311 completed, 147 recruiting, 88 unknown, 57 terminated. 158 Phase 2, 137 Not applicable, 90 Phase 3, 88 Phase 1, 23 Phase 4.
Follow Polyneuropathies: new trials by email Literature Review of Polyneuropathies trials Research Report on Polyneuropathies
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase I/IIa Trial of scAAV1.tMCK.NTF3 for Treatment of CMT1A scAAV1.tMCK.NTF3 - Charcot-Marie-Tooth Neuropathy Type 1A | Phase 1 / Phase 2 | Withdrawn | Nationwide Children's Hospital | 2027-04-01 | 2026-07-29 | |
| A Study of Empasiprubart as Add-On Therapy to IVIg in Adult Participants With Guillain-Barré Syndrome Empasiprubart IV, Empasiprubart Placebo IV, Intravenous immunoglobulin (IVIg) - Guillain-Barré Syndrome (GBS) | Phase 2 | Not yet recruiting | argenx | 63 | 2026-12-01 | 2026-09-25 |
| Muscle MRI Fat Fraction Before Surgery to Predict Strength Recovery After Foot-Drop Surgery in Charcot-Marie-Tooth Disease Tibialis posterior tendon transfer, Individualized adjunct procedures for cavovarus deformity correction, Ankle-foot orthosis (AFO) - Foot Drop, Charcot-Marie-Tooth Disease Type 1A | Not yet recruiting | Peking University Third Hospital | 100 | 2026-12-01 | 2026-10-26 | |
| Clinical, Electrophysiological and Genetic Characteristics of Hereditary and Inflammatory Polyneuropathies in France Genetic and Inflammatory Polyneuropathies | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 1000 | 2026-11-01 | 2026-10-01 | |
| To Evaluate the Long-term Safety and Tolerability of Acoramidis in Participants With Newly Diagnosed ATTR-CM (ACT-EARLY OLE) Acoramidis (AG10) - Amyloidosis in Transthyretin (TTR), Amyloidosis, Familial | Phase 3 | Not yet recruiting | Eidos Therapeutics, a BridgeBio company | 250 | 2026-11-01 | 2026-08-11 |
| Peripheral Nerve Ultrasound in Children With Guillain-Barré Syndrome Guillain-Barre Syndrome | Not yet recruiting | Assiut University | 42 | 2026-10-10 | 2026-10-08 | |
| A Study Investigating Intravenous Human Normal Immune Globulin (IGIV) 10% KIg10 (QIVIGY) in Subjects With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) Immune globulin (human) 10% solution for intravenous administration - Chronic Inflammatory Demyelinating Polyneuropathy | Phase 3 | Recruiting | Kedrion S.p.A. | 161 | 2026-10-01 | 2026-09-11 |
| Multimodal Characterization of Movement Trajectories in Chronic Inflammatory Demyelinating Polyneuropathy Xsens motion suit - CIDP - Chronic Inflammatory Demyelinating Polyneuropathy | Not yet recruiting | Heinrich-Heine University, Duesseldorf | 50 | 2026-10-01 | 2026-10-20 | |
| Rare Disease Registry Database for Movement Disorders in Southern Anhui Province Motor Neuron Diseases, Spinocerebellar Ataxias | Recruiting | First Affiliated Hospital of Wannan Medical College | 180 | 2026-09-30 | 2026-10-23 | |
| Myocardial Changes in Pediatric Guillain-Barré Syndrome Myocardial Dysfunction, Guillain-Barre Syndrome | Not yet recruiting | Assiut University | 72 | 2026-09-26 | 2026-09-25 | |
| Comparative Effectiveness of Nursing Interventions: Using Buerger-Allen Exercises Versus Mechanical Compression Therapy on Lower Limb Perfusion and Peripheral Neuropathy Among Patients Undergoing Chemotherapy. mechanical compression therapy, Exercises - Polyneuropathies, Regional Blood Flow | Not applicable | Active not recruiting | Damanhour University | 100 | 2026-09-06 | 2026-09-30 |
| Single-Center Study Evaluating the Impact of Age on the Diagnostic Performance of the Sural-to-Radial Sensory Amplitude Ratio in Length-Dependent and Non-Length-Dependent Peripheral Polyneuropathies Retrospective Medical Record Review - Polyneuropathies, Electromyography | Not yet recruiting | Centre Hospitalier Universitaire de Nice | 180 | 2026-09-01 | 2026-07-24 | |
| Ultrasound-driven Stratification in CIDP Refractory CIDP, Standard-of-care treatment for CIDP - CIDP, Chronic Inflammation | Not yet recruiting | Centre Hospitalier Universitaire de Nice | 30 | 2026-09-01 | 2026-07-22 | |
| A Study to Assess the Correct Dose, Safety and Efficacy of Empasiprubart in Adolescent Participants Aged 12 to Less Than 18 Years With Chronic Inflammatory Demyelinating Polyradiculoneuropathy Empasiprubart IV - Chronic Inflammatory Demyelinating Polyradiculoneuropathy, CIDP (Chronic Inflammatory Demyelinating Polyradiculoneuropathy) | Phase 2 / Phase 3 | Not yet recruiting | argenx | 6 | 2026-09-01 | 2026-06-10 |
| Efficacy and Safety of Efgartigimod in the Treatment of Guillain-Barré Syndrome(GREAT) Intravenous immunoglobulin (IVIG), Efgartigimod Alfa-Fcab - Guillain-Barré Syndrome | Phase 2 | Not yet recruiting | Beijing Tiantan Hospital | 110 | 2026-09-01 | 2026-09-18 |
| Concurrent Training vs Soleus Push-Ups on Neurogenesis-Related Biomarkers in Diabetic Neuropathy Patients Concurrent Training, Soleus Push-ups - Diabetic Peripheral Neuropathy Type 2 | Not applicable | Not yet recruiting | Riphah International University | 99 | 2026-09-01 | 2026-06-30 |
| Everolimus bAsed caLcineurin inhibiTor frEe immunosuppRession oNe Year AfTer lIver transplantatiON (ALTERNATION) Everolimus, Tacrolimus or Cyclosporine - Liver Allograft, Liver Diseases | Phase 3 | Recruiting | Hannover Medical School | 150 | 2026-08-19 | 2026-10-05 |
| Postoperative Circulating Tumor DNA Monitoring in Stage I-III Driver-Mutant Colon Adenocarcinoma Longitudinal ctDNA-MRD NGS testing at scheduled postoperative time points - Colon Adenocarcinoma, Stage I Colon Cancer | Recruiting | Ruijin Hospital | 392 | 2026-08-14 | 2026-09-02 | |
| Cryotherapy, PGE2, NGF Levels and Pain After Endodontic Retreatment Intracanal cryotherapy, Room-temperature saline irrigation - Asymptomatic Apical Periodontitis, Endodontic Retreatment | Not applicable | Not yet recruiting | Alanya Alaaddin Keykubat University | 100 | 2026-08-01 | 2026-07-29 |
| Is Serum Irisin Level a Biomarker in Diabetic Polyneuropathy? Polyneuropathies, Diabetic Complications Neurological | Not yet recruiting | GÜLDEN ANATACA | 81 | 2026-07-30 | 2026-07-29 |
Showing 20 of 705. Sign in to see all of them.
Hereditary Sensory and Autonomic Neuropathies (174) · Polyradiculoneuropathy, Chronic Inflammatory Demyelinating (136) · Charcot-Marie-Tooth Disease (112) · Guillain-Barre Syndrome (95) · Spastic Paraplegia, Hereditary (49) · Peripheral Nervous System Diseases (34) · Breast Neoplasms (24) · Neuromuscular Diseases (24) · Amyloidosis (23) · Myasthenia Gravis (23) · Multiple Sclerosis (22) · Diabetic Neuropathies (18) · Pain (18) · Amyotrophic Lateral Sclerosis (17)
Nervous System Diseases (695) · Neuromuscular Diseases (681) · Peripheral Nervous System Diseases (671) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (398) · Neurodegenerative Diseases (392) · Genetic Diseases, Inborn (377) · Congenital Abnormalities (368) · Heredodegenerative Disorders, Nervous System (365) · Nervous System Malformations (353) · Pathological Conditions, Signs and Symptoms (345) · Pathologic Processes (275) · Immune System Diseases (262) · Disease Attributes (248) · Demyelinating Diseases (226)
Immunoglobulins, Intravenous (24) · Fulvestrant (10) · Alpelisib (9) · Everolimus (8) · Immunoglobulins (8) · Rituximab (8) · Blood Specimen Collection (7) · Saline Solution (7) · tanezumab (7) · Cetuximab (6) · Cyclophosphamide (6) · Dexamethasone (6) · Hizentra (6) · Nerve Growth Factor (6) · Exercise (5)
Pfizer (15) · Novartis Pharmaceuticals (14) · NYU Langone Health (13) · Assiut University (12) · Assistance Publique - Hôpitaux de Paris (10) · AstraZeneca (10) · argenx (10) · University of Aarhus (9) · Centre Hospitalier Universitaire de Nice (6) · Istituto Clinico Humanitas (6) · National Institute of Neurological Disorders and Stroke (NINDS) (6) · CSL Behring (5) · IRCCS Eugenio Medea (5) · Takeda (5) · Tongji Hospital (5)
United States (264) · France (115) · Germany (89) · Italy (88) · Spain (73) · United Kingdom (70) · China (59) · Canada (57) · Denmark (49) · Netherlands (48) · Belgium (37) · Japan (35) · Turkey (Türkiye) (33) · Australia (31) · Poland (31)
Horacio Kaufmann, MD (5) · Michael E Shy, MD (4) · Adeline Vanderver, MD (2) · Alejandra Gonzalez-Duarte, MD (2) · David Herrmann, MBBCh (2)
PMID 42578463, PMID 30936738, PMID 26554876, PMID 31353964, PMID 32107748, PMID 37460782, PMID 18178525, PMID 24327518, PMID 25519680, PMID 27424289, PMID 27494299, PMID 28672195, PMID 29023494, PMID 29115008, PMID 29383130, PMID 29846250, PMID 30558645, PMID 31101621, PMID 31533931, PMID 31831767, PMID 31882719, PMID 31894292, PMID 37395948, PMID 38353301, PMID 38507752, PMID 38729747, PMID 41491634, PMID 10411196, PMID 10540002, PMID 11232233, PMID 11344264, PMID 1135616, PMID 11382253, PMID 11383973, PMID 12084892, PMID 12235608, PMID 12437775, PMID 12473512, PMID 12671856, PMID 12851579, PMID 12959218, PMID 13211501, PMID 14564276, PMID 14610153, PMID 15607214, PMID 15610704, PMID 15680560, PMID 15703014, PMID 1577335, PMID 16267188
2025 (8), 2018 (7), 2023 (6), 2017 (5), 2019 (5), 2009 (4), 2016 (4), U54NS065712 (4), 2015 (3), 2008 (2), U01TR001263 (2), U54NS092091 (2), 2005 (1), 2014 (1), 5RC1NS068179-02 (1)