24 completed, 12 recruiting, 9 unknown, 6 active not recruiting. 37 Not applicable, 5 Phase 2, 2 Early Phase 1, 1 Phase 3.
Follow Subjective Cognitive Decline: new trials by email Literature Review of Subjective Cognitive Decline trials Research Report on Subjective Cognitive Decline
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Under-Represented Communities Diagnosed With SCD or MCI Through Tele-Cog Assessments, Neuroimaging volumetric measures, Biofluid samples - Mild Cognitive Impairment, Subjective Cognitive Decline | Enrolling by invitation | Ohio State University | 100 | 2027-03-01 | 2026-10-16 | |
| LLM-Driven Daily Conversation for Cognitive Health in Older Adults LLM Conversation Cognitive Interaction, Interest-Based Knowledge Reading, Waitlist Health Education - Subjective Cognitive Decline | Not applicable | Not yet recruiting | Taipei Medical University Shuang Ho Hospital | 75 | 2026-09-01 | 2026-08-07 |
| Using Artificial Intelligence to Detect Early Signs of Alzheimer's Disease in People With Memory Concerns High-frequency Transcranial Magnetic Stimulation (TMS), Digital Cognitive Training, Structured Physical Exercise - Subjective Cognitive Decline, Alzheimer Disease | Not applicable | Not yet recruiting | IRCCS San Raffaele | 300 | 2026-08-01 | 2026-06-17 |
| Chinese Classics Recitation Training in Subjective Cognitive Decline Memory training by Chinese Classics recitation - Subjective Cognitive Decline (SCD), Subjective Cognitive Decline | Not applicable | Recruiting | China Medical University Hospital | 60 | 2026-08-01 | 2026-10-22 |
| Prediction of Cognitive Test Performance Using AI-Based Analysis of Narrative Speech AI-Based Storytelling Speech Assessment - Cognitive Function Assessment, Mild Cognitive Impairment | Not applicable | Recruiting | Chang Gung Memorial Hospital | 150 | 2025-12-01 | 2026-04-06 |
| Internet-based Mind-Body Training for Brain Health Internet-based Mindfulness-Based Stress Reduction (iMBSR), Internet-based Lifestyle Education (iLifeEd) - Subjective Cognitive Decline | Not applicable | Completed | Ohio State University | 60 | 2025-06-13 | 2026-07-27 |
| Attentional Mechanisms in SCD Mecamylamine Challenge, Placebo Comparator Challenge - Subjective Cognitive Decline | Early Phase 1 | Recruiting | Vanderbilt University Medical Center | 80 | 2025-06-06 | 2026-06-04 |
| Exergame-assisted Simultaneous Motor-cognitive Training for Middle-aged Old Adults in China Exergame-assisted simultaneous motor-cognitive training - Subjective Cognitive Decline | Not applicable | Recruiting | The Hong Kong Polytechnic University | 30 | 2025-05-20 | 2025-07-25 |
| Β-OHB Supplementation and Brain Health in Older Adults Ketone monoester (KME) supplement, Placebo supplement - Subjective Cognitive Decline | Phase 2 | Not yet recruiting | McMaster University | 48 | 2025-03-01 | 2025-02-26 |
| Effects of Individualized Theta-tACS on a Working Memory Training at SCD transcranial alternating current stimulation (tACS) - Subjective Cognitive Decline | Not applicable | Unknown | University Hospital Tuebingen | 36 | 2024-07-19 | 2024-07-15 |
| Gut-brain Health Effects of PREbiotics in Older Adults With Suspected COgnitive DEcline Chicory inulin, Resistant dextrin, Seaweed polysaccharide - Subjective Cognitive Decline | Not applicable | Active not recruiting | Wageningen University | 164 | 2024-07-16 | 2025-08-26 |
| REducing the Risk of COgnitive DEcline ad Dementia in Patients With Subjective Cognitive Decline Through an Immersive Virtual Reality and Telemedicine-based Multi-component Intervention: the SCD-ReCODED Study Multi-component Intervention (MC-I): VR Cognitive training and Psychoeducation on health and lifestyle, Cognitive-only intervention (CO-I): VR Cognitive training (+ Psychoeducation active control), Active control intervention (AC-I): VR Cognitive active control + Psychoeducation active control - Subjective Cognitive Decline | Not applicable | Unknown | I.R.C.C.S. Fondazione Santa Lucia | 75 | 2024-07-01 | 2024-10-01 |
| Developing a Peer Support Intervention for Depression in SCD PeersCOG - Subjective Cognitive Decline, Depression in Old Age | Not applicable | Active not recruiting | Massachusetts General Hospital | 30 | 2024-05-01 | 2026-07-13 |
| The Effects of Social Isolation and Social Interaction on the Risk of Dementia Progression and Brain Function in SCD (Subjective Cognitive Decline, SCD) social isolation - Social Isolation, SCD | Recruiting | The First Affiliated Hospital with Nanjing Medical University | 209 | 2024-03-01 | 2024-03-28 | |
| Cognitive Intervention With Go and Chess in Early and Subjective Cognitive Decline Go classes, Chess classes - Mild Cognitive Impairment, Subjective Cognitive Decline | Not applicable | Completed | University of Milano Bicocca | 80 | 2024-02-13 | 2026-03-25 |
| Thinking About Memory: How Confident Are You in Your Memory, and Does it Change With Age? Memory tasks - Mild Cognitive Impairment, Subjective Cognitive Decline | Unknown | King's College London | 72 | 2024-02-08 | 2024-08-06 | |
| HOme-based Brain Monitoring With a GARment-EEG to Study Cognitive Decline in the Aging Population Home Lab - Dementia, Mild Cognitive Impairment | Recruiting | Bitbrain | 500 | 2024-01-15 | 2025-05-28 | |
| dTMS for Subjective Cognitive Decline Active Brainsway H7-Coil Deep TMS System, Sham Brainsway H7-Coil Deep TMS System, Cognitive Training - Alzheimer Disease, Subjective Cognitive Decline | Not applicable | Recruiting | Rotman Research Institute at Baycrest | 30 | 2023-11-15 | 2025-10-27 |
| Efficacy of Tinkering Activities in Individuals With Subjective Cognitive Decline Tinkering Activities - Cognitive Training, Subjective Cognitive Decline | Not applicable | Completed | National Taiwan University Hospital | 12 | 2023-11-13 | 2024-09-20 |
| Effects of Mediterranean Diet on Subjective Cognitive Decline Mediterranean diet, Regular diet - Subjective Cognitive Decline | Not applicable | Completed | Chih-Ping Chung | 57 | 2023-10-26 | 2025-09-09 |
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PMID 29315079, PMID 30104186, PMID 30388439, PMID 30826452, PMID 31118095, PMID 31159873, PMID 31350244, PMID 31518248, PMID 31601583, PMID 31710528, PMID 32716355, PMID 32716358, PMID 33160420, PMID 33827675, PMID 34291850, PMID 34635169, PMID 35139918, PMID 35164860, PMID 35387811, PMID 35431240, PMID 35636733, PMID 35867966, PMID 36253765, PMID 37021284, PMID 37740923, PMID 38212815, PMID 38521736, PMID 39072956, PMID 39482712, PMID 39559867, PMID 39710611, PMID 39812690, PMID 40007441, PMID 40053120, PMID 40349092, PMID 40366507, PMID 40404356, PMID 40718565, PMID 41342683, PMID 41351443, PMID 41673697, PMID 41738969, PMID 41870419, PMID 41973869, PMID 42022545, PMID 42486877, PMID 42548715, PMID 42608580, PMID 8159266
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