193 completed, 160 unknown, 80 recruiting, 50 terminated. 272 Phase 2, 112 Phase 3, 86 Not applicable, 43 Phase 1, 11 Phase 4.
Follow Neoadjuvant Therapy: new trials by email Literature Review of Neoadjuvant Therapy trials Research Report on Neoadjuvant Therapy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| CCR5 Targeting Leronlimab in Combination With Hepatic Arterial Infusion Floxuridine and Systemic Therapy for the Treatment of Colorectal Cancer Liver Metastases, CHAMP Trial Biopsy Procedure, Biospecimen Collection, Computed Tomography - Metastatic Colorectal Carcinoma, Metastatic Malignant Neoplasm in the Liver | Phase 1 | Not yet recruiting | City of Hope Medical Center | 36 | 2027-05-06 | 2026-09-25 |
| A Prospective Study of Concurrent Hyperthermia, Chemotherapy and Radiotherapy in Borderline and Locally Advanced Pancreatic Cancer (PANHEAT) Hyperthermia plus neoadjuvant chemotherapy/radiotherapy Arm Description: Hyperthermia plus neoadjuvant chemotherapy (mFOLFIRINOX/nab Paclitaxel) followed by a) surgically resectable: Hyp - Borderline and Locally Advanced Pancreatic Cancer | Not applicable | Not yet recruiting | Fernando Pessoa Canarias University | 60 | 2027-03-31 | 2026-09-24 |
| Testing Repeat Radiation Therapy for Recurrent Non-small Cell Lung Cancer Biospecimen Collection, Computed Tomography, Immunotherapy - Locally Recurrent Lung Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8 | Phase 2 | Not yet recruiting | NRG Oncology | 138 | 2026-12-18 | 2026-09-23 |
| Intestinal Low-Dose Radiotherapy Combined With Immune Checkpoint Inhibitors in Solid Tumors With Liver Metastases Intestinal Low-Dose Radiotherapy (ILDR), PD-1/PD-L1 inhibitors, Combined Chemotherapy - Liver Metastases, Non-Small Cell Lung Cancer | Phase 2 | Not yet recruiting | Bing Xia | 120 | 2026-10-01 | 2026-10-15 |
| Becotatug Vedotin Plus Pucotenlimab and Capecitabine Followed by Concurrent Chemoradiotherapy-Immunotherapy for Locally Advanced Squamous Cell Carcinoma of the Anal Canal Induction therapy, Concurrent chemoradiotherapy-immunotherapy, Maintenance therapy - Squamous Cell Carcinoma of the Anal Canal | Phase 2 | Not yet recruiting | Wang Xin | 34 | 2026-09-20 | 2026-09-08 |
| Prediction Of Lymphedema In Patients With Inflammatory BreastCancer Using Preoperative Bioimpedance Measurements Neoadjuvant therapy - Lymphedema, Inflammatory Breast Cancer (IBC) | Recruiting | M.D. Anderson Cancer Center | 150 | 2026-09-16 | 2026-10-02 | |
| Neoadjuvant Complete Response Customized Treatment Approach for Definitive Management of Breast Cancer Neoadjuvant Chemotherapy, Radiation Therapy, MRI - Breast Cancer, HER2-positive Breast Cancer | Phase 1 / Phase 2 | Not yet recruiting | Ohio State University Comprehensive Cancer Center | 84 | 2026-09-15 | 2026-06-24 |
| Neoadjuvant Iruplinalkib and Bevacizumab in ALK-positive NSCLC: A Phase II Single-arm Trial Bevacizumab combined with iruplinalkib as neoadjuvant therapy in ALK-positive NSCLC: - ALK, NSCLC | Not applicable | Not yet recruiting | Shanghai Pulmonary Hospital, Shanghai, China | 40 | 2026-09-15 | 2026-10-13 |
| Radiotherapy Combined With Capeox Chemotherapy, Sintilimab and Suvemcitug in Locally Advanced pMMR Rectal Cancer:a Prospective Clinical Trial Drug：sintilimab, Drug：Capecitabine, Drug：Suvemcitug - Rectal Cancer | Phase 2 | Not yet recruiting | Sun Yat-sen University | 18 | 2026-09-01 | 2026-08-19 |
| Two Modalities of Ventilation on the Occurrence of Respiratory Complications During Inhalational Anaesthetic Induction in Children Induction with PEEP (5 cmH2O) and PSV (2-12 cmH2O), Induction in spontaneous breathing - Anaesthetic Induction, Respiratory Complications of Care | Not applicable | Not yet recruiting | Hospices Civils de Lyon | 2032 | 2026-09-01 | 2026-08-17 |
| Partial Cystectomy & Extended Pelvic Lymph Node Dissection With SOC Perioperative Systemic Therapy Neoadjuvant Chemotherapy, Partial cystectomy with Extended pelvic lymph node dissection, Adjuvant systemic therapy - Malignant Neoplasm of Bladder, Muscle Invasive Bladder Carcinoma | Phase 2 | Withdrawn | Case Comprehensive Cancer Center | 2026-09-01 | 2026-09-24 | |
| GI-05: The Impact of Olanzapine Among Patients Receiving Neoadjuvant Chemotherapy for Gastric Cancer Neoadjuvant chemotherapy, Olanzapine - Gastric Adenocarcinoma, Gastric Cancer | Phase 2 | Not yet recruiting | University of Illinois at Chicago | 26 | 2026-09-01 | 2026-08-21 |
| Penpulimab Combined With Chemotherapy for Patients With Locally Advanced Hypopharyngeal Carcinoma Finotonlimab, Nab-paclitaxel, carboplatin - Head & Neck Cancer | Phase 2 | Not yet recruiting | Tang-Du Hospital | 15 | 2026-08-23 | 2026-08-07 |
| Neoadjuvant Disitamab Vedotin, Toripalimab, and Radiotherapy for High-risk UTUC ( LUXUS07.1 ) Neoadjuvant radiotherapy, ADC + PD1 monoclonal antibody - Urothelial Carcinoma of the Renal Pelvis and Ureter, Neoadjuvant Therapy | Phase 2 | Not yet recruiting | Peking University First Hospital | 20 | 2026-08-01 | 2026-07-22 |
| Luminal Bladder Cancer Effective Response to Neoadjuvant Chemotherapy (LUMBER-NAC) Neoadjuvant Therapy, Upfront radical cystectomy - Bladder Cancer | Phase 2 | Recruiting | Rutgers, The State University of New Jersey | 60 | 2026-07-10 | 2026-08-13 |
| Preoperative Radiotherapy and Anlotinib With or Without Penpulimab for Soft Tissue Sarcoma Anlotinib, Penpulimab, Preoperative Radiotherapy - Soft Tissue Sarcoma (STS) | Phase 2 | Not yet recruiting | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 274 | 2026-07-01 | 2026-05-28 |
| Cadonilimab Plus Chemotherapy in LACC: A Prospective, Multicenter, Randomized Phase II Trial Neoadjuvant Therapy Plus Surgery, Concurrent Chemoradiotherapy - Cervical Cancer | Phase 2 | Not yet recruiting | Obstetrics & Gynecology Hospital of Fudan University | 134 | 2026-06-06 | 2026-06-16 |
| Iparomlimab and Tuvonralimab Plus Chemotherapy as Neoadjuvant Therapy for Ovarian Cancer（Phase II） Neoadjuvant Therapy Plus Surgery - Ovarian Cancer | Phase 2 | Not yet recruiting | Obstetrics & Gynecology Hospital of Fudan University | 49 | 2026-06-06 | 2026-06-29 |
| Neoadjuvant Ivonescimab（AK112） Combined With Chemotherapy in Patients With Resectable Esophageal Squamous Cell Carcinoma Ivonescimab（AK112), Albumin paclitaxel, carboplatin AUC=5, neoadjuvant therapy, Esophagectomy, Sample - Esophageal Squamous Cell Carcinoma, Neoadjuvant Therapy | Phase 2 | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 49 | 2026-06-03 | 2026-10-02 |
| Multimodal Ablation Combined With Perioperative Tislelizumab and Chemotherapy for Resectable II-IIIB NSCLC Multimodal Ablation, Neoadjuvant therapy, Surgery - NSCLC | Phase 2 | Not yet recruiting | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 42 | 2026-06-01 | 2026-07-27 |
Showing 20 of 575. Sign in to see all of them.
Breast Neoplasms (97) · Colorectal Neoplasms (47) · Rectal Neoplasms (46) · Carcinoma, Non-Small-Cell Lung (32) · Esophageal Neoplasms (28) · Esophageal Squamous Cell Carcinoma (25) · Stomach Neoplasms (22) · Lung Neoplasms (21) · Pancreatic Neoplasms (20) · Colonic Neoplasms (18) · Squamous Cell Carcinoma of Head and Neck (18) · Neoplasms (16) · Sarcoma (16) · Adenocarcinoma Of Esophagus (15) · Head and Neck Neoplasms (15)
Sun Yat-sen University (18) · European Organisation for Research and Treatment of Cancer - EORTC (13) · Second Affiliated Hospital, Zhejiang University, School of Medicine (11) · Roswell Park Cancer Institute (10) · Memorial Sloan Kettering Cancer Center (9) · Fudan University (8) · National Cancer Institute (NCI) (8) · Cancer Institute and Hospital, Chinese Academy of Medical Sciences (7) · Assiut University (6) · Barbara Ann Karmanos Cancer Institute (6) · First Affiliated Hospital of Zhejiang University (6) · Mayo Clinic (6) · Shanghai Zhongshan Hospital (6) · Zhejiang Cancer Hospital (6) · Case Comprehensive Cancer Center (5)
China (172) · United States (148) · France (46) · United Kingdom (40) · Germany (28) · Canada (24) · Spain (23) · Italy (22) · Netherlands (22) · Belgium (18) · Egypt (16) · Switzerland (16) · South Korea (15) · Japan (12) · Austria (11)
A. Bapsi Chakravarthy, MD (3) · Ann Barrett (3) · Andrew David J. Pearson, MD, FRCP, DCh (2) · Bernard Nordlinger, MD (2) · David Cunningham, MD (2) · David J. Adelstein, MD (2) · Fernando Cabanillas, MD (2) · Florian Lordick, MD (2) · Helena Earl, MBBS, PhD, FRCP (2) · Janice A. Kohler, MD, FRCP (2) · Jia Fan, MD & PhD (2) · John N. Primrose, MD (2) · Kim N. Chi, MD (2) · Lei Tao, Dr. (2) · Lijie Tan, MD (2)
PMID 24982463, PMID 38979716, PMID 20818904, PMID 40197799, PMID 10030449, PMID 1026855, PMID 10580511, PMID 10646846, PMID 10813118, PMID 11302933, PMID 11478689, PMID 11813623, PMID 11814066, PMID 11814067, PMID 11937133, PMID 14211150, PMID 14530720, PMID 15192785, PMID 1581359, PMID 15949912, PMID 16145049, PMID 16170164, PMID 1629283, PMID 16399443, PMID 16524973, PMID 16791447, PMID 16921048, PMID 17030548, PMID 17401004, PMID 17544497, PMID 17882490, PMID 17971585, PMID 18024211, PMID 18026089, PMID 18191265, PMID 18191528, PMID 18320278, PMID 18358928, PMID 18372134, PMID 18417462, PMID 18418009, PMID 18565686, PMID 18751418, PMID 18779504, PMID 18801470, PMID 18845990, PMID 19176454, PMID 19181369, PMID 19231157, PMID 19269519
P30CA015083 (7), P30CA022453 (4), P30CA033572 (4), P30CA043703 (4), P30CA006927 (3), P30CA036727 (3), 2004 (2), 2008 (2), 2009 (2), 2015 (2), 2018 (2), 2025 (2), N01CM00071 (2), P30CA008748 (2), P30CA069533 (2)