26 completed, 19 recruiting, 18 unknown, 9 not yet recruiting. 43 Not applicable, 9 Phase 2, 4 Phase 3, 1 Phase 1.
Follow Low Anterior Resection Syndrome: new trials by email Literature Review of Low Anterior Resection Syndrome trials Research Report on Low Anterior Resection Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Bowel Management Program (Retrograde Rectal Enema) for the Treatment of Low Anterior Resection Syndrome in Rectal Cancer Patients Dietary Fiber, Enema Administration, Loperamide Hydrochloride - Low Anterior Resection Syndrome, Rectal Carcinoma | Not applicable | Recruiting | Ohio State University Comprehensive Cancer Center | 80 | 2027-02-15 | 2026-10-06 |
| Efficacy of a Novel High Intensive Percutaneous Tibial Nerve Stimulation on Faecal Incontinence in Patients With Low Anterior Resection Cancer Syndrome After Rectal Cancer Surgery Percutaneous Tibial Nerve Stimulation - Faecal Incontinence With Faecal Urgency, Rectal Cancer | Not applicable | Not yet recruiting | Region Skane | 60 | 2026-10-05 | 2026-10-23 |
| Transanal Irrigation for the Management of Early Low Anterior Resection Syndrome (LARS) Peristeen Plus Irrigation kit, LARS mobile application - Colorectal Cancer, Low Anterior Resection Syndrome | Not applicable | Not yet recruiting | Case Comprehensive Cancer Center | 60 | 2026-10-01 | 2026-08-18 |
| Evaluating the Optimal Timing of Trans-Anal Irrigation for Low Anterior Resection Syndrome Post-rectal Cancer Surgery Water-based transanal irrigation system - Low Anterior Resection Syndrome (LARS) | Not applicable | Not yet recruiting | Simona Ascanelli | 250 | 2026-09-01 | 2026-07-10 |
| Early Implementation of Sacral Neuromodulation in Patients With Low Anterior Resection Syndrome. Sacral neuromodulation - Low Anterior Resection Syndrome (LARS) | Not applicable | Not yet recruiting | Hospital Universitari Vall d'Hebron Research Institute | 40 | 2026-08-01 | 2026-08-12 |
| Antegrade Intestinal Fluid Reinfusion for Prevention of Low Anterior Resection Syndrome After Low Anterior Resection: a Single-Center, Prospective Randomized Controlled Trial. intestinal fluid infusion, potable water - Low Anterior Resection Syndrome, Rectal Cancer | Phase 2 / Phase 3 | Recruiting | Pei-Rong Ding | 160 | 2026-04-10 | 2026-04-17 |
| Efficacy and Safety of Transcutaneous Posterior Tibial Nerve Stimulation on Fecal Continence in Patients Undergoing Surgery for Rectal Neoplasia Posterior tibial nerve stimulation intervention group, Control group - Low Anterior Resection Syndrome (LARS), Rectal Neoplasm Malignant | Not applicable | Recruiting | Althaia Xarxa Assistencial Universitària de Manresa | 84 | 2026-02-06 | 2026-06-08 |
| The Effects of Kegel Exercise Combined With Biofeedback Therapy on Bowel Function Recovery, Emotional Distress, and Quality of Life in Patients Following Low Anterior Resection for Rectal Cancer Kegel Exercise with Biofeedback, Kegel Exercise Only - Rectal Cancer, Low Anterior Resection Syndrome | Not applicable | Enrolling by invitation | National Taiwan University Hospital | 66 | 2026-01-05 | 2026-05-11 |
| Aerobic Exercise and Guided Imagery in Low Anterior Resection Syndrome Exercise, guided imagery - Rectal Cancer, Fecal Incontinence and Constipation | Not applicable | Recruiting | Biruni University | 50 | 2025-12-30 | 2026-07-29 |
| Improving Functional Outcomes and Quality of Life in Patients With Rectal Cancer After Surgery With Intensified Follow-up & Surveillance Intensified follow-up program - LARS - Low Anterior Resection Syndrome, Rectal Cancer Surgery | Phase 3 | Recruiting | University Hospital, Basel, Switzerland | 140 | 2025-12-01 | 2026-05-06 |
| Effect of Thread Embedding Acupuncture on Postoperative Ileus Recovery After Colorectal Cancer Surgery: A Multicenter Randomized Controlled Trial Thread Embedding Acupuncture+Electroacupuncture, Electroacupuncture - Colorectal Cancer, Postoperative Ileus | Not applicable | Recruiting | Northern Jiangsu People's Hospital | 300 | 2025-08-01 | 2025-07-18 |
| The Efficacy of Antegrade and Retrograde Enemas Management in Low Anterior Resection Syndrome and Improving the Rate of Ileostomy Reversal antegrade enema, retrograde enema - LARS - Low Anterior Resection Syndrome | Not applicable | Not yet recruiting | Sichuan Cancer Hospital and Research Institute | 72 | 2025-07-20 | 2025-07-24 |
| Knowledge-enhanced Digital Intervention to Prevent Low Anterior Resection Syndrome Mobile app, standard - Rectal Neoplasm | Not applicable | Not yet recruiting | National Cancer Center, Korea | 320 | 2025-07-01 | 2025-06-27 |
| Personalized Care Pathways for Bowel Symptoms in Rectal Cancer Patients_contributing Factors (Treatable) Electronic bowel diary, Faecal Incontinence Quality of Life questionnaire (FIQL), EuroQoL 5 dimensions, 5 levels (EQ-5D-5L) - Rectal Cancer, LARS - Low Anterior Resection Syndrome | Not applicable | Recruiting | KU Leuven | 150 | 2025-04-28 | 2026-01-23 |
| Autologous Fecal Microbiota Transplantation for Anal Function Recovery After Ileostomy Reversal in Rectal Cancer Autologous Fecal Microbiota Transplantation - Rectal Cancer, Low Anterior Resection Syndrome | Not applicable | Active not recruiting | Peking University People's Hospital | 35 | 2025-03-25 | 2026-07-17 |
| Retrograde and Antegrade Enema for Prevention of LARS After LAR: a Randomized Controlled Trial transanal irrigation, antegrade enema - Low Anterior Resection Syndrome | Not applicable | Not yet recruiting | Sichuan Cancer Hospital and Research Institute | 72 | 2025-03-25 | 2025-03-30 |
| Transanal Irrigation for Low Anterior Resection Syndrome Transanal Irrigation (TAI) - Low Anterior Resection Syndrome, Rectal Cancer Surgery | Not applicable | Not yet recruiting | Seoul National University Hospital | 94 | 2025-02-01 | 2025-01-28 |
| Total Neoadjuvant Therapy and Organ Preservation Versus Surgery for Rectal Cancer. Radiation Therapy, Chemoradiotherapy, Consolidation Chemotherapy - Rectal Cancer, Total Neoadjuvant Treatment | Phase 2 / Phase 3 | Recruiting | National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos | 400 | 2025-01-06 | 2026-05-11 |
| Bowel Dysfunction After Low Rectal Resection. An Pilot Study Using Psyllium Husk In Rectal Cancer Patients. Psyllium husk - Low Anterior Resection Syndrome, Quality of Life (QOL) | Not applicable | Completed | Sykehuset Telemark | 24 | 2025-01-01 | 2026-05-11 |
| Fecal Microbiota Transplantation in the Treatment of Major LARS fecal microbiota transplantation, Formulated probiotic supplements - Low Anterior Resection Syndrome, Fecal Microbiota Transplantation | Not applicable | Not yet recruiting | Peking University People's Hospital | 40 | 2025-01-01 | 2024-06-26 |
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Rectal Neoplasms (50) · Encopresis (7) · Fecal Incontinence (7) · Colorectal Neoplasms (6) · Intestinal Diseases (5) · Sleep Initiation and Maintenance Disorders (3) · Anastomotic Leak (2) · Constipation (2) · Ovarian Neoplasms (2) · Patient Participation (2) · Anus Neoplasms (1) · Behavior (1) · Colonic Neoplasms (1) · Ejaculatory Dysfunction (1)
Colonic Diseases (80) · Digestive System Diseases (80) · Gastrointestinal Diseases (80) · Pathologic Processes (80) · Pathological Conditions, Signs and Symptoms (80) · Postoperative Complications (79) · Rectal Diseases (79) · Intestinal Diseases (75) · Neoplasms (58) · Neoplasms by Site (58) · Digestive System Neoplasms (57) · Gastrointestinal Neoplasms (57) · Intestinal Neoplasms (57) · Colorectal Neoplasms (51) · Signs and Symptoms (11)
Botulinum Toxins, Type A (2) · Exercise (2) · Interviews as Topic (2) · Surveys and Questionnaires (2) · Acupuncture Therapy (1) · Biofeedback, Psychology (1) · Chemoradiotherapy (1) · Consolidation Chemotherapy (1) · Control Groups (1) · Cytoreduction Surgical Procedures (1) · Device Removal (1) · Dietary Fiber (1) · Dosage Forms (1) · Drinking Water (1) · Electroacupuncture (1)
National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos (5) · Seoul National University Hospital (5) · Jewish General Hospital (4) · Sixth Affiliated Hospital, Sun Yat-sen University (4) · University Hospital, Ghent (3) · Cardiff and Vale University Health Board (2) · Hadassah Medical Organization (2) · Hospital Universitari Vall d'Hebron Research Institute (2) · KU Leuven (2) · Northern Jiangsu People's Hospital (2) · Peking University People's Hospital (2) · Region Skane (2) · Sichuan Cancer Hospital and Research Institute (2) · University of Aarhus (2) · Aalborg University Hospital (1)
China (11) · Spain (8) · Denmark (6) · South Korea (6) · Belgium (5) · Canada (5) · Lithuania (5) · United States (4) · Italy (3) · Sweden (3) · Austria (2) · France (2) · Israel (2) · Taiwan (2) · United Kingdom (2)
Inge Geraerts, PhD (2) · Qiyuan Qin, M.D. (2) · Alessandra C Gasior, DO (1) · Antonino Spinelli, MD,PhD (1) · Audrius Dulskas, PhD (1) · Carole S Richard, MD FCRSC (1) · Cheng-Le Zhuang, MD, PhD (1) · Craig A Messick, MD (1) · Daniel Steinemann, Deputy chief physician (1) · Felix Aigner, Prof. Dr. (1) · Franco Marinello, MD, PhD (1) · Gernot Hudelist, MD, MSc (1) · Guillaume Meurette, MD (1)
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