5 completed, 3 unknown, 2 not yet recruiting, 2 recruiting. 12 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 12 | Completed 5, Unknown 3, Not yet recruiting 2, Recruiting 2 |
Follow Syphilis: new trials by email Literature Review of Syphilis trials Research Report on Syphilis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Clinical Study to Assess the Efficacy of Weekly Doxycycline Prophylaxis to Reduce Bacterial Sexually Transmitted Infections (STI) in Young African Women Doxycycline hyclate, Standard of Care for STI prevention - Sexually Transmitted Infection (STI), Gonorrhea | Phase 3 | Not yet recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 580 | 2026-11-30 | 2026-10-20 |
| Efficacy and Safety of Minocycline Add-on in Patients With Neurosyphilis Minocycline, Minocycline placebo, Aqueous crystalline penicillin G - Neurosyphilis | Phase 3 | Not yet recruiting | Beijing Ditan Hospital | 778 | 2026-11-15 | 2026-10-29 |
| LIMIT Trial - Lidocaine With Intramuscular Injection of Benzathine Penicillin G for Treponema Pallidum Treatment normal Saline, Lidocaine - Syphilis Infection, Benzathine Penicillin Adverse Reaction | Phase 3 | Recruiting | Washington University School of Medicine | 48 | 2024-07-01 | 2025-03-25 |
| Clinical Trial of Doxycycline VS BPG for Early Syphilis (SY-DOXY) BPG, Doxycycline - Syphilis | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 200 | 2021-12-06 | 2025-11-20 |
| Alternative Antibiotics for Syphilis Linezolid 600 mg (post-interim), Benzathine Penicilllin G (post-interim) - Early Latent Syphilis, Primary Syphilis | Phase 3 | Completed | Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia | 165 | 2021-10-14 | 2026-07-29 |
| Cefixime Clinical Trial Cefixime 400mg, benzathine penicillin - Syphilis, Human Immunodeficiency Virus | Phase 3 | Recruiting | University of Southern California | 400 | 2021-06-20 | 2026-05-04 |
| Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases in Neurological Disorders in DRC Immunochromatographic HAT tests (DSD), Card Agglutination Trypanosoma Test, TB POC Nucleic Acid Amplification Test (Molbio Diagnostics) - Neurological Disorders, Cerebral Malaria | Phase 3 | Completed | Institute of Tropical Medicine, Belgium | 352 | 2012-09-01 | 2016-01-18 |
| (Men Who Have Sex With Men) MSM Community Intervention Trial behavior intervention and male circumcision - HIV, Syphilis | Phase 3 | Unknown | National Center for AIDS/STD Control and Prevention, China CDC | 3214 | 2009-06-01 | 2010-04-08 |
| Injecting Drug Use Community Intervention Trial Intervention - HIV, Hepatitis C | Phase 3 | Unknown | National Center for AIDS/STD Control and Prevention, China CDC | 12000 | 2009-06-01 | 2010-05-07 |
| Trial of Male Circumcision: HIV, Sexually Transmitted Disease (STD) and Behavioral Effects in Men, Women and the Community Male circumcision - HIV Infections, Sexually Transmitted Diseases | Phase 3 | Unknown | Wawer, Maria J., M.D. | 5200 | 2003-08-01 | 2007-08-10 |
| Male Circumcision for HIV Prevention in Rakai, Uganda Adult male circumcision - HIV Infections, Herpesvirus 2, Human | Phase 3 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 5000 | 2002-08-01 | 2007-08-24 |
| Azithromycin/Bicillin Syphilis Azithromycin, Benzathine Penicillin, Doxycycline - Syphilis | Phase 3 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 593 | 2000-06-01 | 2013-04-29 |
HIV Infections (3) · Sexually Transmitted Diseases (3) · Chlamydia Infections (2) · Gonorrhea (2) · Neurosyphilis (2) · Treponemal Infections (2) · Acquired Immunodeficiency Syndrome (1) · Chancroid (1) · Drug Misuse (1) · Genital Diseases, Male (1) · Hepatitis C (1) · Herpes Genitalis (1) · Malaria, Cerebral (1) · Meningitis, Bacterial (1)
Bacterial Infections (12) · Bacterial Infections and Mycoses (12) · Gram-Negative Bacterial Infections (12) · Infections (12) · Spirochaetales Infections (12) · Communicable Diseases (10) · Genital Diseases (10) · Sexually Transmitted Diseases, Bacterial (10) · Treponemal Infections (10) · Urogenital Diseases (10) · Sexually Transmitted Diseases (7) · Blood-Borne Infections (4) · Disease Attributes (4) · Immune System Diseases (4) · Immunologic Deficiency Syndromes (4)
Doxycycline (3) · Circumcision, Male (2) · Penicillin G Benzathine (2) · Azithromycin (1) · Cefixime (1) · Lidocaine (1) · Linezolid (1) · Methods (1) · Minocycline (1) · Saline Solution (1) · Standard of Care (1)
National Institute of Allergy and Infectious Diseases (NIAID) (3) · National Center for AIDS/STD Control and Prevention, China CDC (2) · Assistance Publique - Hôpitaux de Paris (1) · Beijing Ditan Hospital (1) · Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia (1) · Institute of Tropical Medicine, Belgium (1) · University of Southern California (1) · Washington University School of Medicine (1) · Wawer, Maria J., M.D. (1)
China (3) · Uganda (3) · United States (3) · Botswana (1) · Democratic Republic of the Congo (1) · Eswatini (1) · France (1) · Madagascar (1) · Malawi (1) · Spain (1) · United Kingdom (1)
Zunyou Wu, MD, PHD (2) · David Serwadda, MBChB,MPH (1) · Emmanuel Bottieau, MD (1) · Godfrey Kigozi, MBChB, MPH (1) · Jeffrey D Klausner, MD MPH (1) · Jie Xu, MD, MS, MPH (1) · Marleen Boelaert, MD, PhD (1) · Ronald H. Gray, MD (1) · Xia Meng, MD (1)
PMID 18532873, PMID 19220138, PMID 19321868, PMID 19389002, PMID 19936044, PMID 21216000, PMID 17321311, PMID 17545184, PMID 18086100, PMID 19571722, PMID 19616720, PMID 20370481, PMID 20370483, PMID 20402591, PMID 21489882, PMID 21998287, PMID 22210632, PMID 26094162, PMID 38211601, PMID 38914204
2019 (1)