6 recruiting, 4 completed, 3 unknown, 1 active not recruiting. 7 Not applicable, 1 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 7 | Recruiting 3, Active not recruiting 1, Completed 1, Enrolling by invitation 1, Unknown 1 |
| Phase 2 | 1 | Completed 1 |
| Phase 3 | 1 | Completed 1 |
Follow Small Vessel Cerebrovascular Disease: new trials by email Literature Review of Small Vessel Cerebrovascular Disease trials Research Report on Small Vessel Cerebrovascular Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Small Vessel Disease and Cerebral Infarct Healing InErvation Via Limb Distant Adaptation Medical-grade ischemic preconditioning training instrument, Standard Treatment - Stroke, Small Vessel Cerebrovascular Disease | Not applicable | Enrolling by invitation | Second Affiliated Hospital, Zhejiang University, School of Medicine | 80 | 2026-02-01 | 2026-03-31 |
| Targeting Neurovascular Coupling in Cognitive Decline Via Nitrate-Based Supplementation Beetroot Juice - Active, Beetroot Juice - Placebo - Small Vessel Cerebrovascular Disease, Diabete Mellitus | Not applicable | Recruiting | University of Coimbra | 25 | 2025-05-09 | 2026-01-09 |
| Telecoached Exercise Intervention for Connectivity Enhancement in Small Vessel Disease (TELECONNECT-SVD) Physical activity - Lacunar Stroke, Small Vessel Cerebrovascular Disease | Not applicable | Recruiting | University of L'Aquila | 60 | 2025-05-02 | 2025-12-02 |
| Antiplatelet Therapy and Endothelial-stabilizing Agents in Cerebral Small Vessel Diseases Clopidogrel, Aspirin, Cilostazol + Isosorbide Mononitrate - Stroke, Ischemic, Small Vessel Cerebrovascular Disease | Recruiting | The First Affiliated Hospital with Nanjing Medical University | 300 | 2024-12-20 | 2025-03-28 | |
| Optimal Target Low-density Lipoprotein Cholesterol Level for Small Vessel Occlusion Stroke Statins and/or Ezetimibe, PCSK9 inhibitor - Ischemic Stroke, Small Vessel Cerebrovascular Disease | Not applicable | Recruiting | Seoul National University Hospital | 4016 | 2024-10-04 | 2026-09-11 |
| Intensive Blood Pressure Control in Ischaemic Stroke Patients With Severe Cerebral Small Vessel Disease Intensive treatment, Standard treatment - Small Vessel Cerebrovascular Disease, Stroke | Not applicable | Unknown | The University of Hong Kong | 104 | 2023-01-09 | 2023-02-03 |
| Remote Ischemic Conditioning With Novel Optical Sensor Feedback Device in Acute Ischemic Stroke Remote Ischemic Conditioning with Novel Optical Sensor Feedback Device, Sham Remote Ischemic Conditioning with Novel Optical Sensor Feedback Device - Stroke, Acute Ischemic, Small Vessel Cerebrovascular Disease | Not applicable | Completed | University of Alberta | 51 | 2022-07-07 | 2024-08-28 |
| The Imperial Comprehensive Cognitive Assessment in Cerebrovascular Disease (IC3) MRI brain, Blood tests, cognitive assessments - Stroke, Stroke (CVA) or TIA | Recruiting | Imperial College London | 700 | 2021-12-01 | 2023-06-01 | |
| Hyperintense: Midlife Hypertension and the Brain Antihypertensive medication withdrawal - Hypertension, Small Vessel Cerebrovascular Disease | Unknown | Radboud University Medical Center | 130 | 2021-07-06 | 2023-12-19 | |
| Coronary Microvascular Angina Cardiac Magnetic Resonance Imaging (CorCMR) Trial CMR results disclosed, CMR performed but results not disclosed - Microvascular Angina, Angina Pectoris | Not applicable | Active not recruiting | NHS National Waiting Times Centre Board | 280 | 2021-02-09 | 2025-01-30 |
| Prognosis of Cerebral Small Vessel Disease Cerebral Amyloid Angiopathy, Small Vessel Cerebrovascular Disease | Recruiting | Insel Gruppe AG, University Hospital Bern | 900 | 2020-12-01 | 2023-03-08 | |
| Evaluation of Small Vessel Disease by 3D-rotational Angiography Stroke, Acute, Stroke | Completed | Chinese University of Hong Kong | 24 | 2020-11-05 | 2026-02-24 | |
| Development of a Global Scale Assessing Impairment in Cerebral Small Vessel Diseases Small Vessel Cerebrovascular Disease | Unknown | Assistance Publique - Hôpitaux de Paris | 150 | 2019-12-15 | 2020-07-07 | |
| Oxford Haemodynamic Adaptation to Reduce Pulsatility Trial Sildenafil, Cilostazol, Placebo - Small Vessel Cerebrovascular Disease | Phase 2 | Completed | University of Oxford | 75 | 2019-07-11 | 2025-11-19 |
| Start or STop Anticoagulants Randomised Trial (SoSTART) Apixaban, Rivaroxaban, Edoxaban - Intracranial Hemorrhages, Intracranial Hemorrhage, Hypertensive | Phase 3 | Completed | University of Edinburgh | 203 | 2018-03-28 | 2022-04-08 |
Cerebral Small Vessel Diseases (15) · Stroke (5) · Ischemic Stroke (4) · Alzheimer Disease (1) · Angina Pectoris (1) · Angina, Stable (1) · Aphasia (1) · Atrial Fibrillation (1) · Atrial Flutter (1) · CADASIL (1) · Cardiovascular Diseases (1) · Cerebral Amyloid Angiopathy (1) · Cerebral Amyloid Angiopathy, Familial (1) · Cerebrovascular Disorders (1) · Charcot-Marie-Tooth disease, Type 1F (1)
Brain Diseases (15) · Central Nervous System Diseases (15) · Nervous System Diseases (15) · Vascular Diseases (15) · Cardiovascular Diseases (14) · Cerebrovascular Disorders (14) · Pathological Conditions, Signs and Symptoms (5) · Stroke (4) · Pathologic Processes (3) · Arterial Occlusive Diseases (2) · Arteriosclerosis (2) · Brain Infarction (2) · Heart Diseases (2) · Infarction (2) · Intracranial Arterial Diseases (2)
Cilostazol (2) · Acenocoumarol (1) · Aspirin (1) · Clopidogrel (1) · Dabigatran (1) · Exercise (1) · Hematologic Tests (1) · Phenindione (1) · Rivaroxaban (1) · Sildenafil Citrate (1) · Warfarin (1) · apixaban (1) · edoxaban (1) · isosorbide-5-mononitrate (1)
Assistance Publique - Hôpitaux de Paris (1) · Chinese University of Hong Kong (1) · Imperial College London (1) · Insel Gruppe AG, University Hospital Bern (1) · NHS National Waiting Times Centre Board (1) · Radboud University Medical Center (1) · Second Affiliated Hospital, Zhejiang University, School of Medicine (1) · Seoul National University Hospital (1) · The First Affiliated Hospital with Nanjing Medical University (1) · The University of Hong Kong (1) · University of Alberta (1) · University of Coimbra (1) · University of Edinburgh (1) · University of L'Aquila (1) · University of Oxford (1)
United Kingdom (4) · China (2) · Hong Kong (2) · Canada (1) · France (1) · Italy (1) · Netherlands (1) · Portugal (1) · South Korea (1) · Switzerland (1)
Colin Berry, MBChB, PhD (1) · David J Seiffge, Prof, MD (1) · Dr A Webb, DPhil (1) · Frank-Erik de Leeuw (1) · Mahesh Kate (1) · Rustam Al-Shahi Salman, MA PhD FRCP (1) · Seung-Hoon Lee, MD, PhD (1) · Yiu Ming Bonaventure IP, MBChB, MRCP (1)
PMID 34022170, PMID 34487722, PMID 34746425, PMID 36700520, PMID 38000822, PMID 38832504, PMID 39614707, PMID 39806582, PMID 41091964, PMID 41214345, PMID 41997615, PMID 42047198, PMID 42858287
2016 (1)