21 unknown, 20 completed, 18 recruiting, 5 not yet recruiting. 26 Not applicable, 2 Phase 4, 1 Phase 1, 1 Phase 2, 1 Phase 3.
Follow Defecation: new trials by email Literature Review of Defecation trials Research Report on Defecation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Assessing Residual Inflammation and Macrophage Presence in Lupus Nephritis After 3 Months of Intensified Treatment With Prednisolone, Mycofenolate Mofetil and Voclosporin as Compared to Mycofenolate Mofetil and Prednisolone Kidney Biopsy, Voclosporin (LUPKYNIS), Blood, feces and urine sample collection - Lupus Nephritis, Systemic Lupus Erythematosus (SLE) | Phase 4 | Recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 55 | 2026-04-23 | 2026-08-12 |
| Role of the Microbiota in Intestinal Adaptation During Short Bowel Syndrome collection of blood and stool/chyme and intestinal biopsy - Short Bowel Syndrome (SBS) | Not applicable | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 15 | 2026-04-01 | 2026-04-15 |
| Gut Microbiota, Diet-INDuced Obesity and Type 2 Diabetes in New Caledonia - MIND 25 ml blood sample, Urine sample, Stools - Diabetes Mellitus, Type 2, Obesity | Not yet recruiting | Institut Pasteur | 270 | 2026-02-15 | 2026-03-09 | |
| Research and Follow-up of the Determinants of the Progression and Complications of Inflammatory Bowel Diseases Treated or Not With Immunosuppressants. Blood, fecal, saliva, intestinal content samples and biopsies - Crohn, Ulcerative Colitis (UC) | Not applicable | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 4500 | 2025-09-01 | 2025-09-15 |
| Single-cell Immune Response to Controlled Gluten Ingestion in Pediatric Celiac Disease Placebo, Gluten 50 mg, Gluten 5 g - Celiac Disease, Gluten Sensitivity | Not applicable | Recruiting | Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud | 51 | 2025-07-07 | 2026-04-27 |
| Study of Sleep Disorders in Prodromal and Definite Parkinsons Disease Polysomnography - Parkinson Disease, REM Sleep Behavior Disorder (iRBD) | Not applicable | Recruiting | Assistance Publique - Hôpitaux de Paris | 457 | 2025-03-18 | 2026-03-06 |
| Genetic Carbohydrate Maldigestion As Model to Study Food Hypersensitivity Mechanism (WORK PACKAGE 2) Blood, stool and saliva collection, Questionnaire completion, Magnetic Resonance Imaging (MRI) and Breath test - Sucrase Isomaltase Deficiency | Not yet recruiting | University of Nottingham | 80 | 2025-03-01 | 2025-01-13 | |
| Effects of Bariatric Surgery on Cardiovascular Risk Profile in Relation to Inflammatory Parameters: Endothelial Phenotyping and Analysis of the Cross-talk Between Adipose Tissue and Endothelium Before bariatric surgery, both blood and biological samples (stool and urine) will be collected. Patients will also undergo a cardiology examination - Obesity (Disorder) | Not applicable | Recruiting | Maria Cecilia Hospital | 85 | 2024-11-11 | 2026-05-08 |
| AI-driven Narrow-band Imaging Score for Disease Assessment and Outcome Prediction in Ulcerative Colitis Colonoscopy after bowel cleansing, Intestinal biopsies, blood sampling - Ulcerative Colitis (UC) | Recruiting | University College Cork | 300 | 2024-11-04 | 2024-12-03 | |
| Predictive Role of Microbiome in Patients With Urothelial Carcinoma DNA extraction from urine, stool and biopsy. Isolation of serum and PBMC from peripheral blood. - Urinary Bladder Cancer | Not yet recruiting | IRCCS San Raffaele | 420 | 2024-11-01 | 2024-11-05 | |
| Association of Helicobacter Pylori Infection and Migraine Helicobacter pylori antigen in stool - Migraine in Children | Not applicable | Unknown | Sohag University | 50 | 2024-08-01 | 2024-08-26 |
| Genetic Carbohydrate Maldigestion as a Model to Study Food Hypersensitivity Stool and saliva sample collection, Questionnaire completion - Irritable Bowel Syndrome (IBS), Sucrase Isomaltase Deficiency | Active not recruiting | Nottingham University Hospitals NHS Trust | 2000 | 2024-07-23 | 2025-12-19 | |
| Alteration of Symbiosis Intestinal Microbiota on Patients With Anorexia Nervosa Stool and blood samples - Anorexia Nervosa, Dysbiosis | Recruiting | Assistance Publique - Hôpitaux de Paris | 120 | 2024-05-23 | 2025-11-24 | |
| AI-enabled Endoscopic Prediction of Post-operative Recurrence in Crohn's Disease Colonoscopy, Intestinal biopsies, Confocal laser endomicroscopy - Crohn Disease | Unknown | University College Cork | 225 | 2024-05-01 | 2024-07-18 | |
| Development of a New Rapid Diagnostic Test to Support Onchocerciasis Elimination Biological samples collection (blood drawing + feces) - Onchocerciasis, Loiasis | Not applicable | Completed | Bioaster | 1128 | 2024-04-15 | 2026-09-30 |
| Multi-omics Based Prediction of Treatment Response to Immunotherapy Combined with Chemotherapy in Advanced Gastric/Gastroesophageal Junction Cancer. Peripheral blood, tougue coating, saliva, and feces - Advanced Gastric Carcinoma, Advanced Gastroesophageal Junction Adenocarcinoma | Unknown | Xiangdong Cheng | 150 | 2024-03-25 | 2024-10-15 | |
| Investigation of the Influence of the Human Microbiome on Giant Cell Arteritis Analysis of blood and microbiome samples (stool, oral lavage) - Giant Cell Arteritis | Recruiting | University of Bonn | 50 | 2024-02-29 | 2024-05-09 | |
| A Study of Pembrolizumab With Trastuzumab and Chemotherapy in People With Esophagogastric Cancer Pembrolizumab, Trastuzumab, Oxaliplatin - Esophageal Cancer, Gastric Adenocarcinoma | Phase 2 | Recruiting | Memorial Sloan Kettering Cancer Center | 49 | 2024-02-01 | 2026-10-13 |
| Antibiotyping and Prevalence of Virulent Genotypes Among Helicobacter Pylori and Their Impact on Response to Therapy detection of vacuolating cytotoxin A (Vac A) and cytotoxin-associated gene A (Cag A) virulent H.Pylori genotypes by polymerase chain reaction amplification(PCR) in gastric biopsies :, Culture and sensitivity of endoscopic gastric biopsies:, Histopathological examination endoscopic gastric biopsies: - H Pylori Infection | Not applicable | Completed | Assiut University | 100 | 2024-01-20 | 2026-03-13 |
| Machine Learning Approach to Study the Interactions Between Environment and Intestinal Tissue Homeostasis in IBD Environmental factor monitoring; collection of blood, feces and urine. For UC: collection of 8 additional biopsies - Diabetes Mellitus, Type 1, Ulcerative Colitis | Unknown | IRCCS San Raffaele | 300 | 2023-11-01 | 2023-11-07 |
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Parkinson Disease (4) · COVID-19 (3) · Colitis, Ulcerative (3) · Irritable Bowel Syndrome (3) · Celiac Disease (2) · Communicable Diseases (2) · Crohn Disease (2) · Diabetes Mellitus, Type 1 (2) · Diabetes Mellitus, Type 2 (2) · Disease (2) · Dysbiosis (2) · Inflammatory Bowel Diseases (2) · Metabolic Diseases (2) · Milk Hypersensitivity (2) · Neoplasms (2)
Assistance Publique - Hôpitaux de Paris (7) · Asan Medical Center (2) · Bioaster (2) · IRCCS San Raffaele (2) · Institut Pasteur (2) · Memorial Sloan Kettering Cancer Center (2) · University College Cork (2) · University Ghent (2) · University Hospital, Toulouse (2) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Assiut University (1) · Centre Hospitalier Universitaire Dijon (1) · Chinese University of Hong Kong (1) · Corewell Health West (1) · Corporacion Parc Tauli (1)
France (20) · United States (11) · China (6) · Italy (5) · United Kingdom (5) · Belgium (4) · Germany (3) · South Korea (3) · Spain (3) · Canada (2) · Egypt (2) · Ireland (2) · Israel (2) · Netherlands (2) · Cameroon (1)
Ashok Sriram, MD, MS (1) · Carolina Sousa, Professor (1) · Colleen S Kraft, MD, MSc (1) · Corinne Miceli-Richard, MD, PhD (1) · Cosmin Voican, Dr (1) · George Raptis (1)
PMID 22258271, PMID 33029623, PMID 33538338, PMID 34197702, PMID 34840700, PMID 36825238, PMID 36854054, PMID 37427566, PMID 37495367, PMID 37667968, PMID 37910603, PMID 38084725, PMID 38446309, PMID 38798893, PMID 38843950, PMID 39148008, PMID 42105779
2025 (1), U01CA210138 (1)