14 completed, 9 unknown, 7 recruiting, 3 active not recruiting. 8 Phase 2, 7 Not applicable, 4 Phase 3, 1 Phase 1.
Follow Cerebral Amyloid Angiopathy: new trials by email Literature Review of Cerebral Amyloid Angiopathy trials Research Report on Cerebral Amyloid Angiopathy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Application of Digital Twins' Technology in Patients Who Had a Stroke, With Moyamoya Disease and With Cerebral Amyloid Angiopathy (CAA) During the Secondary Prevention Phase: A Proof of Concept Using a Randomized Control Trial (Clinical Study 6, STRATIF-AI Project) AI, healthy dialogue - Stroke, Moyamoya Disease | Not applicable | Recruiting | Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta | 20 | 2026-10-01 | 2026-08-28 |
| Jiedu Huayu Oral Prescription in the Treatment of Intracranial Hemorrhage Associated With Cerebral Amyloid Angiopathy Jiedu Huayu Oral Prescription, Placebo - Cerebral Amyloid Angiopathy | Phase 3 | Recruiting | Beijing Tiantan Hospital | 436 | 2026-01-30 | 2026-09-30 |
| Colchicine for the Prevention of Recurrence in Cerebral Amyloid Angiopathy RElated IntraCerebral Hemorrhage Colchicine 0.5mg, Matching placebo - Cerebral Amyloid Angiopathy, Intracerebral Hemorrhage Lobar | Phase 2 | Recruiting | Huashan Hospital | 80 | 2025-06-18 | 2025-06-26 |
| Dilated Perivascular Spaces in the Dentate Nucleus on MRI in Patients With Hypertensive Angiopathy or Cerebral Amyloid Angiopathy Hypertensive Arteriopathy, Cerebral Amyloid Angiopathy | Completed | Centre Hospitalier Universitaire de Nīmes | 72 | 2025-04-01 | 2026-05-29 | |
| Stimulating Amyloid Clearance in Cerebral Amyloid Angiopathy XYWAV, gammaCore Sapphire - Cerebral Amyloid Angiopathy | Phase 2 | Enrolling by invitation | Leiden University Medical Center | 60 | 2025-03-27 | 2026-02-24 |
| ApoE Genotyping Analysis in Patients With Suspected Non-haemorrhagic Amyloid Angiopathy Amyloid Angiopathy | Completed | Centre Hospitalier Universitaire de Nīmes | 100 | 2025-02-01 | 2026-06-18 | |
| Effect of the Mediterranean Diet in Patients Affected by CADASIL and Cerebral Amyloid Angiopathy. Mediterranean Diet with Extra Virgin Olive Oil, Mediterranean Diet with Walnuts, Low-Fat Control Diet - Cerebral Amyloid Angiopathy, CAA - Cerebral Amyloid Angiopathy | Recruiting | Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta | 86 | 2024-10-10 | 2026-09-01 | |
| A Study of AMDX-2011P in Participants With CAA AMDX-2011P - Cerebral Amyloid Angiopathy | Phase 2 | Recruiting | Amydis Inc. | 25 | 2024-07-09 | 2026-02-13 |
| A Phase 2 Trial of ALN-APP in Patients With Cerebral Amyloid Angiopathy Placebo, ALN-APP - Cerebral Amyloid Angiopathy | Phase 2 | Active not recruiting | Alnylam Pharmaceuticals | 210 | 2024-05-17 | 2026-10-20 |
| Safety, Tolerability and Efficacy of NPI-001 in Patients With Hereditary Cystatin C Amyloid Angiopathy (HCCAA) NACA - Hereditary Cystatin C Amyloid Angiopathy (HCCAA), Hemorrhage Brain | Phase 2 | Active not recruiting | Arctic Therapeutics | 15 | 2024-04-03 | 2026-07-21 |
| Brain Hemorrhage and Functional Outcome in Stroke Patients With CAA Features on Pre-thrombolysis MRI Treated With Intravenous Thrombolysis (Thrombolysis in CAA) ( Thromb in CAA ) None, pure observational study - Hemorrhage, Cerebral Amyloid Angiopathy | Completed | Centre Hospitalier Universitaire de Nīmes | 15 | 2022-10-02 | 2025-12-10 | |
| Periventricular White Matter Hyperintensities in Cerebral Amyloid Angiopathy and Hypertensive Arteriopathy None, pure observational study - Cerebral Amyloid Angiopathy, Hypertensive Arteriopathy | Completed | Centre Hospitalier Universitaire de Nīmes | 315 | 2022-09-05 | 2025-12-04 | |
| MRI-markers to Monitor Small Vessel Disease Dynamics in the Prognosis of Small Vessel Disease-associated, Cerebrovascular Events Combined 3- and 7 Tesla-MRI - Intracerebral Hemorrhage, CAA - Cerebral Amyloid Angiopathy | Unknown | Insel Gruppe AG, University Hospital Bern | 60 | 2022-07-01 | 2023-03-17 | |
| Cerebellar Superficial Siderosis in Cerebral Amyloid Angiopathy None, pure observational study - Cerebral Amyloid Angiopathy, Siderosis | Completed | Centre Hospitalier Universitaire de Nīmes | 111 | 2022-06-01 | 2025-12-04 | |
| Coach Pilot Study: Assessing Cognitive Function and Related Small Vessel Disease Markers After Intracerebral Hemorrhage Cerebral Amyloid Angiopathy, Intracerebral Hemorrhage | Terminated | Leiden University Medical Center | 2 | 2022-04-03 | 2024-11-18 | |
| Safety and Efficacy of Remote Ischemic Conditioning on Cerebral Amyloid Angiopathy. (RIC-CAA) Remote ischemic conditioning - Cerebral Amyloid Angiopathy | Not applicable | Unknown | Capital Medical University | 30 | 2022-01-20 | 2022-01-26 |
| Enpowering Progression Risk of Cerebral Amyloid Angiopathy Cerebral Amyloid Angiopathy, CAA - Cerebral Amyloid Angiopathy | Completed | Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta | 200 | 2021-11-01 | 2026-03-27 | |
| Remote Ischemic Conditioning for Cerebral Amyloid Angiopathy-related Intracerebral Hemorrhage Remote ischemic conditioning - Intracerebral Hemorrhage Lobar, Cerebral Amyloid Angiopathy | Not applicable | Unknown | Capital Medical University | 30 | 2021-02-24 | 2021-06-16 |
| the Safety and Efficacy of Antiplatelet Therapy in Patients of CAA Aspirin/Clopidogrel - Cerebral Amyloid Angiopathy | Unknown | Shenzhen Second People's Hospital | 43 | 2021-02-20 | 2021-02-08 | |
| Detailed Clinical and MRI Characteristics in Primary Non-traumatic Convexity Subarachnoid Haemorrhage Elderly Patients. usual care - Cerebral Amyloid Angiopathy, Subarachnoid Hemorrhage | Completed | Centre Hospitalier Universitaire de Nīmes | 50 | 2021-02-01 | 2021-04-01 |
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Cerebral Hemorrhage (12) · Stroke (6) · Alzheimer Disease (5) · Cerebral Amyloid Angiopathy, Familial (5) · Intracranial Hemorrhages (3) · CADASIL (2) · Cerebral Small Vessel Diseases (2) · Cognitive Dysfunction (2) · Hemorrhage (2) · Ischemic Stroke (2) · Amyloid angiopathy (1) · Dementia (1) · Disease Progression (1) · Hemorrhagic Stroke (1)
Amyloidosis (38) · Brain Diseases (38) · Cardiovascular Diseases (38) · Central Nervous System Diseases (38) · Cerebral Arterial Diseases (38) · Cerebrovascular Disorders (38) · Intracranial Arterial Diseases (38) · Metabolic Diseases (38) · Nutritional and Metabolic Diseases (38) · Proteostasis Deficiencies (38) · Vascular Diseases (38) · Nervous System Diseases (37) · Pathologic Processes (18) · Pathological Conditions, Signs and Symptoms (18) · Hemorrhage (13)
Aspirin (1) · Clopidogrel (1) · Colchicine (1) · Diet, Mediterranean (1) · Magnetic Resonance Imaging (1) · Magnetic Resonance Spectroscopy (1) · Minocycline (1) · NC 758 (1) · Olive Oil (1) · Pharmaceutical Preparations (1) · Positron-Emission Tomography (1) · Ticagrelor (1) · caficrestat (1) · florbetapir (1) · ponezumab (1)
Centre Hospitalier Universitaire de Nīmes (7) · Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta (4) · Leiden University Medical Center (3) · National Taiwan University Hospital (3) · Capital Medical University (2) · Insel Gruppe AG, University Hospital Bern (2) · University Hospital, Toulouse (2) · Alnylam Pharmaceuticals (1) · Amydis Inc. (1) · Anna Olczak (1) · Arctic Therapeutics (1) · Auburn University (1) · Beijing Tiantan Hospital (1) · Bellus Health Inc. - a GSK company (1) · Huashan Hospital (1)
France (10) · China (5) · Netherlands (5) · United States (5) · Italy (4) · Canada (3) · Switzerland (3) · Taiwan (3) · Germany (2) · United Kingdom (2) · Australia (1) · Iceland (1) · Poland (1)
David J Seiffge, Prof, MD (2) · Amal Kaddoumi, PhD (1) · Anna Olczak, PhD (1) · Christian Opherk, MD (1) · Dimitri Renard, MD (1) · Dongsheng Fan, doctor (1) · Ellis van Etten, MD, PhD (1) · Frank Wollenweber, MD (1) · Jennifer Linn, MD (1) · Marco Duering, MD (1) · Martin Dichgans, MD (1)
PMID 28570698, PMID 31958082, PMID 32394598, PMID 34000646, PMID 35972776, PMID 36241843, PMID 36442282, PMID 36878206, PMID 37277877, PMID 37620982, PMID 38228908, PMID 38920025, PMID 40626372, PMID 40932118, PMID 41813043, PMID 42085649
2023 (2), 2015 (1), 2019 (1)