170 completed, 75 unknown, 26 recruiting, 20 terminated. 149 Not applicable, 46 Phase 4, 43 Phase 3, 25 Phase 2, 8 Phase 1.
Follow Surgical Site Infection: new trials by email Literature Review of Surgical Site Infection trials Research Report on Surgical Site Infection
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Betadine Vaginal Cleansing Before Cesarean Section to Reduce Postoperative Infectious Morbidity Povidone-iodine 5% solution - Cesarean Section, Surgical Site Infection | Not applicable | Not yet recruiting | Mohamed Mousa Mohamed Mousa | 600 | 2027-05-01 | 2026-07-20 |
| Prevention of Vaginal Cuff Infection After Hysterectomy by Addition of Vaginal Clindamycin Clindamycin Vaginal Gel - Surgical Site Infection, Vaginal Cuff Cellulitis | Enrolling by invitation | Baylor Research Institute | 900 | 2026-12-01 | 2026-10-22 | |
| The Mepilex Cesarean Delivery Trial / MEPIDEL Mepilex Border Post-Op Ag, Standard Postoperative Dressing - Surgical Site Infection | Not applicable | Not yet recruiting | Montefiore Medical Center | 240 | 2026-11-01 | 2026-11-03 |
| Cyanoacrylate Skin Adhesive After Mohs Surgery or Wide Local Excision Cyanoacrylate Skin Adhesive, Fast Gut Running Epidermal Suture Closure, Vicryl Rapide Running Epidermal Suture Closure - Surgical Site Infection, Skin Cancer | Not applicable | Not yet recruiting | University of Minnesota | 300 | 2026-10-26 | 2026-10-20 |
| Comparative Outcomes of Mammary Artery Harvesting: Infection, Occlusion Rates and Thoracic Pain Assessment Skeletonized LIMA Harvesting, Non-Skeletonized LIMA Harvesting - Coronary Artery Disease, Coronary Artery Bypass Grafting | Not applicable | Withdrawn | Hamilton Health Sciences Corporation | 2026-09-01 | 2026-07-28 | |
| Hernia Sac Flap Coverage of Mesh in Bony-Edged Ventral Hernia Repair Sac-flap peritonealization of the mesh, Retromuscular (sublay) synthetic mesh repair - Incisional Hernia, Abdominal Hernia | Not applicable | Recruiting | Minia University | 180 | 2026-08-15 | 2026-08-18 |
| Post-Amputation Stump Infection as a Predictor of Persistent Residual Limb Pain: A Prospective Cohort Study Residual Limb Pain, Stump Pain | Not yet recruiting | Ukrainian Society of Regional Anesthesia and Pain Therapy | 150 | 2026-06-23 | 2026-06-03 | |
| Steri-Strip Application Versus Standard Wound Closure for Cesarean Section Incisions Steri-Strip™ Skin Closures, Standard Cesarean Wound Closure - Cesarean Section, Surgical Site Infection | Not applicable | Recruiting | Riverside University Health System Medical Center | 610 | 2026-06-01 | 2026-07-07 |
| Gut Decolonisation With Neomycin/Metronidazole or Rifaximin Before Colon Surgery Rifaximin (Xifaxan), Metronidazole, Neomycin Sulfate - Surgical Site Infection, Colon Surgery | Phase 4 | Not yet recruiting | Universität Luzern | 458 | 2026-06-01 | 2025-09-18 |
| Innovative Sternal Closure Techniques: Evaluating STRATAFIX™ and DERMABOND™ for Reduced Complications in CABG Patients Knotless Barbed Sutures, Mesh-based Topical Skin Adhesive - Cardiovascular Disease, Surgical Site Infection | Phase 4 | Not yet recruiting | Unity Health Toronto | 401 | 2026-05-01 | 2026-04-13 |
| Investigating the Impact of Cold Atmospheric Plasma Treatment on Wound Healing at Cannulation Sites in Patients Following Extracorporeal Life Support Cold Atmospheric Plasma (CAP) Therapy, Standard wound care - ExtraCorporeal Life Support (ECLS), Wound Infection | Not applicable | Recruiting | National Taiwan University Hospital | 65 | 2026-03-12 | 2026-03-30 |
| Skin Staples vs Polypropylene in Elective Laparotomy Skin staples, Polypropylene skin suture - Surgical Site Infection | Not applicable | Recruiting | Pakistan Institute of Medical Sciences | 130 | 2026-01-31 | 2026-10-13 |
| Prospective Clinical Evaluation of High-Purity Type I Collagen in Select High-Risk Hernia Repair Scenarios High-Purity Type I Collagen Mesh - Hernia, Ventral Hernia | Not applicable | Completed | Adichunchanagiri Institute of Medical Sciences, B G Nagara | 30 | 2026-01-05 | 2026-04-23 |
| Treating Emergency Laparotomy Incisions With Negative Pressure Wound Therapy Negative pressure wound therapy, Standard postoperative dressing - Surgical Incision, Wound Dehiscence | Not applicable | Recruiting | Uppsala University | 720 | 2025-12-16 | 2026-07-07 |
| Local Subcutaneous Gentamicin for Prevention of Surgical Site Infection After Elective Cesarean Section Gentamicin, Standard antibiotic prophylaxis, Placebo (saline) - Surgical Site Infection | Not applicable | Recruiting | Western Galilee Hospital-Nahariya | 100 | 2025-12-08 | 2026-06-26 |
| A Novel Surgical Irrigation Solution in Post-Mastectomy Reconstruction: Evaluating Xperience™ Xperience™ Advanced Surgical Irrigation, Dilute Povidone-Iodine - Surgical Site Infection, Surgical Complication | Not applicable | Recruiting | University of North Carolina, Chapel Hill | 224 | 2025-06-30 | 2025-08-07 |
| Antibacterial (Triclosan-Coated) Versus Conventional Sutures in Septoplasty Triclosan-Coated Polyglactin 910 Suture, Conventional Polyglactin 910 Suture - Nasal Septal Deviation, Surgical Wound Healing | Not applicable | Completed | Sakarya University | 142 | 2025-06-01 | 2026-11-05 |
| PRevention Of Trauma-related Infections Through an Embedded Clinical Trials Network Ertapenem, Cefazolin and Metronidazole. - Surgical Site Infection | Phase 4 | Not yet recruiting | The University of Texas Health Science Center, Houston | 300 | 2025-05-01 | 2025-04-11 |
| The Effects of Different Time Reminder On Surgical Hand Scrubing Listening Music, Alarm - Surgical Site Infection | Not applicable | Active not recruiting | Saglik Bilimleri Universitesi Gulhane Tip Fakultesi | 66 | 2025-04-15 | 2025-06-05 |
| Intraoperative Oxygen Concentration on Incidence of Surgical Site Infection FIO2=0.8, FIO2=0.33 - Surgical Site Infection | Not applicable | Completed | Assiut University | 146 | 2025-04-03 | 2026-06-29 |
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Surgical Wound Infection (329) · Wound Infection (28) · Infections (22) · Surgical Wound (18) · Postoperative Complications (15) · Colorectal Neoplasms (12) · Staphylococcal Infections (9) · Seroma (8) · Cross Infection (6) · Incisional Hernia (5) · Pain, Postoperative (5) · Wounds and Injuries (5) · Abscess (4) · Cellulitis (4) · Diabetes Mellitus (4)
Pathological Conditions, Signs and Symptoms (329) · Pathologic Processes (328) · Postoperative Complications (314) · Infections (307) · Wound Infection (301) · Wounds and Injuries (26) · Digestive System Diseases (22) · Neoplasms (22) · Neoplasms by Site (22) · Gastrointestinal Diseases (19) · Intestinal Diseases (18) · Signs and Symptoms (18) · Digestive System Neoplasms (16) · Colonic Diseases (15) · Gastrointestinal Neoplasms (15)
Povidone-Iodine (20) · chlorhexidine gluconate (16) · Vancomycin (15) · Negative-Pressure Wound Therapy (11) · Cefazolin (10) · Saline Solution (10) · Sodium Chloride (10) · Chlorhexidine (9) · Ethanol (9) · Anti-Bacterial Agents (8) · Metronidazole (8) · Cephalexin (6) · Chromogranins (6) · Standard of Care (6) · citrate, isopropyl alcohol, methylene blue, parabens drug combination (5)
Hospital de Granollers (8) · Insel Gruppe AG, University Hospital Bern (7) · Ain Shams University (6) · University of Birmingham (6) · Zurex Pharma, Inc. (6) · Hospital General Universitario Elche (5) · Assiut University (4) · Azienda Ospedaliera Universitaria Integrata Verona (3) · Daniela Francescato Veiga (3) · Durata Therapeutics Inc., an affiliate of Allergan plc (3) · Hamilton Health Sciences Corporation (3) · PolyPid Ltd. (3) · University Hospital, Basel, Switzerland (3) · University of British Columbia (3) · University of Southern California (3)
United States (102) · Spain (28) · Switzerland (17) · Egypt (15) · Canada (13) · Pakistan (9) · Turkey (Türkiye) (9) · United Kingdom (9) · Brazil (8) · Germany (7) · Italy (7) · Sweden (7) · France (6) · Israel (6) · Mexico (6)
Daniela F Veiga, MD, PhD (3) · Emad R Issak, Diploma (2) · Gerard Slobogean, MD (2) · Guido Beldi (2) · Jaroslaw Kobiela, Prof. (2) · Lydia M Ferreira, MD, PhD (2) · Michael Dunne, MD (2) · Mohit Bhandari, MD (2) · Sheila Sprague, PhD (2) · Abdul H Sultan (1) · Abida K. Sattar, MD, FACS (1) · Adeyemi Ogunleye, MD (1)
PMID 36748942, PMID 40260835, PMID 32580252, PMID 34905144, PMID 41159585, PMID 23231938, PMID 24201395, PMID 24897082, PMID 31481559, PMID 32259266, PMID 32335895, PMID 32787892, PMID 10219875, PMID 12641893, PMID 1332552, PMID 14633566, PMID 15221572, PMID 16003309, PMID 17119142, PMID 17143850, PMID 17180584, PMID 17629996, PMID 17981197, PMID 18090752, PMID 18461895, PMID 18564784, PMID 19212189, PMID 19285307, PMID 19911098, PMID 20309522, PMID 21146207, PMID 21444695, PMID 21768407, PMID 21804414, PMID 21868417, PMID 22186564, PMID 22265220, PMID 22513974, PMID 22549748, PMID 22868327, PMID 23111014, PMID 2316800, PMID 23375758, PMID 23539123, PMID 23557410, PMID 23743467, PMID 23883481, PMID 23950762, PMID 24106562, PMID 24272023
2019 (4), 2018 (2), 2014 (1), 2017 (1), 2025 (1), R44GM095005 (1), T32AI078875 (1), U01CK000557 (1), U54CK000613 (1)