20 completed, 11 unknown, 8 recruiting, 4 terminated. 17 Not applicable, 8 Phase 2, 3 Phase 1, 2 Phase 4, 1 Phase 3.
Follow Small Fiber Neuropathy: new trials by email Literature Review of Small Fiber Neuropathy trials Research Report on Small Fiber Neuropathy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Magnetic Brain Stimulation in Small Fiber Neuropathy Transcranial Magnetic Stimulation, Transcranial Magnetic Stimulation Sham - Small Fiber Neuropathy | Not applicable | Recruiting | Maastricht University Medical Center | 124 | 2026-09-01 | 2026-09-21 |
| Pilot Study to Evaluate Changes in Intra-Epidermal Nerve Fiber Density (IENFD) in Patients With Small-Fiber Neuropathy Evoke SCS system - Small Fiber Neuropathy | Not applicable | Enrolling by invitation | TriCity Research Center | 10 | 2026-07-01 | 2026-07-15 |
| Effect of Tirzepatide on Diabetic Peripheral Sensorimotor Neuropathy Tirzepatide 2.5mg weekly, all standard of care to diabetic patient besides tirzepatide - Neuropathy, Small Fiber, Diabete Mellitus | Phase 4 | Not yet recruiting | Post Graduate Institute of Medical Education and Research, Chandigarh | 40 | 2026-07-01 | 2026-07-15 |
| Safety and Tolerability Study of ST-503 for Refractory Pain Due to Peripheral Neuropathy (Small Fiber Predominant, SFN) ST-503, Sham (No Treatment) - Chronic Neuropathic Pain | Phase 1 / Phase 2 | Recruiting | Sangamo Therapeutics | 27 | 2025-12-04 | 2026-06-01 |
| Diagnostic Accuracy of The Water Immersion Wrinkle Test for Small Fiber Neuropathy Small-Fiber Neuropathy, Dysautonomia | Completed | HOSPITAL BRITANICO DE BUENOS AIRES | 38 | 2024-11-01 | 2025-12-08 | |
| Effects of Virtual Reality-Based Balance Training Compared to Conventional Balance Training to Reduce Risk of Fall in Patients With Diabetic Peripheral Neuropathy: A Randomized Control Trial Virtual Reality-Based Balance Training, Conventional Balance Training - Diabetic Peripheral Neuropathy, Balance | Not applicable | Completed | Foundation University Islamabad | 30 | 2024-07-10 | 2025-01-27 |
| IVIG in Painful Sensory Neuropathy Intravenous immunoglobulin, Placebo - Sensory Neuropathy, Small Fiber Neuropathy | Phase 4 | Not yet recruiting | Sorlandet Hospital HF | 20 | 2024-02-01 | 2023-12-27 |
| Analysis of Cutaneous Nerve Biopsies in Gastrointestinal Motility Disorders Skin biopsy - Small Fiber Neuropathy, Gastrointestinal Dysmotility | Not applicable | Withdrawn | Johns Hopkins University | 2023-12-22 | 2023-11-13 | |
| IVIG in the Treatment of Autoimmune Small Fiber Neuropathy With TS-HDS, FGFR-3, or Plexin D1 Antibodies Panzyga IVIG, Placebo - Small Fiber Neuropathy, Autoimmune Small Fiber Neuropathy | Phase 2 | Recruiting | Endeavor Health | 20 | 2023-12-15 | 2026-01-09 |
| Characterization and Prediction of Early Onset Diabetic Peripheral Neuropathy Skin biopsies with quantification of intra-epidermal nerve fibre density, Perception Threshold Tracking, Thermal perception thresholds - Neuropathy, Diabetic, Small Nerve Fiber Neuropathy | Recruiting | Aalborg University Hospital | 200 | 2023-10-01 | 2024-06-28 | |
| Comparison of Histamine and Local Heating for Evoking the Axon-reflex Flare Response in Diabetes Histamin-induced axon-reflex flare response, Local heating-induced axon-reflex flare response, 2-point discrimination tasks - Diabetes, Diabetes Mellitus, Type 1 | Completed | Aalborg University Hospital | 40 | 2023-06-17 | 2024-07-30 | |
| Chronic Pain Rehabilitation in Patients With Small Fiber Neuropathy Chronic pain rehabilitation: exposure in vivo, Chronic pain rehabilitation: graded activity, Chronic pain rehabilitation: acceptance and commitment therapy - Small Fiber Neuropathy | Not applicable | Unknown | Academisch Ziekenhuis Maastricht | 10 | 2023-03-09 | 2023-04-05 |
| Diabetic Small Fiber Neuropathy: Clinical, Electrophysiological and Neurosonographic Study Clinical Evaluation/Questionnaires, Nerve Conduction Study, Small fiber electrodiagnostic tests - Small Fiber Neuropathy, Diabetic Neuropathies | Completed | Tanta University | 45 | 2023-01-01 | 2024-04-10 | |
| Chronic Cough and Small Fiber Neuropathy Cough assessment, Neurological tests and cardiovascular tests, Skin biopsy - Chronic Cough, Type 2 Diabetes | Not applicable | Terminated | University Hospital, Toulouse | 7 | 2022-06-14 | 2026-06-01 |
| Diabetes, Falls, and Fractures Quantative Sensory Testing, NCStat-DPN-Check, Composite Autonomic Symptom Score 31 - Diabetic Peripheral Neuropathy, Diabetes | Completed | Aalborg University Hospital | 110 | 2022-05-06 | 2024-08-09 | |
| Reference Values of Intraepidermal Nerve Fiber Density in Children and Small Fiber Neuropathy in Neurodevelopmental Disorders Skin biopsy - Mitochondrial Diseases, Developmental Delay Disorder | Completed | Heinrich-Heine University, Duesseldorf | 203 | 2022-02-01 | 2025-11-28 | |
| Detection of Small Fiber Neuropathy Using Skin Properties Image processing of skin - Small Fiber Neuropathy | Recruiting | Brigham and Women's Hospital | 400 | 2021-07-01 | 2025-02-06 | |
| Small Fiber Assessment by Cutaneous Silent Period cutaneous silent period - Small Fiber Neuropathy | Unknown | Cairo University | 64 | 2021-04-27 | 2021-04-28 | |
| Cutaneous Silent Period Assessment in Primary Sjögren's Syndrome cutaneous silent period (CSP) measurement - Small Fiber Neuropathy, Primary Sjögren Syndrome | Completed | Marmara University | 72 | 2021-01-04 | 2022-05-19 | |
| Preventing Chemotherapy-induced Peripheral Neuropathy Using PRESIONA Exercise Program PRESIONA - Breast Neoplasm | Not applicable | Recruiting | Universidad de Granada | 25 | 2021-01-01 | 2025-11-18 |
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Diabetes Mellitus (8) · Pain (5) · Peripheral Nervous System Diseases (5) · Diabetic Neuropathies (4) · Neuralgia (4) · Fibromyalgia (3) · Chronic Pain (2) · Diabetes Mellitus, Type 1 (2) · Fabry Disease (2) · Mitochondrial Diseases (2) · Neuropathy, Painful (2) · Polyneuropathies (2) · Agnosia (1) · Arthritis, Rheumatoid (1)
Nervous System Diseases (47) · Neuromuscular Diseases (47) · Peripheral Nervous System Diseases (43) · Pathological Conditions, Signs and Symptoms (14) · Nutritional and Metabolic Diseases (13) · Signs and Symptoms (13) · Metabolic Diseases (12) · Neurologic Manifestations (12) · Endocrine System Diseases (10) · Glucose Metabolism Disorders (10) · Pain (5) · Diabetes Complications (4) · Muscular Diseases (4) · Musculoskeletal Diseases (4) · Brain Diseases (3)
Immunoglobulins, Intravenous (3) · Magnetic Resonance Imaging (2) · Nerve Conduction Studies (2) · Sodium Chloride (2) · ABX-1431 (1) · Absorptiometry, Photon (1) · Acceptance and Commitment Therapy (1) · Cold Temperature (1) · Diffusion Tensor Imaging (1) · Duloxetine Hydrochloride (1) · Lacosamide (1) · Neurologic Examination (1) · Physical Examination (1) · Pregabalin (1) · Saline Solution (1)
Academisch Ziekenhuis Maastricht (5) · Aalborg University Hospital (3) · Assistance Publique - Hôpitaux de Paris (2) · Johns Hopkins University (2) · RWTH Aachen University (2) · Abide Therapeutics (1) · Actinogen Medical (1) · Beth Israel Deaconess Medical Center (1) · Biogen (1) · Brigham and Women's Hospital (1) · Cairo University (1) · Endeavor Health (1) · Erasmus Medical Center (1) · Foundation University Islamabad (1) · HOSPITAL BRITANICO DE BUENOS AIRES (1)
United States (11) · Netherlands (9) · France (6) · Germany (5) · Denmark (4) · Canada (2) · Egypt (2) · Italy (2) · Spain (2) · Switzerland (2) · Turkey (Türkiye) (2) · Argentina (1) · Australia (1) · Belgium (1) · Bulgaria (1)
Catharina G Faber, MD, PhD (2) · Ahmet Hoke (1) · AlShaimaa S Khalil, MD (1) · Amel Karaa, MD (1) · Andrea Maier (1) · Bill Ketelbey, MD (1) · Christopher Gibbons, MD (1) · Felix Distelmaier (1) · Georg Dimcevski, MD, PhD (1) · Hebatallah R Rashad, Professor (1) · Irene Cantarero-Villanueva, PhD (1)
PMID 16190912, PMID 27215701, PMID 27363506, PMID 27439408, PMID 30649227, PMID 31705738, PMID 33766992, PMID 35079838, PMID 36192280, PMID 36300662, PMID 36437696, PMID 37152360, PMID 37515636, PMID 37568391, PMID 37921732, PMID 39606707
2017 (2), 2015 (1)