12 recruiting, 7 completed, 5 not yet recruiting, 3 active not recruiting. 31 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 31 | Recruiting 12, Completed 7, Not yet recruiting 5, Active not recruiting 3, Unknown 3, Enrolling by invitation 1 |
Follow Primary Aldosteronism: new trials by email Literature Review of Primary Aldosteronism trials Research Report on Primary Aldosteronism
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| [11C]Metomidate PET-CT vs Usual Care for People With Primary Aldosteronism: a Proof-of-concept Study [11C] Metomidate PETCT, Adrenal Venous Sampling - Primary Aldosteronism | Not applicable | Recruiting | Chinese University of Hong Kong | 32 | 2026-11-01 | 2026-10-26 |
| Comparing Inclisiran Versus Statin for Primary Aldosteronism inclisiran, Lipophilic statins (such as Simvastatin, Atorvastatin, Fluvastatin, Lovastatin,Pitavastatin), Spironolactone (drug) - Primary Aldosteronism | Not applicable | Recruiting | Third Military Medical University | 50 | 2026-10-01 | 2026-10-21 |
| Regular Sauna Use to Lower Blood Pressure in Primary Aldosteronism sauna session - Primary Aldosteronism, Hypertension | Not applicable | Not yet recruiting | University of Calgary | 10 | 2026-09-30 | 2026-08-31 |
| Baxdrostat and Molecular Imaging of Adrenal Cytoreduction in Primary Aldosteronism baxdrostat - Primary Aldosteronism | Not applicable | Not yet recruiting | Queen Mary University of London | 30 | 2026-09-15 | 2026-09-02 |
| Endoscopic Ultrasound-Guided Ethanol Ablation for Aldosterone-Producing Adenoma Endoscopic Ultrasound-Guided Ethanol Ablation - Primary Aldosteronism, Aldosterone-Producing Adenoma | Not applicable | Not yet recruiting | Chongqing Medical University | 30 | 2026-07-15 | 2026-07-14 |
| Intensive vs. Standard Blood Pressure Control in Primary Aldosteronism Intensive BP control, Standard BP control - Primary Aldosteronism | Not applicable | Recruiting | Chongqing Medical University | 3830 | 2026-07-07 | 2026-09-21 |
| EndoSense: Continuous Real-Time Monitoring of Health Markers in Endocrine and Metabolic Disorders Sequential Dietary Sodium Modulation - Endocrine Disorders, Hypertension | Not applicable | Active not recruiting | Felix Beuschlein | 100 | 2026-07-03 | 2026-07-27 |
| Efficacy and Safety of Finerenone Compared to Spironolactone in Treatment of Primary Aldosteronism Finerenone - Primary Aldosteronism, Endocrine Hypertension | Not applicable | Recruiting | Bangladesh Medical University | 104 | 2026-04-15 | 2026-07-07 |
| Genetic Predisposition to High Blood Pressure Adrenalectomy - Hypertension, Primary Aldosteronism | Not applicable | Enrolling by invitation | Linkoeping University | 76 | 2026-01-01 | 2026-02-02 |
| Sequential Combined Versus Single-Strategy Adrenal Venous Sampling for Primary Aldosteronism(SCOPE) sequential combined AVS - Primary Aldosteronism | Not applicable | Recruiting | Shumin Yang | 456 | 2025-12-25 | 2025-12-24 |
| PETAL Trial: Impact of Gallium-68 Pentixafor PET-CT on Surgical Outcomes in Primary Aldosteronism 68Ga-pentixafor PET/CT - Primary Aldosteronism, Secondary Hypertension | Not applicable | Recruiting | Seoul National University Hospital | 90 | 2025-06-25 | 2025-06-18 |
| Continuous Steroid Monitoring in Interstitial Fluid With Wearable and Nanoparticle-enhanced Biosensors for Improved Management of Adrenal Disorders Participants will use the biossensor for 48 h - Cushing Syndrome, Primary Aldosteronism | Not applicable | Not yet recruiting | University of Sao Paulo General Hospital | 246 | 2025-06-01 | 2025-05-20 |
| The Comparison of Single Catheter and Double Catheter Adrenal Vein Sampling Methods Based on the Upper Limb Approach Single catheter adrenal vein sampling, Double catheters adrenal vein sampling - Primary Aldosteronism | Not applicable | Not yet recruiting | Army Medical University, China | 70 | 2024-12-30 | 2024-12-17 |
| 68Ga-Pentixafor PET/CT Versus Adrenal Vein Sampling in Diagnosing Unilateral Subtype of Primary Aldosteronism Concurrent With Autonomous Cortisol Secretion (PREDICT) 68Ga-Pentixafor PET/CT, AVS - Primary Aldosteronism, Autonomous Cortisol Secretion | Not applicable | Recruiting | Qifu Li | 178 | 2024-08-01 | 2026-02-05 |
| Primary Aldosteronism: Superselective Embolization vs. Laparoscopic Endocrine Curative Therapy Superselective adrenal artery embolization or adrenalectomy - Primary Aldosteronism, Suprarenalectomy | Not applicable | Recruiting | Xinjiang Medical University | 570 | 2024-08-01 | 2025-04-15 |
| REnin-guided TherApy With MinEralocorticoid Receptor Antagonists in Primary Aldosteronism - Feasibility Study Renin measurements - Primary Aldosteronism | Not applicable | Recruiting | Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal | 58 | 2024-04-25 | 2026-03-17 |
| Electronic Alert to Improve Testing For Primary Aldosteronism in Patients With Hypertension Best Practice Advisory Computerized Alert - Primary Aldosteronism, Resistant Hypertension | Not applicable | Active not recruiting | Brigham and Women's Hospital | 12501 | 2024-03-13 | 2026-11-03 |
| 68Ga-Pentixafor PET/CT Versus Adrenal Vein Sampling in Primary Aldosteronism: The GAPA Randomized Clinical Trial 68Ga-Pentixafor PET/CT - Primary Aldosteronism | Not applicable | Completed | Chongqing Medical University | 320 | 2024-01-09 | 2026-09-25 |
| A Single Center Randomized Controlled Study on the Promotion of Rapid Recovery Tubeless laparoscopic adrenalectomy, Drainage tube - Nonfunctional Adrenal Cortex Adenoma, Primary Aldosteronism | Not applicable | Recruiting | Zhe Meng | 200 | 2024-01-03 | 2024-02-13 |
| Effect of a Proposed Cav1.3 Inhibitor in Primary Aldosteronism Cinnarizine, NIFEdipine ER - Primary Aldosteronism, Endocrine Hypertension | Not applicable | Completed | Queen Mary University of London | 15 | 2023-04-24 | 2024-07-08 |
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Hyperaldosteronism (31) · Hypertension (6) · Adrenocortical Adenoma (3) · Cushing Syndrome (3) · ACTH Syndrome, Ectopic (2) · Adrenal Insufficiency (1) · Atrial Fibrillation (1) · Endocrine System Diseases (1) · Genetic Predisposition to Disease (1) · Obesity (1) · Overweight (1) · Ventricular Remodeling (1)
Adrenal Gland Diseases (31) · Adrenocortical Hyperfunction (31) · Endocrine System Diseases (30) · Cardiovascular Diseases (7) · Vascular Diseases (6) · Neoplasms (5) · Pathological Conditions, Signs and Symptoms (4) · Adrenal Cortex Diseases (3) · Adrenal Cortex Neoplasms (3) · Adrenal Gland Neoplasms (3) · Endocrine Gland Neoplasms (3) · Neoplasms by Site (3) · Paraneoplastic Endocrine Syndromes (2) · Paraneoplastic Syndromes (2) · Pathologic Processes (2)
Adrenalectomy (2) · Spironolactone (2) · ALN-PCS (1) · Adrenocorticotropic Hormone (1) · Amlodipine (1) · Atorvastatin (1) · Cinnarizine (1) · Dexamethasone (1) · Fluvastatin (1) · Lovastatin (1) · Nifedipine (1) · Pharmaceutical Preparations (1) · Radiofrequency Ablation (1) · Simvastatin (1) · Tablets (1)
Chongqing Medical University (4) · Queen Mary University of London (3) · Third Military Medical University (2) · Army Medical University, China (1) · Bangladesh Medical University (1) · Brigham and Women's Hospital (1) · Centre Hospitalier de PAU (1) · Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal (1) · Chinese University of Hong Kong (1) · Daiichi Sankyo Co., Ltd. (1) · Felix Beuschlein (1) · Haukeland University Hospital (1) · Linkoeping University (1) · Qifu Li (1) · Second Affiliated Hospital of Nanchang University (1)
China (13) · United Kingdom (4) · France (2) · Bangladesh (1) · Brazil (1) · Canada (1) · Hong Kong (1) · Japan (1) · Norway (1) · South Korea (1) · Sweden (1) · Switzerland (1) · United States (1)
Shumin Yang, MD, PhD (2) · Felix Beuschlein, Prof. Dr. med. (1) · Jenifer M Brown, MD (1) · Li Li, MD (1) · Liang Deng, MD, PhD (1) · Marianne Grytaas, MD phd (1) · Mark Gurnell, PhD, FRCP (1) · Morris Brown (1) · Morris Brown, MD FRCP (1) · Morris J Brown, FMedSci, FRS (1) · Qifu Li (1) · Qifu Li, MD, PhD (1)
PMID 26934393, PMID 28576687, PMID 32327102, PMID 36795418, PMID 15657580, PMID 17161262, PMID 21828936, PMID 29279316, PMID 29987110, PMID 32890265, PMID 35218017, PMID 37870836, PMID 16508586, PMID 18398342, PMID 19349554, PMID 21270113, PMID 22331382, PMID 22743644, PMID 23603377, PMID 25002246, PMID 26199389, PMID 26760044, PMID 27315757, PMID 27325147, PMID 28385310, PMID 28420172, PMID 29129575, PMID 30403797, PMID 30590677, PMID 30601318, PMID 31176302, PMID 31536622, PMID 32206838, PMID 32355223, PMID 32403203, PMID 33196558, PMID 33447758, PMID 33796078, PMID 33993726, PMID 35418526, PMID 35487459, PMID 35881462, PMID 36070424, PMID 36380152, PMID 36974473, PMID 38167540, PMID 39207956, PMID 39626105, PMID 39824204, PMID 39884776
2018 (1), 2025 (1), R01HL153004 (1)