml blood sample at H0, 16 ml blood sample at H3 - Leptospirosis, Jarisch Herxheimer Reaction		Not yet recruiting	Institut Pasteur	70	2026-12-01	2026-11-03
A Clinical Study to Assess the Efficacy of Weekly Doxycycline Prophylaxis to Reduce Bacterial Sexually Transmitted Infections (STI) in Young African Women Doxycycline hyclate, Standard of Care for STI prevention - Sexually Transmitted Infection (STI), Gonorrhea	Phase 3	Not yet recruiting	National Institute of Allergy and Infectious Diseases (NIAID)	580	2026-11-30	2026-10-20
Efficacy and Safety of Minocycline Add-on in Patients With Neurosyphilis Minocycline, Minocycline placebo, Aqueous crystalline penicillin G - Neurosyphilis	Phase 3	Not yet recruiting	Beijing Ditan Hospital	778	2026-11-15	2026-10-29
Natural History of Trisomy 8-Associated Autoinflammatory Disease (TRIAD) and Related Disorders Trisomy 8 Mosaicism, Trisomy 8 Associated Autoinflammatory Disease		Recruiting	National Institute of Allergy and Infectious Diseases (NIAID)	750	2026-11-11	2026-11-06
Congenital Syphilis Treatment Trial (CONSISTENT) in Neonates Benzathine Penicillin, Amoxicillin - Syphilis, Congenital	Phase 4	Not yet recruiting	University of Alabama at Birmingham	374	2026-11-01	2026-09-02
These Studies That Evaluated the Efficacy of Antibiotics for Leptospirosis Treatment. Doxycycline, Placebo - Leptospirosis, Chemoprophylaxis	Phase 4	Not yet recruiting	Chulalongkorn University	1000	2026-11-01	2026-10-08
The Precision Mito- Mito Map COMPASS Study Mito Map Energy Score and Home Functional Assessments - Mitochondrial Diseases, Myalgic Encephalomyelitis Chronic Fatigue Syndrome		Not yet recruiting	AI Agent Vault, Inc. d/b/a Precision Mito	400	2026-11-01	2026-10-02
Pilot HIV Self-Testing And Self-collected STI Testing Strategy for Sex Worker Empowerment Study Venue-based, peer-enhanced strategy for integrated HIV self-testing (and self-collected STI testing - HIV, Syphilis	Not applicable	Not yet recruiting	University of North Carolina, Chapel Hill	232	2026-11-01	2026-10-29
Assessment of the Risk of Zoonotic Infections in Prisons in French Guiana Q Fever, Leptospirosis		Not yet recruiting	Centre Hospitalier de Cayenne	450	2026-10-01	2026-10-19
Blood Donation Study for ALPCO Syphilis-T and Syphilis-NT Assay Development ALPCO Syphilis-T, ALPCO Syphilis-NT CLIA Kits - Healthy Volunteers, Syphilis Serologic Assay Development		Enrolling by invitation	American Laboratory Products Company	50	2026-10-01	2026-09-22
Strengthening, Guidance, Health, Empowerment Self-sampling for six sexually transmitted infections - HIV Infection, Syphilis	Not applicable	Not yet recruiting	University Hospital, Montpellier	200	2026-09-01	2026-08-26
Flow Cytometric Immune Monitoring of B. Afzelii-Specific T Lymphocytes Lyme Borreliosis, Lyme Disease		Not yet recruiting	University Hospital, Strasbourg, France	20	2026-09-01	2026-07-14
Improving Maternal and Child Health Through Point-of-care STI Testing Point-of-care STI tests, Standard of care STI testing - Treponema Pallidum Infection, Chlamydia Trachomatis Infection	Not applicable	Recruiting	Emory University	756	2026-08-11	2026-08-19
Evaluating VM100 Nutritional Supplement for Improving Quality of Life in Duchenne Muscular Dystrophy Patients VM100 Nutritional Supplement - Duchenne Muscular Dystrophy, Duchenne Disease	Phase 2	Recruiting	University of Florida	20	2026-07-27	2026-10-08
Ceftriaxone for Post-Treatment Lyme Disease Ceftriaxone treatment, Placebo - Post-Treatment Lyme Disease Syndrome	Phase 1 / Phase 2	Withdrawn	Hackensack Meridian Health		2026-05-14	2026-05-18
Comprehensive Ambulatory Antibiotics for the Treatment of Congenital Syphilis Linezolid (LZD), Amoxicillin, Benzathine Penicillin G - Syphilis, Congenital	Phase 2	Recruiting	London School of Hygiene and Tropical Medicine	90	2026-05-04	2026-10-22
Ultrasound-Guided Long vs Short Peripheral IV Catheters in Neonates With Congenital Syphilis Receiving Antibiotics Ultrasound-Guided Long Peripheral Intravenous Catheter, Short Peripheral Intravenous Catheter (Conventional Technique) - Infant, Newborn, Syphilis, Congenital	Not applicable	Not yet recruiting	Hospital de Clinicas de Porto Alegre	104	2026-05-01	2026-05-11
Maitland Mobilization With and Without Stroking Release Technique of Rotator Cuff Muscle in Frozen Shoulder Maitland mobilization combined with Stroking release technique, Maitland Mobilization, along with baseline treatment - Adhesive Capsulitis	Not applicable	Recruiting	Riphah International University	44	2026-05-01	2026-10-02

Showing 20 of 301. Sign in to see all of them.

Narrower conditions

Syphilis (119)  ·  Lyme Disease (95)  ·  Sexually Transmitted Diseases (35)  ·  Chlamydia Infections (31)  ·  Gonorrhea (31)  ·  HIV Infections (28)  ·  Leptospirosis (24)  ·  Post-Lyme Disease Syndrome (22)  ·  Lyme Neuroborreliosis (19)  ·  Yaws (16)  ·  Acquired Immunodeficiency Syndrome (15)  ·  Glossitis, Benign Migratory (15)  ·  Treponemal Infections (13)  ·  Borrelia Infections (11)  ·  Hepatitis B (10)

Broader conditions

Bacterial Infections (300)  ·  Bacterial Infections and Mycoses (300)  ·  Gram-Negative Bacterial Infections (300)  ·  Infections (296)  ·  Treponemal Infections (145)  ·  Vector Borne Diseases (131)  ·  Urogenital Diseases (130)  ·  Genital Diseases (126)  ·  Communicable Diseases (121)  ·  Sexually Transmitted Diseases, Bacterial (118)  ·  Tick-Borne Diseases (113)  ·  Borrelia Infections (111)  ·  Pathological Conditions, Signs and Symptoms (90)  ·  Sexually Transmitted Diseases (88)

Interventions

Doxycycline (29)  ·  Ceftriaxone (13)  ·  Azithromycin (10)  ·  Penicillin G (10)  ·  Blood Specimen Collection (7)  ·  Penicillin G Benzathine (7)  ·  Amoxicillin (5)  ·  Cefixime (4)  ·  Linezolid (4)  ·  Counseling (3)  ·  Ivermectin (3)  ·  Methods (3)  ·  Standard of Care (3)  ·  Albendazole (2)  ·  Anti-Bacterial Agents (2)

Sponsors

National Institute of Allergy and Infectious Diseases (NIAID) (20)  ·  University Medical Centre Ljubljana (19)  ·  London School of Hygiene and Tropical Medicine (9)  ·  University Hospital, Strasbourg, France (9)  ·  Pfizer (8)  ·  Lihir Medical Centre (5)  ·  Columbia University (4)  ·  Institut Pasteur (4)  ·  University of Washington (4)  ·  Yale University (4)  ·  Centers for Disease Control and Prevention (3)  ·  Centre Hospitalier Universitaire de la Réunion (3)  ·  Hospital de Niños R. Gutierrez de Buenos Aires (3)  ·  Institute of Tropical Medicine, Belgium (3)  ·  Johns Hopkins University (3)

Countries

United States (109)  ·  France (24)  ·  Slovenia (18)  ·  Canada (15)  ·  China (12)  ·  Papua New Guinea (10)  ·  Switzerland (6)  ·  Taiwan (6)  ·  United Kingdom (6)  ·  South Africa (5)  ·  Thailand (5)  ·  Uganda (5)  ·  Argentina (4)  ·  Belgium (4)  ·  Democratic Republic of the Congo (4)

Top investigators

Adriana R Marques, M.D. (8)  ·  Brian A Fallon, MD (4)  ·  Franc Strle, MD, PhD (4)  ·  Franc Strle, MD (3)  ·  Jeffrey D Klausner, MD MPH (3)  ·  Chris Kenyon, MD (2)  ·  Dasa Stupica, MD, PhD (2)  ·  Franc Strle, MD PhD (2)  ·  Fredrikke C Knudtzen, MD (2)  ·  Irene Stafford, MD (2)  ·  Michael Marks (2)  ·  Patrick Hochedez, MD (2)  ·  Sabine Hazan, MD (2)

Results publications

PMID 30075748, PMID 18532873, PMID 19220138, PMID 19321868, PMID 19389002, PMID 19936044, PMID 21216000, PMID 37018493, PMID 38830375, PMID 39248571, PMID 15075545, PMID 16837678, PMID 17321311, PMID 17545184, PMID 18032943, PMID 18086100, PMID 18567539, PMID 19571722, PMID 19616720, PMID 19693024, PMID 20095074, PMID 20336078, PMID 20370481, PMID 20370483, PMID 20402591, PMID 20678190, PMID 21173675, PMID 21482866, PMID 21489882, PMID 21998287, PMID 22082722, PMID 22210632, PMID 22240407, PMID 22260085, PMID 22441648, PMID 22523260, PMID 23107285, PMID 23657208, PMID 23759262, PMID 23949590, PMID 24236175, PMID 24325737, PMID 24431188, PMID 24523212, PMID 25053721, PMID 25103395, PMID 25262105, PMID 25560566, PMID 25585069, PMID 25591391

NIH funding

2023 (3), 2025 (2), 1IK2CX002822-01A1 (1), 2009 (1), 2015 (1), 2019 (1), D43TW009340 (1), K23MH084611 (1), K24NR018621 (1), P60AR036308 (1), R01AI031561 (1), R01AI045468 (1), R01AI143439 (1), R01AI179838 (1), R01AI187414 (1)