5 completed, 5 recruiting, 1 active not recruiting, 1 enrolling by invitation. 13 Phase 2, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 13 | Completed 5, Recruiting 5, Active not recruiting 1, Enrolling by invitation 1, Unknown 1 |
| Phase 1 | 2 | Completed 1, Unknown 1 |
Follow Syphilis: new trials by email Literature Review of Syphilis trials Research Report on Syphilis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluating VM100 Nutritional Supplement for Improving Quality of Life in Duchenne Muscular Dystrophy Patients VM100 Nutritional Supplement - Duchenne Muscular Dystrophy, Duchenne Disease | Phase 2 | Recruiting | University of Florida | 20 | 2026-07-27 | 2026-10-08 |
| Comprehensive Ambulatory Antibiotics for the Treatment of Congenital Syphilis Linezolid (LZD), Amoxicillin, Benzathine Penicillin G - Syphilis, Congenital | Phase 2 | Recruiting | London School of Hygiene and Tropical Medicine | 90 | 2026-05-04 | 2026-10-22 |
| Evaluation of Antimicrobial Prophylaxis to Prevent Syphilis in Pregnancy in Patients at Risk in Rio de Janeiro, Brazil Benzathine penicillin 2.4 million units, Counseling and intensified testing. - Congenital Syphilis | Phase 2 | Recruiting | University of California, Los Angeles | 500 | 2025-09-24 | 2026-06-01 |
| Daily Doxycycline for Early Syphillis Doxycycline 200mg daily for 14 days - Syphilis | Phase 2 | Recruiting | University of Washington | 15 | 2025-03-03 | 2025-06-25 |
| Peer Delivered HIV/Syphilis Self-Testing With Assisted Partner Notification Services Peer distribution of self testking kits - HIV, Syphilis | Phase 2 | Enrolling by invitation | Makerere University | 200 | 2024-08-25 | 2025-01-24 |
| Vasodilator and Exercise Study for DMD (VASO-REx) Tadalafil, Placebo, Exercise Training - Duchenne Muscular Dystrophy, Duchenne Disease | Phase 2 | Recruiting | University of Florida | 50 | 2024-06-05 | 2026-05-15 |
| Linezolid for Syphilis Pilot Study Group B, Linezolid 10d, Group A, Penicillin - Syphilis | Phase 2 | Active not recruiting | University of Southern California | 24 | 2023-09-28 | 2026-03-12 |
| Trial Evaluating the Clinical Efficacy of Cefixime for Treatment of Early Syphilis in Non-pregnant Women Cefixime, Benzathine penicillin 2.4 million units - Syphilis Female | Phase 1 / Phase 2 | Unknown | World Health Organization | 180 | 2019-11-22 | 2020-02-05 |
| Cefixime for Alternative Syphilis Treatment Cefixime 400 milligram Oral Capsule [Suprax], Benzathine Penicillin G - Syphilis, Early Syphilis | Phase 2 | Completed | University of California, Los Angeles | 58 | 2018-09-03 | 2022-07-26 |
| Safer Sex Program for Young African-American Men Intervention - Gonorrhea, Chlamydia | Phase 2 | Completed | Richard Crosby | 620 | 2012-09-01 | 2019-02-21 |
| Lay Health Advisors for Sexually Transmitted Disease Prevention HoMBReS: A lay health advisor approach to STD prevention - Syphilis, Gonorrhea | Phase 1 / Phase 2 | Completed | Centers for Disease Control and Prevention | 354 | 2004-10-01 | 2012-09-11 |
| Safety, Acceptability and Preliminary Effectiveness of PC-515 for Vaginal Use as a Possible Microbicide Carraguard (PC-515) - HIV Infections, Chlamydia Trachomatis | Phase 2 | Completed | Population Council | 165 | 2000-02-01 | 2017-08-14 |
| Safety, Acceptability and Preliminary Effectiveness of Carraguard™ (PC-515) in Preventing HIV/STI Transmission Carraguard (PC-515) - HIV Infections, Chlamydia Trachomatis | Phase 2 | Completed | Population Council | 400 | 1999-10-01 | 2017-08-14 |
HIV Infections (4) · Sexually Transmitted Diseases (3) · Chlamydia Infections (2) · Gonorrhea (2) · Muscular Dystrophies (2) · Muscular Dystrophy, Duchenne (2) · Syphilis, Congenital (2) · Tabes Dorsalis (2) · Trichomonas Vaginitis (2) · Aneurysm (1) · Fatigue (1) · Herpes Simplex (1) · Motor Activity (1) · Treponemal Infections (1)
Bacterial Infections (13) · Bacterial Infections and Mycoses (13) · Gram-Negative Bacterial Infections (13) · Infections (13) · Spirochaetales Infections (13) · Treponemal Infections (12) · Communicable Diseases (9) · Genital Diseases (9) · Sexually Transmitted Diseases, Bacterial (9) · Urogenital Diseases (9) · Sexually Transmitted Diseases (6) · Blood-Borne Infections (4) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (4) · Immune System Diseases (4) · Immunologic Deficiency Syndromes (4)
Cefixime (2) · Linezolid (2) · Methods (2) · Penicillin G (2) · Amoxicillin (1) · Counseling (1) · Doxycycline (1) · Exercise (1) · Penicillin G Benzathine (1) · Penicillins (1) · Tadalafil (1)
Population Council (2) · University of California, Los Angeles (2) · University of Florida (2) · Centers for Disease Control and Prevention (1) · London School of Hygiene and Tropical Medicine (1) · Makerere University (1) · Richard Crosby (1) · University of Southern California (1) · University of Washington (1) · World Health Organization (1)
United States (7) · Brazil (2) · South Africa (2) · Indonesia (1) · Malawi (1) · Thailand (1) · Uganda (1)
Jeffrey D Klausner, MD MPH (2) · Barbara A Castelnuovo, MD, MPH. PhD (1) · Bridget Freyne (1) · Charlotte E. Ellertson, MPA, Ph.D. (1) · David Tellalian, MD (1) · Edna O Kara, MD (1) · Leandro A Mena, MD (1) · Melanie M Taylor, MD (1) · Michael Marks (1) · Nathalie JN Broutet, MD (1) · Richard A Crosby, PhD (1) · Scott Rhodes, PhD (1) · Stephen Okoboi, BSc, MPH, PhD (1) · Tanja Taivassalo, MD (1)
PMID 32522244, PMID 33298143, PMID 33640982
R01AI045468 (1), R01AI187414 (1), R01MH092226 (1), R21AR079755 (1)