19 completed, 11 unknown, 6 withdrawn, 2 recruiting. 10 Phase 2, 10 Phase 4, 7 Not applicable, 7 Phase 1, 6 Phase 3.
Follow isosorbide-5-mononitrate: new trials by email Literature Review of isosorbide-5-mononitrate trials Research Report on isosorbide-5-mononitrate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Vasodilator Therapy With Isosorbide Mononitrate or Diltiazem to Reduce Vasotoxicity in Patients With Gastrointestinal Cancer Receiving Fluoropyrimidine Therapy Biospecimen Collection, Capecitabine, Diltiazem Hydrochloride - Malignant Digestive System Neoplasm | Phase 1 / Phase 2 | Recruiting | Mayo Clinic | 60 | 2026-04-30 | 2026-06-02 |
| Isosorbide Mononitrate and Butylphthalide to Reduce the Risk of Disability in Patients With Acute Lacunar Stroke (IMPACT) Isosorbide Mononitrate, Butylphthalide, Isosorbide Mononitrate Placebo - Stroke, Lacunar, Stroke, Acute Ischemic | Phase 3 | Not yet recruiting | Beijing Tiantan Hospital | 3156 | 2025-12-01 | 2025-11-26 |
| Antiplatelet Therapy and Endothelial-stabilizing Agents in Cerebral Small Vessel Diseases Clopidogrel, Aspirin, Cilostazol + Isosorbide Mononitrate - Stroke, Ischemic, Small Vessel Cerebrovascular Disease | Recruiting | The First Affiliated Hospital with Nanjing Medical University | 300 | 2024-12-20 | 2025-03-28 | |
| Cervical Ripening With Misoprostol vs Isosorbide Mononitrate ; A Parallel -Arm Randomized Controlled Trial Misoprostol 25 µg Vaginal, Isosorbide Mononitrate - Cervical Ripening | Not applicable | Active not recruiting | Raid M. Al-Ani | 80 | 2024-01-01 | 2025-08-13 |
| Nitric Oxide Donor Isosorbide Mono Nitrate for Cervical Ripening in Induction of Labor isosorbide mononitrate, Placebos - Induction of Labor Affected Fetus / Newborn | Phase 4 | Completed | ahmed nagy shaker ramadan | 160 | 2023-12-01 | 2024-08-22 |
| The Effect of Oral Isosorbide Mononitrate Therapy on Umbilical Artery Doppler Resistance Index in Pregnancies With Intrauterine Growth Restriction: Prospective Randomized Control Trial Isosorbid mononitrate, Placebo - Intrauterine Growth Restriction | Phase 4 | Completed | Ain Shams University | 46 | 2022-06-08 | 2023-04-10 |
| Uterine Artery Doppler Changes After Vaginal Administration of Isosorbide Mononitrate In Patients With URPL isosorbide mononitrate, Placebo - Recurrent Pregnancy Loss | Early Phase 1 | Unknown | Al-Azhar University | 60 | 2022-05-01 | 2022-04-22 |
| Efficacy and Safety of Wen Xin Granules for the Treatment of Unstable Angina Pectoris Wen Xin granule, Clopidogrel Hydrogen Sulfate 75 MG Oral Tablet, Atorvastatin Calcium - Coronary Heart Disease, Unstable Angina | Phase 4 | Unknown | Guang'anmen Hospital of China Academy of Chinese Medical Sciences | 502 | 2021-03-01 | 2021-01-25 |
| Pharmacokinetics Trial of Isosorbide Mononitrate 0.5% Gel for Intra Anal Application in Healthy Subjects Isosorbide mononitrate - Pharmacokinetics, Healthy Subjects | Phase 1 | Withdrawn | Biolab Sanus Farmaceutica | 2020-12-20 | 2021-02-01 | |
| Isosorbide Mononitrate in Induction of Labour Isosorbide Mononitrate 40 MG, Isosorbide Mononitrate 60 MG, Misoprostol - Labor Fast | Early Phase 1 | Unknown | Aljazeera Hospital | 130 | 2020-07-21 | 2020-07-23 |
| Different Anti-Spastic Therapy Strategies After CABG Using Radial Artery Grafts Nicorandil 5mg tid, Diltiazem 180mg qd, Isosorbide Mononitrate 50mg qd - Coronary Artery Bypass Graft, Radial Artery Grafts | Phase 4 | Completed | Ruijin Hospital | 150 | 2020-06-02 | 2026-07-09 |
| the Effect of Isosorbide Mononitrate in Reducing Pain During Cooper Intrauterine Device Insertion Isosorbide mononitrate, placebo - IUD Insertion Pain | Phase 3 | Completed | Cairo University | 110 | 2020-04-15 | 2021-01-20 |
| Safety and Efficacy of the Effect of Isosorbide Mononitrate in Reducing Pain During Levonorgestrel-releasing Intrauterine Device Insertion Isosorbide Mononitrate 40 MG, Placebo - Contraception | Phase 3 | Unknown | Cairo University | 88 | 2020-03-30 | 2020-03-17 |
| Headache Provocation of People Who Are Unable to Have Headache Isosorbide Mononitrate 60 MG - Headache, Healthy | Not applicable | Completed | Danish Headache Center | 58 | 2019-12-02 | 2021-03-25 |
| Multiomics After Headache Provocation of People Who Are Unable to Have Headache Isosorbide Mononitrate 60 MG Extended Release Oral Tablet [Imdur], Blood sample - Headache, Healthy | Not applicable | Completed | Danish Headache Center | 58 | 2019-10-10 | 2021-03-25 |
| Isosorbide Mononitrate For Anti-Vascular Endothelial Growth Factor (VEGF) Induced Kidney Injury Isosorbide Mononitrate, Placebo oral tablet - Kidney Injury, Proteinuria | Phase 2 | Terminated | The University of Texas Health Science Center, Houston | 9 | 2019-09-26 | 2022-08-03 |
| Using Isosorbide Mononitrate in Reducing Time in Induction of Labor in Post Date Women Isosorbide mononitrate, Misoprostol - Induction of Labor | Phase 2 | Unknown | Abdelrahman Ali Fadel Youssef Mohamed | 100 | 2019-03-03 | 2019-03-12 |
| Pain Relief During IUD Insertion in Women Delivered Only by Elective Cesarean Section Misoprostol, Placebos, isosorbide mononitrate - IUD Insertion Complication | Not applicable | Unknown | Assiut University | 113 | 2018-09-01 | 2018-07-16 |
| Nitric Oxide Donor Isosorbide Mono Nitrate for Induction of Labor With Pre-labor Rupture of Membranes isosorbide mononitrate, Placebo - Induction of Labor Affected Fetus / Newborn, Rupture of Membranes Prior to Onset of Labor | Phase 3 | Completed | ahmed nagy shaker ramadan | 140 | 2018-08-01 | 2020-06-23 |
| Intravaginal Isosorbide Mononitrate in Addition to Misoprostol Versus Misoprostol Only for Induction of Labor Isosorbide Mononitrate 40 MG to study group - Induction of Labor | Phase 1 / Phase 2 | Unknown | Dina Yahia Mansour | 50 | 2018-01-01 | 2018-08-07 |
Showing 20 of 41. Sign in to see all of them.
Hypertension (4) · Cerebral Small Vessel Diseases (3) · Coronary Artery Disease (3) · Coronary Disease (2) · Fissure in Ano (2) · Headache (2) · Ischemic Stroke (2) · Abortion, Missed (1) · Angina, Stable (1) · Angina, Unstable (1) · Bone Diseases (1) · Cognitive Dysfunction (1) · Diabetes Mellitus, Type 2 (1) · Fetal Growth Retardation (1) · Fetal Membranes, Premature Rupture (1)
Cairo University (3) · Danish Headache Center (3) · Ain Shams University (2) · Assiut University (2) · Biolab Sanus Farmaceutica (2) · Jun Li (2) · ahmed nagy shaker ramadan (2) · Abdelrahman Ali Fadel Youssef Mohamed (1) · Adrian Hernandez (1) · Al-Azhar University (1) · Aljazeera Hospital (1) · Baker Heart Research Institute (1) · Bayer (1) · Beijing Tiantan Hospital (1) · Benha University (1)
Egypt (10) · United States (6) · Denmark (3) · China (2) · United Kingdom (2) · Australia (1) · Brazil (1) · Germany (1) · Iraq (1) · Spain (1)
Jes Olesen, Professor (2) · Jie Wang, MD (2) · Ahmed N Shaker, MD (1) · Ahmed Walid Anwar Murad (1) · Bronwyn A Kingwell, PhD (1) · Dina Y. Mansour, MD (1) · Dmitriy G Lisovetz, MD, CMedSc (1) · Edward Jude, MD, MRCP (1) · Emma Katrine Hansen, Doctor (1) · Eugene Braunwald, MD (1) · Gilberto De Nucci, PhD (1)
PMID 20432394, PMID 20531008, PMID 20567177, PMID 20681275, PMID 22019563, PMID 23303884, PMID 27480425, PMID 27847338, PMID 21130977, PMID 22719784, PMID 23173251, PMID 26142341, PMID 26549714, PMID 26972437, PMID 27491230, PMID 28588021, PMID 29444778, PMID 32150314, PMID 33458819, PMID 33652160, PMID 34774099, PMID 34847709, PMID 35299288, PMID 40123490, PMID 8694046
2015 (1), 2016 (1), U10HL084904 (1)