8 completed, 5 unknown, 3 recruiting, 1 not yet recruiting. 5 Not applicable, 5 Phase 4, 3 Phase 1, 3 Phase 2, 1 Early Phase 1.
Follow Trehalose: new trials by email Literature Review of Trehalose trials Research Report on Trehalose
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Clostridium Butyricum in Stenosing Crohn's Disease Clostridum Butyricum Capsule, Trehalose - Crohn Disease (CD) | Phase 1 / Phase 2 | Recruiting | San Giovanni Addolorata Hospital | 40 | 2026-05-08 | 2026-09-04 |
| Evaluation of the Effectiveness of Three Tear Substitute Formulations in Postoperative Discomfort After Cataract Surgery Sodium Hyaluronate 0.15% and Dexpanthenol 2% drops (Hylopan max), Sodium Hyaluronate 0.15% and Trehalose 3% drops (Thealoz duo), Sodium Hyaluronate 0.2% and Amino acids drops (Helenvision ultra) - Cataract, Dry Eye | Not yet recruiting | Democritus University of Thrace | 300 | 2026-05-01 | 2026-05-12 | |
| The Effects of 3% Trehalose Ophthalmic Solution on Corneal Epithelial Barrier Function 3% trehalose - Dry Eye Disease (DED) | Phase 4 | Recruiting | Southern California College of Optometry at Marshall B. Ketchum University | 30 | 2026-03-01 | 2026-05-05 |
| The Effect of a Pre-cataract Surgical Ocular Hygiene Regime on Microbial Load, Tear Osmolarity, Dry Eye, and Inflammatory Markers Omega-3, Trehalose, Zocular Eyelid System Treatment - Dry Eye, Dry Eye Syndromes | Phase 4 | Unknown | Uptown Eye Specialists | 68 | 2023-09-01 | 2023-08-14 |
| Role of Autophagy in Type 2 Diabetes Microvascular Dysfunction Trehalose, Placebo - Type 2 Diabetes, Healthy Aging | Early Phase 1 | Recruiting | Medical College of Wisconsin | 60 | 2023-01-01 | 2025-10-30 |
| Study to Evaluate the Efficacy of Lagricel® Ofteno PF Compared to Thealoz® Duo After Photorefractive Keratectomy Sodium Hyaluronate Ophthalmic 0.4%, Trehalose 3% / Sodium Hyaluronate Ophthalmic 0.15% - Photorefractive Keratectomy, Corneal De-epithelialization | Phase 4 | Completed | Laboratorios Sophia S.A de C.V. | 96 | 2022-09-03 | 2026-04-07 |
| Efficacy of Oral Administration of Trehalose in Patients With Parkinson Disease Trehalose - Parkinson Disease | Phase 4 | Unknown | Neuromed IRCCS | 20 | 2022-05-01 | 2022-05-02 |
| Mycose AdminiStration for HealIng Alzheimer NEuropathy (MASHIANE) Trehalose - Alzheimer Disease | Phase 1 | Unknown | Mashhad University of Medical Sciences | 20 | 2020-08-20 | 2020-12-11 |
| Inflammation Reduction by TREhalose AdminisTration Trehalose, Normal saline - Acute Coronary Syndrome | Phase 2 | Unknown | Mashhad University of Medical Sciences | 15 | 2020-08-20 | 2020-09-21 |
| Efficacy Of Oral Trehalose In Spinocerebellar Ataxia 3 Trehalose, Maltose - Spinocerebellar Ataxia Type 3 | Not applicable | Unknown | National University of Malaysia | 20 | 2020-02-24 | 2022-08-16 |
| Clinical Effects of Oral Trehalose In Patients With Spinocerebellar Ataxia 3 trehalose - Spinocerebellar Ataxia 3 | Not applicable | Completed | National University of Malaysia | 13 | 2018-03-07 | 2020-06-11 |
| Treatment of Oculopharyngeal Muscular Dystrophy With Trehalose Trehalose - Oculopharyngeal Muscular Dystrophy | Phase 2 | Withdrawn | Bioblast Pharma Ltd. | 2017-06-15 | 2020-01-13 | |
| Clinical Study of 12-week Trehalose Intake in Patients With Fatty Liver Disease Trehalose, Placebo - Non-alcoholic Fatty Liver | Not applicable | Completed | Samsung Medical Center | 39 | 2016-06-30 | 2019-01-30 |
| Trehalose as add-on Therapy in Bipolar Depression Trehalose, Maltose - Bipolar Disorder, Bipolar Depression | Phase 3 | Completed | Consorcio Centro de Investigación Biomédica en Red (CIBER) | 60 | 2016-06-01 | 2023-02-08 |
| A Study to Establish Safety and Maximum Tolerated Dose of IV Trehalose in Healthy Subjects Trehalose for IV Infusion, Saline 0.9% IV - Healthy Volunteer Subjects | Phase 1 | Completed | Bioblast Pharma Ltd. | 24 | 2016-03-01 | 2016-11-22 |
| Efficacy and Safety of a Treatment for Dry Eye Syndrome: Thealoz Thealoz, Vehicle - Moderate Dry Eye Syndrome | Phase 4 | Completed | Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA | 50 | 2012-12-01 | 2015-01-08 |
| Use of a Synthetic Macromolecule (Hydroxypropyl Cellulose ) and Trehalose as Additives for Oocyte Vitrification Synthetic macromolecule HPC and trehalose, SSS containing HSA and sucrose - Infertility | Not applicable | Completed | Instituto Valenciano de Infertilidad, IVI VALENCIA | 440 | 2012-11-01 | 2015-03-10 |
| Oral Trehalose Therapy to Reverse Arterial Aging in Middle-Aged and Older Adults Placebo, High-dose trehalose - Vascular Aging | Not applicable | Completed | University of Colorado, Boulder | 110 | 2012-05-01 | 2015-12-11 |
| Intermediate-Sized Expanded Access Study Trehalose - Amyotrophic Lateral Sclerosis | No longer available | Seelos Therapeutics, Inc. | 2025-09-02 |
Dry Eye Syndromes (4) · Cataract (2) · Machado-Joseph Disease (2) · Acute Coronary Syndrome (1) · Alzheimer Disease (1) · Amyotrophic Lateral Sclerosis (1) · Arteritis (1) · Bipolar Disorder (1) · Cerebellar Cognitive Affective Syndrome (1) · Crohn Disease (1) · Deglutition Disorders (1) · Diabetes Mellitus, Type 2 (1) · Infertility (1) · Inflammation (1) · Muscular Dystrophy, Oculopharyngeal (1)
Bioblast Pharma Ltd. (2) · Mashhad University of Medical Sciences (2) · National University of Malaysia (2) · Consorcio Centro de Investigación Biomédica en Red (CIBER) (1) · Democritus University of Thrace (1) · Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA (1) · Instituto Valenciano de Infertilidad, IVI VALENCIA (1) · Laboratorios Sophia S.A de C.V. (1) · Medical College of Wisconsin (1) · Neuromed IRCCS (1) · Samsung Medical Center (1) · San Giovanni Addolorata Hospital (1) · Seelos Therapeutics, Inc. (1) · Southern California College of Optometry at Marshall B. Ketchum University (1) · University of Colorado, Boulder (1)
United States (5) · Spain (3) · Canada (2) · Iran (2) · Malaysia (2) · Greece (1) · Italy (1) · Mexico (1)
Ana Cobo, PhD (1) · Bernard Brais, MD (1) · Douglas R Seals, PhD (1) · Eduard Vieta, MD,PhD (1) · Georgios Labiris, MD, Prof (1) · James D Berry, MD,MPH (1) · Maria Jesus Gonzalez, PhD (1) · Norlinah Mohamed Ibrahim, MRCP (1) · Rachelle E Kaplon, MS (1) · Sabrina Paganoni, MD,PhD (1) · Suma Babu, MD,MPH,MBBS (1) · William Hughes, Ph.D. (1)
UF1NS131791 (1)