132 completed, 40 recruiting, 25 unknown, 21 active not recruiting. 71 Phase 2, 58 Not applicable, 35 Phase 1, 32 Phase 3, 4 Phase 4.
Follow Spinocerebellar Degenerations: new trials by email Literature Review of Spinocerebellar Degenerations trials Research Report on Spinocerebellar Degenerations
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Umbilical Cord Mesenchymal Stem Cells Therapy (19#iSCLife®-SA) for Patients With Spinocerebellar Ataxia Intravenous infusion, Intrathecal injection, umbilical cord mesenchymal stem cell - Spinocerebellar Ataxia Type 1, Spinocerebellar Ataxia Type 2 | Phase 2 | Not yet recruiting | Sclnow Biotechnology Co., Ltd. | 45 | 2026-12-31 | 2026-04-23 |
| Multi-Modal Digital Monitoring of Disease Symptoms in Spinocerebellar Ataxia Spinocerebellar Ataxia (SCA) | Not yet recruiting | BioSensics | 25 | 2026-12-15 | 2026-10-01 | |
| GV101 for Friedreich's Ataxia (FA) Treatment GV101, Placebo - Friedreich's Ataxia | Phase 2 | Not yet recruiting | Graviton Bioscience Corporation | 48 | 2026-11-01 | 2026-10-15 |
| A Study to Evaluate the Efficacy and Safety of Subcutaneous Nomlabofusp in Subjects With Friedreich's Ataxia Nomlabofusp, Placebo - Friedreich Ataxia, Friedreich's Ataxia | Phase 3 | Recruiting | Larimar Therapeutics, Inc. | 150 | 2026-10-26 | 2026-10-09 |
| A Study to Learn How BIIB141 (Omaveloxolone) Affects the Health of Participants With Friedrich's Ataxia Who Took it During Pregnancy and/or During Breastfeeding and About the Health of Their Babies Omaveloxolone - Friedreich Ataxia | Recruiting | Biogen | 10 | 2026-10-26 | 2026-07-10 | |
| A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of ATI-105 in Healthy Adults ATI-105, Placebo - Friedreich Ataxia, Cardiomyopathies | Phase 1 | Not yet recruiting | Adjuvia Therapeutics, Inc. | 60 | 2026-10-26 | 2026-10-09 |
| A Study to Learn More About Friedrich's Ataxia in People Living in the Gulf Cooperation Council (GCC) Region of the World Friedreich's Ataxia | Not yet recruiting | Biogen | 40 | 2026-10-15 | 2026-10-21 | |
| Neoadjuvant Pembrolizumab and Porustobart in Resectable pMMR/MSS Colon Cancer Pembrolizumab, Porustobart - Colon Cancer | Phase 2 | Recruiting | Solstice Oncology, Inc. | 100 | 2026-09-30 | 2026-10-22 |
| Rare Disease Registry Database for Movement Disorders in Southern Anhui Province Motor Neuron Diseases, Spinocerebellar Ataxias | Recruiting | First Affiliated Hospital of Wannan Medical College | 180 | 2026-09-30 | 2026-10-23 | |
| Pivotal Study of N-acetyl-L-leucine for CACNA1A N-Acetyl-L-Leucine, Placebo - CACNA1A, Spinocerebellar Ataxia Type 6 | Phase 3 | Recruiting | IntraBio Inc | 60 | 2026-08-17 | 2026-09-08 |
| Long-Term Efficacy Study of Vatiquinone for the Treatment of Friedreich's Ataxia (FA) Vatiquinone - Friedreich's Ataxia | Phase 3 | Not yet recruiting | PTC Therapeutics | 120 | 2026-08-15 | 2026-08-14 |
| Optimizing Parameters of Transcranial Temporal Interference Stimulation for Spinocerebellar Ataxia Type 3 Transcranial Temporal Interference Stimulation (tTIS) - Spinocerebellar Ataxia Type 3 | Not applicable | Not yet recruiting | First Affiliated Hospital of Fujian Medical University | 24 | 2026-08-07 | 2026-09-01 |
| FOLFIRI Plus Bevacizuamb and QL1706 in Second-Line Treatment for mCRC FOLFIRI + bevacizumab + QL1706, FOLFIRI + bevacizumab - Colorectal Cancer Metastatic, Microsatellite Stable (MSS) Colorectal Cancer (CRC) | Phase 3 | Not yet recruiting | Sun Yat-sen University | 270 | 2026-07-30 | 2026-07-27 |
| Digital Outcome Assessment Using AI Active Gaming and Motion Capture in Friedreich Ataxia Laboratory validation session (VSimulator), Home-based active gaming assessment - Friedreich Ataxia | Not yet recruiting | University of Exeter | 40 | 2026-07-30 | 2026-07-28 | |
| Cardiac Output and Fatigue in Friedreich's Ataxia Aerobic Exercise - Friedreich's Ataxia | Not applicable | Recruiting | Scott Barbuto | 30 | 2026-07-15 | 2026-09-22 |
| Study of LX2006 Gene Therapy in Friedreich Ataxia Cardiomyopathy LX2006, Usual Care - Friedreich Ataxia, Cardiomyopathy, Secondary | Phase 2 | Recruiting | Lexeo Therapeutics | 26 | 2026-06-25 | 2026-09-02 |
| Interposed Nucleus aDBS for Ataxia Deep Brain Stimulation - Spinocerebellar Ataxia (SCA), Spinocerebellar Ataxia Type 6 | Not applicable | Recruiting | University of Florida | 5 | 2026-06-02 | 2026-07-20 |
| SCRT Based iTNT vs. LCRT Based TNT for MSS Locally Advanced Rectal Cancer short-course radiaotherapy, long-course chemoradiaothearpy, Capecitabine - Locally Advanced Rectal Cancer (LARC), MSS (Microsatellite Stable) | Phase 3 | Not yet recruiting | Fudan University | 612 | 2026-05-01 | 2026-04-24 |
| Deep Brain Stimulation for Spinocerebellar Ataxia Deep Brain Stimulation (DBS) - Spinocerebellar Ataxia (SCA), Spinocerebellar Ataxia Type 6 | Not applicable | Recruiting | University of California, San Francisco | 5 | 2026-04-27 | 2026-07-13 |
| A Study to Investigate the Safety, Pharmacokinetics, and Preliminary Efficacy of IDE574 Therapy in Adult Participants With Advanced Solid Tumors IDE574, Fulvestrant injection - ER+, HER 2- Breast Cancer, Non-small Cell Lung Cancer (NSCLC) | Phase 1 | Recruiting | IDEAYA Biosciences | 160 | 2026-03-17 | 2026-06-16 |
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Friedreich Ataxia (110) · Spinocerebellar Ataxias (92) · Ataxia (33) · Machado-Joseph Disease (32) · Cerebellar Ataxia (19) · Colorectal Neoplasms (12) · Cardiomyopathies (10) · Rare Diseases (9) · Multiple System Atrophy (7) · Neurodegenerative Diseases (6) · Genetic Diseases, Inborn (5) · Huntington Disease (5) · Movement Disorders (5) · Parkinson Disease (5)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (254) · Heredodegenerative Disorders, Nervous System (254) · Spinal Cord Diseases (254) · Brain Diseases (253) · Central Nervous System Diseases (252) · Nervous System Diseases (251) · Cerebellar Diseases (250) · Genetic Diseases, Inborn (249) · Neurodegenerative Diseases (248) · Neurologic Manifestations (126) · Dyskinesias (124) · Nutritional and Metabolic Diseases (113) · Metabolic Diseases (111) · Mitochondrial Diseases (106)
alpha-tocotrienol quinone (7) · idebenone (7) · omaveloxolone (6) · pembrolizumab (6) · Blood Specimen Collection (5) · Transcranial Magnetic Stimulation (4) · interferon gamma-1b (4) · Bevacizumab (3) · Deep Brain Stimulation (3) · Fluorouracil (3) · Immunoglobulins, Intravenous (3) · Leucovorin (3) · Lithium Carbonate (3) · Magnetic Resonance Spectroscopy (3) · Nivolumab (3)
Kissei Pharmaceutical Co., Ltd. (9) · Larimar Therapeutics, Inc. (8) · Biogen (7) · University of South Florida (7) · Children's Hospital of Philadelphia (6) · Institut National de la Santé Et de la Recherche Médicale, France (6) · National Institute of Neurological Disorders and Stroke (NINDS) (6) · PTC Therapeutics (6) · University of Florida (6) · Assistance Publique - Hôpitaux de Paris (5) · Chang Gung University (5) · Hospital de Clinicas de Porto Alegre (5) · Columbia University (4) · Design Therapeutics, Inc. (4) · IRCCS Eugenio Medea (4)
United States (123) · France (40) · Italy (34) · Germany (27) · Spain (22) · Australia (20) · Canada (16) · China (16) · Austria (15) · Brazil (15) · United Kingdom (14) · Belgium (13) · Netherlands (12) · Taiwan (12) · Japan (11)
Theresa Zesiewicz, MD (5) · David Lynch, MD, PhD (4) · Alberto Benussi, MD (3) · Barbara Borroni, MD (3) · David Lynch, MD (3) · Magdy Shenouda, M.D. (3) · Susan Perlman, MD (3) · Alessandro Filla, MD (2) · Alexandra Durr, MD, PhD (2) · Arnold Munnich, M.D. (2) · Carlos Gordon, Prof. (2) · Cherie Marvel, PhD (2)
PMID 40739200, PMID 17562928, PMID 21779958, PMID 24780882, PMID 31937586, PMID 34115419, PMID 42307907, PMID 15313841, PMID 15365159, PMID 15496622, PMID 16055926, PMID 16193476, PMID 16267188, PMID 16501573, PMID 16849828, PMID 16900450, PMID 17098887, PMID 17597328, PMID 17605047, PMID 17826341, PMID 17957230, PMID 18378516, PMID 18853458, PMID 19387333, PMID 20090835, PMID 20599042, PMID 20697044, PMID 21392622, PMID 22003934, PMID 22491195, PMID 22633670, PMID 22744651, PMID 23151076, PMID 23707147, PMID 24399647, PMID 25434572, PMID 25449974, PMID 25773989, PMID 26297649, PMID 26321318, PMID 26377379, PMID 26417459, PMID 26480849, PMID 26644294, PMID 26943780, PMID 27389519, PMID 27839651, PMID 27848087, PMID 28168524, PMID 28365204
2025 (5), 2017 (2), 2019 (2), 2008 (1), R01DC016275 (1), R01NS072248 (1), R21NS085491 (1), R21NS094946 (1), R21NS125546 (1), R61HL151355 (1), U01NS106670 (1), UL1TR000064 (1)