16 terminated. 16 Phase 3, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 16 | Terminated 16 |
| Phase 2 | 2 | Terminated 2 |
Follow Respiratory Insufficiency: new trials by email Literature Review of Respiratory Insufficiency trials Research Report on Respiratory Insufficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Furosemide as Supportive Therapy for COVID-19 Respiratory Failure Nebulized Furosemide, Nebulized Saline - Covid19, Respiratory Failure | Phase 2 / Phase 3 | Terminated | Dr. John Muscedere | 40 | 2021-04-16 | 2023-12-11 |
| VA CoronavirUs Research and Efficacy Studies-1 Convalescent Plasma, Masked Saline Placebo - COVID-19 | Phase 3 | Terminated | VA Office of Research and Development | 75 | 2020-11-16 | 2022-09-23 |
| Azithromycin Added to Hydrochloroquine in Patients Admitted to Intensive Care With COVID-19: Randomised Controlled Trial Azithromycin, Hydroxychloroquine, Placebo - COVID-19, Respiratory Failure | Phase 3 | Terminated | Frantisek Duska, MD, PhD | 3 | 2020-05-13 | 2020-11-06 |
| COVID-19-associated ARDS Treated With Dexamethasone: Alliance Covid-19 Brasil III Dexamethasone - Coronavirus Infection, Pneumonia, Viral | Phase 3 | Terminated | Hospital Sirio-Libanes | 299 | 2020-04-13 | 2020-08-07 |
| Efficacy and Safety of FP-1201-lyo (Interferon Beta-1a) in Patients Having Acute Respiratory Distress Syndrome (ARDS) Interferon beta-1a, Placebo - Respiratory Distress Syndrome, Adult | Phase 3 | Terminated | Faron Pharmaceuticals Ltd | 301 | 2015-12-23 | 2020-03-30 |
| Early Stage Amyotrophic Lateral Sclerosis Phrenic Stimulation phenique nerve stimulation NeurX™ (Synapse Biomedical), sham phrenic nerve stimulation - Amyotrophic Lateral Sclerosis, Respiratory Insufficiency | Phase 3 | Terminated | Assistance Publique - Hôpitaux de Paris | 74 | 2012-09-01 | 2015-12-22 |
| Dexmedetomidine Pharmacokinetics-pharmacodynamics in Mechanically Ventilated Children With Single-organ Respiratory Failure dexmedetomidine, Vital signs, blood sampling - Respiratory Failure | Phase 3 | Terminated | University Hospital, Ghent | 1 | 2009-12-01 | 2011-10-04 |
| A Study to Evaluate the Efficacy and Safety of IV Peramivir in Addition to Standard of Care Compared to Standard of Care Alone in Adults and Adolescents Who Are Hospitalized Due to Influenza Peramivir+SOC, Placebo+SOC - Cough, Sore Throat | Phase 3 | Terminated | BioCryst Pharmaceuticals | 405 | 2009-11-01 | 2015-02-12 |
| Comparative Evaluation of Albumin and Starch Effects in Acute Lung Injury (ALI) 5% human albumin, 6% hetastarch - Lung Injury, Acute (ALI), Respiratory Distress Syndrome, Acute (ARDS) | Phase 3 | Terminated | Emory University | 31 | 2009-01-01 | 2017-04-28 |
| Enteral Glutamine in Critical Illness Glutamine - Critical Illness, Sepsis | Phase 2 / Phase 3 | Terminated | Christiana Care Health Services | 20 | 2006-05-01 | 2008-03-13 |
| Early Tracheotomy Versus Prolonged Endotracheal Intubation in Intensive Care Unit (ICU) Patients early tracheotomy, prolonged endotracheal intubation - Respiratory Insufficiency | Phase 3 | Terminated | Gustave Roussy, Cancer Campus, Grand Paris | 468 | 2002-04-01 | 2005-08-25 |
| Effects of Inhaled Nitric Oxide in the Treatment of Acute Hypoxemic Respiratory Failure (AHRF) in Pediatrics Nitrogen gas, inhaled nitric oxide - Respiratory Insufficiency, Anoxemia | Phase 3 | Terminated | Mallinckrodt | 55 | 2002-01-01 | 2016-07-26 |
| Early Surfactant to Reduce Use of Mechanical Breathing in Low Birth Weight Infants Early surfactant, Standard practice - Infant, Newborn, Respiratory Distress Syndrome | Phase 3 | Terminated | NICHD Neonatal Research Network | 61 | 2000-05-01 | 2015-06-08 |
| Early Inhaled Nitric Oxide for Respiratory Failure in Newborns Inhaled Nitric Oxide, Standard iNO therapy - Infant, Newborn, Hypertension, Pulmonary | Phase 3 | Terminated | NICHD Neonatal Research Network | 302 | 1998-08-01 | 2017-09-26 |
| Minimal Breathing Support and Early Steroids to Prevent Chronic Lung Disease in Extremely Premature Infants (SAVE) Minimal mechanical ventilation management, Routine mechanical ventilation management, Dexamethasone - Bronchopulmonary Dysplasia, Respiratory Distress Syndrome | Phase 3 | Terminated | NICHD Neonatal Research Network | 220 | 1998-02-01 | 2015-06-08 |
| Inhaled Nitric Oxide Study for Respiratory Failure in Newborns Inhaled nitric oxide, Placebo - Infant, Newborn, Hypertension, Pulmonary | Phase 3 | Terminated | NICHD Neonatal Research Network | 235 | 1995-10-01 | 2017-09-26 |
Respiratory Distress Syndrome (7) · COVID-19 (3) · Hypertension, Pulmonary (2) · Meconium Aspiration Syndrome (2) · Methemoglobinemia (2) · Persistent Fetal Circulation Syndrome (2) · Pneumonia, Aspiration (2) · Respiratory Distress Syndrome, Newborn (2) · Acute Lung Injury (1) · Amyotrophic Lateral Sclerosis (1) · Bronchopulmonary Dysplasia (1) · Coronavirus Infections (1) · Cough (1) · Critical Illness (1)
Respiration Disorders (16) · Respiratory Tract Diseases (16) · Lung Diseases (10) · Infections (8) · Respiratory Tract Infections (7) · Pneumonia (5) · RNA Virus Infections (5) · Virus Diseases (5) · Coronaviridae Infections (4) · Nidovirales Infections (4) · Pathological Conditions, Signs and Symptoms (4) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (3) · Coronavirus Infections (3) · Female Urogenital Diseases and Pregnancy Complications (3) · Infant, Newborn, Diseases (3)
Dexamethasone (2) · Azithromycin (1) · Blood Specimen Collection (1) · COVID-19 Serotherapy (1) · Calcium Dobesilate (1) · Dexmedetomidine (1) · Endothelium-Dependent Relaxing Factors (1) · Glutamine (1) · Hydroxychloroquine (1) · Hydroxyethyl Starch Derivatives (1) · Interferon beta-1a (1) · Nitrogen (1) · Saline Solution (1) · Serum Albumin, Human (1) · Sodium Chloride (1)
NICHD Neonatal Research Network (4) · Assistance Publique - Hôpitaux de Paris (1) · BioCryst Pharmaceuticals (1) · Christiana Care Health Services (1) · Dr. John Muscedere (1) · Emory University (1) · Faron Pharmaceuticals Ltd (1) · Frantisek Duska, MD, PhD (1) · Gustave Roussy, Cancer Campus, Grand Paris (1) · Hospital Sirio-Libanes (1) · Mallinckrodt (1) · University Hospital, Ghent (1) · VA Office of Research and Development (1)
United States (9) · Belgium (3) · Canada (3) · Czechia (3) · France (3) · Brazil (2) · Germany (2) · United Kingdom (2) · Argentina (1) · Bosnia and Herzegovina (1) · Bulgaria (1) · Chile (1) · Finland (1) · Hungary (1) · India (1)
Avroy A. Fanaroff, MD (4) · Edward F. Donovan, MD (4) · Lu-Ann Papile, MD (4) · Richard A. Ehrenkranz, MD (4) · Seetha Shankaran, MD (4) · Sheldon B. Korones, MD (4) · Barbara J. Stoll, MD (3) · Charles R. Bauer, MD (3) · David K. Stevenson, MD (3) · Waldemar A. Carlo, MD (3) · William Oh, MD (3) · James A. Lemons, MD (2) · Jon E. Tyson, MD MPH (2) · Mary Wearden, MD (2) · A. Johnston, MD (1)
PMID 10802492, PMID 11150359, PMID 11416871, PMID 12219057, PMID 14510322, PMID 14993550, PMID 17307536, PMID 25115871, PMID 27751553, PMID 30523161, PMID 32065831, PMID 32641163, PMID 32876695, PMID 35229691, PMID 36927455, PMID 37560085, PMID 40400480, PMID 9036320, PMID 9190553
M01RR000070 (4), M01RR000750 (4), M01RR000997 (4), M01RR001032 (4), M01RR006022 (4), M01RR008084 (4), U10HD021385 (4), U10HD021397 (4), U10HD021415 (4), U10HD027853 (4), U10HD027871 (4), U10HD027880 (4), U10HD027881 (4), U10HD027904 (4), U10HD034167 (4)