18 completed. 18 Phase 2, 3 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 18 | Completed 18 |
| Phase 1 | 3 | Completed 3 |
| Phase 3 | 2 | Completed 2 |
Follow Speech Disorders: new trials by email Literature Review of Speech Disorders trials Research Report on Speech Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Remotely Supervised Transcranial Direct Current Stimulation (tDCS) for Primary Progressive Aphasia (PPA) Transcranial Direct Current Stimulation (tDCS), Word-Naming Activity - Primary Progressive Aphasia | Phase 2 | Completed | NYU Langone Health | 11 | 2022-12-24 | 2024-09-19 |
| Dopaminergic Therapy for Frontotemporal Dementia Patients Rotigotine 4Mg/24Hrs Patch, Rotigotine 6Mg/24Hrs Patch, Placebo - Frontotemporal Dementia, Dementia | Phase 2 | Completed | I.R.C.C.S. Fondazione Santa Lucia | 75 | 2021-06-03 | 2024-10-22 |
| Effects of Ecopipam or Placebo in Adults With Stuttering (Speak Freely) Ecopipam, Placebo - Childhood-Onset Fluency Disorder (Stuttering) | Phase 2 | Completed | Emalex Biosciences Inc. | 68 | 2020-10-22 | 2026-09-23 |
| Speech Entrainment for Aphasia Recovery SET (Speech Entrainment Therapy) 3 weeks, SET (Speech Entrainment Therapy) 4.5 weeks, SET (Speech Entrainment Therapy) 6 weeks - Aphasia, Aphasia Non Fluent | Phase 2 | Completed | Medical University of South Carolina | 80 | 2020-08-21 | 2025-11-14 |
| Treating Primary Progressive Aphasia (PPA) Using High-definition tDCS high-definition transcranial direct current stimulation, modified constraint-induced language therapy - Primary Progressive Aphasia | Phase 2 | Completed | University of Pennsylvania | 76 | 2020-08-17 | 2026-10-19 |
| Intranasal Inhalations of M2 Macrophage Soluble Factors in Children With Developmental Speech Disorders Bioactive Factors, Produced by M2 Type Macrophages (M2-BFs). - Language Delay, Language; Developmental Disorder, Expressive | Phase 1 / Phase 2 | Completed | Russian Academy of Medical Sciences | 14 | 2020-02-01 | 2022-05-02 |
| Transcranial Magnetic Stimulation and Constraint Induced Language Therapy for Chronic Aphasia Active TMS, Sham TMS, CILT - Aphasia | Phase 2 | Completed | H. Branch Coslett | 86 | 2019-03-28 | 2025-10-14 |
| PCT for Speech, Language, and Cognitive Intervention in Stroke Patients PCT, Workbooks - Aphasia, Acquired | Phase 2 | Completed | The Learning Corp | 36 | 2019-03-18 | 2020-07-27 |
| Brief Behavioral Treatment for Anxiety in Young Children Parent-Led Exposure Therapy, Treatment As Usual - Obsessive-compulsive Disorder, Social Phobia | Phase 1 / Phase 2 | Completed | University of South Florida | 58 | 2014-01-01 | 2016-10-06 |
| Evaluating the Results of Physician and Parent Decisions to Treat Selective Mutism With Fluoxetine Fluoxetine - Selective Mutism, Social Anxiety | Phase 2 | Completed | Michigan State University | 6 | 2014-01-01 | 2022-05-18 |
| Brain Stimulation and Aphasia Treatment Activa Dose II Real tDCS, Activa Dose II Sham tDCS - Aphasia | Phase 2 | Completed | University of South Carolina | 74 | 2012-04-01 | 2019-08-20 |
| Effect of Verb Network Strengthening Treatment (VNeST) on Lexical Retrieval in Aphasia Verb Network Strengthening Treatment - Aphasia | Phase 2 | Completed | US Department of Veterans Affairs | 11 | 2011-03-01 | 2015-06-09 |
| Randomised Controlled Treatment Study of Selective Mutism Stimulus fading procedures, Guidance on defocused communication - Selective Mutism | Phase 2 | Completed | Regionsenter for barn og unges psykiske helse | 24 | 2009-06-01 | 2014-06-20 |
| Percutaneous Recanalization in Ischemic Stroke Management (PRIISM): A Feasibility Clinical Study MindFrame System - Ischemic Stroke | Phase 2 | Completed | MindFrame, Inc. | 40 | 2009-03-01 | 2012-07-26 |
| A Study to Assess the Efficacy and Safety of Pagoclone for Adults With Stuttering pagoclone, placebo - Stuttering | Phase 2 / Phase 3 | Completed | Endo USA Inc., a Keenova Therapeutics Company | 321 | 2009-02-01 | 2012-08-28 |
| Effect of Repetitive Transcranial Magnetic Stimulation on Language in Alzheimer's Disease Repetitive Transcranial Magnetic Coil Stimulation (rTMS) - Alzheimer's Disease, Aphasia | Phase 2 | Completed | The New York Memory Services | 12 | 2008-12-01 | 2014-01-28 |
| Augmenting Language Therapy for Aphasia: Levodopa levodopa/carbidopa, Placebo comparator - Nonfluent Aphasia, Stroke | Phase 2 / Phase 3 | Completed | Shirley Ryan AbilityLab | 36 | 2007-10-01 | 2013-12-25 |
| Treating Intention In Aphasia: Neuroplastic Substrates Word-finding with intention component, Word-finding with no intention component - Aphasia, Cerebrovascular Accident | Phase 1 / Phase 2 | Completed | University of Florida | 14 | 2007-03-01 | 2012-05-03 |
Aphasia (11) · Stroke (4) · Aphasia, Primary Progressive (3) · Language (3) · Mutism (3) · Aphasia, Broca (2) · Central Nervous System Diseases (2) · Communication Disorders (2) · Dementia (2) · Ischemic Stroke (2) · Language Disorders (2) · Stuttering (2) · Alzheimer Disease (1) · Anxiety Disorders (1)
Pathological Conditions, Signs and Symptoms (18) · Signs and Symptoms (18) · Nervous System Diseases (17) · Neurobehavioral Manifestations (17) · Neurologic Manifestations (17) · Communication Disorders (16) · Language Disorders (16) · Mental Disorders (8) · Brain Diseases (7) · Central Nervous System Diseases (6) · Neurodevelopmental Disorders (6) · Behavior (4) · Cardiovascular Diseases (4) · Cerebrovascular Disorders (4)
Fluoxetine (1) · Methods (1) · SET protein, human (1) · Therapeutics (1) · Transcranial Direct Current Stimulation (1) · carbidopa, levodopa drug combination (1) · ecopipam (1) · pagoclone (1) · rotigotine (1)
Emalex Biosciences Inc. (1) · Endo USA Inc., a Keenova Therapeutics Company (1) · H. Branch Coslett (1) · I.R.C.C.S. Fondazione Santa Lucia (1) · Medical University of South Carolina (1) · Michigan State University (1) · MindFrame, Inc. (1) · NYU Langone Health (1) · Regionsenter for barn og unges psykiske helse (1) · Russian Academy of Medical Sciences (1) · Shirley Ryan AbilityLab (1) · The Learning Corp (1) · The New York Memory Services (1) · US Department of Veterans Affairs (1) · University of Florida (1)
United States (14) · Germany (1) · Italy (1) · Norway (1) · Russia (1)
Alessandro Martorana, MD, PhD (1) · Alexander A Ostanin, MD, PhD (1) · Atul R Mahableshwarkar, MD, DFAPA (1) · Bruce Crosson, PhD (1) · Elena R Chernykh, MD, PhD (1) · Gayatri Devi, MD (1) · Giacomo Koch, MD (1) · H. Branch Coslett, MD (1) · Hanne Kristensen, MD, PhD (1) · Jed Magen, DO (1) · Joel Sanchez, MD (1) · John Carlson, PhD (1) · Julius Fridriksson, PhD (1) · Justin Barterian, MA (1) · Leigh Charvet, PhD (1)
PMID 25267381, PMID 29357099, PMID 30128538, PMID 32878377, PMID 33643204, PMID 40809903
R01DC007387 (1), R01DC016800 (1), U01DC011739 (1), U01DC017521 (1)