6 completed, 3 recruiting, 3 unknown, 2 terminated. 16 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 16 | Completed 6, Recruiting 3, Unknown 3, Terminated 2, Active not recruiting 1, Not yet recruiting 1 |
Follow Syphilis: new trials by email Literature Review of Syphilis trials Research Report on Syphilis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Congenital Syphilis Treatment Trial (CONSISTENT) in Neonates Benzathine Penicillin, Amoxicillin - Syphilis, Congenital | Phase 4 | Not yet recruiting | University of Alabama at Birmingham | 374 | 2026-11-01 | 2026-09-02 |
| Doxycycline Prophylaxis for Prevention of Sexually Transmitted Infections Doxycycline hyclate delayed released 200 mg, Doxycycline hyclate delayed released 200 mg weekly, Per standard of care with quarterly STI testing/treatment and sexual health counseling - Gonorrhea, Chlamydia | Phase 4 | Recruiting | Westat | 760 | 2026-02-27 | 2026-10-16 |
| Periodic Presumptive Treatment vs. doxyPEP for STI Control in Kenyan MSM WHO-recommended periodic presumptive treatment, Doxycycline post-exposure prophylaxis - Gonorrhea Male, Chlamydia (Male) | Phase 4 | Recruiting | University of Washington | 2900 | 2025-10-29 | 2025-11-19 |
| The Efficacy of Doxycycline Post Exposure Prophylaxis for Preventing STIs Among MSM in Bangkok, Thailand. Doxycycline (200mg/day) - Syphilis Infection, Gonorrhea | Phase 4 | Recruiting | Bangrak STIs Center | 400 | 2025-10-06 | 2026-02-09 |
| Superiority of On-demand PrEP Versus PEP on Using Doxycycline for Preventing STI in MSM DoxyODPrEP, DoxyPEP - Sexually Transmitted Diseases, Bacterial, Syphilis | Phase 4 | Active not recruiting | Chinese University of Hong Kong | 300 | 2025-03-29 | 2026-06-05 |
| Treatment Responses of Early Syphilis to Ceftriaxone Plus Doxycycline Doxycycline, Ceftriaxone, benzathine penicillin G - Early Syphilis | Phase 4 | Terminated | National Taiwan University Hospital | 109 | 2023-03-10 | 2026-02-25 |
| Cefixime Versus Benzathine Penicillin G in Treatment of Early Syphilis Cefixime 400mg, Benzathine penicillin 2.4 million units - Syphilis | Phase 4 | Terminated | Bulovka Hospital | 61 | 2021-07-13 | 2025-04-02 |
| Syphilis Self-testing to Expand Test Uptake Among Men Who Have Sex With Men (SST) Access to Facility based Syphilis Testing, Syphilis Self-Test - Syphilis | Phase 4 | Completed | London School of Hygiene and Tropical Medicine | 100 | 2020-10-14 | 2022-07-25 |
| Evaluation of Doxycycline Post-exposure Prophylaxis to Reduce Sexually Transmitted Infections in PrEP Users and HIV-infected Men Who Have Sex With Men Doxycycline Hyclate Delayed-Release 200 mg - Gonorrhea, Chlamydia | Phase 4 | Completed | University of California, San Francisco | 641 | 2019-11-26 | 2024-07-12 |
| Oral Doxycycline for the Prevention of Syphilis in Men Who Have Sex with Men (DaDHS) Doxycycline, Placebo - Syphilis, Sexually Transmitted Infections | Phase 4 | Completed | British Columbia Centre for Disease Control | 52 | 2019-08-15 | 2025-02-12 |
| Phase 4 Comparative Trial of Benzathine Penicillin G for Treatment of Early Syphilis in Subjects With or Without HIV Infection Benzathine Penicillin - Syphilis | Phase 4 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 249 | 2018-10-31 | 2025-01-14 |
| Tenofovir/Emtricitabine With Doxycycline for Combination HIV and Syphilis Pre-exposure Prophylaxis in HIV-negative MSM Doxycycline 100mg PO daily x 12 months, Tenofovir/emtricitabine 200/300mg PO daily, Doxycycline 100mg PO daily x 6 months - HIV, Syphilis | Phase 4 | Completed | British Columbia Centre for Disease Control | 52 | 2018-05-15 | 2024-08-02 |
| The Association Between Molecular Typing of Treponema Pallidum and Treatment Efficacy and Clinical Findings Benzathine Penicillin G - Syphilis | Phase 4 | Unknown | Peking Union Medical College Hospital | 150 | 2016-08-01 | 2018-11-16 |
| One Dose Versus Three Weekly Doses of Benzathine Penicillin G for Patients With Early Syphilis Benzathine Penicillin G - Syphilis | Phase 4 | Unknown | Jun Li | 150 | 2016-08-01 | 2018-11-16 |
| Serological Response to Retreatment of Serofast Early Syphilis Cases With Benzathine Penicillin benzathine penicillin - Syphilis | Phase 4 | Unknown | Peking Union Medical College Hospital | 150 | 2016-08-01 | 2018-11-16 |
| Syphilis Response to Higher Penicillin Dosage: The 2.4 Versus 7.2 Study Benzathine penicillin G intramuscular 7.2 million units, Benzathine penicillin G intramuscular 2.4 million units - Syphilis | Phase 4 | Completed | Baylor College of Medicine | 64 | 2008-09-01 | 2016-05-17 |
Chlamydia Infections (6) · Gonorrhea (6) · Sexually Transmitted Diseases (6) · Homosexuality (4) · Acquired Immunodeficiency Syndrome (1) · Sexually Transmitted Diseases, Bacterial (1) · Syphilis, Congenital (1) · Treponemal Infections (1)
Bacterial Infections (16) · Bacterial Infections and Mycoses (16) · Gram-Negative Bacterial Infections (16) · Infections (16) · Spirochaetales Infections (16) · Communicable Diseases (15) · Genital Diseases (15) · Treponemal Infections (15) · Urogenital Diseases (15) · Sexually Transmitted Diseases, Bacterial (14) · Sexually Transmitted Diseases (9) · Chlamydiaceae Infections (6) · Disease Attributes (6) · Neisseriaceae Infections (6) · Pathologic Processes (6)
Doxycycline (4) · Penicillin G (3) · Penicillin G Benzathine (3) · Amoxicillin (1) · Cefixime (1) · Ceftriaxone (1) · Emtricitabine (1) · Standard of Care (1) · Tenofovir (1) · Therapeutics (1)
British Columbia Centre for Disease Control (2) · Peking Union Medical College Hospital (2) · Bangrak STIs Center (1) · Baylor College of Medicine (1) · Bulovka Hospital (1) · Chinese University of Hong Kong (1) · Jun Li (1) · London School of Hygiene and Tropical Medicine (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · National Taiwan University Hospital (1) · University of Alabama at Birmingham (1) · University of California, San Francisco (1) · University of Washington (1) · Westat (1)
United States (4) · China (3) · Canada (2) · Czechia (1) · Hong Kong (1) · Kenya (1) · Taiwan (1) · Thailand (1) · Zimbabwe (1)
Troy Grennan, MD (2) · Anne Luetkemeyer, MD (1) · Cherie Blaire, MD, PhD (1) · David Kimberlin, MD (1) · Jenell Stewart, DO, MPH (1) · Jodie Dionne, MD (1) · Jose A Serpa-Alvarez, MD (1) · Kuan-Yin Lin (1) · Susan M Graham, MD, PhD, MPH (1) · Tsz Ho Kwan, PhD (1)
PMID 37018493, PMID 25585069, PMID 25870333, PMID 28200045, PMID 29229440, PMID 33835852, PMID 34143341, PMID 34392717, PMID 34852691, PMID 35067599, PMID 38118022, PMID 38124508, PMID 38656217, PMID 38797183, PMID 39363100, PMID 39946129, PMID 40147465, PMID 40637301, PMID 40902161, PMID 41494183, PMID 41873979
R01AI143439 (1), R01AI179838 (1), UM2HD111076 (1), UM2HD111102 (1)