370 completed, 242 unknown, 164 recruiting, 69 not yet recruiting. 317 Not applicable, 277 Phase 2, 90 Phase 3, 88 Phase 1, 6 Phase 4.
Follow Rectal Cancer: new trials by email Literature Review of Rectal Cancer trials Research Report on Rectal Cancer
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates High Rare Dose Rectal Brachytherapy Boost - Rectal Adenocarcinoma, Rectal Cancer | Phase 2 | Recruiting | University of Colorado, Denver | 44 | 2026-11-01 | 2026-09-02 |
| A Prospective, Biomarker-Stratified Phase 2 Study: β-Hydroxybutyrate as a Predictive Biomarker for Short-Course Radiotherapy Followed by Chemotherapy Plus PD-1 Inhibitor Versus Chemotherapy Alone in Locally Advanced Rectal Cancer Short-course radiotherapy, Capecitabine, Oxaliplatin - Rectal Cancer, Radiotherapy | Phase 2 | Not yet recruiting | Tao Zhang | 144 | 2026-11-01 | 2026-10-06 |
| Leveraging Digital Health Solutions to Collect Patient-Reported Outcomes in Rectal Cancer Quality of Life Surveys - Rectal Cancer, Non Metastatic Rectal Cancer | Not yet recruiting | University of California, San Francisco | 150 | 2026-10-31 | 2026-09-09 | |
| Efficacy of a Novel High Intensive Percutaneous Tibial Nerve Stimulation on Faecal Incontinence in Patients With Low Anterior Resection Cancer Syndrome After Rectal Cancer Surgery Percutaneous Tibial Nerve Stimulation - Faecal Incontinence With Faecal Urgency, Rectal Cancer | Not applicable | Not yet recruiting | Region Skane | 60 | 2026-10-05 | 2026-10-23 |
| ctDNA-Informed Management of Early-Stage Rectal Cancer Signatera Genome ultra-sensitive ctDNA blood test + total neoadjuvant therapy (TNT) - Rectal Adenocarcinoma, Rectal Cancer | Phase 2 | Not yet recruiting | University of California, Davis | 200 | 2026-10-01 | 2026-08-05 |
| Use of a Novel Camera to Check the Bowel After Polyp or Tumour Removal LumenEye X1 digital rectoscope - Bowel Cancer, Polyp Rectal | Not yet recruiting | University of Edinburgh | 30 | 2026-10-01 | 2026-08-26 | |
| A Phase 1 Study of DEM301 in Participants With Metastatic Colorectal Cancer DEM301 - Metastatic Colorectal Cancer, Colon Cancer | Phase 1 | Recruiting | DEM BioPharma, Inc. | 60 | 2026-10-01 | 2026-10-15 |
| Combining DCSZ11 With Radiation and Chemotherapy as Neoadjuvant Treatment for pMMR Locally Advanced Rectal Cancer DCSZ11, Radiation, Capecitabine - Rectal Cancer | Phase 2 | Not yet recruiting | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 30 | 2026-10-01 | 2026-07-28 |
| Multidimensional Study Designed to Develop a Methodological Framework Based on MRI Data to Predict Pathological Complete Response (pCR) in Patients With Locally Advanced Rectal Cancer After Neoadjuvant Treatment questionnaire completion - Rectal Cancer, Chemoradiotherapy | Not yet recruiting | Institut du Cancer de Montpellier - Val d'Aurelle | 115 | 2026-10-01 | 2026-09-14 | |
| ctDNA and Organ Preservation/Pathologic CR in Rectal Cancer ctDNA - Rectal Cancer, Non Metastatic Rectal Cancer | Not yet recruiting | Massachusetts General Hospital | 60 | 2026-10-01 | 2026-07-01 | |
| Improving Colorectal Cancer Screening Uptake Through Education and Stool-Based Testing Outreach Colorectal Cancer Education Materials, Cologuard test kit, Fecal immunochemical test kit - Colorectal Cancer (CRC) Screening, CRC Screening | Not applicable | Not yet recruiting | Washington University School of Medicine | 200 | 2026-09-30 | 2026-08-24 |
| External Beam Radiotherapy Combined With Endorectal High-dose-rate Brachytherapy in Elderly and Frail Patients With Rectal Cancer radiotherapy - Rectal Cancer | Not applicable | Not yet recruiting | University Hospital of Cologne | 80 | 2026-09-30 | 2026-05-01 |
| Examination of Rectal Blood Supply During Rectal Cancer Surgery Using Laser Speckle Contrast Imaging Laser speckle contrast imaging - Rectal Cancer, Total Mesorectal Excision | Not applicable | Not yet recruiting | University of Aarhus | 100 | 2026-09-01 | 2026-09-11 |
| Radiotherapy Combined With Capeox Chemotherapy, Sintilimab and Suvemcitug in Locally Advanced pMMR Rectal Cancer:a Prospective Clinical Trial Drug：sintilimab, Drug：Capecitabine, Drug：Suvemcitug - Rectal Cancer | Phase 2 | Not yet recruiting | Sun Yat-sen University | 18 | 2026-09-01 | 2026-08-19 |
| ABCSG R07 Rectal Cancer Registry Rectal Cancer, Adenocarcinoma of Rectum | Not yet recruiting | Austrian Breast & Colorectal Cancer Study Group | 600 | 2026-09-01 | 2026-09-17 | |
| SCARLET - Italian proSpeCtionAl obseRvationaL multicEntre Study on Treatment for recTal pT1 Cancer Rectal Cancer, Rectal Adenocarcinoma | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 196 | 2026-09-01 | 2026-07-10 | |
| Randomized Controlled Trial of the SurgDiff Model for Predicting Surgical Difficulty to Help Choose Approach in Mid-Low Rectal Cancer AI-assisted decision-making - Rectal Cancer | Not applicable | Not yet recruiting | Peking Union Medical College Hospital | 68 | 2026-08-30 | 2026-08-12 |
| Total Neoadjuvant mFOLFOX6 Plus Suvemcitug and Enlonstobart With Selective Omission of Pelvic Radiotherapy for High-Risk Mid-Rectal Locally Advanced Rectal Cancer mFOLFOX6, Suvemcitug, Enlonstobart - Rectal Cancer | Phase 2 | Not yet recruiting | Fudan University | 52 | 2026-08-28 | 2026-09-09 |
| Quality of Life of Patients After Rectal Cancer Resection . Rectal Cancer | Not yet recruiting | University Hospital, Grenoble | 22 | 2026-08-01 | 2026-08-13 | |
| Distribution and Analysis of Metastatic Lymph Nodes in Colorectal Cancer Patients (DIAMOND) Colon Cancer, Rectal Cancer | Not yet recruiting | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 1200 | 2026-07-01 | 2026-06-09 |
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