14 terminated. 14 Phase 2, 2 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 14 | Terminated 14 |
| Phase 1 | 2 | Terminated 2 |
| Phase 3 | 2 | Terminated 2 |
Follow Respiratory Insufficiency: new trials by email Literature Review of Respiratory Insufficiency trials Research Report on Respiratory Insufficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Steroid Treatment for Elimination of Rebound Obstruction From Intranasal Decongestants Oxymetazoline + Triamcinolone - Nasal Obstruction, Chronic Rhinitis | Phase 2 | Terminated | Washington University School of Medicine | 3 | 2025-11-10 | 2026-03-23 |
| Furosemide as Supportive Therapy for COVID-19 Respiratory Failure Nebulized Furosemide, Nebulized Saline - Covid19, Respiratory Failure | Phase 2 / Phase 3 | Terminated | Dr. John Muscedere | 40 | 2021-04-16 | 2023-12-11 |
| Study to Evaluate the Safety, Tolerability, and Efficacy of BGE-175 in Hospitalized Adults With Coronavirus Disease 2019 (COVID-19) That Are Not in Respiratory Failure BGE-175, Placebo - Covid19 | Phase 2 | Terminated | BioAge Labs, Inc. | 194 | 2021-03-18 | 2023-07-03 |
| A Study of Micro Dose Ambrisentan in Hospitalized Patients With Respiratory Insufficiency Due to COVID-19 Ambrisentan, Placebo - Covid19, Hypoxemia | Phase 2 | Terminated | Noorik Biopharmaceuticals AG | 88 | 2021-02-08 | 2023-03-21 |
| Pemziviptadil (PB1046), a Long-acting, Sustained Release Human VIP Analogue, Intended to Provide Clinical Improvement to Hospitalized COVID-19 Patients at High Risk for Rapid Clinical Deterioration and Acute Respiratory Distress Syndrome (ARDS). Pemziviptadil (PB1046), Low Dose (10 mg) Control - Acute Respiratory Distress Syndrome, Coronavirus | Phase 2 | Terminated | PhaseBio Pharmaceuticals Inc. | 54 | 2020-07-15 | 2020-12-11 |
| Self-Propelled Versus Standard Percutaneous Endoscopic Gastrojejunostomy(PEG-J); RCT PEG-J placement - Feeding Tube | Phase 2 | Terminated | Johns Hopkins University | 19 | 2013-09-06 | 2017-05-17 |
| Self-Propelled Percutaneous Endoscopic GastroJejunostomy (PEG-J) PEGJ tube - GERD | Phase 2 | Terminated | Johns Hopkins University | 7 | 2012-01-01 | 2017-03-31 |
| Inhaled Prostaglandin E1 (IPGE1) for Hypoxemic Respiratory Failure (NHRF) Aerosolized Normal Saline, Inhaled PGE1 - Prematurity, Respiratory Insufficiency | Phase 2 | Terminated | NICHD Neonatal Research Network | 7 | 2011-11-01 | 2019-04-24 |
| Study of Sildenafil to Treat Newborns With Persistent Pulmonary Hypertension Intravenous Sildenafil, Placebo - Persistent Pulmonary Hypertension, Respiratory Failure | Phase 2 | Terminated | University of Colorado, Denver | 3 | 2011-07-01 | 2019-02-01 |
| Study on the Effects of Sitaxsentan on Airway Remodeling in Patients With Severe Asthma sitaxentan, placebo - Effect of Sitaxsentan on Airway Remodeling in Severe Asthma | Phase 2 | Terminated | Institut National de la Santé Et de la Recherche Médicale, France | 17 | 2009-11-01 | 2012-05-10 |
| Study of Polyester Implants for the Treatment of External Nasal Valve Collapse (NVC) Polyester Implants - Nasal Alar Collapse, Bilateral | Phase 1 / Phase 2 | Terminated | Medtronic Xomed, Inc. | 45 | 2008-04-01 | 2012-01-06 |
| Level of Continuous Positive Airway Pressure (CPAP) in Preterm Infants After Extubation (L-CPAP Study) Nasal CPAP, level 7 to 9 cmH2O, Nasal CPAP, level 4 to 6 cmH2O - Respiratory Insufficiency of Prematurity | Phase 2 | Terminated | Hamilton Health Sciences Corporation | 23 | 2007-07-01 | 2009-02-10 |
| Enteral Glutamine in Critical Illness Glutamine - Critical Illness, Sepsis | Phase 2 / Phase 3 | Terminated | Christiana Care Health Services | 20 | 2006-05-01 | 2008-03-13 |
| Inhaled Nitric Oxide in Neonates With Elevated A-a DO2 Gradients Not Requiring Mechanical Ventilation nitric oxide for inhalation, Oxygen - Lung Disease, Hypoxemia | Phase 1 / Phase 2 | Terminated | Mallinckrodt | 7 | 2002-05-01 | 2016-10-19 |
COVID-19 (4) · Respiratory Distress Syndrome (3) · Gastroesophageal Reflux (2) · Gastroparesis (2) · Hypertension, Pulmonary (2) · Hypoxia (2) · Nasal Obstruction (2) · Pancreatitis (2) · Stroke (2) · Acidosis, Respiratory (1) · Airway Obstruction (1) · Airway Remodeling (1) · Asthma (1) · Cardiovascular Diseases (1)
Respiration Disorders (14) · Respiratory Tract Diseases (14) · Lung Diseases (8) · Pathological Conditions, Signs and Symptoms (7) · Infections (5) · Signs and Symptoms (5) · Vascular Diseases (5) · Cardiovascular Diseases (4) · Coronaviridae Infections (4) · Nidovirales Infections (4) · Pneumonia, Viral (4) · RNA Virus Infections (4) · Respiratory Tract Infections (4) · Virus Diseases (4)
Endothelium-Dependent Relaxing Factors (1) · Glutamine (1) · Inhalation (1) · Nitric Oxide (1) · Oxygen (1) · Oxymetazoline (1) · Propylene Glycol (1) · Saline Solution (1) · Sildenafil Citrate (1) · Triamcinolone (1) · VIP-ELP fusion molecule PB1046 (1) · ambrisentan (1) · asapiprant (1) · sitaxsentan (1)
Johns Hopkins University (2) · BioAge Labs, Inc. (1) · Christiana Care Health Services (1) · Dr. John Muscedere (1) · Hamilton Health Sciences Corporation (1) · Institut National de la Santé Et de la Recherche Médicale, France (1) · Mallinckrodt (1) · Medtronic Xomed, Inc. (1) · NICHD Neonatal Research Network (1) · Noorik Biopharmaceuticals AG (1) · PhaseBio Pharmaceuticals Inc. (1) · University of Colorado, Denver (1) · Washington University School of Medicine (1)
United States (10) · Argentina (1) · Brazil (1) · Canada (1) · Croatia (1) · France (1) · Spain (1)
Mouen Khashab, MD (2) · Abhik Das, PhD (1) · Beena Sood, MD (1) · C. Michael Cotten, MD (1) · Giulherme M SantAnna, MD (1) · John Kinsella, MD (1) · John Muscedere, MD (1) · Jonathan M Klein, MD (1) · Krisa P Van Meurs, MD (1) · Leif Nelin, MD (1) · Martin Keszler, MD (1) · Michael DePietro, M.D. (1) · Namasivayam Ambalavanan, MD (1) · Nyssa Farrell, MD (1) · Pablo J Sanchez, MD (1)
PMID 15725047, PMID 19183804, PMID 23622977, PMID 25496504
U01HL102235 (1), U10HD021385 (1), U10HD027880 (1), U10HD027904 (1), U10HD034216 (1), U10HD036790 (1), U10HD040461 (1), U10HD040492 (1), U10HD040689 (1), U10HD053109 (1), U10HD068263 (1), U10HD068270 (1), U10HD068278 (1)