7 completed, 3 unknown, 2 recruiting, 2 terminated. 16 Phase 2, 3 Phase 3, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 16 | Completed 7, Unknown 3, Recruiting 2, Terminated 2, Withdrawn 2 |
| Phase 3 | 3 | Completed 1, Recruiting 1, Withdrawn 1 |
| Phase 1 | 1 | Completed 1 |
Follow Shock, Hemorrhagic: new trials by email Literature Review of Shock, Hemorrhagic trials Research Report on Shock, Hemorrhagic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparison of Early Proton Pump Inhibitor Initiation Versus Usual Care on Acute Kidney Injury in Hemorrhagic Shock Patients Protonix (Pantoprazole) 40 mg q 12 hrs for 2 days, Protonix (pantoprazole) 40 mg q 24 hrs for 2 days - Acute Kidney Injury | Phase 2 / Phase 3 | Recruiting | The University of Texas Health Science Center, Houston | 100 | 2024-09-07 | 2026-02-19 |
| CAlcium and VAsopressin Following Injury Early Resuscitation (CAVALIER) Trial Calcium Gluconate, Vasopressin, saline placebo - Trauma, Hemorrhage | Phase 2 | Recruiting | Jason Sperry | 1050 | 2024-06-30 | 2026-10-30 |
| Cold Stored Platelet in Hemorrhagic Shock Cold Stored Platelets (CSP), Standard Care - Trauma, Hemorrhage | Phase 2 | Completed | Jason Sperry | 200 | 2022-06-21 | 2024-12-18 |
| Prehospital Kcentra for Hemorrhagic Shock Prothrombin Complex Concentrate, Human, Placebo - Trauma Injury | Phase 2 | Unknown | Oregon Health and Science University | 166 | 2021-03-15 | 2023-12-15 |
| Emergency Preservation and Resuscitation (EPR) for Cardiac Arrest From Trauma Emergency preservation and resuscitation, Standard resuscitation - Cardiac Arrest From Trauma | Phase 2 | Terminated | University of Maryland, Baltimore | 20 | 2016-10-01 | 2026-06-16 |
| Use of Nitroglycerine to Improve Signs of Poor Peripheral Perfusion in Patients With Traumatic Hemorrhagic Shock Nitroglycerin patch 5mg, placebo - Hemorrhagic Shock | Phase 2 | Unknown | Assiut University | 100 | 2016-03-01 | 2017-08-01 |
| Pre-Hospital Use of Plasma for Traumatic Hemorrhage Plasma, Normal saline - Shock, Hemorrhagic | Phase 2 / Phase 3 | Withdrawn | Virginia Commonwealth University | 2014-11-01 | 2016-02-23 | |
| Control of Major Bleeding After Trauma Study Type AB plasma, Crystalloid fluid (standard of care for resuscitation) - Trauma, Hemorrhagic Shock | Phase 2 | Terminated | Denver Health and Hospital Authority | 144 | 2014-04-07 | 2019-01-08 |
| Phase 2c Dose Comparison Study of MP4OX in Trauma MP4OX, Control - Trauma, Hemorrhagic Shock | Phase 2 | Withdrawn | Sangart | 2013-12-01 | 2013-10-31 | |
| Polydatin Injectable (HW6) for Shock Treatment Polydatin Injectable - Shock, Hemorrhagic, Shock, Traumatic | Phase 2 | Unknown | Neptunus Pharmaceuticals Inc. | 240 | 2013-02-01 | 2013-01-30 |
| Field Trial of Hypotensive Versus Standard Resuscitation for Hemorrhagic Shock After Trauma 0.9% Sodium Chloride 250 mL bolus, 0.9% Sodium Chloride 2000 mL bolus - Blunt Trauma, Penetrating Wound | Phase 2 | Completed | University of Washington | 192 | 2012-03-01 | 2015-01-13 |
| Phase IIb Study of MP4OX in Traumatic Hemorrhagic Shock Patients MP4OX, Saline - Shock, Hemorrhagic, Shock, Traumatic | Phase 2 | Completed | Sangart | 348 | 2011-05-01 | 2013-08-22 |
| Vasopressin in Traumatic Hemorrhagic Shock Study Vasopressin, Saline placebo - Shock, Hypovolemia | Phase 2 / Phase 3 | Completed | Volker Wenzel | 64 | 2010-07-01 | 2014-11-05 |
| Phase IIa Study of MP4OX in Traumatic Hemorrhagic Shock Patients MP4OX, Ringers Lactate solution - Shock, Hemorrhagic, Shock, Traumatic | Phase 2 | Completed | Sangart | 51 | 2009-12-01 | 2013-08-19 |
| The Trauma- Formula-Driven Versus Lab-Guided Study (TRFL Study) Massive transfusion protocol, Standard of care - Hemorrhagic Shock, Trauma Coagulopathy | Phase 1 / Phase 2 | Completed | Sunnybrook Health Sciences Centre | 70 | 2009-07-01 | 2011-12-02 |
| Resuscitative Endocrinology: Single-dose Clinical Uses for Estrogen-Traumatic Hemorrhagic Shock (RESCUE - Shock) Premarin IV, Placebo - Hemorrhagic Shock | Phase 2 | Completed | University of Texas Southwestern Medical Center | 50 | 2009-07-01 | 2020-03-19 |
Wounds and Injuries (11) · Hemorrhage (7) · Acidosis, Lactic (3) · Shock, Traumatic (3) · Diabetes Insipidus (2) · Hemostatic Disorders (2) · Shock (2) · Accidental Injuries (1) · Acute Kidney Injury (1) · Heart Arrest (1) · Hypovolemia (1) · Multiple Trauma (1) · Shock, Septic (1) · Wounds, Nonpenetrating (1)
Pathologic Processes (16) · Pathological Conditions, Signs and Symptoms (16) · Shock (14) · Hemorrhage (9) · Acid-Base Imbalance (3) · Acidosis (3) · Cardiovascular Diseases (3) · Female Urogenital Diseases (3) · Female Urogenital Diseases and Pregnancy Complications (3) · Kidney Diseases (3) · Male Urogenital Diseases (3) · Metabolic Diseases (3) · Nutritional and Metabolic Diseases (3) · Urogenital Diseases (3) · Urologic Diseases (3)
Saline Solution (4) · PEG-hemoglobin (3) · Sodium Chloride (3) · Standard of Care (3) · maleimide-polyethylene glycol-modified hemoglobin, MP4 (3) · Resuscitation (2) · Vasopressins (2) · polynitroxylated pegylated hemoglobin (2) · Calcium Gluconate (1) · Factor IX (1) · Nitroglycerin (1) · Pantoprazole (1) · Ringer's Lactate (1)
Sangart (3) · Jason Sperry (2) · Assiut University (1) · Denver Health and Hospital Authority (1) · Neptunus Pharmaceuticals Inc. (1) · Oregon Health and Science University (1) · Sunnybrook Health Sciences Centre (1) · The University of Texas Health Science Center, Houston (1) · University of Maryland, Baltimore (1) · University of Texas Southwestern Medical Center (1) · University of Washington (1) · Virginia Commonwealth University (1) · Volker Wenzel (1)
United States (10) · Germany (4) · France (3) · South Africa (3) · United Kingdom (3) · Australia (2) · Austria (2) · Brazil (2) · Canada (2) · Israel (2) · New Zealand (2) · Norway (2) · Switzerland (2) · Belgium (1) · Colombia (1)
Karim Brohi, MD (3) · Bruce D Spiess, MD, FAHA (1) · David Hoyt, MD (1) · Ernest E Moore, MD (1) · Frank Guyette, MD, MPH (1) · Frank V. Booth, BCh, FACS (1) · Gordon D Rubenfeld, MD, MSc (1) · Hassan Kotb, professor (1) · Homer C Tien, MD, MSc (1) · Jason Sperry, MD (1) · Jason Sperry, MD, MPH (1) · Martin A Schreiber, MD (1) · Myron L Weisfeldt, MD (1) · Prof. Dr. Volker Wenzel, M.Sc., M.D. (1) · Rob Schmickers (1)
PMID 26220293, PMID 22071998, PMID 23857856, PMID 25784527, PMID 25947955, PMID 28183347, PMID 30032977, PMID 31851290, PMID 38708880, PMID 40766812, PMID 40983029
U01HL077863 (1)