84 completed, 28 recruiting, 18 unknown, 13 not yet recruiting. 55 Not applicable, 19 Phase 3, 19 Phase 4, 15 Phase 2, 4 Phase 1.
Follow Treponemal Infections: new trials by email Literature Review of Treponemal Infections trials Research Report on Treponemal Infections
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Integrated Care Versus Usual Care for Opioid Use Disorder and Infectious Diseases in Veterans Integrated care - Opioid Use Disorder, HIV | Not applicable | Not yet recruiting | VA Office of Research and Development | 60 | 2028-04-03 | 2026-04-24 |
| A Clinical Study to Assess the Efficacy of Weekly Doxycycline Prophylaxis to Reduce Bacterial Sexually Transmitted Infections (STI) in Young African Women Doxycycline hyclate, Standard of Care for STI prevention - Sexually Transmitted Infection (STI), Gonorrhea | Phase 3 | Not yet recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 580 | 2026-11-30 | 2026-10-20 |
| Efficacy and Safety of Minocycline Add-on in Patients With Neurosyphilis Minocycline, Minocycline placebo, Aqueous crystalline penicillin G - Neurosyphilis | Phase 3 | Not yet recruiting | Beijing Ditan Hospital | 778 | 2026-11-15 | 2026-10-29 |
| Congenital Syphilis Treatment Trial (CONSISTENT) in Neonates Benzathine Penicillin, Amoxicillin - Syphilis, Congenital | Phase 4 | Not yet recruiting | University of Alabama at Birmingham | 374 | 2026-11-01 | 2026-09-02 |
| Pilot HIV Self-Testing And Self-collected STI Testing Strategy for Sex Worker Empowerment Study Venue-based, peer-enhanced strategy for integrated HIV self-testing (and self-collected STI testing - HIV, Syphilis | Not applicable | Not yet recruiting | University of North Carolina, Chapel Hill | 232 | 2026-11-01 | 2026-10-29 |
| Daily, Weekly, or Event-driven Doxycycline for STI Prevention Among Men Who Have Sex With Men (MSM) Engaging in Chemsex: The DOSE Non-inferiority Trial On demand doxycycline hyclate 200mg, Daily doxycycline hyclate 100mg, Weekly doxycycline hyclate 100mg - Gonorrhea, Chlamydia | Phase 4 | Not yet recruiting | University of California, Los Angeles | 300 | 2026-11-01 | 2026-11-12 |
| Blood Donation Study for ALPCO Syphilis-T and Syphilis-NT Assay Development ALPCO Syphilis-T, ALPCO Syphilis-NT CLIA Kits - Healthy Volunteers, Syphilis Serologic Assay Development | Enrolling by invitation | American Laboratory Products Company | 50 | 2026-10-01 | 2026-09-22 | |
| Strengthening, Guidance, Health, Empowerment Self-sampling for six sexually transmitted infections - HIV Infection, Syphilis | Not applicable | Not yet recruiting | University Hospital, Montpellier | 200 | 2026-09-01 | 2026-08-26 |
| Improving Maternal and Child Health Through Point-of-care STI Testing Point-of-care STI tests, Standard of care STI testing - Treponema Pallidum Infection, Chlamydia Trachomatis Infection | Not applicable | Recruiting | Emory University | 756 | 2026-08-11 | 2026-08-19 |
| Evaluating VM100 Nutritional Supplement for Improving Quality of Life in Duchenne Muscular Dystrophy Patients VM100 Nutritional Supplement - Duchenne Muscular Dystrophy, Duchenne Disease | Phase 2 | Recruiting | University of Florida | 20 | 2026-07-27 | 2026-10-08 |
| Comprehensive Ambulatory Antibiotics for the Treatment of Congenital Syphilis Linezolid (LZD), Amoxicillin, Benzathine Penicillin G - Syphilis, Congenital | Phase 2 | Recruiting | London School of Hygiene and Tropical Medicine | 90 | 2026-05-04 | 2026-10-22 |
| Ultrasound-Guided Long vs Short Peripheral IV Catheters in Neonates With Congenital Syphilis Receiving Antibiotics Ultrasound-Guided Long Peripheral Intravenous Catheter, Short Peripheral Intravenous Catheter (Conventional Technique) - Infant, Newborn, Syphilis, Congenital | Not applicable | Not yet recruiting | Hospital de Clinicas de Porto Alegre | 104 | 2026-05-01 | 2026-05-11 |
| Maitland Mobilization With and Without Stroking Release Technique of Rotator Cuff Muscle in Frozen Shoulder Maitland mobilization combined with Stroking release technique, Maitland Mobilization, along with baseline treatment - Adhesive Capsulitis | Not applicable | Recruiting | Riphah International University | 44 | 2026-05-01 | 2026-10-02 |
| Early Detection and AI-Based Management of Skin-Related Neglected Tropical Diseases in Sub-Saharan Africa by Frontline Health Workers A mobile app with AI functionality for diagnosing skin-related NTDs - Skin and Connective Tissue Diseases, Neglected Tropical Diseases | Not applicable | Not yet recruiting | Kenya Medical Research Institute | 2420 | 2026-05-01 | 2026-04-02 |
| Evaluation of Free STI Testing Pilot Projects in Lucerne and Zurich, Switzerland HIV (Human Immunodeficiency Virus), Chlamydia | Not yet recruiting | University of Zurich | 1800 | 2026-04-07 | 2026-04-08 | |
| MAGIA H3S Point of Care Test Performance for HIV, HBV, HCV, and Syphilis Screening in Pregnant Women in DR Congo MAGIA H3S - HIV - Human Immunodeficiency Virus, HBV (Hepatitis B Virus) | Not yet recruiting | Gardiens de Vies | 7500 | 2026-03-01 | 2026-02-05 | |
| Doxycycline Prophylaxis for Prevention of Sexually Transmitted Infections Doxycycline hyclate delayed released 200 mg, Doxycycline hyclate delayed released 200 mg weekly, Per standard of care with quarterly STI testing/treatment and sexual health counseling - Gonorrhea, Chlamydia | Phase 4 | Recruiting | Westat | 760 | 2026-02-27 | 2026-10-16 |
| Study of Ceftriaxone and Benzathine Penicillin G During Pregnancy Ceftriaxon, Benzathine penicillin G - Pregnancy | Recruiting | International Maternal Pediatric Adolescent AIDS Clinical Trials Group | 110 | 2026-02-16 | 2026-08-06 | |
| Rapid HIV, Hep C, and Syphilis Screening in a Rural Street Medicine Clinic Rapid Fingerstick Test, Blood Draw for lab test - HIV Testing, HEPATITIS C (HCV) | Recruiting | West Virginia University | 200 | 2026-01-21 | 2026-08-13 | |
| This Study Evaluates the ALPCO Syphilis-T and Syphilis-NT CLIA Kits for Detecting Syphilis Antibodies in Serum and Plasma. Samples From At-risk, HIV-positive, Pregnant, and Healthy Individuals Will Assess Assay Performance Versus Established Comparator Tests. ALPCO Syphilis-T, ALPCO Syphilis-NT CLIA Kits - Treponema Pallidum, Treponema Pallidum Infection | Recruiting | American Laboratory Products Company | 1000 | 2025-12-10 | 2026-09-16 |
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Syphilis (120) · Sexually Transmitted Diseases (36) · Gonorrhea (32) · Chlamydia Infections (31) · HIV Infections (28) · Yaws (16) · Acquired Immunodeficiency Syndrome (15) · Hepatitis B (10) · Hepatitis C (10) · Syphilis, Congenital (10) · Homosexuality (9) · Neurosyphilis (7) · Elephantiasis, Filarial (5) · Neglected Diseases (4)
Bacterial Infections (159) · Bacterial Infections and Mycoses (159) · Gram-Negative Bacterial Infections (159) · Spirochaetales Infections (159) · Infections (158) · Genital Diseases (123) · Urogenital Diseases (123) · Communicable Diseases (122) · Sexually Transmitted Diseases, Bacterial (118) · Sexually Transmitted Diseases (87) · Virus Diseases (51) · Pathological Conditions, Signs and Symptoms (49) · Blood-Borne Infections (48) · RNA Virus Infections (48)
Doxycycline (11) · Azithromycin (10) · Penicillin G (10) · Penicillin G Benzathine (7) · Cefixime (4) · Linezolid (4) · Amoxicillin (3) · Ceftriaxone (3) · Ivermectin (3) · Methods (3) · Albendazole (2) · Circumcision, Male (2) · Counseling (2) · Diethylcarbamazine (2) · Emtricitabine (2)
London School of Hygiene and Tropical Medicine (9) · National Institute of Allergy and Infectious Diseases (NIAID) (7) · Lihir Medical Centre (5) · University of California, Los Angeles (4) · University of Washington (4) · Centers for Disease Control and Prevention (3) · Hospital de Niños R. Gutierrez de Buenos Aires (3) · Institute of Tropical Medicine, Belgium (3) · National Taiwan University Hospital (3) · Peking Union Medical College Hospital (3) · Population Council (3) · The University of Texas Health Science Center, Houston (3) · University of North Carolina, Chapel Hill (3) · Yale University (3) · American Laboratory Products Company (2)
United States (46) · Canada (12) · China (12) · Papua New Guinea (10) · South Africa (5) · Taiwan (5) · Uganda (5) · United Kingdom (5) · Argentina (4) · France (4) · Kenya (4) · Brazil (3) · Democratic Republic of the Congo (3) · Malawi (3) · Thailand (3)
Jeffrey D Klausner, MD MPH (3) · Chris Kenyon, MD (2) · Irene Stafford, MD (2) · Michael Marks (2) · Troy Grennan, MD (2) · Zunyou Wu, MD, PHD (2) · Akshay Sharma, PhD (1) · Ann N Burchell, PhD (1) · Anne Luetkemeyer, MD (1) · Anthony LaMarca, M.D. (1) · Audun J Lier, MD (1) · Barbara A Castelnuovo, MD, MPH. PhD (1) · Bridget Freyne (1) · Bridget Haire, PhD (1)
PMID 18532873, PMID 19220138, PMID 19321868, PMID 19389002, PMID 19936044, PMID 21216000, PMID 37018493, PMID 15075545, PMID 17321311, PMID 17545184, PMID 18032943, PMID 18086100, PMID 19571722, PMID 19616720, PMID 19693024, PMID 20095074, PMID 20336078, PMID 20370481, PMID 20370483, PMID 20402591, PMID 20678190, PMID 21173675, PMID 21482866, PMID 21489882, PMID 21998287, PMID 22082722, PMID 22210632, PMID 22240407, PMID 23107285, PMID 23759262, PMID 23949590, PMID 24236175, PMID 24325737, PMID 24431188, PMID 25053721, PMID 25103395, PMID 25262105, PMID 25560566, PMID 25585069, PMID 25591391, PMID 25693010, PMID 25870333, PMID 26006260, PMID 26094162, PMID 26286026, PMID 26741583, PMID 26772390, PMID 26879979, PMID 27124895, PMID 27375613
1IK2CX002822-01A1 (1), 2019 (1), D43TW009340 (1), K23MH084611 (1), K24NR018621 (1), R01AI045468 (1), R01AI143439 (1), R01AI179838 (1), R01AI187414 (1), R01DA029910 (1), R01DA030234 (1), R01DA066392 (1), R01DK135645 (1), R01HD108201 (1), R01MD020754 (1)